DK2215092T3 - Substitueret piperidino-dihydrothienopyrimidin - Google Patents

Substitueret piperidino-dihydrothienopyrimidin

Info

Publication number: DK2215092T3
Authority: DK; Denmark
Prior art keywords: dihydrothienopyrimidine; substituted piperidino; piperidino; substituted; piperidino dihydrothienopyrimidine
Prior art date: 2007-10-19

Application number

DK08839793.0T

Other languages

English (en)

Inventor

Pascale Pouzet

Ralf Anderskewitz

Horst Dollinger

Dennis Fiegen

Thomas Fox

Rolf Goeggel

Christoph Hoenke

Domnic Martyres

Peter Nickolaus

Klaus Klinder

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-19

Filing date

2008-10-16

Publication date

2012-05-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39154006&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2215092(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-10-16 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2012-05-07 Application granted granted Critical

2012-05-07 Publication of DK2215092T3 publication Critical patent/DK2215092T3/da

Links

JMUGMZBGUVOSPU-UHFFFAOYSA-N 1-piperidin-1-yl-2h-thieno[3,2-d]pyrimidine Chemical class C1CCCCN1N1C(C=CS2)=C2C=NC1 JMUGMZBGUVOSPU-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Dermatology (AREA)
Oncology (AREA)
Psychology (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK08839793.0T 2007-10-19 2008-10-16 Substitueret piperidino-dihydrothienopyrimidin DK2215092T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07118901		2007-10-19
PCT/EP2008/063999 WO2009050248A1 (de)	2007-10-19	2008-10-16	Substituierte piperidino-dihydrothienopyrimidine

Publications (1)

Publication Number	Publication Date
DK2215092T3 true DK2215092T3 (da)	2012-05-07

Family

ID=39154006

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK08839793.0T DK2215092T3 (da)	2007-10-19	2008-10-16	Substitueret piperidino-dihydrothienopyrimidin
DK13154790.3T DK2610258T3 (da)	2007-10-19	2008-10-16	Substituerede piperidindihydrothienopyrimidiner

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK13154790.3T DK2610258T3 (da)	2007-10-19	2008-10-16	Substituerede piperidindihydrothienopyrimidiner

Country Status (33)

Country	Link
US (1)	US8754073B2 (da)
EP (3)	EP2215092B1 (da)
JP (2)	JP5150728B2 (da)
KR (1)	KR101548975B1 (da)
CN (2)	CN104069112A (da)
AR (1)	AR069075A1 (da)
AT (1)	ATE542825T1 (da)
AU (1)	AU2008313660B2 (da)
BR (1)	BRPI0818006B8 (da)
CA (1)	CA2705414C (da)
CL (1)	CL2008003096A1 (da)
CY (2)	CY1112703T1 (da)
DK (2)	DK2215092T3 (da)
EA (1)	EA019480B1 (da)
EC (1)	ECSP10010156A (da)
ES (2)	ES2381452T3 (da)
HR (2)	HRP20120334T1 (da)
MA (1)	MA31845B1 (da)
ME (1)	ME01330B (da)
MX (1)	MX2010004026A (da)
MY (1)	MY153979A (da)
NZ (1)	NZ585346A (da)
PE (2)	PE20131463A1 (da)
PL (2)	PL2610258T3 (da)
PT (2)	PT2215092E (da)
RS (1)	RS52271B (da)
SI (2)	SI2215092T1 (da)
TN (1)	TN2010000175A1 (da)
TW (1)	TWI421077B (da)
UA (1)	UA99309C2 (da)
UY (1)	UY31405A1 (da)
WO (1)	WO2009050248A1 (da)
ZA (1)	ZA201001683B (da)

