PL2254586T3 - Cząstki mezenchymalnych komórek macierzystych - Google Patents

Cząstki mezenchymalnych komórek macierzystych

Info

Publication number
PL2254586T3
PL2254586T3 PL09712571T PL09712571T PL2254586T3 PL 2254586 T3 PL2254586 T3 PL 2254586T3 PL 09712571 T PL09712571 T PL 09712571T PL 09712571 T PL09712571 T PL 09712571T PL 2254586 T3 PL2254586 T3 PL 2254586T3
Authority
PL
Poland
Prior art keywords
stem cell
mesenchymal stem
cell particles
particles
mesenchymal
Prior art date
Application number
PL09712571T
Other languages
English (en)
Inventor
Sai Kiang Lim
Original Assignee
Agency For Science Tech And Research Astarstar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency For Science Tech And Research Astarstar filed Critical Agency For Science Tech And Research Astarstar
Publication of PL2254586T3 publication Critical patent/PL2254586T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
PL09712571T 2008-02-22 2009-02-21 Cząstki mezenchymalnych komórek macierzystych PL2254586T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6667108P 2008-02-22 2008-02-22
PCT/SG2009/000062 WO2009105044A1 (en) 2008-02-22 2009-02-21 Mesenchymal stem cell particles
EP09712571.0A EP2254586B1 (en) 2008-02-22 2009-02-21 Mesenchymal stem cell particles

Publications (1)

Publication Number Publication Date
PL2254586T3 true PL2254586T3 (pl) 2015-09-30

Family

ID=40688500

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09712571T PL2254586T3 (pl) 2008-02-22 2009-02-21 Cząstki mezenchymalnych komórek macierzystych

Country Status (14)

Country Link
US (3) US20110003008A1 (pl)
EP (1) EP2254586B1 (pl)
JP (1) JP5718648B2 (pl)
KR (1) KR101640381B1 (pl)
CN (2) CN104127438B (pl)
AU (1) AU2009215934C1 (pl)
DK (1) DK2254586T3 (pl)
ES (1) ES2537516T3 (pl)
HR (1) HRP20150510T1 (pl)
HU (1) HUE026536T2 (pl)
PL (1) PL2254586T3 (pl)
PT (1) PT2254586E (pl)
SI (1) SI2254586T1 (pl)
WO (1) WO2009105044A1 (pl)

