BRPI0813237A2 - Composto, método para preparar o composto, composição, medicamento, e, uso do composto. - Google Patents

Composto, método para preparar o composto, composição, medicamento, e, uso do composto.

Info

Publication number
BRPI0813237A2
BRPI0813237A2 BRPI0813237-2A2A BRPI0813237A BRPI0813237A2 BR PI0813237 A2 BRPI0813237 A2 BR PI0813237A2 BR PI0813237 A BRPI0813237 A BR PI0813237A BR PI0813237 A2 BRPI0813237 A2 BR PI0813237A2
Authority
BR
Brazil
Prior art keywords
compound
medicine
composition
preparing
preparing compound
Prior art date
Application number
BRPI0813237-2A2A
Other languages
English (en)
Inventor
Goldmann Siegfried
Jing Li
Yisong Liu
Original Assignee
Zhongneng Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40155886&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0813237(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zhongneng Zhang filed Critical Zhongneng Zhang
Publication of BRPI0813237A2 publication Critical patent/BRPI0813237A2/pt
Publication of BRPI0813237B1 publication Critical patent/BRPI0813237B1/pt
Publication of BRPI0813237B8 publication Critical patent/BRPI0813237B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0813237A 2007-06-18 2008-06-18 composto, método para preparar o composto, medicamento, e, uso do composto BRPI0813237B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200710119019 2007-06-18
PCT/CN2008/001187 WO2008154817A1 (en) 2007-06-18 2008-06-18 Bromo-phenyl substituted thiazolyl dihydropyrimidines

Publications (3)

Publication Number Publication Date
BRPI0813237A2 true BRPI0813237A2 (pt) 2014-12-23
BRPI0813237B1 BRPI0813237B1 (pt) 2020-01-07
BRPI0813237B8 BRPI0813237B8 (pt) 2021-05-25

Family

ID=40155886

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0813237A BRPI0813237B8 (pt) 2007-06-18 2008-06-18 composto, método para preparar o composto, medicamento, e, uso do composto

Country Status (14)

Country Link
US (4) USRE45004E1 (pt)
EP (2) EP2159224B1 (pt)
JP (2) JP5361879B2 (pt)
KR (1) KR101173892B1 (pt)
CN (2) CN101328171A (pt)
AU (1) AU2008265397C1 (pt)
BR (1) BRPI0813237B8 (pt)
CA (1) CA2691056C (pt)
DK (2) DK2514750T5 (pt)
ES (2) ES2442907T3 (pt)
PL (2) PL2514750T3 (pt)
PT (2) PT2514750E (pt)
RU (1) RU2443703C2 (pt)
WO (1) WO2008154817A1 (pt)

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PT2514750E (pt) 2007-06-18 2014-01-23 Sunshine Lake Pharma Co Ltd Tiazolil dihidropirimidinas substituídas com bromo-fenilo
WO2010069147A1 (zh) * 2008-12-17 2010-06-24 张中能 二氢嘧啶类化合物、其组合物及其应用
CN101744823B (zh) * 2008-12-17 2013-06-19 广东东阳光药业有限公司 一种二氢嘧啶类化合物的固体分散体及其药用制剂
CN101575318B (zh) * 2009-06-25 2012-02-08 中国人民解放军军事医学科学院毒物药物研究所 二氢嘧啶类化合物及其用于制备治疗和/或预防病毒性疾病的药物的用途
AR089671A1 (es) 2012-01-06 2014-09-10 Janssen R & D Ireland 1,4-dihidropirimidinas 4,4-disustituidas y su uso como medicamentos para el tratamiento de la hepatitis b
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
MY182403A (en) 2012-08-24 2021-01-25 Sunshine Lake Pharma Co Ltd Dihydropyrimidine compounds and their application in pharmaceuticals
CN103664897B (zh) * 2012-09-01 2018-04-03 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
CN103664925B (zh) * 2012-09-07 2018-01-23 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
CA2881322A1 (en) * 2012-09-10 2014-03-13 F. Hoffmann-La Roche Ag 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CN103664899B (zh) * 2012-09-11 2017-06-16 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
CN103724339B (zh) 2012-09-27 2015-10-14 广东东阳光药业有限公司 二氢嘧啶衍生物的晶型
MX2015013363A (es) * 2013-03-20 2016-01-08 Univ Indiana Res & Tech Corp Heteroarildihidropirimidina (hap) fluorescente: tinte de diagnostico para nucleos de virus de la hep b (hbv) en celulas.
CA2920415A1 (en) 2013-11-19 2015-05-28 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
KR102284944B1 (ko) * 2013-11-27 2021-08-03 선샤인 레이크 파르마 컴퍼니 리미티드 다이하이드로피리미딘 유도체 및 이의 중간산물의 제조 방법
MX2016012573A (es) 2014-03-28 2018-02-19 Sunshine Lake Pharma Co Ltd Compuestos de dihidropirimidina y su aplicacion en productos farmaceuticos.
WO2015172128A1 (en) * 2014-05-09 2015-11-12 Indiana University Research And Technology Corporation Methods and compositions for treating hepatitis b virus infections
AU2016214799A1 (en) 2015-02-07 2017-06-15 Sunshine Lake Pharma Co., Ltd. Complexes and salts of dihydropyrimidine derivatives and their application in pharmaceuticals
WO2017076791A1 (en) 2015-11-03 2017-05-11 F. Hoffmann-La Roche Ag Combination therapy of an hbv capsid assembly inhibitor and an interferon
EP3503894A1 (en) 2016-08-24 2019-07-03 H. Hoffnabb-La Roche Ag Combination therapy of an hbv capsid assembly inhibitor and a nucleos(t)ide analogue
PT3587420T (pt) 2017-02-23 2021-06-04 Fujian Cosunter Pharmaceutical Co Ltd Composto tricíclico e suas aplicações
JP6813665B2 (ja) * 2017-03-31 2021-01-13 富士フイルム株式会社 ４−ピリドン化合物またはその塩、それを含む医薬組成物および剤
EP3645516A4 (en) 2017-06-27 2021-07-07 Janssen Pharmaceutica NV HETEROARYLDIHYDROPYRIMIDE DERIVATIVES AND METHODS OF TREATMENT OF HEPATITIS B INFECTIONS
CN107501257B (zh) * 2017-08-17 2020-05-29 山东大学 二氢嘧啶-三氮唑类衍生物及其制备方法与应用
SG11202011685QA (en) 2018-05-25 2020-12-30 Chia Tai Tianqing Pharmaceutical Group Co Ltd 2,3-dihydro-1h-pyrrolizine-7-formamide derivative and application thereof
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
WO2020038456A1 (zh) 2018-08-23 2020-02-27 福建广生堂药业股份有限公司 三并环类化合物的晶型及其应用
WO2020255016A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
EP4063366A4 (en) 2019-11-22 2023-12-20 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. CRYSTAL FORM OF NUCLEOPROTEIN INHIBITOR AND USE THEREOF
WO2022166923A1 (zh) 2021-02-05 2022-08-11 和博医药有限公司 苯基二氢嘧啶类化合物及其应用
WO2022268154A1 (zh) * 2021-06-24 2022-12-29 上海齐鲁制药研究中心有限公司 新型抗乙肝化合物

