PL2344465T3 - Krystaliczne postacie (R)-5-[3-chloro-4-(2,3-dihydroksypropoksy)benz[Z]-ylideno]-2-[Z]-propyloimino)-3-O-tolilotiazolidyn-4-onu - Google Patents

Krystaliczne postacie (R)-5-[3-chloro-4-(2,3-dihydroksypropoksy)benz[Z]-ylideno]-2-[Z]-propyloimino)-3-O-tolilotiazolidyn-4-onu

Info

Publication number: PL2344465T3
Authority: PL; Poland
Prior art keywords: propylimino; thiazolidin; benz; ylidene; tolyl
Prior art date: 2008-10-20

Application number

PL09741441T

Other languages

English (en)

Inventor

Nicholas Bonham

Stephan Buchmann

Alex Eberlin

Christoph Imboden

Raumer Markus Von

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-10-20

Filing date

2009-10-19

Publication date

2015-06-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40097688&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2344465(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-10-19 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2015-06-30 Publication of PL2344465T3 publication Critical patent/PL2344465T3/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Developing Agents For Electrophotography (AREA)
Plural Heterocyclic Compounds (AREA)

PL09741441T 2008-10-20 2009-10-19 Krystaliczne postacie (R)-5-[3-chloro-4-(2,3-dihydroksypropoksy)benz[Z]-ylideno]-2-[Z]-propyloimino)-3-O-tolilotiazolidyn-4-onu PL2344465T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0819182.7A GB0819182D0 (en)	2008-10-20	2008-10-20	Crystalline forms
EP09741441.1A EP2344465B1 (en)	2008-10-20	2009-10-19	Crystalline forms of (r) -5- [3-chloro-4-( 2, 3-dihydroxy-propoxy)-benz [z]ylidene]-2- [z]-propylimino) -3-o-tolyl-thiazolidin-4-one
PCT/IB2009/054592 WO2010046835A1 (en)	2008-10-20	2009-10-19	Crystalline forms of (r) -5- [3-chloro-4- ( 2, 3-dihydroxy-propoxy) -benz [z] ylidene] -2- ( [z] -propylimino) -3-0-tolyl-thiazolidin-4-one

Publications (1)

Publication Number	Publication Date
PL2344465T3 true PL2344465T3 (pl)	2015-06-30

Family

ID=40097688

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL09741441T PL2344465T3 (pl)	2008-10-20	2009-10-19	Krystaliczne postacie (R)-5-[3-chloro-4-(2,3-dihydroksypropoksy)benz[Z]-ylideno]-2-[Z]-propyloimino)-3-O-tolilotiazolidyn-4-onu

Country Status (27)

