PL2215092T3 - Podstawione piperydyno-dihydrotienopirymidyny - Google Patents

Podstawione piperydyno-dihydrotienopirymidyny

Info

Publication number: PL2215092T3
Authority: PL; Poland
Prior art keywords: dihydrothienopyrimidines; substituted piperidino; piperidino; substituted
Prior art date: 2007-10-19

Application number

PL08839793T

Other languages

English (en)

Inventor

Pascale Pouzet

Ralf Anderskewitz

Horst Dollinger

Dennis Fiegen

Thomas Fox

Rolf Goeggel

Christoph Hoenke

Domnic Martyres

Peter Nickolaus

Klaus Klinder

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-19

Filing date

2008-10-16

Publication date

2012-07-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39154006&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2215092(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-10-16 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2012-07-31 Publication of PL2215092T3 publication Critical patent/PL2215092T3/pl

Links

JMUGMZBGUVOSPU-UHFFFAOYSA-N 1-piperidin-1-yl-2h-thieno[3,2-d]pyrimidine Chemical class C1CCCCN1N1C(C=CS2)=C2C=NC1 JMUGMZBGUVOSPU-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
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- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
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- A61P11/10—Expectorants
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Otolaryngology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Gastroenterology & Hepatology (AREA)
Psychology (AREA)
Hematology (AREA)
Dermatology (AREA)
Oncology (AREA)
Physical Education & Sports Medicine (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL08839793T 2007-10-19 2008-10-16 Podstawione piperydyno-dihydrotienopirymidyny PL2215092T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP07118901		2007-10-19
EP08839793A EP2215092B1 (de)	2007-10-19	2008-10-16	Substituierte piperidino-dihydrothienopyrimidine
PCT/EP2008/063999 WO2009050248A1 (de)	2007-10-19	2008-10-16	Substituierte piperidino-dihydrothienopyrimidine

Publications (1)

Publication Number	Publication Date
PL2215092T3 true PL2215092T3 (pl)	2012-07-31

Family

ID=39154006

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL08839793T PL2215092T3 (pl)	2007-10-19	2008-10-16	Podstawione piperydyno-dihydrotienopirymidyny
PL13154790T PL2610258T3 (pl)	2007-10-19	2008-10-16	Podstawione piperydyno-dihydrotienopirymidyny

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL13154790T PL2610258T3 (pl)	2007-10-19	2008-10-16	Podstawione piperydyno-dihydrotienopirymidyny

Country Status (33)

Country	Link
US (1)	US8754073B2 (pl)
EP (3)	EP2380891B1 (pl)
JP (2)	JP5150728B2 (pl)
KR (1)	KR101548975B1 (pl)
CN (2)	CN101827852B (pl)
AR (1)	AR069075A1 (pl)
AT (1)	ATE542825T1 (pl)
AU (1)	AU2008313660B2 (pl)
BR (1)	BRPI0818006B8 (pl)
CA (1)	CA2705414C (pl)
CL (1)	CL2008003096A1 (pl)
CY (2)	CY1112703T1 (pl)
DK (2)	DK2610258T3 (pl)
EA (1)	EA019480B1 (pl)
EC (1)	ECSP10010156A (pl)
ES (2)	ES2524910T3 (pl)
HR (2)	HRP20120334T1 (pl)
MA (1)	MA31845B1 (pl)
ME (1)	ME01330B (pl)
MX (1)	MX2010004026A (pl)
MY (1)	MY153979A (pl)
NZ (1)	NZ585346A (pl)
PE (2)	PE20091386A1 (pl)
PL (2)	PL2215092T3 (pl)
PT (2)	PT2215092E (pl)
RS (1)	RS52271B (pl)
SI (2)	SI2215092T1 (pl)
TN (1)	TN2010000175A1 (pl)
TW (1)	TWI421077B (pl)
UA (1)	UA99309C2 (pl)
UY (1)	UY31405A1 (pl)
WO (1)	WO2009050248A1 (pl)
ZA (1)	ZA201001683B (pl)