Families Citing this family (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
GB0818725D0 (en) * 2008-10-13 2008-11-19 Habib Nagy A Pharmaceutical composition
SG10201403202XA (en) * 2009-07-23 2014-08-28 Agency Science Tech & Res Pre-natal mesenchymal stem cells
CN106619515A (zh) 2009-08-27 2017-05-10 工业研究与发展基金会有限公司 脂质体组合物及其用途
WO2011029903A1 (en) * 2009-09-10 2011-03-17 Flemming Velin Method for the preparation of micro-rna and its therapeutic application
KR20110038569A (ko) * 2009-10-08 2011-04-14 주식회사 알앤엘바이오 인간 유래 성체 줄기세포를 함유하는 항암용 조성물
EP2333047A1 (en) * 2009-12-09 2011-06-15 Fresenius Medical Care Deutschland GmbH Adult stem cell derived conditioned medium and/or adult stem cells for use in the therapeutic treatment of a tumor disease
US20110171323A1 (en) * 2010-01-09 2011-07-14 The Translational Genomics Research Institute Methods and kits to predict prognostic and therapeutic outcome in small cell lung cancer
EP2363136A1 (en) * 2010-03-02 2011-09-07 Fresenius Medical Care Deutschland GmbH Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
CN101890050B (zh) * 2010-07-14 2012-07-04 江苏大学 脐带间质干细胞来源膜性囊泡及其应用
EP3563858A1 (en) 2010-10-18 2019-11-06 Agency For Science, Technology And Research Use of exosomes to promote or enhance wound healing
WO2012087241A1 (en) * 2010-12-20 2012-06-28 Agency For Science, Technology And Research Method of purifying exosomes
US20220008618A1 (en) * 2010-12-20 2022-01-13 Cormatrix Cardiovascular, Inc. Cardiovascular Prostheses
SG183579A1 (en) * 2011-02-11 2012-09-27 Agency Science Tech & Res Methods of detecting therapeutic exosomes
US9901600B2 (en) * 2011-03-11 2018-02-27 Children's Medical Center Corporation Methods and compositions relating to mesenchymal stem cell exosomes
CN102225054B (zh) * 2011-06-20 2013-01-16 河北科技大学 一种载有抗肿瘤药物微粒的制剂及其制备方法
ITRM20110403A1 (it) 2011-07-28 2013-01-29 Ospedale Pediatrico Bambino Gesu Microvescicole isolate da cellule mesenchimali come agenti immunosoppressori.
KR101405437B1 (ko) * 2011-08-16 2014-06-11 사회복지법인 삼성생명공익재단 줄기세포 유래 미세소포를 포함하는 신경 생성 촉진용 조성물
EP2756847A1 (en) * 2011-09-13 2014-07-23 Takahiro Ochiya Pharmaceutical product for preventing or treating alzheimer's disease
AU2012346594B2 (en) 2011-11-30 2017-12-21 Agency For Science, Technology And Research GM1 ganglioside to Annexin V microparticle polypeptide ratio for biological monitoring
WO2013082458A1 (en) 2011-12-02 2013-06-06 The Regents Of The University Of California Reperfusion protection solution and uses thereof
ITRM20110685A1 (it) 2011-12-23 2013-06-24 Internat Ct For Genetic En Gineering And Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci
WO2013122950A1 (en) * 2012-02-13 2013-08-22 Wuyi Kong Nprcps, pfdncs and uses thereof
US11286463B2 (en) 2012-03-08 2022-03-29 Advanced ReGen Medical Technologies, LLC Reprogramming of aged adult stem cells
GB201302468D0 (en) 2013-02-12 2013-03-27 Reneuron Ltd Stem cell product
JP6450673B2 (ja) 2012-04-03 2019-01-09 リニューロン・リミテッドＲｅＮｅｕｒｏｎ Ｌｉｍｉｔｅｄ 幹細胞微粒子
WO2013158913A1 (en) * 2012-04-18 2013-10-24 Rhode Island Hospital, A Lifespan-Partner Treating cancer
WO2013163479A1 (en) * 2012-04-25 2013-10-31 General Istrazivanja D.O.O. Methods and compositions for treating and diagnosing acute myocardial infarction
EP2850178A4 (en) * 2012-05-18 2015-10-28 Agency Science Tech & Res EXOSOMES OF MESHCHYMIC STROKE CELL OF UMBILICAL CORD
WO2013184527A1 (en) 2012-06-05 2013-12-12 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
EP2687219A1 (en) 2012-07-18 2014-01-22 Universität Duisburg-Essen Use of preparations comprising exosomes derived from mesenchymal stem cells (MSCs) in the prevention and therapy of inflammatory conditions
JP2015529450A (ja) * 2012-07-19 2015-10-08 リニューロン・リミテッドＲｅＮｅｕｒｏｎ Ｌｉｍｉｔｅｄ 幹細胞微粒子
IN2015DN00934A (pl) 2012-08-01 2015-06-12 United Therapeutics Corp
ES2869701T3 (es) 2012-08-01 2021-10-25 United Therapeutics Corp Tratamiento de hipertensión arterial pulmonar con células progenitoras endoteliales tratadas con prostaciclina
