BRPI0916544A2 - Rotas de síntese para 2(s), 4(s), 5(s), 7(s) - 2, 7 dialquil-4-hidroxi-2-amino-8-aril-octanoil amida - Google Patents
Rotas de síntese para 2(s), 4(s), 5(s), 7(s) - 2, 7 dialquil-4-hidroxi-2-amino-8-aril-octanoil amidaInfo
- Publication number
- BRPI0916544A2 BRPI0916544A2 BRPI0916544-4A BRPI0916544A BRPI0916544A2 BR PI0916544 A2 BRPI0916544 A2 BR PI0916544A2 BR PI0916544 A BRPI0916544 A BR PI0916544A BR PI0916544 A2 BRPI0916544 A2 BR PI0916544A2
- Authority
- BR
- Brazil
- Prior art keywords
- dialkyl
- aryl
- hydroxy
- amino
- synthesis routes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C251/16—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08160971 | 2008-07-23 | ||
| PCT/EP2009/059526 WO2010010165A1 (en) | 2008-07-23 | 2009-07-23 | Synthesis routes to 2(s),4(s),5(s),7(s)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0916544A2 true BRPI0916544A2 (pt) | 2015-08-04 |
Family
ID=40149676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0916544-4A BRPI0916544A2 (pt) | 2008-07-23 | 2009-07-23 | Rotas de síntese para 2(s), 4(s), 5(s), 7(s) - 2, 7 dialquil-4-hidroxi-2-amino-8-aril-octanoil amida |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20110244531A1 (pt) |
| EP (1) | EP2313386B1 (pt) |
| JP (1) | JP5579178B2 (pt) |
| CN (1) | CN102164903B (pt) |
| AT (1) | ATE540032T1 (pt) |
| BR (1) | BRPI0916544A2 (pt) |
| CA (1) | CA2731262A1 (pt) |
| EA (1) | EA023266B1 (pt) |
| ES (1) | ES2378507T3 (pt) |
| MX (1) | MX2011000863A (pt) |
| PL (1) | PL2313386T3 (pt) |
| PT (1) | PT2313386E (pt) |
| WO (1) | WO2010010165A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8203005B2 (en) * | 2009-10-29 | 2012-06-19 | Carbo Design Llc | Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren |
| TW201202178A (en) | 2010-06-04 | 2012-01-16 | Chemo Iberica Sa | Process for producing Aliskiren |
| IT1400961B1 (it) * | 2010-06-04 | 2013-07-05 | Chemo Iberica Sa | Processo per la produzione di aliskiren |
| WO2012116307A1 (en) | 2011-02-25 | 2012-08-30 | Massachusetts Institute Of Technology | Microbial production of 3,4-dihydroxybutyrate (3,4-dhba), 2,3-dihydroxybutyrate (2,3-dhba) and 3-hydroxybutyrolactone (3-hbl) |
| CN102432466B (zh) * | 2011-09-22 | 2013-10-16 | 武汉武药制药有限公司 | 一种阿利克仑中间体的制备方法 |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
| ITMI20120354A1 (it) * | 2012-03-07 | 2013-09-08 | Friulchem Spa | Processo per la produzione di aliskirene |
| CN105294478B (zh) * | 2014-07-01 | 2017-06-13 | 华润双鹤药业股份有限公司 | 阿利吉仑的一种非对映异构体、其制备方法及用途 |
| CN106146339B (zh) * | 2015-04-23 | 2018-02-23 | 华润双鹤药业股份有限公司 | 阿利吉仑的5‑位差向异构体、其制备方法及用途 |
| CN112930336A (zh) * | 2018-10-18 | 2021-06-08 | 勃林格殷格翰国际有限公司 | 光学活性的1-环丙基烷基-1-胺的可放大合成 |
| CN116478203B (zh) * | 2023-04-04 | 2025-12-02 | 苏州美诺医药科技有限公司 | 一种软海绵素类似物的中间体的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008506746A (ja) * | 2004-07-22 | 2008-03-06 | ディーエスエム アイピー アセッツ ビー．ブイ． | ジアステレオマーに富んだ化合物の調製方法 |
-
2009
- 2009-07-23 JP JP2011519179A patent/JP5579178B2/ja not_active Expired - Fee Related
- 2009-07-23 WO PCT/EP2009/059526 patent/WO2010010165A1/en not_active Ceased
- 2009-07-23 EA EA201100264A patent/EA023266B1/ru not_active IP Right Cessation
- 2009-07-23 EP EP09800073A patent/EP2313386B1/en not_active Not-in-force
- 2009-07-23 AT AT09800073T patent/ATE540032T1/de active
- 2009-07-23 MX MX2011000863A patent/MX2011000863A/es active IP Right Grant
- 2009-07-23 CA CA2731262A patent/CA2731262A1/en not_active Abandoned
- 2009-07-23 CN CN200980137418.4A patent/CN102164903B/zh not_active Expired - Fee Related
- 2009-07-23 US US13/055,572 patent/US20110244531A1/en not_active Abandoned
- 2009-07-23 BR BRPI0916544-4A patent/BRPI0916544A2/pt not_active Application Discontinuation
- 2009-07-23 PL PL09800073T patent/PL2313386T3/pl unknown
- 2009-07-23 PT PT09800073T patent/PT2313386E/pt unknown
- 2009-07-23 ES ES09800073T patent/ES2378507T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EA023266B1 (ru) | 2016-05-31 |
| ATE540032T1 (de) | 2012-01-15 |
| HK1161592A1 (en) | 2012-07-27 |
| CN102164903A (zh) | 2011-08-24 |
| JP2011528699A (ja) | 2011-11-24 |
| PT2313386E (pt) | 2012-03-06 |
| MX2011000863A (es) | 2011-03-15 |
| EP2313386B1 (en) | 2012-01-04 |
| US20110244531A1 (en) | 2011-10-06 |
| CA2731262A1 (en) | 2010-01-28 |
| EP2313386A1 (en) | 2011-04-27 |
| EA201100264A1 (ru) | 2011-10-31 |
| PL2313386T3 (pl) | 2012-05-31 |
| JP5579178B2 (ja) | 2014-08-27 |
| ES2378507T3 (es) | 2012-04-13 |
| CN102164903B (zh) | 2015-01-14 |
| WO2010010165A1 (en) | 2010-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
| B25H | Request for change of headquarter rejected |
Owner name: DSM IP ASSETS B.V. (NL) |