PL2336132T3 - Pochodne morfolinopuryny - Google Patents
Pochodne morfolinopurynyInfo
- Publication number
- PL2336132T3 PL2336132T3 PL09820579T PL09820579T PL2336132T3 PL 2336132 T3 PL2336132 T3 PL 2336132T3 PL 09820579 T PL09820579 T PL 09820579T PL 09820579 T PL09820579 T PL 09820579T PL 2336132 T3 PL2336132 T3 PL 2336132T3
- Authority
- PL
- Poland
- Prior art keywords
- morpholinopurine
- derivative
- morpholinopurine derivative
- Prior art date
Links
- IBVOXEAVUMUIBU-UHFFFAOYSA-N 4-(7h-purin-2-yl)morpholine Chemical class C1COCCN1C1=NC=C(NC=N2)C2=N1 IBVOXEAVUMUIBU-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008264797 | 2008-10-14 | ||
| JP2009121690 | 2009-05-20 | ||
| EP09820579.2A EP2336132B1 (en) | 2008-10-14 | 2009-10-13 | Morpholinopurine derivative |
| PCT/JP2009/067738 WO2010044401A1 (ja) | 2008-10-14 | 2009-10-13 | モルホリノプリン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2336132T3 true PL2336132T3 (pl) | 2014-06-30 |
Family
ID=42106564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09820579T PL2336132T3 (pl) | 2008-10-14 | 2009-10-13 | Pochodne morfolinopuryny |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8097622B2 (pl) |
| EP (1) | EP2336132B1 (pl) |
| JP (1) | JP5090423B2 (pl) |
| KR (1) | KR101614976B1 (pl) |
| CN (1) | CN102245607B (pl) |
| AU (1) | AU2009304789B2 (pl) |
| BR (1) | BRPI0920199A2 (pl) |
| CA (1) | CA2740471C (pl) |
| CO (1) | CO6362009A2 (pl) |
| DK (1) | DK2336132T3 (pl) |
| ES (1) | ES2452541T3 (pl) |
| IL (1) | IL212278A (pl) |
| MX (1) | MX2011003490A (pl) |
| MY (1) | MY156456A (pl) |
| NZ (1) | NZ592761A (pl) |
| PL (1) | PL2336132T3 (pl) |
| PT (1) | PT2336132E (pl) |
| RU (1) | RU2490269C2 (pl) |
| TW (1) | TWI378933B (pl) |
| WO (1) | WO2010044401A1 (pl) |
| ZA (1) | ZA201102449B (pl) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2721851A1 (en) * | 2008-05-30 | 2009-12-03 | Genentech, Inc. | Purine pi3k inhibitor compounds and methods of use |
| TWI378933B (en) * | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
| JP5579864B2 (ja) * | 2009-11-12 | 2014-08-27 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｎ−９−置換プリン化合物、組成物及び使用の方法 |
| CN102260263A (zh) * | 2010-05-26 | 2011-11-30 | 四川大学 | 一类二苯胺基嘌呤衍生物及制备方法和医药用途 |
| ES2536780T3 (es) | 2010-07-14 | 2015-05-28 | F. Hoffmann-La Roche Ag | Compuestos de purina selectivos para I3 p110 delta, y métodos de uso |
| TW201500358A (zh) | 2010-12-16 | 2015-01-01 | 赫夫門羅氏藥廠股份有限公司 | 三環ｐｉ３ｋ抑制劑化合物及其使用方法 |
| PT2771342T (pt) | 2011-10-28 | 2016-08-17 | Novartis Ag | Derivados de purina e o seu uso no tratamento de doença |
| CN103012284A (zh) * | 2012-12-26 | 2013-04-03 | 无锡捷化医药科技有限公司 | 一种2-氨基-5-溴嘧啶类化合物的制备方法 |
| TW201520215A (zh) * | 2013-05-13 | 2015-06-01 | Daiichi Sankyo Co Ltd | Ｎ－□啉基嘌呤衍生物之製造方法 |
| WO2014185368A1 (ja) * | 2013-05-13 | 2014-11-20 | 第一三共株式会社 | ５－｛８－［（３ｒ）－４－アセチル－３－メチルピペラジン－１－イル］－６－モルホリン－４－イル－９－（２，２，２－トリフルオロエチル）－９ｈ－プリン－２－イル｝ピリミジン－２－アミン、およびその薬理上許容される塩の新規な結晶、およびその製造方法 |