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MX2010004026A (es)	2007-10-19	2010-04-30	Boehringer Ingelheim Int	Piperidino-dihidrotienopirimidinas sustituidas.
ATE537175T1 (de)	2007-10-19	2011-12-15	Boehringer Ingelheim Int	Neue piperazino-dihydrothienopyrimidin-derivate
EP2205609B1 (de)	2007-10-19	2017-03-29	Boehringer Ingelheim International GmbH	Heterocyclus-substituierte piperazino-dihydrothienopyrimidine
EP2400962B1 (de) *	2009-02-27	2017-11-08	Boehringer Ingelheim International GmbH	Arzneimittelkombinationen enthaltend pde4-inhibitoren und nsaids
EP2555773A1 (de)	2010-04-08	2013-02-13	Boehringer Ingelheim International GmbH	Arzneimittelkombinationen enthaltend pde4-inhibitoren und ep4-rezeptor-antagonisten
EP2555774B1 (de)	2010-04-08	2015-10-21	Boehringer Ingelheim International GmbH	Arnzeimittelkombinationen enthaltend pde4-inhibitoren und ep4-rezeptor-antagonisten
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US9802954B2 (en)	2011-08-24	2017-10-31	Boehringer Ingelheim International Gmbh	Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
US9013997B2 (en)	2012-06-01	2015-04-21	Broadcom Corporation	System for performing distributed data cut-through
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JP6307525B2 (ja)	2013-02-04	2018-04-04	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	新規の置換縮合ピリミジン化合物
WO2014124860A1 (en)	2013-02-14	2014-08-21	Boehringer Ingelheim International Gmbh	Specific pde4b-inhibitors for the treatment of diabetes mellitus
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IL273169B2 (en)	2017-10-23	2024-05-01	Boehringer Ingelheim Int	New combination of active agents for the treatment of progressive fibrosing interstitial lung diseases (pf-ild)
CN111712503B (zh) *	2017-12-15	2024-04-09	联合疗法公司	取代的四氢吡喃二氢噻吩并嘧啶类化合物及其作为磷酸二酯酶抑制剂的用途
ES2935615T3 (es)	2017-12-15	2023-03-08	Union Therapeutics As	Azetidina dihidrotienopiridinas sustituidas y su uso como inhibidores de la fosfodiesterasa
JP7198820B2 (ja) *	2017-12-15	2023-01-04	ユニオン・セラピューティクス・アクティエセルスカブ	置換アゼチジンジヒドロチエノピリミジンおよびホスホジエステラーゼ阻害剤としてのそれらの使用
WO2020048827A1 (en) *	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	1, 3, 9-triazaspiro[5.5] undecan-2-one compounds
ES3041145T3 (en)	2021-12-09	2025-11-07	Boehringer Ingelheim Int	New oral pharmaceutical composition and dose regimen for the therapy of progressive fibrosing interstitial lung diseases
EP4520394A3 (en)	2021-12-09	2025-04-02	Boehringer Ingelheim International GmbH	New therapeutic combinations for the treatment of progressive fibrosing interstitial lung diseases
EP4534540A4 (en) *	2022-06-02	2026-04-15	Xizang Haisco Pharmaceutical Co Ltd	PDE4B INHIBITOR AND ITS USES
CN117247395A (zh) *	2022-06-16	2023-12-19	武汉人福创新药物研发中心有限公司	Pde4b抑制剂
CN115040503B (zh) *	2022-07-26	2023-10-10	云南民族大学	螺环二烯酮型木脂素类化合物在制药中的应用
EP4570804A1 (en) *	2022-08-09	2025-06-18	Xizang Haisco Pharmaceutical Co., Ltd.	Pde4b inhibitor and use thereof
CN119947728A (zh)	2022-09-28	2025-05-06	勃林格殷格翰国际有限公司	生物标志物在用pde4b抑制剂治疗纤维化病症中的用途
WO2024067660A1 (zh) *	2022-09-29	2024-04-04	苏州爱科百发生物医药技术有限公司	氮杂稠环类化合物、其制备方法及其在医药上的应用
EP4674852A1 (en) *	2023-02-28	2026-01-07	Innovstone Therapeutics Limited	Preparation method for and use of dihydrothienopyrimidine derivative
CN121127461A (zh) *	2023-04-03	2025-12-12	上海壹迪生物技术有限公司	二氢噻吩并嘧啶类化合物、其制备方法和应用
WO2024213089A1 (zh)	2023-04-13	2024-10-17	上海壹迪生物技术有限公司	取代的二氢噻吩并嘧啶类化合物、其制备方法和应用
CN116925099B (zh) *	2023-07-21	2025-06-03	厦门大学	手性二氢噻吩并嘧啶亚砜的制备方法及其应用与其2、4位取代化合物
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CN121889398A (zh) *	2023-09-25	2026-04-17	苏州爱科百发生物医药技术有限公司	氮杂稠环类化合物及其制备方法和用途
WO2025161532A1 (zh) *	2024-02-01	2025-08-07	艾派克斯生物科技有限公司	Pde4b抑制剂及其药物组合物和用途
WO2025162431A1 (zh) *	2024-02-04	2025-08-07	西藏海思科制药有限公司	一种pde4b抑制剂化合物的口服药物组合物及其制备方法