AU2013302799B2 (en) 2012-08-13 2018-03-01 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
WO2014028763A1 (en) 2012-08-15 2014-02-20 The University Of Chicago Exosome-based therapeutics against neurodegenerative disorders
US20190178879A1 (en) * 2012-08-23 2019-06-13 Stemcell Technologies Canada Inc. Compositions and methods for rapid and reversible biomolecular labeling
CN103865873B (zh) * 2012-12-12 2017-04-05 中国医学科学院基础医学研究所 亚全能干细胞分泌的外来体及其应用
AU2014205557B2 (en) 2013-01-09 2017-08-10 United Therapeutics Corporation Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
US20160120818A1 (en) * 2013-02-07 2016-05-05 Glaxosmithline Biological Sa Pharmaceutical compositions comprising vesicles
CN105142646A (zh) 2013-02-12 2015-12-09 兰诺龙有限公司 产生微粒的方法
JP6388606B2 (ja) * 2013-02-14 2018-09-12 メタノミクス ヘルス ゲーエムベーハー 生物学的サンプルの質を評価するための手段及び方法
US12558316B2 (en) 2013-03-13 2026-02-24 University Of Miami Methods and compositions for the treatment of epidermolysis bullosa
CA2906502A1 (en) 2013-03-13 2014-10-02 University Of Miami Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids
US20140314872A1 (en) * 2013-04-22 2014-10-23 Hans Klingemann Methods of Use of Culture Supernatant Obtained from Mesenchymal Stem Cells from Dogs and Cats for Treatment of Organ Dysfunction
CA2914615C (en) 2013-06-05 2023-10-17 Biotime, Inc. Compositions and methods for induced tissue regeneration in mammalian species
DK3016665T3 (da) 2013-07-05 2019-11-25 Univ Catholique Louvain Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser
CN103409369A (zh) * 2013-07-31 2013-11-27 江苏大学 一种快速建立间质干细胞衰老模型的方法
WO2015016761A2 (en) * 2013-08-01 2015-02-05 Isletone Ab Mscs in the treatment of inflammatory pulmonary diseases
BR112016003053A2 (pt) * 2013-08-14 2017-09-12 Reneuron Ltd micropartículas de células tronco e mirna
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
WO2016043654A1 (en) 2014-09-15 2016-03-24 Agency For Science, Technology And Research Methods of treating graft versus host disease (gvhd) or epidermolysis bullosa (eb) with exosomes
SG11201601939VA (en) * 2013-09-16 2016-04-28 Agency Science Tech & Res Method
GB201317889D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product and use
EP3701957B1 (en) 2013-11-01 2022-12-28 ImmunityBio, Inc. Tumoricidal and antimicrobial compositions and methods
US9309314B2 (en) 2013-12-03 2016-04-12 Agency For Science, Technology And Research (A*Star) Polypeptides, nucleic acids and uses thereof
CR20160307A (es) 2013-12-20 2016-11-08 Advanced Regen Medical Tech Llc Composiciones para la restauración de células y métodos para la preparación y utilización de las mismas
US10772911B2 (en) 2013-12-20 2020-09-15 Advanced ReGen Medical Technologies, LLC Cell free compositions for cellular restoration and methods of making and using same
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
TWI558421B (zh) * 2014-03-06 2016-11-21 芯芮生技開發股份有限公司 幹細胞條件培養基用於製備抑制氧化作用達到皮膚抗老化之組成物的用途
US9284528B2 (en) 2014-04-18 2016-03-15 Growgene Biotech Inc. Use of stem cell conditioned medium to inhibit oxidation for anti-aging skin
US10568945B2 (en) 2014-04-25 2020-02-25 University Of Cincinnati Compositions and methods for inducing liver regeneration by administering hepatocyte-derived exosomes
US10624929B2 (en) 2014-05-18 2020-04-21 Children's Medical Center Corporation Methods and compositions relating to exosomes
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
WO2016051983A1 (ja) * 2014-09-29 2016-04-07 株式会社カネカ 細胞培養培地及びそれを用いた培養方法
WO2016054591A1 (en) 2014-10-03 2016-04-07 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
KR101673059B1 (ko) * 2014-11-26 2016-11-07 가톨릭관동대학교산학협력단 중간엽줄기세포 유래 미세소포체를 포함하는 발모촉진 또는 창상 치료용 약제학적 조성물
RU2644650C2 (ru) 2014-12-01 2018-02-13 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток и способ его получения
KR101784050B1 (ko) * 2014-12-23 2017-10-10 영남대학교 산학협력단 엑소솜을 유효성분으로 함유하는 피부 노화 예방 또는 치료용 약학조성물
