PL2404922T3 - Związki chinoksalinowe - Google Patents
Związki chinoksalinoweInfo
- Publication number
- PL2404922T3 PL2404922T3 PL10748823T PL10748823T PL2404922T3 PL 2404922 T3 PL2404922 T3 PL 2404922T3 PL 10748823 T PL10748823 T PL 10748823T PL 10748823 T PL10748823 T PL 10748823T PL 2404922 T3 PL2404922 T3 PL 2404922T3
- Authority
- PL
- Poland
- Prior art keywords
- quinoxaline compounds
- quinoxaline
- compounds
- Prior art date
Links
- 125000001567 quinoxalinyl group Chemical class N1=C(C=NC2=CC=CC=C12)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009052577 | 2009-03-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2404922T3 true PL2404922T3 (pl) | 2017-03-31 |
Family
ID=42709784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10748823T PL2404922T3 (pl) | 2009-03-05 | 2010-03-04 | Związki chinoksalinowe |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8357688B2 (pl) |
| EP (1) | EP2404922B1 (pl) |
| JP (1) | JP5609861B2 (pl) |
| KR (1) | KR20110132559A (pl) |
| CN (1) | CN102341399A (pl) |
| AU (1) | AU2010219598A1 (pl) |
| BR (1) | BRPI1009287A2 (pl) |
| CA (1) | CA2754457A1 (pl) |
| ES (1) | ES2612954T3 (pl) |
| IL (1) | IL214918A0 (pl) |
| MX (1) | MX2011009314A (pl) |
| PL (1) | PL2404922T3 (pl) |
| PT (1) | PT2404922T (pl) |
| RU (1) | RU2011140333A (pl) |
| TW (1) | TW201043632A (pl) |
| WO (1) | WO2010101230A1 (pl) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011009314A (es) * | 2009-03-05 | 2011-10-11 | Astellas Pharma Inc | Compuesto de quinoxalina. |
| AU2010289397B2 (en) | 2009-09-03 | 2016-05-26 | Bioenergenix | Heterocyclic compounds for the inhibition of PASK |
| KR20130097178A (ko) * | 2010-09-07 | 2013-09-02 | 아스텔라스세이야쿠 가부시키가이샤 | 퀴녹살린 화합물 |
| KR101567610B1 (ko) | 2010-11-04 | 2015-11-09 | 주식회사 엘지화학 | 신규한 질소 함유 헤테로환 화합물 및 이를 이용한 유기 전자 소자 |
| WO2012119046A2 (en) * | 2011-03-02 | 2012-09-07 | Bioenergenix | Heterocyclic compounds for the inhibition of pask |
| WO2013000924A1 (en) | 2011-06-27 | 2013-01-03 | Janssen Pharmaceutica Nv | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES |
| JO3116B1 (ar) * | 2011-10-07 | 2017-09-20 | Eisai R&D Man Co Ltd | مشتق بيرازولوكينولين كمثبطات ل pde9 |
| EP2828267B1 (en) | 2012-03-23 | 2019-10-30 | Memorial Sloan-Kettering Cancer Center | TREATMENT OF PANCREATIC AND RELATED CANCERS WITH 5-ACYL-6,7-DIHYDROTHIENO[3,2-c]PYRIDINES |
| WO2014001314A1 (en) | 2012-06-26 | 2014-01-03 | Janssen Pharmaceutica Nv | Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
| JP6244353B2 (ja) | 2013-04-05 | 2017-12-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピリジニルピラゾロキノリン化合物 |
| US9573947B2 (en) | 2013-04-05 | 2017-02-21 | Eisai R&D Management Co., Ltd. | Salt of pyrazoloquinoline derivative, and crystal thereof |
| KR20200010220A (ko) | 2017-06-01 | 2020-01-30 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 피라졸로퀴놀린 유도체를 함유하는 루이소체 질병 치료제 |
| RU2019135834A (ru) | 2017-06-01 | 2021-07-13 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Терапевтическое средство для лечения деменции, представляющее собой комбинацию производного пиразолохинолина и донепезила |
| KR20200010211A (ko) | 2017-06-01 | 2020-01-30 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Pde9 저해제를 포함하는 약제학적 조성물 |
| SG10202113199RA (en) | 2017-06-01 | 2021-12-30 | Eisai R&D Man Co Ltd | Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine |
| CN114560862A (zh) * | 2022-03-08 | 2022-05-31 | 山东龙辰药业有限公司 | 一种吡咯并[1,2-a]喹喔啉-4(5h)-酮及其衍生物的合成方法 |
| WO2024099416A1 (zh) * | 2022-11-10 | 2024-05-16 | 上海海和药物研究开发股份有限公司 | 一种稠合三环类parp1抑制剂、其制备方法及用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4035893A (en) | 1991-12-17 | 1993-07-19 | Upjohn Company, The | 3-substituted imidazo (1,5-a) and imidazo (1,5-a)-triazolo (1,5-c) quinoxalines and quinazolines with cns activity |
