PL2215092T3 - Podstawione piperydyno-dihydrotienopirymidyny - Google Patents

Podstawione piperydyno-dihydrotienopirymidyny

Info

Publication number: PL2215092T3
Authority: PL; Poland
Prior art keywords: dihydrothienopyrimidines; substituted piperidino; piperidino; substituted
Prior art date: 2007-10-19

Application number

PL08839793T

Other languages

English (en)

Inventor

Pascale Pouzet

Ralf Anderskewitz

Horst Dollinger

Dennis Fiegen

Thomas Fox

Rolf Goeggel

Christoph Hoenke

Domnic Martyres

Peter Nickolaus

Klaus Klinder

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-19

Filing date

2008-10-16

Publication date

2012-07-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39154006&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2215092(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-10-16 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2012-07-31 Publication of PL2215092T3 publication Critical patent/PL2215092T3/pl

Links

JMUGMZBGUVOSPU-UHFFFAOYSA-N 1-piperidin-1-yl-2h-thieno[3,2-d]pyrimidine Chemical class C1CCCCN1N1C(C=CS2)=C2C=NC1 JMUGMZBGUVOSPU-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
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- A61P11/10—Expectorants
- A—HUMAN NECESSITIES
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- A61P11/12—Mucolytics
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Rheumatology (AREA)
Oncology (AREA)
Physical Education & Sports Medicine (AREA)
Psychology (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL08839793T 2007-10-19 2008-10-16 Podstawione piperydyno-dihydrotienopirymidyny PL2215092T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP07118901		2007-10-19
PCT/EP2008/063999 WO2009050248A1 (de)	2007-10-19	2008-10-16	Substituierte piperidino-dihydrothienopyrimidine
EP08839793A EP2215092B1 (de)	2007-10-19	2008-10-16	Substituierte piperidino-dihydrothienopyrimidine

Publications (1)

Publication Number	Publication Date
PL2215092T3 true PL2215092T3 (pl)	2012-07-31

Family

ID=39154006

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL08839793T PL2215092T3 (pl)	2007-10-19	2008-10-16	Podstawione piperydyno-dihydrotienopirymidyny
PL13154790T PL2610258T3 (pl)	2007-10-19	2008-10-16	Podstawione piperydyno-dihydrotienopirymidyny

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL13154790T PL2610258T3 (pl)	2007-10-19	2008-10-16	Podstawione piperydyno-dihydrotienopirymidyny

Country Status (33)

Country	Link
US (1)	US8754073B2 (pl)
EP (3)	EP2380891B1 (pl)
JP (2)	JP5150728B2 (pl)
KR (1)	KR101548975B1 (pl)
CN (2)	CN101827852B (pl)
AR (1)	AR069075A1 (pl)
AT (1)	ATE542825T1 (pl)
AU (1)	AU2008313660B2 (pl)
BR (1)	BRPI0818006B8 (pl)
CA (1)	CA2705414C (pl)
CL (1)	CL2008003096A1 (pl)
CY (2)	CY1112703T1 (pl)
DK (2)	DK2610258T3 (pl)
EA (1)	EA019480B1 (pl)
EC (1)	ECSP10010156A (pl)
ES (2)	ES2381452T3 (pl)
HR (2)	HRP20120334T1 (pl)
MA (1)	MA31845B1 (pl)
ME (1)	ME01330B (pl)
MX (1)	MX2010004026A (pl)
MY (1)	MY153979A (pl)
NZ (1)	NZ585346A (pl)
PE (2)	PE20091386A1 (pl)
PL (2)	PL2215092T3 (pl)
PT (2)	PT2215092E (pl)
RS (1)	RS52271B (pl)
SI (2)	SI2610258T1 (pl)
TN (1)	TN2010000175A1 (pl)
TW (1)	TWI421077B (pl)
UA (1)	UA99309C2 (pl)
UY (1)	UY31405A1 (pl)
WO (1)	WO2009050248A1 (pl)
ZA (1)	ZA201001683B (pl)