CN104673749B (zh) 2015-02-12 2017-10-20 江苏大学 一种粒细胞样髓源性抑制细胞来源exosomes及其应用
US20180042847A1 (en) * 2015-03-16 2018-02-15 Duncan ROSS Method of treatment comprising membrane-enclosed vesicle
WO2016157142A1 (en) * 2015-04-02 2016-10-06 Stegi-Ra Trust Composition for use in treating celiac disease
GB201505747D0 (en) * 2015-04-02 2015-05-20 Univ Bristol Exosomes
US20160324898A1 (en) * 2015-05-04 2016-11-10 Stemedica International, Sa Compositions and methods for the treatment of alzheimer's disease
US11291689B2 (en) 2015-06-03 2022-04-05 Aelan Cell Technologies, Inc. Methods and devices for the production and delivery of beneficial factors from adipose-derived stem cells
EP4667487A2 (en) * 2015-06-03 2025-12-24 Aelan Cell Technologies, Inc. Companion methods and kits for il-2-based therapies and mesenchymal stem cell-based therapies
KR101751513B1 (ko) * 2015-06-23 2017-06-27 한국과학기술연구원 인 비트로 섬유증 모델, 그의 제조방법 및 용도
HUE063486T2 (hu) * 2015-07-31 2024-01-28 Exotropin Llc Exoszóma kompozíciók és eljárások azok elõállítására és alkalmazásukra a bõr és a haj állapotának szabályozására és kondicionálására
US11357798B2 (en) 2015-08-03 2022-06-14 Osaka University Mesenchymal stem cell-derived exosome
DE102015115158B4 (de) * 2015-09-09 2017-07-13 Fresenius Medical Care Deutschland Gmbh Verfahren und Kit zur Diagnose von epithelial-mesenchymaler Transition (EMT) des Peritoneums
WO2017054086A1 (en) * 2015-10-01 2017-04-06 Exerkine Corporation Treatment of genetic myopathies using bioengineered exosomes
US11857575B2 (en) 2015-11-02 2024-01-02 Takeda Pharmaceutical Company Limited Mesenchymal stem cell-derived exosomes and their uses
US20170121685A1 (en) * 2015-11-02 2017-05-04 Tigenix S.A.U. Mesenchymal stem cell-derived exosomes and their uses
CN108779435B (zh) 2015-12-07 2022-05-03 再生疗法有限公司 用于重新衍生不同的多能干细胞衍生的褐色脂肪细胞的方法
US11253551B2 (en) 2016-01-11 2022-02-22 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
WO2017123022A1 (ko) * 2016-01-12 2017-07-20 주식회사 강스템바이오텍 고함량의 성장인자를 함유한 줄기세포 유래 엑소좀
CN108601930B (zh) 2016-02-08 2021-12-14 祥丰医疗私人有限公司 药物洗脱球囊
US10792477B2 (en) 2016-02-08 2020-10-06 Orbusneich Medical Pte. Ltd. Drug eluting balloon
EP3427060B1 (en) 2016-03-07 2025-08-13 Father Flanagan's Boys' Home doing Business as Boys Town National Research Hospital Noninvasive molecular controls
WO2017181166A1 (en) 2016-04-15 2017-10-19 Temple University-Of The Commonwealth System Of Higher Education Microrna-294 and ln28a as a driver of cardiac tissue proliferation in response to pathological injury
WO2017190000A1 (en) 2016-04-29 2017-11-02 Advanced ReGen Medical Technologies, LLC Microrna compositions and methods of making and using same
EP3452100B1 (en) * 2016-05-06 2020-12-16 Unicyte EV AG Pharmaceutical carriers containing mirnas for use in the treatment of fibrotic diseases caused by hyperglycemia
EP3458574A4 (en) * 2016-05-16 2019-12-25 Exostem Biotec Ltd. MESENCHYMAL STEM CELL AND THE USE THEREOF FOR TREATING MUSCLE INJURIES AND MUSCLE-ASSOCIATED DISEASES
RU2708329C2 (ru) 2016-05-31 2019-12-05 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток, композиции и способы применения
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
US10946047B2 (en) * 2016-06-17 2021-03-16 United Therapeutics Corporation Extracellular vesicles with enhanced potency
TWI601741B (zh) * 2016-07-11 2017-10-11 財團法人國家衛生研究院 利用前列腺素受體ｅｐ４－拮抗劑誘導幹細胞製造含有高囊泡含物之外泌體囊泡的方法及其應用
AU2017311684B2 (en) 2016-08-14 2023-05-04 Ramot At Tel-Aviv University Ltd. Mesenchymal cell-derived exosomes to treat neurological disorders
EP3515459A4 (en) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS
CN106265899A (zh) * 2016-09-30 2017-01-04 广州赛莱拉干细胞科技股份有限公司 一种组合物及其在制备改善慢性鼻炎的产品中的应用
WO2018070939A1 (en) 2016-10-12 2018-04-19 Agency For Science, Technology And Research Method for lyophilising an exosome
EP3308795A1 (en) * 2016-10-12 2018-04-18 Unicyte EV AG A composition of extracellular vesicles (evs) and medical uses thereof
