PL2178888T3 - Inhibitory proteasomów - Google Patents

Inhibitory proteasomów

Info

Publication number
PL2178888T3
PL2178888T3 PL07811087T PL07811087T PL2178888T3 PL 2178888 T3 PL2178888 T3 PL 2178888T3 PL 07811087 T PL07811087 T PL 07811087T PL 07811087 T PL07811087 T PL 07811087T PL 2178888 T3 PL2178888 T3 PL 2178888T3
Authority
PL
Poland
Prior art keywords
proteasome inhibitors
proteasome
inhibitors
Prior art date
Application number
PL07811087T
Other languages
English (en)
Polish (pl)
Inventor
Edward J Olhava
Miheala D Danca
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38691782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2178888(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of PL2178888T3 publication Critical patent/PL2178888T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL07811087T 2007-08-06 2007-08-06 Inhibitory proteasomów PL2178888T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07811087A EP2178888B1 (en) 2007-08-06 2007-08-06 Proteasome inhibitors
PCT/US2007/017440 WO2009020448A1 (en) 2007-08-06 2007-08-06 Proteasome inhibitors

Publications (1)

Publication Number Publication Date
PL2178888T3 true PL2178888T3 (pl) 2012-11-30

Family

ID=38691782

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07811087T PL2178888T3 (pl) 2007-08-06 2007-08-06 Inhibitory proteasomów

Country Status (32)

Country Link
EP (3) EP3210987A1 (sr)
JP (1) JP5261488B2 (sr)
KR (6) KR20160040735A (sr)
CN (1) CN101772507B (sr)
AU (1) AU2007357338B2 (sr)
BR (1) BRPI0721905B8 (sr)
CA (1) CA2695082C (sr)
CY (2) CY1113386T1 (sr)
DK (1) DK2178888T3 (sr)
EA (1) EA028622B1 (sr)
EC (1) ECSP10010015A (sr)
ES (1) ES2390606T3 (sr)
FR (1) FR17C1011I2 (sr)
GE (1) GEP20125599B (sr)
HR (1) HRP20120745T1 (sr)
HU (1) HUS1700018I1 (sr)
IL (4) IL203641A (sr)
LT (1) LTC2178888I2 (sr)
LU (1) LUC00013I2 (sr)
MY (1) MY161991A (sr)
NL (1) NL300871I2 (sr)
NZ (1) NZ582693A (sr)
PH (1) PH12014500053B1 (sr)
PL (1) PL2178888T3 (sr)
PT (1) PT2178888E (sr)
RS (1) RS52435B (sr)
SG (1) SG10201508712QA (sr)
SI (1) SI2178888T1 (sr)
TN (1) TN2010000060A1 (sr)
UA (1) UA97536C2 (sr)
WO (1) WO2009020448A1 (sr)
ZA (1) ZA201000348B (sr)

