PL2289870T3 - Sposób oczyszczania 5-amino-N,N'-bis(2,3-dihydroksypropylo) izoftalamidu, związku pośredniego w wytwarzaniu niejonowych środków kontrastowych do badań radiologicznych - Google Patents

Sposób oczyszczania 5-amino-N,N'-bis(2,3-dihydroksypropylo) izoftalamidu, związku pośredniego w wytwarzaniu niejonowych środków kontrastowych do badań radiologicznych

Info

Publication number
PL2289870T3
PL2289870T3 PL09176517T PL09176517T PL2289870T3 PL 2289870 T3 PL2289870 T3 PL 2289870T3 PL 09176517 T PL09176517 T PL 09176517T PL 09176517 T PL09176517 T PL 09176517T PL 2289870 T3 PL2289870 T3 PL 2289870T3
Authority
PL
Poland
Prior art keywords
isophthalamide
dihydroxypropyl
purifying
ionic
bis
Prior art date
Application number
PL09176517T
Other languages
English (en)
Inventor
Torfinn Haaland
Ole Magne Homestad
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of PL2289870T3 publication Critical patent/PL2289870T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL09176517T 2009-07-21 2009-11-19 Sposób oczyszczania 5-amino-N,N'-bis(2,3-dihydroksypropylo) izoftalamidu, związku pośredniego w wytwarzaniu niejonowych środków kontrastowych do badań radiologicznych PL2289870T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22708609P 2009-07-21 2009-07-21
EP09176517A EP2289870B1 (en) 2009-07-21 2009-11-19 Method for purifying 5-amino-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide, an intermediate in the preparation of non-ionic X-ray contrast agents

Publications (1)

Publication Number Publication Date
PL2289870T3 true PL2289870T3 (pl) 2013-04-30

Family

ID=41435368

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09176517T PL2289870T3 (pl) 2009-07-21 2009-11-19 Sposób oczyszczania 5-amino-N,N'-bis(2,3-dihydroksypropylo) izoftalamidu, związku pośredniego w wytwarzaniu niejonowych środków kontrastowych do badań radiologicznych

Country Status (7)

Country Link
US (1) US7863484B1 (pl)
EP (1) EP2289870B1 (pl)
KR (1) KR101031382B1 (pl)
CN (1) CN101955444A (pl)
CA (1) CA2710095C (pl)
ES (1) ES2397246T3 (pl)
PL (1) PL2289870T3 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015082719A1 (en) * 2013-12-06 2015-06-11 Ge Healthcare As Alternative acetylation process in the synthesis of non-ionic xray contrast agents
CN107857714B (zh) * 2017-11-29 2020-11-13 上海司太立制药有限公司 一种碘海醇中间体杂质的制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6137006A (en) 1997-05-23 2000-10-24 Nycomed Imaging As Preparation of tri-iodo benzene compounds
GB9710725D0 (en) 1997-05-23 1997-07-16 Nycomed Imaging As Process
GB9825095D0 (en) 1998-11-16 1999-01-13 Nycomed Imaging As Chemical process
IT1319670B1 (it) 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di 5-ammino-n,n'-bis(2-idrossi-1-(idrossimetil)etil))-1,3-benzendicarbossammide (i) e 5-ammino-n,n'-

Also Published As

Publication number Publication date
EP2289870B1 (en) 2012-11-07
ES2397246T3 (es) 2013-03-05
CA2710095A1 (en) 2011-01-11
CA2710095C (en) 2011-07-19
US20110021814A1 (en) 2011-01-27
KR101031382B1 (ko) 2011-04-25
KR20110009053A (ko) 2011-01-27
CN101955444A (zh) 2011-01-26
US7863484B1 (en) 2011-01-04
EP2289870A1 (en) 2011-03-02

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