PL2211875T3 - Zastosowanie mikropęcherzyków (MV) pochodzących z komórek macierzystych do wytwarzania leku do regeneracji śródbłonkowej/nabłonkowej uszkodzonych lub poddanych urazowi tkanek lub narządów i związane z nimi sposoby in vitro i in vivo - Google Patents

Zastosowanie mikropęcherzyków (MV) pochodzących z komórek macierzystych do wytwarzania leku do regeneracji śródbłonkowej/nabłonkowej uszkodzonych lub poddanych urazowi tkanek lub narządów i związane z nimi sposoby in vitro i in vivo

Info

Publication number
PL2211875T3
PL2211875T3 PL07849722T PL07849722T PL2211875T3 PL 2211875 T3 PL2211875 T3 PL 2211875T3 PL 07849722 T PL07849722 T PL 07849722T PL 07849722 T PL07849722 T PL 07849722T PL 2211875 T3 PL2211875 T3 PL 2211875T3
Authority
PL
Poland
Prior art keywords
microvesicles
mvs
endo
organs
medicament
Prior art date
Application number
PL07849722T
Other languages
English (en)
Inventor
Vincenzo Cantaluppi
Maria Chiara Amilde Deregibus
Giovanni Camussi
Original Assignee
Fresenius Medical Care Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Medical Care Deutschland Gmbh filed Critical Fresenius Medical Care Deutschland Gmbh
Publication of PL2211875T3 publication Critical patent/PL2211875T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
PL07849722T 2007-10-29 2007-10-29 Zastosowanie mikropęcherzyków (MV) pochodzących z komórek macierzystych do wytwarzania leku do regeneracji śródbłonkowej/nabłonkowej uszkodzonych lub poddanych urazowi tkanek lub narządów i związane z nimi sposoby in vitro i in vivo PL2211875T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IT2007/000753 WO2009057165A1 (en) 2007-10-29 2007-10-29 Use of microvesicles (mvs) derived from stem cells for preparing a medicament for endo/epithelial regeneration of damaged or injured tissues or organs, and related in vitro and in vivo methods
EP07849722.9A EP2211875B1 (en) 2007-10-29 2007-10-29 Use of microvesicles (mvs) derived from stem cells for preparing a medicament for endo/epithelial regeneration of damaged or injured tissues or organs, and related in vitro and in vivo methods

Publications (1)

Publication Number Publication Date
PL2211875T3 true PL2211875T3 (pl) 2013-11-29

Family

ID=39471842

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07849722T PL2211875T3 (pl) 2007-10-29 2007-10-29 Zastosowanie mikropęcherzyków (MV) pochodzących z komórek macierzystych do wytwarzania leku do regeneracji śródbłonkowej/nabłonkowej uszkodzonych lub poddanych urazowi tkanek lub narządów i związane z nimi sposoby in vitro i in vivo

Country Status (7)