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JP5538231B2 (ja) *	2007-10-18	2014-07-02	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ジヒドロチエノ［３，２−ｄ］ピリミジンおよびその中で使用される中間体の調製
RU2500681C2 (ru)	2007-10-19	2013-12-10	Берингер Ингельхайм Интернациональ Гмбх	Замещенные гетероциклом пиперазинодигидротиенопиримидины
SI2610258T1 (sl) *	2007-10-19	2014-12-31	Boehringer Ingelheim International Gmbh	Substituirani piperidino-dihidrotienopirimidini
EP2215093B1 (de)	2007-10-19	2011-12-14	Boehringer Ingelheim International GmbH	Neue piperazino-dihydrothienopyrimidin-derivate
JP2012519160A (ja) *	2009-02-27	2012-08-23	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｐｄｅ４阻害剤及びｎｓａｉｄを含有する組み合わせ薬
EP2555773A1 (de)	2010-04-08	2013-02-13	Boehringer Ingelheim International GmbH	Arzneimittelkombinationen enthaltend pde4-inhibitoren und ep4-rezeptor-antagonisten
WO2011124525A1 (de)	2010-04-08	2011-10-13	Boehringer Ingelheim International Gmbh	Arnzeimittelkombinationen enthaltend pde4-inhibitoren und ep4-rezeptor-antagonisten
WO2011143057A1 (en)	2010-05-11	2011-11-17	Merck Sharp & Dohme Corp.	Novel prolylcarboxypeptidase inhibitors
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EP3480198B1 (en) *	2016-06-30	2021-05-05	Riken	Novel compound or pharmaceutically acceptable salt thereof
US11365204B2 (en)	2017-09-20	2022-06-21	UNION therapeutics A/S	Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
LT3700529T (lt)	2017-10-23	2025-10-10		Naujas veikliųjų medžiagų derinys, skirtas progresuojančių fibrozinių intersticinių plaučių ligų (pf-ild) gydymui
WO2019115775A1 (en)	2017-12-15	2019-06-20	Leo Pharma A/S	Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
WO2019115774A1 (en)	2017-12-15	2019-06-20	Leo Pharma A/S	Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
WO2019115776A1 (en)	2017-12-15	2019-06-20	Leo Pharma A/S	Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors
WO2020048827A1 (en) *	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	1, 3, 9-triazaspiro[5.5] undecan-2-one compounds
CA3234847A1 (en)	2021-12-09	2023-06-15	Boehringer Ingelheim International Gmbh	New oral pharmaceutical composition and dose regimen for the therapy of progressive fibrosing interstitial lung diseases
PL4426298T3 (pl)	2021-12-09	2026-07-20	Boehringer Ingelheim International Gmbh	Nowe kombinacje terapeutyczne zawierające pirfenidon i inhibitor pde4 do leczenia postępujących włókniejących śródmiąższowych chorób płuc
CN119343352A (zh) *	2022-06-02	2025-01-21	西藏海思科制药有限公司	Pde4b抑制剂及其用途
TW202408518A (zh) *	2022-06-16	2024-03-01	大陸商武漢人福創新藥物研發中心有限公司	Pde4b抑制劑
CN115040503B (zh) *	2022-07-26	2023-10-10	云南民族大学	螺环二烯酮型木脂素类化合物在制药中的应用
JP2025528779A (ja) *	2022-08-09	2025-09-02	シーザンハイスークファーマシューティカルカンパニーリミテッド	Ｐｄｅ４ｂ阻害剤及びその用途
CN119947728A (zh)	2022-09-28	2025-05-06	勃林格殷格翰国际有限公司	生物标志物在用pde4b抑制剂治疗纤维化病症中的用途
EP4596554A4 (en)	2022-09-29	2025-12-10	Suzhou Arkbiopharmaceutical Co Ltd	Fused AZA Cyclic Compound, its Preparation Process and its Use in Medicine
CN118871444A (zh) *	2023-02-28	2024-10-29	上海翊石医药科技有限公司	二氢噻吩并嘧啶衍生物的制备方法和用途
CN121127461A (zh) *	2023-04-03	2025-12-12	上海壹迪生物技术有限公司	二氢噻吩并嘧啶类化合物、其制备方法和应用
EP4678644A1 (en)	2023-04-13	2026-01-14	Shanghai Yidi Biotechnology Co., Ltd.	Substituted dihydrothienopyrimidine compound, preparation method therefor, and use thereof
CN116925099B (zh) *	2023-07-21	2025-06-03	厦门大学	手性二氢噻吩并嘧啶亚砜的制备方法及其应用与其2、4位取代化合物
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WO2025067168A1 (zh) *	2023-09-25	2025-04-03	苏州爱科百发生物医药技术有限公司	氮杂稠环类化合物及其制备方法和用途
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WO2025162431A1 (zh) *	2024-02-04	2025-08-07	西藏海思科制药有限公司	一种pde4b抑制剂化合物的口服药物组合物及其制备方法