Country	Link
US (1)	US9062014B2 (pl)
EP (1)	EP2344465B1 (pl)
JP (1)	JP5008777B2 (pl)
KR (1)	KR101409597B1 (pl)
CN (1)	CN102177144B (pl)
AR (1)	AR073904A1 (pl)
AU (1)	AU2009305980C1 (pl)
BR (1)	BRPI0919673B1 (pl)
CA (1)	CA2740313C (pl)
CL (1)	CL2011000867A1 (pl)
CY (1)	CY1116118T1 (pl)
DK (1)	DK2344465T3 (pl)
ES (1)	ES2534333T3 (pl)
GB (1)	GB0819182D0 (pl)
HR (1)	HRP20150391T1 (pl)
IL (1)	IL212351A (pl)
MA (1)	MA32797B1 (pl)
MX (1)	MX2011003988A (pl)
MY (1)	MY160703A (pl)
NZ (1)	NZ592854A (pl)
PL (1)	PL2344465T3 (pl)
PT (1)	PT2344465E (pl)
RU (1)	RU2519548C2 (pl)
SI (1)	SI2344465T1 (pl)
TW (1)	TWI462911B (pl)
WO (1)	WO2010046835A1 (pl)
ZA (1)	ZA201103691B (pl)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7435828B2 (en)	2003-11-21	2008-10-14	Actelion Pharmaceuticals Ltd.	Thiazolidin-4-one derivatives
USRE43833E1 (en)	2003-11-21	2012-11-27	Actelion Pharmaceuticals Ltd.	Thiazolidin-4-one derivatives
MX2009005048A (es) *	2006-11-23	2009-05-25	Actelion Pharmaceuticals Ltd	Nuevo proceso para la preparacion de derivados de 2-imino-tiazolidin-4-ona.
US8912340B2 (en)	2006-11-23	2014-12-16	Actelion Pharmaceuticals Ltd.	Process for the preparation of 2-imino-thiazolidin-4-one derivatives
WO2009115954A1 (en) *	2008-03-17	2009-09-24	Actelion Pharmaceuticals Ltd	Dosing regimen for a selective s1p1 receptor agonist
CN106278982B (zh) *	2011-06-02	2019-06-14	奇诺因私人有限公司	用于制备前列腺素酰胺的新的方法
SMT202000298T1 (it)	2012-08-17	2020-07-08	Actelion Pharmaceuticals Ltd	Processo per la produzione di (2z,5z)-5-(3-cloro-4((r)-2,3-diidrossipropossi) benziliden)-2-(propilimmino)-3-(o-tolil)tiazolidin-4-one e intermedio usato in detto processo
MA41139B1 (fr)	2014-12-11	2026-02-27	Laboratoires Juvise Pharmaceuticals	Combinaison pharmaceutique comprenant du ponesimod et son utilisation dans le traitement de la sclérose en plaque
DK3256125T3 (da)	2014-12-11	2022-03-21	Actelion Pharmaceuticals Ltd	Doseringsregimen for ponesimod, en selektiv s1p1-receptoragonist
WO2017107972A1 (zh) *	2015-12-25	2017-06-29	苏州晶云药物科技有限公司	一种选择性s1p1受体激动剂的新晶型及其制备方法
JOP20190207A1 (ar)	2017-03-14	2019-09-10	Actelion Pharmaceuticals Ltd	تركيبة صيدلانية تشتمل على بونيسيمود
WO2019060147A1 (en) *	2017-09-19	2019-03-28	Teva Pharmaceuticals Usa, Inc.	NEW CRYSTALLINE POLYMORPHE FROM PONESIMOD
US11014897B1 (en)	2018-10-16	2021-05-25	Celgene Corporation	Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof
US11013723B1 (en)	2018-10-16	2021-05-25	Celgene Corporation	Solid forms of a thiazolidinone compound, compositions and methods of use thereof
US11186556B1 (en)	2018-10-16	2021-11-30	Celgene Corporation	Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
US11014940B1 (en)	2018-10-16	2021-05-25	Celgene Corporation	Thiazolidinone and oxazolidinone compounds and formulations
EP4003338A1 (en)	2019-07-22	2022-06-01	Actelion Pharmaceuticals Ltd	Methods of treating multiple sclerosis
TW202131921A (zh)	2019-10-31	2021-09-01	瑞士商愛杜西亞製藥有限公司	Cxcr7拮抗劑與s1p1受體調節劑之組合
WO2021143414A1 (zh) *	2020-01-19	2021-07-22	苏州科睿思制药有限公司	一种ponesimod的晶型及其制备方法和用途
BR112022017754A2 (pt)	2020-03-06	2022-10-18	Actelion Pharmaceuticals Ltd	Métodos para retardar a perda de volume cerebral
WO2023022896A1 (en)	2021-08-17	2023-02-23	Teva Czech Industries S.R.O	Polymorphs of ponesimod
CA3220684A1 (en)	2021-10-11	2023-04-20	Actelion Pharmaceuticals Ltd	Methods of treating multiple sclerosis
CA3220715A1 (en)	2021-10-11	2023-04-20	Krista Spiller	Methods of treating multiple sclerosis
US11951097B2 (en)	2021-10-11	2024-04-09	Vanda Pharmaceuticals Inc.	Methods of treating multiple sclerosis
CA3220723A1 (en)	2021-10-11	2023-04-20	Allitia DIBERNARDO	Methods of treating multiple sclerosis
WO2023079079A1 (en)	2021-11-05	2023-05-11	Actelion Pharmaceuticals Ltd	Methods for treating multiple sclerosis
EP4212156A1 (en)	2022-01-13	2023-07-19	Abivax	Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator
WO2023152290A1 (en)	2022-02-11	2023-08-17	Actelion Pharmaceuticals Ltd	Methods of slowing an increase in brain ventricular volume

