PL2231627T3 - Nowy sposób syntezy moguisteiny - Google Patents
Nowy sposób syntezy moguisteinyInfo
- Publication number
- PL2231627T3 PL2231627T3 PL08857548T PL08857548T PL2231627T3 PL 2231627 T3 PL2231627 T3 PL 2231627T3 PL 08857548 T PL08857548 T PL 08857548T PL 08857548 T PL08857548 T PL 08857548T PL 2231627 T3 PL2231627 T3 PL 2231627T3
- Authority
- PL
- Poland
- Prior art keywords
- moguisteine
- synthesis
- methoxyphenoxy
- methyl
- new process
- Prior art date
Links
- WSYVIAQNTFPTBI-UHFFFAOYSA-N ethyl 3-[2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidin-3-yl]-3-oxopropanoate Chemical compound CCOC(=O)CC(=O)N1CCSC1COC1=CC=CC=C1OC WSYVIAQNTFPTBI-UHFFFAOYSA-N 0.000 title abstract 3
- 229950009623 moguisteine Drugs 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- HGINADPHJQTSKN-UHFFFAOYSA-N Monoethyl malonic acid Chemical compound CCOC(=O)CC(O)=O HGINADPHJQTSKN-UHFFFAOYSA-N 0.000 abstract 2
- NPYIWLOZUFQMDZ-UHFFFAOYSA-N 2-[(2-methoxyphenoxy)methyl]-1,3-dioxolane Chemical compound COC1=CC=CC=C1OCC1OCCO1 NPYIWLOZUFQMDZ-UHFFFAOYSA-N 0.000 abstract 1
- -1 2-methoxyphenoxy Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07425770A EP2070915A1 (en) | 2007-12-03 | 2007-12-03 | New process for the synthesis of moguisteine |
| PCT/EP2008/066591 WO2009071528A2 (en) | 2007-12-03 | 2008-12-02 | New process for the synthesis of moguisteine |
| EP08857548A EP2231627B1 (en) | 2007-12-03 | 2008-12-02 | New process for the synthesis of moguisteine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2231627T3 true PL2231627T3 (pl) | 2011-11-30 |
Family
ID=39450286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08857548T PL2231627T3 (pl) | 2007-12-03 | 2008-12-02 | Nowy sposób syntezy moguisteiny |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP2070915A1 (pl) |
| KR (1) | KR20110086503A (pl) |
| CN (1) | CN101883761B (pl) |
| AT (1) | ATE511505T1 (pl) |
| CY (1) | CY1112328T1 (pl) |
| ES (1) | ES2367466T3 (pl) |
| PL (1) | PL2231627T3 (pl) |
| PT (1) | PT2231627E (pl) |
| RS (1) | RS51931B (pl) |
| RU (1) | RU2492165C2 (pl) |
| SI (1) | SI2231627T1 (pl) |
| WO (1) | WO2009071528A2 (pl) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102653527A (zh) * | 2011-12-22 | 2012-09-05 | 东莞达信生物技术有限公司 | 一种莫吉司坦合成工艺 |
| CN105399701A (zh) * | 2013-01-06 | 2016-03-16 | 天津市汉康医药生物技术有限公司 | 噻唑烷衍生物、其制备方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU195492B (en) * | 1984-07-27 | 1988-05-30 | Boehringer Biochemia Srl | Process for producing 2-substituted thiazolidine derivatives with antitussive and mucus regulating action and pharmaceuticals comprising these compounds as active ingredient |
| IT1216119B (it) * | 1988-03-17 | 1990-02-22 | Boehringer Biochemia Srl | Beta_carbonil_carbossiamidi di 1,3_tiazolidine. |
| IT1318650B1 (it) * | 2000-07-28 | 2003-08-27 | Dompe Spa | 1,3-diossolani ad attivita' antitosse. |
-
2007
- 2007-12-03 EP EP07425770A patent/EP2070915A1/en not_active Withdrawn
-
2008
- 2008-12-02 PT PT08857548T patent/PT2231627E/pt unknown
- 2008-12-02 SI SI200830359T patent/SI2231627T1/sl unknown
- 2008-12-02 WO PCT/EP2008/066591 patent/WO2009071528A2/en not_active Ceased
- 2008-12-02 RU RU2010127348/04A patent/RU2492165C2/ru not_active IP Right Cessation
- 2008-12-02 PL PL08857548T patent/PL2231627T3/pl unknown
- 2008-12-02 ES ES08857548T patent/ES2367466T3/es active Active
- 2008-12-02 EP EP08857548A patent/EP2231627B1/en active Active
- 2008-12-02 CN CN200880118955XA patent/CN101883761B/zh not_active Expired - Fee Related
- 2008-12-02 RS RS20110364A patent/RS51931B/sr unknown
- 2008-12-02 AT AT08857548T patent/ATE511505T1/de not_active IP Right Cessation
- 2008-12-02 KR KR1020107014918A patent/KR20110086503A/ko not_active Ceased
-
2011
- 2011-08-24 CY CY20111100811T patent/CY1112328T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009071528A2 (en) | 2009-06-11 |
| EP2231627A2 (en) | 2010-09-29 |
| ATE511505T1 (de) | 2011-06-15 |
| CN101883761A (zh) | 2010-11-10 |
| RU2010127348A (ru) | 2012-01-10 |
| RU2492165C2 (ru) | 2013-09-10 |
| SI2231627T1 (sl) | 2011-10-28 |
| ES2367466T3 (es) | 2011-11-03 |
| KR20110086503A (ko) | 2011-07-28 |
| CY1112328T1 (el) | 2015-12-09 |
| EP2070915A1 (en) | 2009-06-17 |
| EP2231627B1 (en) | 2011-06-01 |
| PT2231627E (pt) | 2011-09-13 |
| CN101883761B (zh) | 2013-03-27 |
| RS51931B (sr) | 2012-02-29 |
| WO2009071528A3 (en) | 2009-08-13 |
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