PL2274303T3 - Sposoby otrzymywania sunitynibu i jego soli - Google Patents

Sposoby otrzymywania sunitynibu i jego soli

Info

Publication number: PL2274303T3
Authority: PL; Poland
Prior art keywords: salts; processes; preparing sunitinib; sunitinib; preparing
Prior art date: 2008-03-31

Application number

PL09728114T

Other languages

English (en)

Inventor

Ettore Bigatti

Augusto Canavesi

Peter Lindsay Macdonald

Francesca Scarpitta

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-03-31

Filing date

2009-03-31

Publication date

2013-03-29

2009-03-31 Application filed by Teva Pharma filed Critical Teva Pharma

2013-03-29 Publication of PL2274303T3 publication Critical patent/PL2274303T3/pl

Links

239000002147 L01XE04 - Sunitinib Substances 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 title 1
229960001796 sunitinib Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL09728114T 2008-03-31 2009-03-31 Sposoby otrzymywania sunitynibu i jego soli PL2274303T3 (pl)

Applications Claiming Priority (9)

Application Number	Priority Date	Filing Date	Title
US4110308P	2008-03-31	2008-03-31
US8240508P	2008-07-21	2008-07-21
US8268108P	2008-07-22	2008-07-22
US8899808P	2008-08-14	2008-08-14
US9434108P	2008-09-04	2008-09-04
US9759208P	2008-09-17	2008-09-17
US11304408P	2008-11-10	2008-11-10
PCT/US2009/038934 WO2009124037A1 (en)	2008-03-31	2009-03-31	Processes for preparing sunitinib and salts thereof
EP09728114A EP2274303B1 (en)	2008-03-31	2009-03-31	Processes for preparing sunitinib and salts thereof

Publications (1)

Publication Number	Publication Date
PL2274303T3 true PL2274303T3 (pl)	2013-03-29

Family

ID=40791224

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL09728114T PL2274303T3 (pl)	2008-03-31	2009-03-31	Sposoby otrzymywania sunitynibu i jego soli

Country Status (8)

Country	Link
US (2)	US20090247767A1 (pl)
EP (1)	EP2274303B1 (pl)
JP (1)	JP2011516488A (pl)
KR (1)	KR20100119582A (pl)
CA (1)	CA2720164A1 (pl)
ES (1)	ES2391501T3 (pl)
PL (1)	PL2274303T3 (pl)
WO (1)	WO2009124037A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20100135910A (ko) *	2008-04-16	2010-12-27	낫코 파마 리미티드	수니티닙 염기의 신규한 다형 형태
WO2012058780A1 (en)	2010-11-01	2012-05-10	Scinopharm (Kunshan) Biochemical Technology Co., Ltd.	Processes for the preparation of 3-(pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles
ES2709110T3 (es) *	2012-03-23	2019-04-15	Laurus Labs Ltd	Un proceso mejorado para la preparación de sunitinib y sus sales de adición de ácido
PT3039424T (pt)	2013-08-28	2020-09-03	Crown Bioscience Inc Taicang	Assinaturas de expressão genética que permitem prever a resposta de um sujeito a um inibidor multiquinase e métodos de utilização do mesmo
CN105622680B (zh) *	2015-12-22	2018-01-19	杭州卢普生物科技有限公司	一种舒尼替尼衍生物及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1255752T1 (sl) *	2000-02-15	2007-12-31	Pharmacia & Upjohn Co Llc	S pirolom substituirani zaviralci 2-indolinon protein kinaza
DE10023484A1 (de) *	2000-05-09	2001-11-22	Schering Ag	Anthranylamide und deren Verwendung als Arzneimittel
AR042586A1 (es) *	2001-02-15	2005-06-29	Sugen Inc	3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
GEP20063777B (en) *	2001-08-15	2006-03-27	Upjohn Co	Crystals Including Malic Acid Salt of N-[2-(Diethylamino) Ethyl]-5-[(5-Fluoro-2-Oxo-3h-Indole-3-Ylidene) Methyl]-2, 4-Dimethyl-1h-Pyrrole-3-Carboxamide, Processes for Its Preparation and Compositions Thereof
WO2003031438A1 (en) *	2001-10-10	2003-04-17	Sugen, Inc.	3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors
EP1476443A2 (en) *	2002-02-15	2004-11-17	PHARMACIA & UPJOHN COMPANY	Process for preparing indolinone derivatives
ES2197003B1 (es) *	2002-04-08	2005-03-16	J. URIACH & CIA S.A.	Nuevos compuestos antagonistas de integrinas alfa.
WO2004002963A1 (ja) *	2002-06-28	2004-01-08	Nippon Shinyaku Co., Ltd.	アミド誘導体及び医薬
US7427611B2 (en) *	2003-09-26	2008-09-23	Solvay Pharmaceuticals Gmbh	Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US20060009510A1 (en) *	2004-07-09	2006-01-12	Pharmacia & Upjohn Company Llc	Method of synthesizing indolinone compounds
SG155188A1 (en) *	2004-07-30	2009-09-30	Exelixis Inc	Pyrrole derivatives as pharmaceutical agents
WO2006076202A1 (en) *	2005-01-10	2006-07-20	Exelixis, Inc.	Heterocyclic carboxamide compounds as steroid nuclear receptors ligands
JP2009522276A (ja) *	2005-12-29	2009-06-11	ザスクリップスリサーチインスティテュート	インドリノンベースのプロテインキナーゼ阻害剤のアミノ酸誘導体
EP2220071A2 (en) *	2007-11-21	2010-08-25	Teva Pharmaceutical Industries Ltd.	Sunitinib hemi-l-malate, polymorphs and preparation thereof, polymorphs of racemic sunitinib malate, compositins containing sunitinib base and malic acid and preparation thereof

2009
- 2009-03-31 CA CA2720164A patent/CA2720164A1/en not_active Abandoned
- 2009-03-31 WO PCT/US2009/038934 patent/WO2009124037A1/en not_active Ceased
- 2009-03-31 ES ES09728114T patent/ES2391501T3/es active Active
- 2009-03-31 KR KR1020107021937A patent/KR20100119582A/ko not_active Ceased
- 2009-03-31 EP EP09728114A patent/EP2274303B1/en not_active Not-in-force
- 2009-03-31 PL PL09728114T patent/PL2274303T3/pl unknown
- 2009-03-31 JP JP2011503093A patent/JP2011516488A/ja active Pending
- 2009-03-31 US US12/415,352 patent/US20090247767A1/en not_active Abandoned
2010
- 2010-03-04 US US12/717,481 patent/US20100160646A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20090247767A1 (en)	2009-10-01
US20100160646A1 (en)	2010-06-24
ES2391501T3 (es)	2012-11-27
EP2274303A1 (en)	2011-01-19
EP2274303B1 (en)	2012-08-29
WO2009124037A1 (en)	2009-10-08
JP2011516488A (ja)	2011-05-26
CA2720164A1 (en)	2009-10-08
KR20100119582A (ko)	2010-11-09

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PL2274303T3 (pl)	2013-03-29	Sposoby otrzymywania sunitynibu i jego soli