ATE402697T1 - 1,3,5-trisubstituierte 4,5-dihydro-1h-pyrazol- derivative mit cb1-antagonistischer aktivität - Google Patents

1,3,5-trisubstituierte 4,5-dihydro-1h-pyrazol- derivative mit cb1-antagonistischer aktivität

Info

Publication number: ATE402697T1
Authority: AT; Austria
Prior art keywords: trisubstituted; dihydro; antagonistic activity; pyrazole derivative; compounds
Prior art date: 2004-01-30

Application number

AT05707857T

Other languages

English (en)

Inventor

Josephus Lange

Cornelis Kruse

Stuivenberg Herman Van

Original Assignee

Solvay Pharm Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-01-30

Filing date

2005-01-27

Publication date

2008-08-15

2005-01-27 Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv

2008-08-15 Application granted granted Critical

2008-08-15 Publication of ATE402697T1 publication Critical patent/ATE402697T1/de

Links

-1 1,3,5-TRISUBSTITUTED 4,5-DIHYDRO-1H-PYRAZOLE Chemical class 0.000 title abstract 2
230000003042 antagnostic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
229940124802 CB1 antagonist Drugs 0.000 abstract 1
230000009286 beneficial effect Effects 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
150000003217 pyrazoles Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Obesity (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Psychology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Virology (AREA)
Addiction (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)

AT05707857T 2004-01-30 2005-01-27 1,3,5-trisubstituierte 4,5-dihydro-1h-pyrazol- derivative mit cb1-antagonistischer aktivität ATE402697T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US53998304P	2004-01-30	2004-01-30
EP04100338		2004-01-30

Publications (1)

Publication Number	Publication Date
ATE402697T1 true ATE402697T1 (de)	2008-08-15

Family

ID=34839806

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05707857T ATE402697T1 (de)	2004-01-30	2005-01-27	1,3,5-trisubstituierte 4,5-dihydro-1h-pyrazol- derivative mit cb1-antagonistischer aktivität

Country Status (20)

Country	Link
EP (1)	EP1713475B1 (de)
JP (1)	JP4693787B2 (de)
KR (1)	KR20060131861A (de)
CN (1)	CN100563651C (de)
AT (1)	ATE402697T1 (de)
AU (1)	AU2005210163B2 (de)
BR (1)	BRPI0507005A (de)
CA (1)	CA2552940A1 (de)
DE (1)	DE602005008555D1 (de)
DK (1)	DK1713475T3 (de)
ES (1)	ES2311972T3 (de)
HR (1)	HRP20080549T3 (de)
IL (1)	IL176547A (de)
MX (1)	MXPA06008593A (de)
NO (1)	NO20063866L (de)
PL (1)	PL1713475T3 (de)
PT (1)	PT1713475E (de)
RU (1)	RU2360904C2 (de)
SI (1)	SI1713475T1 (de)
WO (1)	WO2005074920A1 (de)