Country Link
US (2) US8568771B2 (pl)
EP (2) EP2604271B1 (pl)
JP (1) JP5261494B2 (pl)
CN (1) CN101854941B (pl)
ES (2) ES2523098T3 (pl)
PL (1) PL2211875T3 (pl)
WO (1) WO2009057165A1 (pl)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102596177B (zh) 2009-07-01 2014-05-28 阿昂梅迪克斯公司 来源于有核哺乳动物细胞的微囊泡及其应用
SG177467A1 (en) * 2009-07-23 2012-02-28 Agency Science Tech & Res Pre-natal mesenchymal stem cells
EP2363136A1 (en) * 2010-03-02 2011-09-07 Fresenius Medical Care Deutschland GmbH Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease
CN103154236B (zh) 2010-05-12 2016-08-31 再生医学Tx有限责任公司 生物活性肾细胞
BR112013000024B1 (pt) * 2010-07-01 2021-11-23 Aeon Medix Inc Composição para entregar um agente anticancer e método para preparação de microvesículas carregadas com um agente anticâncer, a partir de protoplastos de células bacterianas
WO2012020308A2 (en) * 2010-08-13 2012-02-16 The University Court Of The University Of Glasgow Cellular and molecular therapies
EP2495025A1 (en) 2011-03-04 2012-09-05 Fresenius Medical Care Deutschland GmbH Filter for the removal of micro-vesicles from biological fluids, methods and devices using such a filter
KR101334404B1 (ko) * 2011-04-28 2013-12-12 포항공과대학교 산학협력단 배아줄기세포 유래의 인공 마이크로베시클을 이용한 역분화 유도만능줄기세포의 제조방법
JP5872041B2 (ja) 2011-08-16 2016-03-01 サムスン ライフ パブリック ウェルフェア ファンデーション 幹細胞由来微小胞を含む神経生成促進用組成物
WO2013142878A1 (en) * 2012-03-23 2013-09-26 Neostem, Inc. Stem cell identification and purification method
EP2838995A4 (en) * 2012-04-16 2016-01-06 Univ California EYE THERAPEUTICS WITH MICROVESICLES FROM EMBRYONAL STEM CELLS
CN103040867A (zh) * 2013-01-04 2013-04-17 江苏省人民医院 骨髓间充质干细胞来源的微泡在制备治疗肾损伤药物中的应用
CN103045534B (zh) * 2013-01-23 2014-10-22 山东大学 一种老年大鼠脑血管内皮细胞培养液
MY177482A (en) 2013-03-13 2020-09-16 Zhong Li Microvesicle and method for producing the same
US12558316B2 (en) 2013-03-13 2026-02-24 University Of Miami Methods and compositions for the treatment of epidermolysis bullosa
WO2014159662A1 (en) * 2013-03-13 2014-10-02 University Of Miami Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids
ES2526816B1 (es) * 2013-06-14 2015-10-27 Fundación Pública Andaluza Progreso Y Salud Composiciones para el tratamiento del daño hepático
ES2759228T3 (es) 2013-07-05 2020-05-08 Univ Catholique Louvain Medio acondicionado de células madre de hígado de adultos y su uso en el tratamiento de trastornos del hígado
US20160193252A1 (en) * 2013-08-14 2016-07-07 Reneuron Limited STEM CELL MICROPARTICLES AND miRNA
US10160955B2 (en) * 2015-06-30 2018-12-25 Board Of Supervisors Of Louisiana State University Method for harvesting stem and progenitor cells and method of treatment of kidney disease and neurological disease
DE102016109067B4 (de) 2016-05-17 2018-07-19 Leibniz-Institut Für Polymerforschung Dresden E.V. Verfahren zur Bildung von Nierentubuli
EP3308795A1 (en) * 2016-10-12 2018-04-18 Unicyte EV AG A composition of extracellular vesicles (evs) and medical uses thereof
CN106692984B (zh) * 2016-12-08 2020-02-18 武汉大学 一种基于细胞源性微囊泡的肿瘤靶向递送载体及制备方法和应用
CN107937342B (zh) * 2017-11-06 2021-07-06 中国人民解放军第四军医大学 一种通过内皮细胞来源的外泌体扩增神经干细胞的方法
ES2724215B2 (es) * 2018-03-01 2020-04-14 Univ Alcala Henares Microvesículas endoteliales con efecto microbicida
KR102015502B1 (ko) 2018-03-29 2019-08-28 아키소스템바이오스트래티지스(주) 인간 제대로부터 줄기세포를 분리하는 방법
EP3786280A4 (en) 2018-04-25 2022-02-16 Sapporo Medical University CELL SHEET FOR VITAL TRANSPLANTATION AND METHODS OF PRODUCTION THEREOF
US20210238552A1 (en) * 2018-08-10 2021-08-05 Unicyte Ev Ag Extracellular vesicles loaded with an exogenous molecule
CN110179826B (zh) * 2019-05-29 2021-08-31 武汉五州润达生物医药科技有限公司 人脐带间充质干细胞来源干细胞因子微囊泡制剂及制备方法
CN112300984A (zh) * 2020-09-21 2021-02-02 四川大学华西医院 一种医用hUC-MSCs-MVs批量制备流程及质控

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004242091C1 (en) * 2003-05-07 2009-12-24 La Jolla Institute For Molecular Medicine Administration of hyaluronic acid to enhance the function of transplanted stem cells
JP2008501336A (ja) * 2004-06-02 2008-01-24 ソースフアーム・インコーポレイテツド Ｒｎａを含有する微小胞およびそのための方法
GB0501129D0 (en) 2005-01-19 2005-02-23 Ribostem Ltd Method of treatment by administration of RNA

Also Published As

Publication number Publication date
US8568771B2 (en) 2013-10-29
WO2009057165A8 (en) 2010-05-06
US20140134264A1 (en) 2014-05-15
CN101854941B (zh) 2013-03-27
ES2523098T3 (es) 2014-11-20
JP2011502142A (ja) 2011-01-20
EP2604271A1 (en) 2013-06-19
EP2604271B1 (en) 2014-09-17
CN101854941A (zh) 2010-10-06
EP2211875A1 (en) 2010-08-04
JP5261494B2 (ja) 2013-08-14
WO2009057165A1 (en) 2009-05-07
US9061018B2 (en) 2015-06-23
ES2423483T3 (es) 2013-09-20
US20110033523A1 (en) 2011-02-10
EP2211875B1 (en) 2013-05-29

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