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CN111108109A (zh)	2017-09-20	2020-05-05	利奥制药有限公司	取代的二氢噻吩并嘧啶及其作为磷酸二酯酶抑制剂的用途
HRP20251042T1 (hr)	2017-10-23	2025-10-24	Boehringer Ingelheim International Gmbh	Nova kombinacija aktivnih sredstava za liječenje progresivnih intersticijskih bolesti pluća s fibroznim promjenama (pf-ild)
US11299497B2 (en)	2017-12-15	2022-04-12	UNION therapeutics A/S	Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
JP7198820B2 (ja) *	2017-12-15	2023-01-04	ユニオン・セラピューティクス・アクティエセルスカブ	置換アゼチジンジヒドロチエノピリミジンおよびホスホジエステラーゼ阻害剤としてのそれらの使用
DK3724196T3 (da)	2017-12-15	2023-01-16	Union Therapeutics As	Substituerede azetidindihydrothienopyridiner og anvendelse deraf som phosphodiesterasehæmmere
WO2020048827A1 (en) *	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	1, 3, 9-triazaspiro[5.5] undecan-2-one compounds
CA3236757A1 (en)	2021-12-09	2023-06-15	Boehringer Ingelheim International Gmbh	New therapeutic combinations for the treatment of progressive fibrosing interstitial lung diseases
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JP2025518257A (ja) *	2022-06-02	2025-06-12	シーザンハイスークファーマシューティカルカンパニーリミテッド	Ｐｄｅ４ｂ阻害剤及びその用途
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CN115040503B (zh) *	2022-07-26	2023-10-10	云南民族大学	螺环二烯酮型木脂素类化合物在制药中的应用
KR20250046278A (ko) *	2022-08-09	2025-04-02	시젱 하이스코 파마수티칼 씨오., 엘티디.	Pde4b 억제제 및 이의 용도
EP4593838A1 (en)	2022-09-28	2025-08-06	Boehringer Ingelheim International GmbH	Use of biomarkers in the treatment of fibrotic conditions with a pde4b-inhibitor
JP2025534418A (ja) *	2022-09-29	2025-10-15	蘇州愛科百発生物医薬技術有限公司	含窒素縮合複素環化合物、その調製方法、および医薬におけるその使用
CU20250021A7 (es) *	2023-02-28	2026-03-10	Innovstone Therapeutics Ltd	Compuesto inhibidor de la pde4b,útil para el tratamiento de enfermedades mediadas por pde4b
CN121127461A (zh) *	2023-04-03	2025-12-12	上海壹迪生物技术有限公司	二氢噻吩并嘧啶类化合物、其制备方法和应用
JP2026514091A (ja)	2023-04-13	2026-05-01	上海壹迪生物技術有限公司	置換ジヒドロチエノピリミジン系化合物、その製造方法及び使用
CN116925099B (zh) *	2023-07-21	2025-06-03	厦门大学	手性二氢噻吩并嘧啶亚砜的制备方法及其应用与其2、4位取代化合物
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CN121889398A (zh) *	2023-09-25	2026-04-17	苏州爱科百发生物医药技术有限公司	氮杂稠环类化合物及其制备方法和用途
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WO2025162431A1 (zh) *	2024-02-04	2025-08-07	西藏海思科制药有限公司	一种pde4b抑制剂化合物的口服药物组合物及其制备方法

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2008
- 2008-10-16 CN CN201410312258.5A patent/CN104069112A/zh active Pending
- 2008-10-16 WO PCT/EP2008/063999 patent/WO2009050248A1/de not_active Ceased
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Also Published As

Publication number	Publication date
EP2215092A1 (de)	2010-08-11
HK1145677A1 (en)	2011-04-29
PT2610258E (pt)	2014-10-24
EP2610258B1 (de)	2014-08-27
MY153979A (en)	2015-04-30
CN101827852B (zh)	2014-07-30
SI2610258T1 (sl)	2014-12-31
US8754073B2 (en)	2014-06-17
TN2010000175A1 (fr)	2011-11-11
EA019480B1 (ru)	2014-04-30
DK2610258T3 (da)	2014-11-10
PE20131463A1 (es)	2013-12-23
MX2010004026A (es)	2010-04-30
RS52271B (sr)	2012-10-31
JP5150728B2 (ja)	2013-02-27
ES2524910T3 (es)	2014-12-15
PE20091386A1 (es)	2009-10-17
CL2008003096A1 (es)	2010-02-12
PT2215092E (pt)	2012-04-10
EP2215092B1 (de)	2012-01-25
PL2610258T3 (pl)	2015-02-27
CY1112703T1 (el)	2016-02-10
KR20100100807A (ko)	2010-09-15
WO2009050248A1 (de)	2009-04-23
TW200918074A (en)	2009-05-01
ZA201001683B (en)	2010-10-27
NZ585346A (en)	2011-09-30
CN101827852A (zh)	2010-09-08
EP2380891A1 (de)	2011-10-26
ECSP10010156A (es)	2010-06-29
JP5615889B2 (ja)	2014-10-29
TWI421077B (zh)	2014-01-01
UY31405A1 (es)	2009-05-29
CN104069112A (zh)	2014-10-01
BRPI0818006A2 (pt)	2015-12-22
HRP20120334T1 (hr)	2012-05-31
US20110021501A1 (en)	2011-01-27
CA2705414C (en)	2016-05-24
AU2008313660A1 (en)	2009-04-23
ME01330B (me)	2013-12-20
MA31845B1 (fr)	2010-11-01
BRPI0818006B8 (pt)	2021-05-25
PL2215092T3 (pl)	2012-07-31
JP2013064001A (ja)	2013-04-11
BRPI0818006B1 (pt)	2019-10-22
AR069075A1 (es)	2009-12-30
EA201000609A1 (ru)	2010-10-29
EP2380891B1 (de)	2013-12-11
JP2011500640A (ja)	2011-01-06
ES2381452T3 (es)	2012-05-28
CY1115858T1 (el)	2017-01-25
HRP20141153T1 (hr)	2015-02-13
UA99309C2 (ru)	2012-08-10
KR101548975B1 (ko)	2015-09-01
SI2215092T1 (sl)	2012-04-30
ATE542825T1 (de)	2012-02-15
EP2610258A1 (de)	2013-07-03
AU2008313660B2 (en)	2013-11-07
CA2705414A1 (en)	2009-04-23

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