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WO2007009705A1 (en) *	2005-07-15	2007-01-25	Laboratorios Del Dr. Esteve, S.A.	(rac)-n-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydr0-1h-pyrazole-3-carboxamide hydrates
WO2007009699A2 (en) *	2005-07-15	2007-01-25	Laboratorios Del Dr. Esteve, S.A	Use of substituted pyrazoline compounds and their derivatives for the treatment of cannabinoid system-associated diseases
EP1910302A1 (de) *	2005-07-15	2008-04-16	Laboratorios del Dr. Esteve S.A.	Carbonylsubstituierte pyrazolinverbindungen, ihre herstellung und ihre verwendung als modulatoren des cb1-rezeptors
EP1849776A1 (de) *	2006-04-26	2007-10-31	Laboratorios Del Dr. Esteve, S.A.	Azepan- oder Azocan-substituierte Pyrazolinderivate, deren Herstellung und Anwendung als Arzneimittel
ES2330992B1 (es) *	2005-07-15	2010-07-06	Laboratorios Del Dr. Esteve, S.A.	Compuestos de pirazolina heterociclilsustituidos, su preparacion y uso como medicamentos.
ES2327379B1 (es) *	2005-07-15	2010-05-28	Laboratorios Del Dr. Esteve, S.A.	Compuestos de pirazolina indolinsustituidos, su preparacion y su uso como medicamentos.
EP1749820A1 (de) *	2005-07-15	2007-02-07	Laboratorios Del Dr. Esteve, S.A.	Salze von substituierten Pyrazolin Derivaten, ihre Herstellung und Anwendung als Arzneimittel
WO2007009682A1 (en) *	2005-07-15	2007-01-25	Laboratorios Del Dr. Esteve, S.A.	Oral pharmaceutical formulations comprising substituted pyrazoline compounds
EP1757589A1 (de) *	2005-07-29	2007-02-28	Laboratorios Del Dr. Esteve, S.A.	Amorphe-Phase von einem substituierten Pyrazolin, deren Herstellung und Verwendung als Medikament
WO2007017124A1 (en) *	2005-07-29	2007-02-15	Laboratorios Del Dr. Esteve, S.A.	Amorphous phase of a substituted pyrazoline, its preparation and use as medicament
EP1911747A1 (de)	2006-10-11	2008-04-16	Laboratorios del Dr. Esteve S.A.	Sulfonamid-substituierte Pyrazolin-derivate, deren Herstellung sowie deren Verwendung als CB1 Modulatoren
ES2328653B1 (es) *	2007-01-15	2010-05-28	Laboratorios Del Dr. Esteve S.A.	Combinacion de sustancias activas para el tratamiento de la diabetes.
EP1946778A1 (de) *	2007-01-16	2008-07-23	Laboratorios del Dr. Esteve S.A.	Wirkstoffzusammensetzung für Diabetesbehandlung
EP1946777A1 (de) *	2007-01-16	2008-07-23	Laboratorios del Dr. Esteve S.A.	Substituierte Pyrazolinderivate zur Vermeidung von Gewichtszunahme
ES2330071B1 (es) *	2007-01-15	2010-07-05	Laboratorios Del Dr. Esteve, S.A.	Combinacion de sustancias activas.
EP1944295A1 (de) *	2007-01-15	2008-07-16	Laboratorios del Dr. Esteve S.A.	Nicht racemische Verbindungen von (R)-N-piperidinyl-5-(4-chlorophenyl)1-1(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-carboxamid und (S)-N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-carboxamid
EP1946779A1 (de) *	2007-01-16	2008-07-23	Laboratorios del Dr. Esteve S.A.	Zusammensetzung enthaltend substituierte Pyrazoline und gegen Dyslipämie wirksame Mittel
EP1947089A1 (de) *	2007-01-18	2008-07-23	Laboratorios del Dr. Esteve S.A.	A-Polymorph eines substituierten Pyrazolins, seine Herstellung und Verwendung als Medikament
KR20100020998A (ko) *	2007-06-15	2010-02-23	솔베이 파마슈티칼스 비. 브이	칸나비노이드 ｃｂ1 수용체 조절제로서의 4,5-디하이드로-(1ｈ)-피라졸 유도체
US8410135B2 (en)	2007-06-15	2013-04-02	Solvay Pharmaceuticals B.V.	4,5 dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators
CA2698527A1 (en) *	2007-09-20	2009-03-26	Solvay Pharmaceuticals B.V.	5-aryl-4,5-dihydro-(1h)-pyrazoles as cannabinoid cb1 receptor agonists
EP2042175A1 (de) *	2007-09-21	2009-04-01	Laboratorios del Dr. Esteve S.A.	Dosierungsschemata von CB1-Rezeptor-Liganden für die Behandlung von Fettleibigkeit
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US11155521B2 (en)	2012-11-13	2021-10-26	The United States Of America As Represented By The Secretary, Department Of Health And Human Services	Cannabinoid receptor mediating compounds
EP2919779B1 (de)	2012-11-13	2021-01-06	The U.S.A. as represented by the Secretary, Department of Health and Human Services	Cannabinoid rezeptor mediatoren
WO2014208939A1 (en) *	2013-06-28	2014-12-31	Hanmi Pharm. Co., Ltd.	1,5-diaryl-4,5-dihydro-1h-pyrazole-3-carboxamidine derivatives as cannabinoid cb1 receptor antagonist, method for preparing same, and pharmaceutical composition comprising same
WO2015172059A1 (en) *	2014-05-09	2015-11-12	The United States Of America, As Represented By The Secretary, Department Of Health & Human Services	Pyrazole derivatives and their use as cannabinoid receptor mediators
CN115536649B (zh) *	2022-10-27	2024-12-20	成都中医药大学	一种多取代吡唑啉类化合物及其合成方法

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WO1992003421A2 (en) *	1990-08-17	1992-03-05	E.I. Du Pont De Nemours And Company	Arthropodicidal pyrazolines, pyrazolidines and hydrazines
EP0629201A1 (de) *	1992-03-02	1994-12-21	E.I. Du Pont De Nemours And Company	Arthropodizide amide
FR2713225B1 (fr) *	1993-12-02	1996-03-01	Sanofi Sa	N-pipéridino-3-pyrazolecarboxamide substitué.
PL208098B1 (pl) *	2000-03-23	2011-03-31	Solvay Pharm Bv	Pochodne 4,5-dihydro-1H-pirazolu, kompozycja farmaceutyczna, sposób wytwarzania związków oraz ich zastosowanie
CZ2003698A3 (cs) *	2001-03-22	2003-06-18	Solvay Pharmaceuticals B. V.	4,5-Dihydro-1H-pyrazolové deriváty mající CB1-antagonistickou účinnost
KR100950430B1 (ko) *	2001-09-21	2010-04-02	솔베이 파마슈티칼스 비. 브이	효력있는 ｃｂ1-길항 작용을 가지는4,5-디하이드로-1ｈ-피라졸 유도체
CN101659639A (zh) *	2001-09-21	2010-03-03	索尔瓦药物有限公司	具有cb1-拮抗活性的新的4,5-二氢-1h-吡唑衍生物

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- 2005-01-27 KR KR1020067017475A patent/KR20060131861A/ko not_active Ceased
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2006
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JP2007519686A (ja)	2007-07-19
NO20063866L (no)	2006-10-27
MXPA06008593A (es)	2006-08-28
JP4693787B2 (ja)	2011-06-01
WO2005074920A1 (en)	2005-08-18
AU2005210163B2 (en)	2010-05-13
BRPI0507005A (pt)	2007-06-05
SI1713475T1 (sl)	2008-12-31
RU2360904C2 (ru)	2009-07-10
EP1713475A1 (de)	2006-10-25
PT1713475E (pt)	2008-11-10
RU2006131132A (ru)	2008-03-10
DK1713475T3 (da)	2008-12-01
CN100563651C (zh)	2009-12-02
DE602005008555D1 (de)	2008-09-11
AU2005210163A1 (en)	2005-08-18
ES2311972T3 (es)	2009-02-16
KR20060131861A (ko)	2006-12-20
IL176547A (en)	2010-06-30
CN1913885A (zh)	2007-02-14
PL1713475T3 (pl)	2009-03-31
HK1099688A1 (en)	2007-08-24
EP1713475B1 (de)	2008-07-30
CA2552940A1 (en)	2005-08-18
IL176547A0 (en)	2006-10-31
HRP20080549T3 (en)	2008-11-30

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