PL2411025T3 - Stabilna w wysokiej temperaturze kompozycja farmaceutyczna zawierająca nośnik tlenu - Google Patents

Stabilna w wysokiej temperaturze kompozycja farmaceutyczna zawierająca nośnik tlenu

Info

Publication number
PL2411025T3
PL2411025T3 PL11746429T PL11746429T PL2411025T3 PL 2411025 T3 PL2411025 T3 PL 2411025T3 PL 11746429 T PL11746429 T PL 11746429T PL 11746429 T PL11746429 T PL 11746429T PL 2411025 T3 PL2411025 T3 PL 2411025T3
Authority
PL
Poland
Prior art keywords
carrier
pharmaceutical composition
temperature stable
containing pharmaceutical
stable oxygen
Prior art date
Application number
PL11746429T
Other languages
English (en)
Inventor
Bing Lou Wong
Sui Yi Kwok
Original Assignee
First Gain International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44314337&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2411025(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/013,847 external-priority patent/US8742073B2/en
Application filed by First Gain International Ltd filed Critical First Gain International Ltd
Publication of PL2411025T3 publication Critical patent/PL2411025T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41Porphyrin- or corrin-ring-containing peptides
    • A61K38/42Haemoglobins; Myoglobins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795Porphyrin- or corrin-ring-containing peptides
    • C07K14/805Haemoglobins; Myoglobins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PL11746429T 2010-05-27 2011-04-15 Stabilna w wysokiej temperaturze kompozycja farmaceutyczna zawierająca nośnik tlenu PL2411025T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US34876410P 2010-05-27 2010-05-27
US13/013,847 US8742073B2 (en) 2010-05-27 2011-01-26 Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
US13/083,639 US7989593B1 (en) 2010-05-27 2011-04-11 Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
PCT/US2011/032594 WO2011149602A1 (en) 2010-05-27 2011-04-15 High-temperature stable oxygen-carrier-containing pharmaceutical composition
EP11746429.7A EP2411025B1 (en) 2010-05-27 2011-04-15 High-temperature stable oxygen-carrier-containing pharmaceutical composition

Publications (1)

Publication Number Publication Date
PL2411025T3 true PL2411025T3 (pl) 2015-04-30

Family

ID=44314337

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11746429T PL2411025T3 (pl) 2010-05-27 2011-04-15 Stabilna w wysokiej temperaturze kompozycja farmaceutyczna zawierająca nośnik tlenu

Country Status (20)

Country Link
US (1) US7989593B1 (pl)
EP (1) EP2411025B1 (pl)
JP (1) JP5261806B2 (pl)
KR (1) KR101185437B1 (pl)
CN (2) CN102405051B (pl)
AR (1) AR081222A1 (pl)
AU (1) AU2011221433B2 (pl)
CA (1) CA2752943C (pl)
CY (1) CY1115986T1 (pl)
DK (1) DK2411025T3 (pl)
ES (1) ES2527608T3 (pl)
NZ (1) NZ594915A (pl)
PL (1) PL2411025T3 (pl)
PT (1) PT2411025E (pl)
RU (1) RU2475252C1 (pl)
SA (1) SA111320476B1 (pl)
SG (1) SG182237A1 (pl)
TW (1) TWI377947B (pl)
WO (1) WO2011149602A1 (pl)
ZA (1) ZA201208726B (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8048856B1 (en) * 2010-06-23 2011-11-01 Billion King, Ltd. Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
US8084581B1 (en) 2011-04-29 2011-12-27 Bing Lou Wong Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus
US20130052232A1 (en) * 2011-08-31 2013-02-28 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
CA2849448C (en) 2011-09-06 2020-03-24 Billion King International Limited Oral delivery for hemoglobin based oxygen carriers
US20140106004A1 (en) * 2012-10-12 2014-04-17 Bing Lou Wong Hemoglobin-based oxygen carrier-containing pharmaceutical composition for cancer targeting treatment and prevention of cancer recurrence
CN103251998B (zh) * 2012-11-08 2015-09-02 亿京国际有限公司 用于血红蛋白氧载体(hboc)溶液的精确输注递送系统
EP2941440B1 (en) 2013-01-07 2021-05-05 Omniox, Inc. Polymeric forms of h-nox proteins
TWI610685B (zh) * 2013-05-13 2018-01-11 視界全球控股有限公司 用於癌症標靶治療及診斷成像之包含經修飾的基於血紅素之治療劑的醫藥組成物
US9814759B2 (en) 2014-07-02 2017-11-14 Cheer Global Ltd. Pharmaceutical composition comprising recombinant hemoglobin protein or subunit-based therapeutic agent for cancer targeting treatment
CA2979974A1 (en) 2015-03-17 2016-09-22 Omniox, Inc. Modulation of tumor immunity by protein-mediated o2 delivery
US9763889B2 (en) 2015-06-29 2017-09-19 Billion King International Ltd. Oral delivery system for hemoglobin based oxygen carriers
US10052290B2 (en) 2016-02-04 2018-08-21 Billion King International Ltd. Enteric-coated hemoglobin multiparticulate for oral delivery of hemoglobin based oxygen carriers
CN106421805B (zh) * 2016-09-14 2019-06-04 中国人民解放军军事医学科学院野战输血研究所 一种右旋糖酐交联血红蛋白氧载体及其制备方法与应用
WO2020080978A2 (ru) * 2018-10-19 2020-04-23 Рахимджан Ахметджанович РОЗИЕВ Cпособ получения кровезаменителя для применения в ветеринарии
CN114341174B (zh) * 2019-08-29 2024-05-17 亿京国际有限公司 硫代琥珀酰基交联的血红蛋白类似物及其使用和制备方法
CN113621055B (zh) * 2021-08-23 2023-05-02 山东仙普爱瑞科技股份有限公司 一种抗菌和抗病毒的猪血红蛋白β链C端片段、表达该片段的枯草芽孢杆菌、制剂以及应用
EP4402242A4 (en) * 2021-09-17 2025-08-06 Univ Yale METHODS, SYSTEMS AND COMPOSITIONS FOR RESTORING AND PRESERVING INTACT ORGANS IN A MAMMAL

