PL2348016T3 - Pochodne fenylopiroloaminoguanidyny - Google Patents
Pochodne fenylopiroloaminoguanidynyInfo
- Publication number
- PL2348016T3 PL2348016T3 PL11164583.4T PL11164583T PL2348016T3 PL 2348016 T3 PL2348016 T3 PL 2348016T3 PL 11164583 T PL11164583 T PL 11164583T PL 2348016 T3 PL2348016 T3 PL 2348016T3
- Authority
- PL
- Poland
- Prior art keywords
- phenyl pyrrole
- aminoguanidine derivatives
- pyrrole aminoguanidine
- derivatives
- present
- Prior art date
Links
- ZIKCHNCVFRYIRB-UHFFFAOYSA-N 2-aminoguanidine 2-phenyl-1H-pyrrole Chemical class NNC(N)=N.C1=CNC(C=2C=CC=CC=2)=C1 ZIKCHNCVFRYIRB-UHFFFAOYSA-N 0.000 title abstract 3
- 102000004378 Melanocortin Receptors Human genes 0.000 abstract 1
- 108090000950 Melanocortin Receptors Proteins 0.000 abstract 1
- 239000000637 Melanocyte-Stimulating Hormone Substances 0.000 abstract 1
- 108010007013 Melanocyte-Stimulating Hormones Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/42—Nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200600780 | 2006-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2348016T3 true PL2348016T3 (pl) | 2016-09-30 |
Family
ID=58709169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11164583.4T PL2348016T3 (pl) | 2006-06-09 | 2007-06-11 | Pochodne fenylopiroloaminoguanidyny |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8058306B2 (pl) |
| EP (2) | EP2348016B1 (pl) |
| JP (1) | JP5444523B2 (pl) |
| CN (1) | CN101466669B (pl) |
| AT (1) | ATE508111T1 (pl) |
| AU (1) | AU2007255366B2 (pl) |
| CA (1) | CA2688485C (pl) |
| CY (1) | CY1117851T1 (pl) |
| DE (1) | DE602007014363D1 (pl) |
| DK (1) | DK2348016T3 (pl) |
| ES (1) | ES2571253T3 (pl) |
| HU (1) | HUE029016T2 (pl) |
| MX (1) | MX2008015454A (pl) |
| NZ (1) | NZ573457A (pl) |
| PL (1) | PL2348016T3 (pl) |
| SI (1) | SI2348016T1 (pl) |
| WO (1) | WO2007141343A1 (pl) |
| ZA (1) | ZA200810347B (pl) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2009071101A1 (en) * | 2007-12-07 | 2009-06-11 | Action Pharma A/S | N-modified aminoguanidine derivatives |
| WO2009074157A1 (en) * | 2007-12-13 | 2009-06-18 | Action Pharma A/S | Fully-modified phenyl pyrrole aminoguanidines |
| UA99555C2 (en) | 2008-11-12 | 2012-08-27 | Элджи Лайф Саенсез Лтд. | Melanocortin receptor agonists |
| CN112292125B (zh) * | 2018-06-22 | 2023-10-31 | 西奈克制药有限公司 | 蛋白尿的治疗 |
| LT3773558T (lt) | 2019-05-10 | 2022-09-12 | Synact Pharma Aps | Kompleksinis artrito gydymas |
| CN120617247A (zh) * | 2020-03-31 | 2025-09-12 | 西奈克制药有限公司 | 症状性病毒性疾病的治疗 |
| EP4359076B1 (en) | 2021-06-21 | 2025-08-06 | SynAct Pharma ApS | Phenyl pyrrole aminoguanidine salts and formulations |
| WO2023218048A1 (en) | 2022-05-12 | 2023-11-16 | Synact Pharma Aps | Resomelagon and its derivatives for the treatment of cardiovascular disease, hypertension and atherosclerosis |
| CN120584099A (zh) * | 2022-12-21 | 2025-09-02 | 西奈克制药有限公司 | 苯基吡咯肼甲脒化合物的多晶型物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9604348D0 (sv) | 1996-11-26 | 1996-11-26 | Wapharm Ab | Användning av hydroxyguanidiner |
| WO1999021571A1 (en) | 1997-10-27 | 1999-05-06 | Trega Biosciences, Inc. | Melanocortin receptor ligands and methods of using same |
| EP1076649A4 (en) | 1998-04-28 | 2010-06-02 | Trega Biosciences Inc | ISOQUINOLINE-BASED COMPOUNDS IN PLACE OF MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USE |
| WO1999064002A1 (en) | 1998-06-11 | 1999-12-16 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| CA2368431C (en) | 1999-03-29 | 2006-01-24 | The Procter & Gamble Company | Melanocortin receptor ligands |