| CN112472699A (zh) | 2013-07-26 | 2021-03-12 | 种族肿瘤学公司 | 改善比生群及衍生物的治疗益处的组合方法 |
| MX364558B (es) * | 2013-10-04 | 2019-04-29 | Univ Basel | INHIBIDORES DE PI3K Y mTOR CONFORMACIONALMENTE RESTRINGIDOS. |
| HK1250161B (en) | 2015-03-30 | 2020-05-15 | Daiichi Sankyo Company, Limited | 6-morpholinyl-2-pyrazolyl-9h-purine derivatives and their use as pi3k inhibitors |
| US10765681B2 (en) | 2016-02-05 | 2020-09-08 | Academia Sinica | Purine compounds possessing anticancer activity |
| WO2017156350A1 (en) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
| ES2911522T3 (es) | 2016-12-02 | 2022-05-19 | Daiichi Sankyo Co Ltd | Novedosa endo-ß-n-acetilglucosaminidasa |
| EP3360865A1 (en) | 2017-02-13 | 2018-08-15 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of cyclopropyldiketopiperazines, and of a key intermediate of ds-5272 |
| TWI837231B (zh) | 2018-11-29 | 2024-04-01 | 日商第一三共股份有限公司 | 含有ｅｚｈ１／２雙重抑制劑之醫藥組合及其用途 |
| CN113368114B (zh) * | 2020-03-10 | 2022-04-22 | 四川大学 | 一种吗啉嘧啶类化合物的抗肿瘤应用 |
| WO2022197892A1 (en) * | 2021-03-17 | 2022-09-22 | Tango Therapeutics, Inc. | Purine derivatives as anticancer agents |
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| TWI378933B (en) * | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
-
2009
- 2009-10-12 TW TW098134442A patent/TWI378933B/zh not_active IP Right Cessation
- 2009-10-13 BR BRPI0920199A patent/BRPI0920199A2/pt not_active IP Right Cessation
- 2009-10-13 AU AU2009304789A patent/AU2009304789B2/en not_active Ceased
- 2009-10-13 KR KR1020117008413A patent/KR101614976B1/ko not_active Expired - Fee Related
- 2009-10-13 ES ES09820579.2T patent/ES2452541T3/es active Active
- 2009-10-13 PT PT98205792T patent/PT2336132E/pt unknown
- 2009-10-13 CN CN200980151585.4A patent/CN102245607B/zh not_active Expired - Fee Related
- 2009-10-13 JP JP2009236444A patent/JP5090423B2/ja not_active Expired - Fee Related
- 2009-10-13 NZ NZ592761A patent/NZ592761A/en not_active IP Right Cessation
- 2009-10-13 MX MX2011003490A patent/MX2011003490A/es active IP Right Grant
- 2009-10-13 PL PL09820579T patent/PL2336132T3/pl unknown
- 2009-10-13 MY MYPI2011001420A patent/MY156456A/en unknown
- 2009-10-13 CA CA2740471A patent/CA2740471C/en not_active Expired - Fee Related
- 2009-10-13 EP EP09820579.2A patent/EP2336132B1/en not_active Not-in-force
- 2009-10-13 RU RU2011119525/04A patent/RU2490269C2/ru not_active IP Right Cessation
- 2009-10-13 WO PCT/JP2009/067738 patent/WO2010044401A1/ja not_active Ceased
- 2009-10-13 DK DK09820579.2T patent/DK2336132T3/da active
- 2009-10-14 US US12/579,175 patent/US8097622B2/en not_active Expired - Fee Related
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2011
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- 2011-04-12 IL IL212278A patent/IL212278A/en not_active IP Right Cessation
- 2011-05-09 CO CO11056552A patent/CO6362009A2/es active IP Right Grant
- 2011-11-30 US US13/308,239 patent/US8309546B2/en not_active Expired - Fee Related
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