PL2241575T3 - Polipeptydy fuzyjne IGF-1 oraz ich zastosowania terapeutyczne - Google Patents

Polipeptydy fuzyjne IGF-1 oraz ich zastosowania terapeutyczne

Info

Publication number
PL2241575T3
PL2241575T3 PL10007017T PL10007017T PL2241575T3 PL 2241575 T3 PL2241575 T3 PL 2241575T3 PL 10007017 T PL10007017 T PL 10007017T PL 10007017 T PL10007017 T PL 10007017T PL 2241575 T3 PL2241575 T3 PL 2241575T3
Authority
PL
Poland
Prior art keywords
igf1
component
igf
fusion
fusion polypeptides
Prior art date
Application number
PL10007017T
Other languages
English (en)
Inventor
David J Glass
George D Yancopoulos
Thomas J Daly
Nicholas J Papadopoulos
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of PL2241575T3 publication Critical patent/PL2241575T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
PL10007017T 2005-01-07 2006-01-06 Polipeptydy fuzyjne IGF-1 oraz ich zastosowania terapeutyczne PL2241575T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64222905P 2005-01-07 2005-01-07
US65658305P 2005-02-25 2005-02-25
EP10007017.6A EP2241575B1 (en) 2005-01-07 2006-01-06 IGF-1 fusion polypeptides and therapeutic uses thereof
EP06717668A EP1833847B1 (en) 2005-01-07 2006-01-06 Igf-1 fusion polypeptides and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
PL2241575T3 true PL2241575T3 (pl) 2015-12-31

Family

ID=42634965

Family Applications (2)

Application Number Title Priority Date Filing Date
PL06717668T PL1833847T3 (pl) 2005-01-07 2006-01-06 Polipeptydy fuzyjne IGF-1 oraz ich zastosowanie terapeutyczne
PL10007017T PL2241575T3 (pl) 2005-01-07 2006-01-06 Polipeptydy fuzyjne IGF-1 oraz ich zastosowania terapeutyczne

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL06717668T PL1833847T3 (pl) 2005-01-07 2006-01-06 Polipeptydy fuzyjne IGF-1 oraz ich zastosowanie terapeutyczne

Country Status (12)

Country Link
US (4) US7396918B2 (pl)
EP (2) EP2241575B1 (pl)
JP (1) JP4988599B2 (pl)
AT (1) ATE517120T1 (pl)
AU (1) AU2006203882B2 (pl)
CA (1) CA2594023C (pl)
DK (1) DK2241575T3 (pl)
ES (1) ES2541810T3 (pl)
HU (1) HUE027645T2 (pl)
PL (2) PL1833847T3 (pl)
PT (1) PT2241575E (pl)
WO (1) WO2006074390A2 (pl)

