PL2222642T3 - Sposób i związki do wytwarzania (+) opiatów - Google Patents

Sposób i związki do wytwarzania (+) opiatów

Info

Publication number
PL2222642T3
PL2222642T3 PL08861695T PL08861695T PL2222642T3 PL 2222642 T3 PL2222642 T3 PL 2222642T3 PL 08861695 T PL08861695 T PL 08861695T PL 08861695 T PL08861695 T PL 08861695T PL 2222642 T3 PL2222642 T3 PL 2222642T3
Authority
PL
Poland
Prior art keywords
opiates
compounds
production
Prior art date
Application number
PL08861695T
Other languages
English (en)
Inventor
Peter X Wang
Tao Jiang
Gary L Cantrell
David W Berberich
Bobby N Trawick
Todd Osiek
Subo Liao
Frank W Moser
Joseph P Mcclurg
Original Assignee
SpecGx LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SpecGx LLC filed Critical SpecGx LLC
Publication of PL2222642T3 publication Critical patent/PL2222642T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
PL08861695T 2007-12-17 2008-12-17 Sposób i związki do wytwarzania (+) opiatów PL2222642T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1409407P 2007-12-17 2007-12-17
PCT/US2008/013776 WO2009078987A1 (en) 2007-12-17 2008-12-17 Process and compounds for the production of (+) opiates
EP08861695.8A EP2222642B1 (en) 2007-12-17 2008-12-17 Process and compounds for the production of (+) opiates

Publications (1)

Publication Number Publication Date
PL2222642T3 true PL2222642T3 (pl) 2014-07-31

Family

ID=40405079

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08861695T PL2222642T3 (pl) 2007-12-17 2008-12-17 Sposób i związki do wytwarzania (+) opiatów

Country Status (10)