Family Cites Families (7)

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Publication number	Priority date	Publication date	Assignee	Title
UA79793C2 (en) *	2002-07-10	2007-07-25	Applied Research Systems	Azolidinone-vinyl fused-benzene derivatives
WO2005037424A1 (en) *	2003-10-06	2005-04-28	Solvias Ag	Process for the parallel detection of crystalline forms of molecular solids
US7435828B2 (en)	2003-11-21	2008-10-14	Actelion Pharmaceuticals Ltd.	Thiazolidin-4-one derivatives
USRE43833E1 (en)	2003-11-21	2012-11-27	Actelion Pharmaceuticals Ltd.	Thiazolidin-4-one derivatives
US8912340B2 (en)	2006-11-23	2014-12-16	Actelion Pharmaceuticals Ltd.	Process for the preparation of 2-imino-thiazolidin-4-one derivatives
MX2009005048A (es)	2006-11-23	2009-05-25	Actelion Pharmaceuticals Ltd	Nuevo proceso para la preparacion de derivados de 2-imino-tiazolidin-4-ona.
WO2009115954A1 (en)	2008-03-17	2009-09-24	Actelion Pharmaceuticals Ltd	Dosing regimen for a selective s1p1 receptor agonist

2008
- 2008-10-20 GB GBGB0819182.7A patent/GB0819182D0/en not_active Ceased
2009
- 2009-10-19 BR BRPI0919673-0A patent/BRPI0919673B1/pt active IP Right Grant
- 2009-10-19 AR ARP090104010A patent/AR073904A1/es unknown
- 2009-10-19 PL PL09741441T patent/PL2344465T3/pl unknown
- 2009-10-19 DK DK09741441.1T patent/DK2344465T3/en active
- 2009-10-19 CN CN200980141327.8A patent/CN102177144B/zh active Active
- 2009-10-19 JP JP2011531624A patent/JP5008777B2/ja active Active
- 2009-10-19 KR KR1020117011262A patent/KR101409597B1/ko active Active
- 2009-10-19 ES ES09741441.1T patent/ES2534333T3/es active Active
- 2009-10-19 NZ NZ592854A patent/NZ592854A/xx unknown
- 2009-10-19 TW TW098135296A patent/TWI462911B/zh active
- 2009-10-19 CA CA2740313A patent/CA2740313C/en active Active
- 2009-10-19 EP EP09741441.1A patent/EP2344465B1/en active Active
- 2009-10-19 PT PT97414411T patent/PT2344465E/pt unknown
- 2009-10-19 MX MX2011003988A patent/MX2011003988A/es active IP Right Grant
- 2009-10-19 AU AU2009305980A patent/AU2009305980C1/en active Active
- 2009-10-19 MY MYPI2011001728A patent/MY160703A/en unknown
- 2009-10-19 SI SI200931161T patent/SI2344465T1/sl unknown
- 2009-10-19 RU RU2011119898/04A patent/RU2519548C2/ru active
- 2009-10-19 HR HRP20150391TT patent/HRP20150391T1/hr unknown
- 2009-10-19 WO PCT/IB2009/054592 patent/WO2010046835A1/en not_active Ceased
- 2009-10-19 US US13/125,102 patent/US9062014B2/en active Active
2011
- 2011-04-14 IL IL212351A patent/IL212351A/en active IP Right Grant
- 2011-04-19 CL CL2011000867A patent/CL2011000867A1/es unknown
- 2011-05-13 MA MA33846A patent/MA32797B1/fr unknown
- 2011-05-19 ZA ZA2011/03691A patent/ZA201103691B/en unknown
2015
- 2015-03-13 CY CY20151100261T patent/CY1116118T1/el unknown