US11571444B2 (en) 2016-10-24 2023-02-07 United Therapeutics Corporation Enhancement of MSC immunomodulatory properties by treprostinil
CN106636305A (zh) * 2016-11-16 2017-05-10 宁夏医科大学总医院 一种检测人胎盘胎儿侧间充质干细胞抗氧化能力的方法
WO2018109525A1 (en) * 2016-12-14 2018-06-21 Università Degli Studi Di Padova New anti-angiogenic extracellurlar vesicles
WO2018186505A1 (ko) * 2017-04-03 2018-10-11 ㈜프로스테믹스 줄기세포 유래 엑소좀을 포함하는 상처 치료, 피부 개선 및 탈모 방지 또는 치료용 조성물 및 그 제조방법
CA3059910A1 (en) 2017-04-19 2018-10-25 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
ES3052812T3 (en) 2017-05-08 2026-01-14 Flagship Pioneering Innovations V Inc Compositions for facilitating membrane fusion and uses thereof
WO2018225440A1 (ja) * 2017-06-09 2018-12-13 国立大学法人大阪大学 拡張型心筋症治療剤
KR102045188B1 (ko) * 2017-06-30 2019-11-14 주식회사 엑소코바이오 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부염 개선 용도
WO2019004738A2 (ko) * 2017-06-30 2019-01-03 주식회사 엑소코바이오 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부염 개선 용도
KR20190003316A (ko) 2017-06-30 2019-01-09 주식회사 엑소코바이오 지방줄기세포 유래의 엑소좀 및/또는 세포외 소포체를 유효성분으로 포함하는 조성물의 피부염 개선 용도
WO2019004757A2 (ko) * 2017-06-30 2019-01-03 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 가려움증 억제 또는 개선 용도
WO2019016799A1 (en) * 2017-07-16 2019-01-24 Ramot At Tel-Aviv University Ltd. SECRETEOME OF HUMAN MUCOSAL MUCOSAL STEM CELLS
CN107189985B (zh) * 2017-07-24 2021-02-02 中国人民解放军军事医学科学院基础医学研究所 miRNA分子及其抑制剂在调控骨间充质干细胞成脂分化中的应用
WO2019028223A1 (en) * 2017-08-04 2019-02-07 Cedars-Sinai Medical Center CARDIOSPHERE-DERIVED CELLS AND THEIR EXTRACELLULAR VESICLES FOR THE TREATMENT AND PREVENTION OF CANCER
US20220023347A9 (en) * 2017-08-15 2022-01-27 Children's Medical Center Corporation Purified mesenchymal stem cell exosomes and uses thereof
KR102197562B1 (ko) * 2017-09-07 2020-12-31 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 포함하는 엑소좀 키트의 새로운 용도
WO2019083201A2 (ko) * 2017-10-24 2019-05-02 주식회사 엑소코바이오 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 신장 기능 개선 용도
WO2019088545A1 (ko) * 2017-10-31 2019-05-09 주식회사 엑소코바이오 엑소좀 키트 및 이를 이용한 엑소좀의 경피 투과 증진 방법
US11766402B2 (en) 2017-11-16 2023-09-26 Board Of Regents, The University Of Texas System Methods for production of MSC-derived exosomes
KR101964991B1 (ko) * 2017-12-10 2019-04-02 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 포함하는 엑소좀 키트의 새로운 용도
KR102755006B1 (ko) * 2017-12-11 2025-01-17 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 민감성 피부의 예방, 억제, 완화 또는 개선용 화장료 조성물
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
KR102096150B1 (ko) * 2018-01-05 2020-04-02 재단법인 아산사회복지재단 인터페론 감마로 전처리된 유도만능 줄기세포 유래 중간엽 줄기세포 및 이로부터 유래된 엑소좀을 포함하는 피부질환의 개선, 예방 또는 치료용 조성물
KR102095628B1 (ko) * 2018-01-05 2020-04-01 재단법인 아산사회복지재단 유도만능 줄기세포 유래 중간엽 줄기세포 및 이로부터 유래된 엑소좀을 포함하는 피부질환의 개선, 예방 또는 치료용 조성물
US10717981B2 (en) 2018-01-18 2020-07-21 Advanced ReGen Medical Technologies, LLC Therapeutic compositions and methods of making and using the same
WO2019152549A1 (en) 2018-02-05 2019-08-08 Cedars-Sinai Medical Center Methods for therapeutic use of exosomes and y-rnas
CN110141577A (zh) * 2018-02-13 2019-08-20 上海三炬生物科技有限公司 miRNA-24-3p核苷酸类似物在制备药物中的应用
CN108414334A (zh) * 2018-02-23 2018-08-17 中山大学附属第医院 一种从精液中分离提纯外泌体的方法
EP3758756B1 (en) 2018-03-02 2025-09-03 The Regents of The University of California Stem cell-derived exosomes for the treatment of corneal scarring
WO2019168281A1 (ko) * 2018-03-02 2019-09-06 주식회사 엑소코바이오 피부에 대한 레이저 빔 조사와 줄기세포 유래의 엑소좀 처리를 병용한 피부 미용방법
JP7326764B2 (ja) * 2018-03-09 2023-08-16 東ソー株式会社 腫瘍マーカーならびに腫瘍細胞を夾雑細胞と区別して回収および検出する方法
IL314908A (en) 2018-03-29 2024-10-01 Technion Res & Dev Foundation Vesicles comprising a pten inhibitor and uses of same
JP2021521141A (ja) 2018-04-09 2021-08-26 オージェネシス インコーポレイテッド バイオキソーム粒子、レドキソーム、それらの作製方法、及びそれらを含む組成物
JP2021520790A (ja) * 2018-04-10 2021-08-26 ブレインストーム セル セラペウティクス リミテッド 細胞型特異的エキソソームおよびそれらの使用