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CN101104617B (zh) 2006-07-10 2010-06-23 北京摩力克科技有限公司 二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
CN101225084A (zh) 2007-01-16 2008-07-23 北京摩力克科技有限公司 二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
WO2008154820A1 (fr) 2007-06-18 2008-12-24 Zhang, Zhongneng Thiazolyl-dihydropyrimidines à substitution carbéthoxy
CN101328170B (zh) 2007-06-18 2011-09-14 张中能 一种氟苯基-取代噻唑二氢嘧啶
PT2514750E (pt) 2007-06-18 2014-01-23 Sunshine Lake Pharma Co Ltd Tiazolil dihidropirimidinas substituídas com bromo-fenilo
WO2008154819A1 (fr) 2007-06-18 2008-12-24 Zhang, Zhongneng Thiazolyl-dihydropyrimidines à substitution carbéthoxy

Also Published As

Publication number Publication date
JP5361879B2 (ja) 2013-12-04
JP2010530374A (ja) 2010-09-09
BRPI0813237B1 (pt) 2020-01-07
AU2008265397C1 (en) 2013-08-29
WO2008154817A1 (en) 2008-12-24
PL2159224T3 (pl) 2012-12-31
PL2514750T3 (pl) 2014-05-30
PT2159224E (pt) 2012-10-24
CA2691056C (en) 2014-03-11
ES2391597T3 (es) 2012-11-28
US20120282221A1 (en) 2012-11-08
RU2010101212A (ru) 2011-07-27
CA2691056A1 (en) 2008-12-24
JP2013231036A (ja) 2013-11-14
EP2159224A4 (en) 2011-08-03
CN102066369A (zh) 2011-05-18
KR101173892B1 (ko) 2012-08-16
US8236797B2 (en) 2012-08-07
AU2008265397B2 (en) 2011-07-21
EP2514750A1 (en) 2012-10-24
EP2159224A1 (en) 2010-03-03
AU2008265397A1 (en) 2008-12-24
KR20100038104A (ko) 2010-04-12
USRE44987E1 (en) 2014-07-01
USRE45004E1 (en) 2014-07-08
DK2159224T3 (da) 2012-08-20
DK2514750T5 (en) 2014-02-17
EP2159224B1 (en) 2012-08-01
DK2514750T3 (da) 2013-12-02
EP2514750B1 (en) 2013-11-20
JP5970421B2 (ja) 2016-08-17
US20100240655A1 (en) 2010-09-23
BRPI0813237B8 (pt) 2021-05-25
ES2442907T3 (es) 2014-02-14
CN102066369B (zh) 2013-05-29
PT2514750E (pt) 2014-01-23
US8343969B2 (en) 2013-01-01
AU2008265397B9 (en) 2011-08-04
RU2443703C2 (ru) 2012-02-27
CN101328171A (zh) 2008-12-24
HK1174035A1 (en) 2013-05-31

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: SUNSHINE LAKE PHARMA CO., LTD. (CN)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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