PL2313386T3 - Drogi syntezy do 2(S),4(S),5(S),7(S)-2,7-dialkilo-4-hydroksy-5-amino-8-arylo-oktanoiloamidów - Google Patents
Drogi syntezy do 2(S),4(S),5(S),7(S)-2,7-dialkilo-4-hydroksy-5-amino-8-arylo-oktanoiloamidówInfo
- Publication number
- PL2313386T3 PL2313386T3 PL09800073T PL09800073T PL2313386T3 PL 2313386 T3 PL2313386 T3 PL 2313386T3 PL 09800073 T PL09800073 T PL 09800073T PL 09800073 T PL09800073 T PL 09800073T PL 2313386 T3 PL2313386 T3 PL 2313386T3
- Authority
- PL
- Poland
- Prior art keywords
- dialkyl
- aryl
- hydroxy
- amino
- synthesis routes
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- UXOWGYHJODZGMF-QORCZRPOSA-N Aliskiren Chemical compound COCCCOC1=CC(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)=CC=C1OC UXOWGYHJODZGMF-QORCZRPOSA-N 0.000 abstract 1
- 229960004601 aliskiren Drugs 0.000 abstract 1
- LTHCSWBWNVGEFE-UHFFFAOYSA-N octanamide Chemical class CCCCCCCC(N)=O LTHCSWBWNVGEFE-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C251/16—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08160971 | 2008-07-23 | ||
| EP09800073A EP2313386B1 (en) | 2008-07-23 | 2009-07-23 | Synthesis routes to 2(s),4(s),5(s),7(s)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides |
| PCT/EP2009/059526 WO2010010165A1 (en) | 2008-07-23 | 2009-07-23 | Synthesis routes to 2(s),4(s),5(s),7(s)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2313386T3 true PL2313386T3 (pl) | 2012-05-31 |
Family
ID=40149676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09800073T PL2313386T3 (pl) | 2008-07-23 | 2009-07-23 | Drogi syntezy do 2(S),4(S),5(S),7(S)-2,7-dialkilo-4-hydroksy-5-amino-8-arylo-oktanoiloamidów |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20110244531A1 (pl) |
| EP (1) | EP2313386B1 (pl) |
| JP (1) | JP5579178B2 (pl) |
| CN (1) | CN102164903B (pl) |
| AT (1) | ATE540032T1 (pl) |
| BR (1) | BRPI0916544A2 (pl) |
| CA (1) | CA2731262A1 (pl) |
| EA (1) | EA023266B1 (pl) |
| ES (1) | ES2378507T3 (pl) |
| MX (1) | MX2011000863A (pl) |
| PL (1) | PL2313386T3 (pl) |
| PT (1) | PT2313386E (pl) |
| WO (1) | WO2010010165A1 (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011051853A1 (en) * | 2009-10-29 | 2011-05-05 | CarboDesign LLC | Manufacturing process for preparing enaniomerically pure 8- aryloctanoic acid derivatives such as aliskiren |
| IT1400961B1 (it) * | 2010-06-04 | 2013-07-05 | Chemo Iberica Sa | Processo per la produzione di aliskiren |
| TW201202178A (en) | 2010-06-04 | 2012-01-16 | Chemo Iberica Sa | Process for producing Aliskiren |
| WO2012116307A1 (en) | 2011-02-25 | 2012-08-30 | Massachusetts Institute Of Technology | Microbial production of 3,4-dihydroxybutyrate (3,4-dhba), 2,3-dihydroxybutyrate (2,3-dhba) and 3-hydroxybutyrolactone (3-hbl) |
| CN102432466B (zh) * | 2011-09-22 | 2013-10-16 | 武汉武药制药有限公司 | 一种阿利克仑中间体的制备方法 |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
| ITMI20120354A1 (it) * | 2012-03-07 | 2013-09-08 | Friulchem Spa | Processo per la produzione di aliskirene |
| CN105294478B (zh) * | 2014-07-01 | 2017-06-13 | 华润双鹤药业股份有限公司 | 阿利吉仑的一种非对映异构体、其制备方法及用途 |
| CN106146339B (zh) * | 2015-04-23 | 2018-02-23 | 华润双鹤药业股份有限公司 | 阿利吉仑的5‑位差向异构体、其制备方法及用途 |
| US20210395185A1 (en) * | 2018-10-18 | 2021-12-23 | Boehringer Ingelheim International Gmbh | Scalable synthesis of optically active 1-cyclopropylalkyl-1-amines |
| CN116478203B (zh) * | 2023-04-04 | 2025-12-02 | 苏州美诺医药科技有限公司 | 一种软海绵素类似物的中间体的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006008171A1 (en) * | 2004-07-22 | 2006-01-26 | Dsm Ip Assets B.V. | Process for the preparation of a diastereomerically enriched compound |
-
2009
- 2009-07-23 AT AT09800073T patent/ATE540032T1/de active
- 2009-07-23 JP JP2011519179A patent/JP5579178B2/ja not_active Expired - Fee Related
- 2009-07-23 EP EP09800073A patent/EP2313386B1/en not_active Not-in-force
- 2009-07-23 BR BRPI0916544-4A patent/BRPI0916544A2/pt not_active Application Discontinuation
- 2009-07-23 MX MX2011000863A patent/MX2011000863A/es active IP Right Grant
- 2009-07-23 WO PCT/EP2009/059526 patent/WO2010010165A1/en not_active Ceased
- 2009-07-23 PT PT09800073T patent/PT2313386E/pt unknown
- 2009-07-23 ES ES09800073T patent/ES2378507T3/es active Active
- 2009-07-23 US US13/055,572 patent/US20110244531A1/en not_active Abandoned
- 2009-07-23 PL PL09800073T patent/PL2313386T3/pl unknown
- 2009-07-23 CN CN200980137418.4A patent/CN102164903B/zh not_active Expired - Fee Related
- 2009-07-23 EA EA201100264A patent/EA023266B1/ru not_active IP Right Cessation
- 2009-07-23 CA CA2731262A patent/CA2731262A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2313386B1 (en) | 2012-01-04 |
| ES2378507T3 (es) | 2012-04-13 |
| EP2313386A1 (en) | 2011-04-27 |
| HK1161592A1 (en) | 2012-07-27 |
| CN102164903A (zh) | 2011-08-24 |
| BRPI0916544A2 (pt) | 2015-08-04 |
| JP2011528699A (ja) | 2011-11-24 |
| EA023266B1 (ru) | 2016-05-31 |
| US20110244531A1 (en) | 2011-10-06 |
| JP5579178B2 (ja) | 2014-08-27 |
| CA2731262A1 (en) | 2010-01-28 |
| CN102164903B (zh) | 2015-01-14 |
| WO2010010165A1 (en) | 2010-01-28 |
| PT2313386E (pt) | 2012-03-06 |
| EA201100264A1 (ru) | 2011-10-31 |
| ATE540032T1 (de) | 2012-01-15 |
| MX2011000863A (es) | 2011-03-15 |
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