US12521418B2 (en) 2018-04-30 2026-01-13 Children's Medical Center Corporation Mesenchymal stromal cell exosomes and uses thereof
RU2710368C2 (ru) * 2018-05-29 2019-12-26 Станислав Евгеньевич Волчков Способ получения и концентрирования микроРНК-содержащих экзосом мультипотентных мезенхимально-стромальных клеток для применения в косметических и лекарственных средствах для стимуляции регенеративных процессов и замедления процессов старения
EP3801028A4 (en) 2018-05-30 2022-04-13 Direct Biologics LLC A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (msc) preparation and methods of use
WO2020014209A1 (en) 2018-07-09 2020-01-16 Flagship Pioneering Innovations V, Inc. Fusosome compositions and uses thereof
CN108865976B (zh) * 2018-07-19 2022-06-28 复旦大学附属中山医院 一种离散汲取收集外泌体(exosome)的方法及试剂
CN109125349A (zh) * 2018-09-27 2019-01-04 天津欣普赛尔生物医药科技有限公司 一种具有外伤修复和抗衰老功能的凝胶的制备方法
CN109543883A (zh) * 2018-10-26 2019-03-29 上海城市交通设计院有限公司 一种基于多源数据融合的枢纽客流时空分布预测建模方法
AU2019378036B2 (en) 2018-11-14 2026-05-07 Flagship Pioneering Innovations V, Inc Compositions and methods for compartment-specific cargo delivery
CN113286603B (zh) * 2018-11-16 2025-07-22 隆萨销售股份公司 工程化的细胞外囊泡及其用途
RU2720800C1 (ru) * 2018-11-28 2020-05-13 Общество с ограниченной ответственностью "НОВИСТЕМ" Средство для крупного рогатого скота, обладающее противовоспалительной, регенеративной, иммуномодулирующей, детоксикационной, адаптогенной активностью и способное регулировать метаболизм
RU2720812C1 (ru) * 2018-11-28 2020-05-13 Общество с ограниченной ответственностью "НОВИСТЕМ" Способ получения средства, обладающего противовоспалительной, регенеративной, иммуномодулирующей, детоксикационной, адаптогенной активностью и способного регулировать метаболизм
SG11202106836UA (en) * 2018-12-26 2021-07-29 Direct Biologics Llc Methods and compositions for treating skin and hair disorders
MX2021009254A (es) * 2019-01-30 2021-09-28 Direct Biologics Llc Metodos y composiciones para el desarrollo de productos de factores de crecimiento y exosomas objetivo especificos.
EP3920946A4 (en) 2019-02-07 2022-11-09 Direct Biologics LLC METHOD FOR TREATING OSTEOARTHRITIS USING A COMBINATION OF EXOSOMES OF MESENCHYMATE STEM CELLS, SYNOVIAL MESENCHYMATE STEM CELLS AND SCAFFOLDS
EP3927317A4 (en) * 2019-02-19 2022-08-10 Direct Biologics, LLC ACELLULAR INTRAVENOUS INFUSION WITH GROWTH FACTORS FROM MESENCHYMAL STEM CELLS AND EXOSOMES
US20220162561A1 (en) 2019-04-04 2022-05-26 Nissan Chemical Corporation Composition for promoting secretion of extracellular vesicles
US10881693B2 (en) 2019-04-09 2021-01-05 Combangio, Inc. Processes for making and using a mesenchymal stem cell derived secretome
EP3999626A4 (en) * 2019-07-18 2023-11-22 Pandorum Technologies Private Limited PROCESSES FOR CULTURE OF STEM CELLS TO OBTAIN PRODUCTS AND THEIR MODES OF PRODUCTION
CA3146433A1 (en) 2019-07-18 2021-01-21 Direct Biologics Llc Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use
CN110447601A (zh) * 2019-08-09 2019-11-15 南京医科大学 一种靶向巨噬细胞过表达基因小鼠模型的制备方法
CN110693912A (zh) * 2019-11-18 2020-01-17 深圳市人民医院 干细胞外泌体在制备促进创面愈合的产品中的应用
EP4090974A1 (en) * 2020-01-17 2022-11-23 Codiak BioSciences, Inc. Cholesterol assays for quantifying extracellular vesicles
CN111494417B (zh) * 2020-02-10 2024-04-09 寇晓星 诱导性细胞外囊泡在制备治疗肿瘤药物中的应用
CN113274408A (zh) * 2020-02-19 2021-08-20 中国医学科学院北京协和医院 一种磁性外泌体在制备创面修复或创面愈合产品中的应用
CN111500607B (zh) * 2020-03-13 2022-05-03 首都医科大学附属北京口腔医院 种植体周围抗炎用融合基因、外泌体、生物涂料以及制备方法和应用
JP7767147B2 (ja) 2020-03-13 2025-11-11 ミナリスアドバンストセラピーズ株式会社 細胞懸濁液の製造方法、及び、接着細胞の製造方法
EP4132479A1 (en) 2020-04-07 2023-02-15 Ramot at Tel-Aviv University Ltd. Cannabidiol-containing compositions and uses thereof
AU2021251785A1 (en) 2020-04-07 2022-11-03 Combangio, Inc. Lyophilized mesenchymal stem cell derived secretome and uses thereof
KR20230004709A (ko) 2020-04-22 2023-01-06 다이렉트 바이오로직스 엘엘씨 감염성 질환과 연관된 염증성 병태를 치료하기 위한 방법 및 조성물
KR102184428B1 (ko) * 2020-05-25 2020-11-30 주식회사 씨케이엑소젠 중배엽줄기세포 유래의 엑소좀 생산방법 및 이로부터 제조된 배양액