| CA2377369A1 (en) | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
| WO2001005401A1 (en) | 1999-07-16 | 2001-01-25 | Trega Biosciences, Inc. | Melanocortin receptor-3 ligands to treat sexual dysfunction |
| GB0002059D0 (en) | 2000-01-28 | 2000-03-22 | Melacure Therapeutics Ab | Novel aromatic amines |
| WO2001055106A2 (en) | 2000-01-28 | 2001-08-02 | Melacure Therapeutics Ab | Novel melanocortin receptor agonists and antagonists |
| WO2001055107A2 (en) | 2000-01-28 | 2001-08-02 | Melacure Therapeutics Ab | Aromatic amines and amides acting on the melanocortin receptors |
| GB0019357D0 (en) | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| US6768024B1 (en) | 2000-08-04 | 2004-07-27 | Lion Bioscience Ag | Triamine derivative melanocortin receptor ligands and methods of using same |
| GB0019359D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel guanidines |
| DZ3415A1 (fr) | 2000-08-31 | 2002-03-07 | Chiron Corp | Guanidinobenzamides comme mc4-r agonistes. |
| GB0119172D0 (en) * | 2001-08-06 | 2001-09-26 | Melacure Therapeutics Ab | Phenyl pyrrole derivatives |
-
2007
- 2007-06-11 NZ NZ573457A patent/NZ573457A/en unknown
- 2007-06-11 AU AU2007255366A patent/AU2007255366B2/en active Active
- 2007-06-11 JP JP2009513710A patent/JP5444523B2/ja active Active
- 2007-06-11 CN CN200780021060XA patent/CN101466669B/zh active Active
- 2007-06-11 SI SI200731768A patent/SI2348016T1/sl unknown
- 2007-06-11 MX MX2008015454A patent/MX2008015454A/es active IP Right Grant
- 2007-06-11 DK DK11164583.4T patent/DK2348016T3/en active
- 2007-06-11 AT AT07730054T patent/ATE508111T1/de not_active IP Right Cessation
- 2007-06-11 CA CA2688485A patent/CA2688485C/en active Active
- 2007-06-11 WO PCT/EP2007/055715 patent/WO2007141343A1/en not_active Ceased
- 2007-06-11 US US12/304,065 patent/US8058306B2/en active Active
- 2007-06-11 EP EP11164583.4A patent/EP2348016B1/en active Active
- 2007-06-11 HU HUE11164583A patent/HUE029016T2/en unknown
- 2007-06-11 PL PL11164583.4T patent/PL2348016T3/pl unknown
- 2007-06-11 ES ES11164583T patent/ES2571253T3/es active Active
- 2007-06-11 DE DE602007014363T patent/DE602007014363D1/de active Active
- 2007-06-11 EP EP07730054A patent/EP2035373B1/en active Active
-
2008
- 2008-12-05 ZA ZA200810347A patent/ZA200810347B/xx unknown
-
2016
- 2016-05-16 CY CY20161100421T patent/CY1117851T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2348016B1 (en) | 2016-02-17 |
| ZA200810347B (en) | 2010-05-26 |
| US20110082183A1 (en) | 2011-04-07 |
| CA2688485C (en) | 2016-01-05 |
| EP2035373B1 (en) | 2011-05-04 |
| EP2348016A1 (en) | 2011-07-27 |
| JP2009539809A (ja) | 2009-11-19 |
| HK1160136A1 (en) | 2012-08-10 |
| AU2007255366A1 (en) | 2007-12-13 |
| NZ573457A (en) | 2011-06-30 |
| AU2007255366B2 (en) | 2013-07-18 |
| US8058306B2 (en) | 2011-11-15 |
| MX2008015454A (es) | 2009-01-30 |
| DK2348016T3 (en) | 2016-05-30 |
| WO2007141343A1 (en) | 2007-12-13 |
| DE602007014363D1 (de) | 2011-06-16 |
| JP5444523B2 (ja) | 2014-03-19 |
| CA2688485A1 (en) | 2007-12-13 |
| CY1117851T1 (el) | 2017-05-17 |
| ES2571253T3 (es) | 2016-05-24 |
| CN101466669B (zh) | 2011-11-30 |
| ATE508111T1 (de) | 2011-05-15 |
| HUE029016T2 (en) | 2017-02-28 |
| SI2348016T1 (sl) | 2016-10-28 |
| EP2035373A1 (en) | 2009-03-18 |
| CN101466669A (zh) | 2009-06-24 |
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