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US7521211B2 (en) 2005-04-05 2009-04-21 Regeneron Pharmaceuticals, Inc IGF-1 and IGF-2 chimeric polypeptides and therapeutic uses thereof
WO2007146689A2 (en) * 2006-06-09 2007-12-21 Novartis Ag Stabilized insulin-like growth factor polypeptides
CL2007002502A1 (es) 2006-08-31 2008-05-30 Hoffmann La Roche Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer.
BRPI0715754A2 (pt) 2006-08-31 2013-07-09 Hoffmann La Roche mÉtodo para a produÇço de fator do crescimento similar Á insulina i
GB0715213D0 (en) * 2007-08-06 2007-09-12 Asterlon Ltd Igf-1
BRPI0912225A2 (pt) 2008-05-07 2018-03-20 Zystor Therapeutics, Inc. peptídeos de direcionamento lisossomais e usos dos mesmos
US8685403B2 (en) 2009-01-30 2014-04-01 The Regents Of The University Of California Insulin-like growth factor signaling and integrin
US7963705B2 (en) * 2009-02-24 2011-06-21 Avago Technologies Fiber Ip (Singapore) Pte. Ltd. Molded interconnect device (MID) optical connector with metal retaining clip
TWI490371B (zh) 2009-07-28 2015-07-01 Industrie De Nora Spa 電解應用上的電極及其製法以及在電極表面上陽極釋氧之電解法和電冶法
US9238080B2 (en) 2010-05-21 2016-01-19 Merrimack Pharmaceuticals, Inc. Bi-specific fusion proteins
US20130274235A1 (en) * 2010-10-08 2013-10-17 The General Hospital Corporation Treatment of motor neuron disease
CN102618575A (zh) * 2011-09-16 2012-08-01 江苏普罗赛生物技术有限公司 哺乳动物细胞大规模生产重组人IGF1-Fc融合蛋白的实验技术
US10030063B2 (en) 2012-12-18 2018-07-24 Novartis Ag Production of therapeutic proteins in genetically modified mammalian cells
CN105121462B (zh) * 2012-12-18 2019-08-02 诺华股份有限公司 稳定化的胰岛素样生长因子多肽
US10076384B2 (en) 2013-03-08 2018-09-18 Symple Surgical, Inc. Balloon catheter apparatus with microwave emitter
WO2015049630A1 (en) 2013-10-02 2015-04-09 Novartis Ag Insulin-like growth factor mimetics for use in therapy
UY35874A (es) 2013-12-12 2015-07-31 Novartis Ag Un proceso para la preparación de una composición de proteínas pegiladas
JP2017510622A (ja) 2014-01-27 2017-04-13 ノバルティス アーゲー 筋萎縮を予測するバイオマーカー、方法および使用
WO2016115171A1 (en) * 2015-01-16 2016-07-21 The Regents Of The University Of California Insulin-like growth factor 2 (igf2) signaling and modulation
EP3355907B1 (en) 2015-10-02 2021-01-20 Silver Creek Pharmaceuticals, Inc. Bi-specific therapeutic proteins for tissue repair
CN118078956A (zh) * 2016-05-06 2024-05-28 免疫新炉有限公司 用于受控和持续释放的elp融合蛋白
EP3609522A4 (en) * 2017-04-10 2021-05-05 Yoram Palti METHODS AND COMPOUNDS FOR THE TREATMENT OF DIABETES
EP3453722A1 (en) * 2017-09-06 2019-03-13 Julius-Maximilians-Universität Würzburg Pharmaceuticals and devices for the covalent immobilization to the extracellular matrix by transglutaminase
CN113214410A (zh) * 2017-11-04 2021-08-06 海南大学 一种表达促皮质素与胰岛素样生长因子1融合蛋白的重组质粒、重组菌的构建方法
EP3569614A1 (en) 2018-05-18 2019-11-20 Julius-Maximilians-Universität Würzburg Compounds and methods for the immobilization of myostatin-inhibitors on the extracellular matrix by transglutaminase
EP4606428A3 (en) * 2018-06-27 2025-11-05 Juvena Therapeutics, Inc. Heparin-associated polypeptides and uses thereof
AU2020361703A1 (en) * 2019-10-10 2022-04-28 Amicus Therapeutics, Inc. Variant IGF2 constructs
CN115379850A (zh) 2019-12-24 2022-11-22 裘美娜治疗公司 再生性多肽及其用途
WO2022079612A1 (en) * 2020-10-13 2022-04-21 Betavive Ltd. Method and compounds for treating diabetes and associated metabolic diseases
AU2022298470A1 (en) 2021-06-21 2024-02-01 Juvena Therapeutics, Inc. Regenerative polypeptides and uses thereof
US12447198B2 (en) 2021-10-12 2025-10-21 Betavive Ltd. Peptides and fragments for treating diabetes and associated metabolic diseases
JP2025516361A (ja) * 2022-05-04 2025-05-27 イムノフォージ カンパニー リミテッド Ｇｌｐ－１と、免疫グロブリンｆｃと、ｉｇｆ－１とを含む融合タンパク質並びにその用途
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Also Published As

Publication number Publication date
WO2006074390A2 (en) 2006-07-13
US20120195896A1 (en) 2012-08-02
CA2594023A1 (en) 2006-07-13
CA2594023C (en) 2015-07-14
US7837999B2 (en) 2010-11-23
US8445434B2 (en) 2013-05-21
WO2006074390A3 (en) 2007-01-11
HUE027645T2 (en) 2016-10-28
AU2006203882B2 (en) 2011-05-12
EP1833847A2 (en) 2007-09-19
AU2006203882A1 (en) 2006-07-13
US20110020342A1 (en) 2011-01-27
JP4988599B2 (ja) 2012-08-01
PT2241575E (pt) 2015-09-16
JP2008526233A (ja) 2008-07-24
EP2241575B1 (en) 2015-06-24
US7396918B2 (en) 2008-07-08
PL1833847T3 (pl) 2011-12-30
EP2241575A1 (en) 2010-10-20
ATE517120T1 (de) 2011-08-15
DK2241575T3 (en) 2015-08-24
US20060166328A1 (en) 2006-07-27
HK1144684A1 (en) 2011-03-04
EP1833847B1 (en) 2011-07-20
US8158581B2 (en) 2012-04-17
ES2541810T3 (es) 2015-07-24
US20090069235A1 (en) 2009-03-12

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