CN113804889A (zh) * 2020-06-15 2021-12-17 首都医科大学附属北京世纪坛医院 尿液XII型胶原蛋白α1链及其多肽片段在烧伤中的应用
CN111690686B (zh) * 2020-07-19 2021-01-15 广西康久生物科技有限公司 一种miRNA高表达在促进脐带间充质干细胞体外增殖和成骨分化方面的应用
CN111888379A (zh) * 2020-08-17 2020-11-06 济宁医学院附属医院 干细胞来源的微囊泡在制备修复瘢痕的制剂中的应用
WO2022114724A1 (ko) * 2020-11-27 2022-06-02 (주)엑셀세라퓨틱스 고효율 및 고순도 엑소좀 생산용 배지 조성물
WO2022126004A1 (en) * 2020-12-11 2022-06-16 Emory University Hydrogels encapsulating enzymes that dephosphorylate adenosine and uses in medical applications
CN112941026B (zh) * 2021-01-27 2023-03-31 上海交通大学 基于密度梯度离心提取细胞内体的方法
US20220296645A1 (en) * 2021-03-22 2022-09-22 Spiritus Therapeutics, Inc. Diagnostic and therapeutic uses of compositions comprising purified, enriched potent exosomes containing disease-based and therapy based signature cargo
CN113373112B (zh) * 2021-06-30 2022-02-01 中国医学科学院阜外医院 基于通心络预处理的间充质干细胞来源外泌体及其制备方法
CN114010756A (zh) * 2021-10-25 2022-02-08 北京医院 一种卵巢再生贴片及其基于真空装置的制备方法
WO2023123215A1 (zh) * 2021-12-30 2023-07-06 医微细胞生物技术(广州)有限公司 细胞外囊泡的应用
CN114848674A (zh) * 2022-03-25 2022-08-05 四川大学华西医院 一种干细胞微粒在制备治疗帕金森的药物中的应用
CN114703274B (zh) * 2022-04-01 2023-08-15 中国人民解放军总医院 Phpt1在预警和/或治疗高原病中的应用
US20250136992A1 (en) 2022-05-15 2025-05-01 Nurexone Biologic Ltd. Anti-pten rna interference oligonucleotides and uses thereof
GB202215142D0 (en) * 2022-10-13 2022-11-30 Univ York Novel cell lines and their use in therapy
GB202215141D0 (en) * 2022-10-13 2022-11-30 Univ York Novel cell line and its use in therapy
CN115572709A (zh) * 2022-10-18 2023-01-06 中晶生物技术股份有限公司 三维培养间充质干细胞微球在制备脱发修复与再生药物或制剂中的应用
AU2024231164A1 (en) * 2023-03-04 2025-08-14 Ronawk, Inc. Tailoring the secretion of biological factors
WO2025205716A1 (ja) * 2024-03-29 2025-10-02 積水化学工業株式会社 アジド脂質含有細胞外小胞、その製法、およびそれを含有する組成物
WO2025226276A1 (en) 2024-04-25 2025-10-30 Direct Biologics, Llc Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles
CN119639663B (zh) * 2024-12-09 2026-03-03 南开大学 一种赋能细胞聚集体来源外泌体与应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675187A (en) 1983-05-16 1987-06-23 Bristol-Myers Company BBM-1675, a new antibiotic complex
DE4117305C2 (de) 1991-05-27 1994-07-21 Weidmueller Interface Zange zum Ergreifen und/oder Verpressen von Bearbeitungsgegenständen
US5661034A (en) 1991-07-18 1997-08-26 Fuji Yakuhin Kogyo Kabushiki Kaisha Serum-free medium for tissue culture containing tissue inhibitor of metalloproteinases and method for growing cells using the medium
WO1994007913A1 (en) 1992-09-25 1994-04-14 Warner-Lambert Company Peptide antagonists of sh2 binding and therapeutic uses thereof
EP0600832A1 (de) 1992-11-27 1994-06-08 Ciba-Geigy Ag Diaminobenzoe- und Diaminophthalsäurederivate und ihre Verfahren als Proteinkinase-Inhibitoren
EP0600831A1 (de) 1992-11-27 1994-06-08 Ciba-Geigy Ag Phthalazinonderivate
US5387584A (en) 1993-04-07 1995-02-07 Pfizer Inc. Bicyclic ansamycins
US5631159A (en) 1993-09-22 1997-05-20 Creative Biomolecules, Inc. Lipid-modified serum free media
US6139524A (en) 1998-10-16 2000-10-31 Scimed Life Systems, Inc. Stent delivery system with perfusion
US7122019B1 (en) 2000-11-28 2006-10-17 Flowmedica Inc. Intra-aortic renal drug delivery catheter
US7063679B2 (en) 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
WO2006007529A2 (en) * 2004-07-01 2006-01-19 University Of Pittsburgh Of The Commonwealth System For Higher Education Immunosuppressive exosomes
USD544957S1 (en) 2005-03-23 2007-06-19 Rexam Dispensing Systems Nasal spray dispenser
WO2006110582A1 (en) * 2005-04-08 2006-10-19 Xcyte Therapies, Inc. Compositions and methods for the treatment of burns and sepsis
JP2010500047A (ja) * 2006-08-15 2010-01-07 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 間葉系幹細胞馴化培地
US20080256435A1 (en) * 2007-01-26 2008-10-16 Citation Technologies, Inc. Interconnection of Document Preparation, Document Viewing, and Alert Processing in Structured Documents
JP2015529450A (ja) * 2012-07-19 2015-10-08 リニューロン・リミテッドＲｅＮｅｕｒｏｎ Ｌｉｍｉｔｅｄ 幹細胞微粒子