| WO1993017025A1 (en) | 1992-02-19 | 1993-09-02 | The Upjohn Company | 3-substituted imidazo(1,5-a)quinoxalines and quinazolines with cns activity |
| DK31093D0 (pl) | 1993-03-19 | 1993-03-19 | Novo Nordisk As | |
| AU694554B2 (en) | 1994-09-16 | 1998-07-23 | Novo Nordisk A/S | {1,2,4}triazolo{4,3-a}quinoxalinone derivatives, their preparation and use |
| DK0783504T3 (da) | 1994-09-16 | 2000-08-14 | Novo Nordisk As | (1,2,4)triazolo (4,3-a)guinoxalinon-derivater, deres fremstilling og anvendelse som antagonister af ampa-receptorer |
| US6235740B1 (en) | 1997-08-25 | 2001-05-22 | Bristol-Myers Squibb Co. | Imidazoquinoxaline protein tyrosine kinase inhibitors |
| US20030195205A1 (en) * | 2001-11-02 | 2003-10-16 | Pfizer Inc. | PDE9 inhibitors for treating cardiovascular disorders |
| HN2002000317A (es) * | 2001-11-02 | 2003-05-21 | Pfizer | Inhibidores de pde9 para tratamiento de trastornos cardiovasculares |
| WO2004085439A1 (en) | 2003-03-27 | 2004-10-07 | Pfizer Products Inc. | Substituted 4-amino[1,2,4]triazolo[4,3-a]quinoxalines |
| CA2612176C (en) | 2005-06-14 | 2015-02-17 | Aska Pharmaceutical Co., Ltd. | Dihydrothieno[2,3-d]pyramidine-6-carboxylic acid derivatives as pde9 inhibitors |
| AU2007282678B2 (en) * | 2006-08-08 | 2012-09-27 | Aska Pharmaceutical Co., Ltd. | Quinazoline derivative |
| WO2008072778A1 (ja) | 2006-12-13 | 2008-06-19 | Aska Pharmaceutical Co., Ltd. | 尿路系疾患の処置剤 |
| US8299080B2 (en) * | 2006-12-13 | 2012-10-30 | Aska Pharmaceutical Co., Ltd. | Substituted imidazo[1,5-A] quinoxalines as a PDE9 inhibitor |
| MX2011009314A (es) * | 2009-03-05 | 2011-10-11 | Astellas Pharma Inc | Compuesto de quinoxalina. |
-
2010
- 2010-03-04 MX MX2011009314A patent/MX2011009314A/es not_active Application Discontinuation
- 2010-03-04 JP JP2011502811A patent/JP5609861B2/ja not_active Expired - Fee Related
- 2010-03-04 PT PT107488231T patent/PT2404922T/pt unknown
- 2010-03-04 CN CN2010800107121A patent/CN102341399A/zh active Pending
- 2010-03-04 KR KR1020117020668A patent/KR20110132559A/ko not_active Withdrawn
- 2010-03-04 CA CA2754457A patent/CA2754457A1/en not_active Abandoned
- 2010-03-04 RU RU2011140333/04A patent/RU2011140333A/ru not_active Application Discontinuation
- 2010-03-04 AU AU2010219598A patent/AU2010219598A1/en not_active Abandoned
- 2010-03-04 WO PCT/JP2010/053586 patent/WO2010101230A1/ja not_active Ceased
- 2010-03-04 ES ES10748823.1T patent/ES2612954T3/es active Active
- 2010-03-04 EP EP10748823.1A patent/EP2404922B1/en active Active
- 2010-03-04 BR BRPI1009287A patent/BRPI1009287A2/pt not_active IP Right Cessation
- 2010-03-04 PL PL10748823T patent/PL2404922T3/pl unknown
- 2010-03-04 US US13/254,368 patent/US8357688B2/en not_active Expired - Fee Related
- 2010-03-05 TW TW099106457A patent/TW201043632A/zh unknown
-
2011
- 2011-09-01 IL IL214918A patent/IL214918A0/en unknown
-
2012
- 2012-11-27 US US13/686,581 patent/US8674096B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2404922A1 (en) | 2012-01-11 |
| RU2011140333A (ru) | 2013-04-10 |
| EP2404922B1 (en) | 2016-11-09 |
| CA2754457A1 (en) | 2010-09-10 |
| TW201043632A (en) | 2010-12-16 |
| US8674096B2 (en) | 2014-03-18 |
| AU2010219598A1 (en) | 2011-09-22 |
| JP5609861B2 (ja) | 2014-10-22 |
| MX2011009314A (es) | 2011-10-11 |
| JPWO2010101230A1 (ja) | 2012-09-10 |
| CN102341399A (zh) | 2012-02-01 |
| IL214918A0 (en) | 2011-11-30 |
| BRPI1009287A2 (pt) | 2019-09-24 |
| PT2404922T (pt) | 2016-12-22 |
| US20130085134A1 (en) | 2013-04-04 |
| US8357688B2 (en) | 2013-01-22 |
| EP2404922A4 (en) | 2013-07-03 |
| ES2612954T3 (es) | 2017-05-19 |
| US20110319385A1 (en) | 2011-12-29 |
| WO2010101230A1 (ja) | 2010-09-10 |
| KR20110132559A (ko) | 2011-12-08 |
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