Country Link
US (1) US8252808B2 (pl)
EP (1) EP2222642B1 (pl)
JP (2) JP5688974B2 (pl)
CN (1) CN101896463B (pl)
AU (1) AU2008338969B2 (pl)
CA (1) CA2709858C (pl)
ES (1) ES2455718T3 (pl)
NZ (1) NZ586203A (pl)
PL (1) PL2222642T3 (pl)
WO (1) WO2009078987A1 (pl)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2709862C (en) * 2007-12-17 2016-03-15 Peter X. Wang Sinomenine derivatives and processes for their synthesis
NZ591756A (en) 2008-09-16 2013-04-26 Mallinckrodt Llc Processes for the synthesis of five and six membered heterocyclic rings
CN102300848B (zh) * 2008-12-02 2014-07-02 马林克罗特公司 使用超酸制备氢可酮的方法
US8563724B2 (en) * 2009-02-23 2013-10-22 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
PL2453895T3 (pl) * 2009-07-16 2018-10-31 Mallinckrodt Llc (+)-morfinany jako antagonisty receptora toll-like 9 i ich zastosowania terapeutyczne
US9213776B1 (en) 2009-07-17 2015-12-15 Open Invention Network, Llc Method and system for searching network resources to locate content
US9645996B1 (en) 2010-03-25 2017-05-09 Open Invention Network Llc Method and device for automatically generating a tag from a conversation in a social networking website
CA2936749C (en) * 2010-06-11 2019-07-09 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
WO2012008984A1 (en) 2010-07-16 2012-01-19 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
US9746968B1 (en) 2010-11-10 2017-08-29 Open Invention Network Llc Touch screen display with tactile feedback using transparent actuator assemblies
KR20140063763A (ko) 2011-09-08 2014-05-27 말린크로트 엘엘씨 중간체를 단리하지 않는 알칼로이드의 제조 방법
CN102532024B (zh) * 2011-12-28 2016-08-03 赵爱国 青藤碱衍生物
EP2931726B1 (en) 2012-12-14 2017-01-25 Purdue Pharma LP Spirocyclic morphinans and their use
ES2631197T3 (es) 2012-12-14 2017-08-29 Purdue Pharma Lp Análogos de piridonamorfinano y actividad biológica sobre los receptores opiodes
US8937084B2 (en) 2012-12-14 2015-01-20 Purdue Pharma L.P. Nitrogen containing morphinan derivatives and the use thereof
CA2896202A1 (en) 2012-12-28 2014-07-03 Purdue Pharma L.P. Substituted morphinans and the use thereof
EP2941430B1 (en) 2012-12-28 2017-04-26 Purdue Pharma LP 7,8-cyclicmorphinan analogs
WO2015097547A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. 10-substituted morphinan hydantoins
WO2015097546A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Propellane-based compounds and their use as opioid receptor modulators
US9862726B2 (en) 2013-12-26 2018-01-09 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
GB201513203D0 (en) * 2015-07-27 2015-09-09 Cambrex Charles City Inc New process
US20230242547A1 (en) 2020-06-10 2023-08-03 Research Center Pharmaceutical Engineering Gmbh Processes for preparing nor-opioid compounds and opioid antagonists by electrochemical n-demethylation
CN115925628B (zh) * 2022-12-30 2024-07-09 浙江震元制药有限公司 青藤碱酯类衍生物及其制备方法和应用、镇痛药物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1602610A (en) 1962-10-10 1971-01-04 10.10.62.-17.4.63. 38445-15209 thebaine derivs
BE638369A (pl) * 1962-10-10
US3438989A (en) 1967-03-10 1969-04-15 Warner Lambert Pharmaceutical Process for the production of ( ) dihydrothebainone
FR2189403A1 (en) 1972-06-15 1974-01-25 Merck & Co Inc Norcodeine prepn - by reduction of 1-halo-norcodeinones, novel intermedi-ates for narcotic antagonists
WO1982000144A1 (en) * 1980-07-03 1982-01-21 Us Commerce A short total synthesis of dihydrothebainone,dihydrocodeinone,and nordihydrocodeinone
US4368326A (en) * 1980-07-03 1983-01-11 Rice Kenner C Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone
US4410700A (en) * 1980-07-03 1983-10-18 The United States Of America As Represented By The Department Of Health And Human Services Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution
DE3581423D1 (de) 1984-03-27 1991-02-28 Mallinckrodt Inc Herstellung von noroxymorphon aus morphin.
HU197750B (en) 1984-07-17 1989-05-29 Alkaloida Vegyeszeti Gyar Process for n-demethylation of morphine alkaloids
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
DE69033035T2 (de) * 1989-10-16 1999-08-05 The United States of America, represented by the Secretary, U.S. Department of Commerce, Washington, D.C. Totale synthese von northebain-, normorphin-, noroxymorphon-enantiomeren und -derivaten via n-nor-zwischenverbindungen
US6372756B1 (en) 1998-02-20 2002-04-16 Avmax, Inc. Epimorphian compound and its use
US7435817B2 (en) * 2001-08-23 2008-10-14 N.V. Organon C-14 oxidation of morphine derivatives
US7932264B2 (en) 2005-12-15 2011-04-26 Naturemed Group Corporation Sinomenine derivatives and preparation and uses thereof
EP2099764B1 (en) * 2006-09-20 2011-07-27 Mallinckrodt Inc. Preparation of substituted morphinan-6-ones and salts and intermediates thereof
CA2709862C (en) * 2007-12-17 2016-03-15 Peter X. Wang Sinomenine derivatives and processes for their synthesis
PL2453895T3 (pl) * 2009-07-16 2018-10-31 Mallinckrodt Llc (+)-morfinany jako antagonisty receptora toll-like 9 i ich zastosowania terapeutyczne

Also Published As

Publication number Publication date
AU2008338969B2 (en) 2013-08-01
CA2709858A1 (en) 2009-06-25
JP2013227349A (ja) 2013-11-07
JP5688974B2 (ja) 2015-03-25
US20090156818A1 (en) 2009-06-18
JP2011506602A (ja) 2011-03-03
ES2455718T3 (es) 2014-04-16
NZ586203A (en) 2012-10-26
AU2008338969A1 (en) 2009-06-25
US8252808B2 (en) 2012-08-28
WO2009078987A1 (en) 2009-06-25
CN101896463A (zh) 2010-11-24
CN101896463B (zh) 2016-08-24
EP2222642A1 (en) 2010-09-01
EP2222642B1 (en) 2014-02-12
CA2709858C (en) 2016-03-29

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