Also Published As

Publication number Publication date
CN102014934B (zh) 2014-08-20
AU2009215934A1 (en) 2009-08-27
JP5718648B2 (ja) 2015-05-13
SI2254586T1 (sl) 2015-07-31
CN104127438B (zh) 2021-01-08
EP2254586B1 (en) 2015-04-08
EP2254586A1 (en) 2010-12-01
US20170189449A1 (en) 2017-07-06
PT2254586E (pt) 2015-05-18
CN104127438A (zh) 2014-11-05
KR20100122087A (ko) 2010-11-19
WO2009105044A1 (en) 2009-08-27
AU2009215934B2 (en) 2013-10-24
US10780128B2 (en) 2020-09-22
AU2009215934C1 (en) 2014-05-08
DK2254586T3 (en) 2015-06-15
US20150190430A1 (en) 2015-07-09
CN102014934A (zh) 2011-04-13
US20110003008A1 (en) 2011-01-06
JP2011513217A (ja) 2011-04-28
HUE026536T2 (en) 2016-06-28
KR101640381B1 (ko) 2016-07-18
ES2537516T3 (es) 2015-06-09
HRP20150510T1 (hr) 2015-06-05

Similar Documents

Publication Publication Date Title
SI2254586T1 (sl) Delci mezenhimske matične celice
SG10201403202XA (en) Pre-natal mesenchymal stem cells
IL247310B (en) Mesenchymal stem cell differentiation
GB0814249D0 (en) Uses of mesenchymal stem cells
ZA201008391B (en) Pluripotent cells
SG10201500674YA (en) Pluripotent stem cells
IL228818A0 (en) Stem cell cultures
IL212368A0 (en) Compounds that expand hematopoietic stem cells
PT2035549E (pt) Células estaminais mesenquimais abcb5 positivas como imunomoduladores
IL216624A0 (en) Fucosylation-deficient cells
SG10201510384UA (en) Cell culture improvements
GB0920775D0 (en) Cells
EP2294182A4 (en) CULTS OF MULTIPOTENT STEM CELLS
GB0919773D0 (en) Induced pluripotent stem cell
GB0818256D0 (en) stem cells
GB0724994D0 (en) Mesenchymal stem cell markers
GB0918471D0 (en) Stem cells
GB0812904D0 (en) Porous particles
GB0808778D0 (en) Cell culture technique
GB0807491D0 (en) Particles
GB0908223D0 (en) Cells
GB0901675D0 (en) Cells
HUE052153T2 (hu) Fukoziláció-deficiens sejtek