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NL124131C (pl)	1963-06-17
DE1470356A1 (de)	1964-01-15	1970-04-30	Thomae Gmbh Dr K	Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung
BE663693A (pl)	1965-03-31
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Publication number	Publication date
CY1112703T1 (el)	2016-02-10
AR069075A1 (es)	2009-12-30
EA201000609A1 (ru)	2010-10-29
MX2010004026A (es)	2010-04-30
RS52271B (sr)	2012-10-31
EP2610258B1 (de)	2014-08-27
MA31845B1 (fr)	2010-11-01
JP5150728B2 (ja)	2013-02-27
EP2380891B1 (de)	2013-12-11
ME01330B (me)	2013-12-20
PL2610258T3 (pl)	2015-02-27
CA2705414A1 (en)	2009-04-23
BRPI0818006B1 (pt)	2019-10-22
SI2610258T1 (sl)	2014-12-31
BRPI0818006B8 (pt)	2021-05-25
CN101827852A (zh)	2010-09-08
CY1115858T1 (el)	2017-01-25
DK2215092T3 (da)	2012-05-07
EP2610258A1 (de)	2013-07-03
CN104069112A (zh)	2014-10-01
EP2215092B1 (de)	2012-01-25
US20110021501A1 (en)	2011-01-27
UA99309C2 (ru)	2012-08-10
NZ585346A (en)	2011-09-30
PE20131463A1 (es)	2013-12-23
UY31405A1 (es)	2009-05-29
CL2008003096A1 (es)	2010-02-12
TN2010000175A1 (fr)	2011-11-11
JP2013064001A (ja)	2013-04-11
JP2011500640A (ja)	2011-01-06
EP2215092A1 (de)	2010-08-11
ES2381452T3 (es)	2012-05-28
ES2524910T3 (es)	2014-12-15
WO2009050248A1 (de)	2009-04-23
BRPI0818006A2 (pt)	2015-12-22
TW200918074A (en)	2009-05-01
HRP20141153T1 (hr)	2015-02-13
DK2610258T3 (da)	2014-11-10
TWI421077B (zh)	2014-01-01
SI2215092T1 (sl)	2012-04-30
ECSP10010156A (es)	2010-06-29
ZA201001683B (en)	2010-10-27
KR20100100807A (ko)	2010-09-15
HK1145677A1 (en)	2011-04-29
PE20091386A1 (es)	2009-10-17
PT2215092E (pt)	2012-04-10
CA2705414C (en)	2016-05-24
US8754073B2 (en)	2014-06-17
PT2610258E (pt)	2014-10-24
AU2008313660A1 (en)	2009-04-23
JP5615889B2 (ja)	2014-10-29
HRP20120334T1 (hr)	2012-05-31
AU2008313660B2 (en)	2013-11-07
CN101827852B (zh)	2014-07-30
MY153979A (en)	2015-04-30
EP2380891A1 (de)	2011-10-26
ATE542825T1 (de)	2012-02-15
EA019480B1 (ru)	2014-04-30
KR101548975B1 (ko)	2015-09-01

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