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US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
RU2453556C2 (ru) 2005-11-09 2012-06-20 Протеоликс, Инк. Соединения для ингибирования фермента
RU2450016C2 (ru) 2006-06-19 2012-05-10 Протеоликс, Инк. Пептидные эпоксикетоны для ингибирования протеасомы
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
KR20170040374A (ko) 2007-10-04 2017-04-12 오닉스 세라퓨틱스, 인크. 결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성
CA2727862C (en) 2008-06-17 2016-04-19 Millennium Pharmaceuticals, Inc. Boronate ester compounds and pharmaceutical compositions thereof
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
AU2009308516B2 (en) 2008-10-21 2016-08-25 Onyx Therapeutics, Inc. Combination therapy with peptide epoxyketones
AR075899A1 (es) 2009-03-20 2011-05-04 Onyx Therapeutics Inc Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
JP5919196B2 (ja) 2009-11-13 2016-05-18 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 転移抑制のためのペプチドエポキシケトンの使用
AU2010341530B2 (en) 2009-12-22 2016-03-10 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
CA2791651C (en) 2010-03-01 2019-08-20 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
US8513218B2 (en) 2010-03-31 2013-08-20 Millennium Pharmaceuticals, Inc. Derivatives of 1-amino-2-cyclopropylethylboronic acid
US20140121182A1 (en) * 2011-06-22 2014-05-01 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
CN108383893A (zh) * 2011-08-30 2018-08-10 塔夫茨大学信托人 用于治疗实体瘤的fap-活化的蛋白酶体抑制剂
SG11201403254QA (en) * 2011-12-22 2014-07-30 Ares Trading Sa Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
JP6215235B2 (ja) * 2012-01-24 2017-10-18 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 癌の治療方法
CA2862320A1 (en) * 2012-01-24 2013-08-01 Millennium Pharmaceuticals, Inc. Method of treatment of nasopharyngeal cancer
JP2015524394A (ja) 2012-07-09 2015-08-24 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． ペプチドエポキシケトンプロテアーゼ阻害剤のプロドラッグ
CN109096370B (zh) * 2012-07-26 2022-03-18 圣特莱国际公司 多肽环氧酮化合物
JP2013006855A (ja) * 2012-09-03 2013-01-10 Millennium Pharmaceuticals Inc プロテアソーム阻害剤
US9464098B2 (en) * 2012-12-03 2016-10-11 Hoffmann-La Roche Inc. Substituted triazole boronic acid compounds
MX2016003979A (es) * 2013-10-03 2016-06-15 Millennium Pharm Inc Metodo para profilaxis o tratamiento de lupus eritematoso sistemico y/o nefritis lupica.
TN2016000492A1 (en) 2014-05-20 2018-04-04 Millennium Pharm Inc Boron-containing proteasome inhibitors for use after primary cancer therapy.
WO2016022955A1 (en) 2014-08-07 2016-02-11 Mayo Foundation For Medical Education And Research Compounds and methods for treating cancer
MA41555A (fr) * 2015-02-17 2017-12-26 Millennium Pharm Inc Polythérapie pour le traitement du cancer
US10144761B2 (en) 2015-06-19 2018-12-04 Hanlin Scientific Inc. Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis
CN106608883A (zh) * 2015-10-21 2017-05-03 北京大学 蛋白酶体抑制剂mln9708的合成方法
CN107400142B (zh) * 2016-05-19 2019-11-19 成都奥璟生物科技有限公司 一种硼酸和硼酸酯类化合物及其应用
CN106008572B (zh) * 2016-05-23 2018-08-17 成都千禧莱医药科技有限公司 一类二肽硼酸化合物及制备方法和用途
JP7164521B2 (ja) 2016-06-21 2022-11-01 オリオン・オフサルモロジー・エルエルシー 炭素環式プロリンアミド誘導体
HUE064412T2 (hu) 2016-06-21 2024-03-28 Orion Ophthalmology LLC Heterociklusos prolinamid-származékok
EP3476850B1 (en) 2016-07-25 2024-12-11 Shenzhen TargetRx, Inc. Substituted boric acid compound, pharmaceutical composition comprising same, and application thereof
TW201831191A (zh) * 2017-01-23 2018-09-01 大陸商成都奥璟生物科技有限公司 一種新的硼酸衍生物及其藥物組合物
EP3589659B1 (en) 2017-02-28 2025-04-09 Mayo Foundation for Medical Education and Research Combinations for use in the treatment of cancer
CN108794516A (zh) * 2017-04-26 2018-11-13 上海时莱生物技术有限公司 硼酸和硼酸酯类化合物及其制备方法和用途
CN109305980B (zh) * 2017-07-28 2022-10-11 成都奥璟生物科技有限公司 一种硼酸酯化合物、其合成方法及其用途
WO2019038406A1 (en) 2017-08-25 2019-02-28 Synthon B.V. PROCESS FOR THE PREPARATION OF IXAZOMIB OR ITS INTERMEDIATES
JP2018024694A (ja) * 2017-10-03 2018-02-15 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． プロテアソーム阻害剤
US11243207B2 (en) 2018-03-29 2022-02-08 Mayo Foundation For Medical Education And Research Assessing and treating cancer
CN110903310B (zh) 2018-09-14 2022-11-22 成都奥璟生物科技有限公司 一种硼酸酯类药物及其用途
CN110357787A (zh) * 2019-08-02 2019-10-22 苏州艾和医药科技有限公司 依沙佐米合成工艺研究
WO2021071932A1 (en) * 2019-10-07 2021-04-15 Cornell University Antimicrobial and antiviral effects of c2-c7alkyl boronic acids
CN110950897B (zh) * 2019-12-12 2021-05-28 山东大学 一种组蛋白去乙酰化酶、蛋白酶体双靶点抑制剂及其制备方法和应用