Also Published As

Publication number	Publication date
ZA201103691B (en)	2015-12-23
AU2009305980A1 (en)	2010-04-29
KR101409597B1 (ko)	2014-06-20
AU2009305980B2 (en)	2014-10-02
MA32797B1 (fr)	2011-11-01
RU2011119898A (ru)	2012-11-27
PT2344465E (pt)	2015-04-23
WO2010046835A1 (en)	2010-04-29
HRP20150391T1 (hr)	2015-05-22
IL212351A (en)	2015-09-24
JP5008777B2 (ja)	2012-08-22
CY1116118T1 (el)	2017-02-08
JP2012505873A (ja)	2012-03-08
BRPI0919673B1 (pt)	2022-02-08
BRPI0919673A2 (pt)	2020-09-15
RU2519548C2 (ru)	2014-06-10
CN102177144B (zh)	2014-12-31
MX2011003988A (es)	2011-05-10
TW201022220A (en)	2010-06-16
IL212351A0 (en)	2011-06-30
ES2534333T3 (es)	2015-04-21
EP2344465A1 (en)	2011-07-20
US20110196004A1 (en)	2011-08-11
TWI462911B (zh)	2014-12-01
AU2009305980C1 (en)	2015-01-22
SI2344465T1 (sl)	2015-04-30
CA2740313A1 (en)	2010-04-29
DK2344465T3 (en)	2015-02-16
HK1159624A1 (en)	2012-08-03
MY160703A (en)	2017-03-15
CA2740313C (en)	2016-09-27
GB0819182D0 (en)	2008-11-26
NZ592854A (en)	2013-01-25
US9062014B2 (en)	2015-06-23
KR20110071133A (ko)	2011-06-28
AR073904A1 (es)	2010-12-09
EP2344465B1 (en)	2015-01-07
CN102177144A (zh)	2011-09-07
CL2011000867A1 (es)	2011-09-23

Publication	Publication Date	Title
PT2344465E (pt)	2015-04-23	Formas cristalinas de (r)-5-[3-cloro-4-(2,3-dihidroxipropoxi)- benz[z]ilideno]-2-([z]-propilimino)-3-o-toliltiazolidin- 4-ona
IL197420A0 (en)	2009-12-24	Polymorphic form of 4-[3-(4-cyclopropanecarbonyl-piperazine-1-
ZA201103887B (en)	2012-10-31	Isoxazole derivatives for use as fungicides
FR2931071B1 (fr)	2010-08-13	Confiserie aux algues pour la prevention des infections buccodentaires
SG10201503828QA (en)	2016-10-28	N-Hydroxylsulfonamide Derivatives As New Physiologically Useful Nitroxyl Donors
GB0812031D0 (en)	2008-08-06	Thiazole derivatives
IL205751A0 (en)	2010-11-30	Aminothiazole derivatives
SI2225238T1 (sl)	2014-12-31	Derivati amidov 6,7-dihidro-5H-imidazo(1,2-a)imidazol-3-karboksilne kisline
ZA201005383B (en)	2011-10-26	Substituted arylamide ozazepinopyrimidone derivatives
AP2010005364A0 (en)	2010-08-31	Novel heterocyclic compounds.
IL209423A0 (en)	2011-01-31	4,5-dihydro-oxazol-2-yl derivatives
SI2049480T1 (sl)	2014-02-28	2-arilindolni derivati kot mPGES-1 inhibitorji
SI2132204T1 (sl)	2013-05-31	Kristalinične oblike 8-azabiciklo(3.2.1) oktanske spojine
PL383550A1 (pl)	2009-04-27	Nowe pochodne benzeno- i pirydopirydazynonów
IT1393048B1 (it)	2012-04-11	Procedimento per la preparazione di una porchetta di maiale a lunga conservazione
AU2009252307B2 (en)	2013-08-08	Heterocyclic compound
PL384052A1 (pl)	2009-06-22	Nowe pochodne N-[1,3-diokso-3a,4,5,6,7,7a-heksahydro-1H-izoindo-2(3H)-ylo]-N-arylobenzimidoamidu oraz sposób ich wytwarzania
HK1155153A (en)	2012-05-11	1, 2 disubstituted heterocyclic compounds
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