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NL122810C (pl)	1963-06-17
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BE663693A (pl)	1965-03-31
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DE1940572A1 (de)	1969-08-08	1971-02-11	Thomae Gmbh Dr K	Neue 2-Aminoalkylamino-thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung
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Also Published As

Publication number	Publication date
EA201000609A1 (ru)	2010-10-29
CN104069112A (zh)	2014-10-01
MA31845B1 (fr)	2010-11-01
ECSP10010156A (es)	2010-06-29
PT2215092E (pt)	2012-04-10
DK2610258T3 (da)	2014-11-10
CA2705414C (en)	2016-05-24
ZA201001683B (en)	2010-10-27
HRP20141153T1 (hr)	2015-02-13
EP2215092A1 (de)	2010-08-11
EP2610258B1 (de)	2014-08-27
PE20131463A1 (es)	2013-12-23
BRPI0818006B8 (pt)	2021-05-25
AU2008313660A1 (en)	2009-04-23
DK2215092T3 (da)	2012-05-07
EA019480B1 (ru)	2014-04-30
BRPI0818006A2 (pt)	2015-12-22
EP2380891B1 (de)	2013-12-11
CL2008003096A1 (es)	2010-02-12
EP2380891A1 (de)	2011-10-26
US8754073B2 (en)	2014-06-17
ES2524910T3 (es)	2014-12-15
CN101827852A (zh)	2010-09-08
JP2013064001A (ja)	2013-04-11
EP2610258A1 (de)	2013-07-03
TWI421077B (zh)	2014-01-01
BRPI0818006B1 (pt)	2019-10-22
HRP20120334T1 (hr)	2012-05-31
KR20100100807A (ko)	2010-09-15
AU2008313660B2 (en)	2013-11-07
UA99309C2 (ru)	2012-08-10
CN101827852B (zh)	2014-07-30
AR069075A1 (es)	2009-12-30
HK1145677A1 (en)	2011-04-29
ATE542825T1 (de)	2012-02-15
JP5615889B2 (ja)	2014-10-29
WO2009050248A1 (de)	2009-04-23
SI2610258T1 (sl)	2014-12-31
SI2215092T1 (sl)	2012-04-30
NZ585346A (en)	2011-09-30
TW200918074A (en)	2009-05-01
JP2011500640A (ja)	2011-01-06
UY31405A1 (es)	2009-05-29
JP5150728B2 (ja)	2013-02-27
TN2010000175A1 (fr)	2011-11-11
ME01330B (me)	2013-12-20
ES2381452T3 (es)	2012-05-28
PL2610258T3 (pl)	2015-02-27
CY1115858T1 (el)	2017-01-25
PE20091386A1 (es)	2009-10-17
MY153979A (en)	2015-04-30
EP2215092B1 (de)	2012-01-25
PT2610258E (pt)	2014-10-24
MX2010004026A (es)	2010-04-30
RS52271B (sr)	2012-10-31
KR101548975B1 (ko)	2015-09-01
US20110021501A1 (en)	2011-01-27
CA2705414A1 (en)	2009-04-23
CY1112703T1 (el)	2016-02-10

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