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US5250720A (en) 1987-06-05 1993-10-05 The Dupont Merck Pharmaceutical Company Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases
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US7223745B2 (en) 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7576206B2 (en) * 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
UA88771C2 (ru) * 2003-08-14 2009-11-25 Сефалон, Инк. Ингибиторы протеасомы и способ их применения (варианты)
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Also Published As

Publication number Publication date
FR17C1011I2 (fr) 2018-04-27
HK1182924A1 (zh) 2013-12-13
EP2178888A1 (en) 2010-04-28
KR20150010802A (ko) 2015-01-28
CY2017016I2 (el) 2017-07-12
ECSP10010015A (es) 2010-04-30
DK2178888T3 (da) 2012-10-01
KR20100059811A (ko) 2010-06-04
JP2010535759A (ja) 2010-11-25
BRPI0721905B8 (pt) 2021-05-25
GEP20125599B (en) 2012-08-10
BRPI0721905A2 (pt) 2014-02-25
NZ582693A (en) 2012-01-12
CN101772507B (zh) 2012-12-12
KR20140042932A (ko) 2014-04-07
KR20170004031A (ko) 2017-01-10
TN2010000060A1 (en) 2011-09-26
LUC00013I2 (sr) 2017-06-19
AU2007357338B2 (en) 2014-03-20
JP5261488B2 (ja) 2013-08-14
IL242291A0 (en) 2015-11-30
EP3210987A1 (en) 2017-08-30
EA028622B1 (ru) 2017-12-29
CN101772507A (zh) 2010-07-07
HK1143595A1 (en) 2011-01-07
IL242290A0 (en) 2015-11-30
CY2017016I1 (el) 2017-07-12
CA2695082C (en) 2015-07-28
LTC2178888I2 (lt) 2018-03-12
SG10201508712QA (en) 2015-11-27
ES2390606T3 (es) 2012-11-14
PH12014500053A1 (en) 2015-03-30
EP2527347A1 (en) 2012-11-28
CA2695082A1 (en) 2009-02-12
LTPA2017010I1 (lt) 2017-05-10
IL203641A (en) 2015-11-30
HRP20120745T1 (hr) 2012-10-31
SI2178888T1 (sl) 2012-11-30
IL242292A0 (en) 2015-11-30
LUC00013I1 (sr) 2017-04-06
BRPI0721905B1 (pt) 2020-11-17
CY1113386T1 (el) 2016-06-22
NL300871I2 (nl) 2017-12-07
EP2178888B1 (en) 2012-07-04
HUS1700018I1 (hu) 2017-05-29
IL242291A (en) 2017-12-31
KR101474831B1 (ko) 2014-12-19
IL242292A (en) 2017-12-31
KR101831674B1 (ko) 2018-02-23
RS52435B (sr) 2013-02-28
ZA201000348B (en) 2011-03-30
AU2007357338A1 (en) 2009-02-12
WO2009020448A1 (en) 2009-02-12
EA201070247A1 (ru) 2010-06-30
KR20160040735A (ko) 2016-04-14
PH12014500053B1 (en) 2015-03-30
UA97536C2 (en) 2012-02-27
KR20140042933A (ko) 2014-04-07
PT2178888E (pt) 2012-10-04
MY161991A (en) 2017-05-31
IL242290A (en) 2017-12-31
FR17C1011I1 (sr) 2017-05-26

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