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529719A (en) 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
FR2548671B1 (fr) 1983-07-07 1986-05-02 Merieux Inst Procede de preparation de globine a partir d'hemoglobine et globine obtenue par ce procede
US4831012A (en) 1984-03-23 1989-05-16 Baxter International Inc. Purified hemoglobin solutions and method for making same
USRE34271E (en) 1984-06-27 1993-06-01 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
US4600531A (en) 1984-06-27 1986-07-15 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
US4598064A (en) 1984-06-27 1986-07-01 University Of Iowa Research Foundation Alpha-alpha cross-linked hemoglobins
JPH0750329B2 (ja) 1986-06-23 1995-05-31 富士写真フイルム株式会社 画像形成材料
US5084558A (en) 1987-10-13 1992-01-28 Biopure Corporation Extra pure semi-synthetic blood substitute
US5955581A (en) 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
CA1312009C (en) 1986-11-10 1992-12-29 Carl W. Rausch Extra pure semi-synthetic blood substitute
US5753616A (en) 1986-11-10 1998-05-19 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5189146A (en) 1987-05-05 1993-02-23 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Pasteurizable, freeze-driable hemoglobin-based blood substitute
US6150506A (en) * 1989-05-10 2000-11-21 Baxter Biotech Technology Sarl Modified hemoglobin-like compounds and methods of purifying same
US5439882A (en) 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
US5250665A (en) 1991-05-31 1993-10-05 The University Of Toronto Innovations Foundation Specifically β-β cross-linked hemoglobins and method of preparation
US5344393A (en) 1992-02-28 1994-09-06 Alliance Pharmaceutical Corp. Use of synthetic oxygen carriers to facilitate oxygen delivery
US6187744B1 (en) 1992-03-11 2001-02-13 Michael W. Rooney Methods and compositions for regulating the intravascular flow and oxygenating activity of hemoglobin in a human or animal subject
US5399671A (en) * 1992-11-18 1995-03-21 Kluger; Ronald Specifically crosslinked hemoglobin with free functionality
US5840851A (en) 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
US5725839A (en) 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
US5840701A (en) 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5767089A (en) 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5741893A (en) 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
TW381022B (en) 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US5817632A (en) 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5807831A (en) 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5804561A (en) 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5824781A (en) 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US6242417B1 (en) 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US5631219A (en) 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
ATE294959T1 (de) 1994-05-13 2005-05-15 Miltenyi Biotec Gmbh An protein gebundene sterile und pyrogenfreie säulen zum binden und entfernen von substanzen aus blut
SE9500724D0 (sv) 1994-06-23 1995-02-24 Pharmacia Ab Filtrering
ATE447324T1 (de) * 1995-03-23 2009-11-15 Biopure Corp Stabiles blutersatzmittel mit polymerisiertem hämoglobin
US5895810A (en) 1995-03-23 1999-04-20 Biopure Corporation Stable polymerized hemoglobin and use thereof
US6610832B1 (en) 1995-03-23 2003-08-26 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6288027B1 (en) * 1995-03-23 2001-09-11 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US5691453A (en) 1995-06-07 1997-11-25 Biopure Corporation Separation of polymerized hemoglobin from unpolymerized hemoglobin on hydroxyapatite using HPLC
US5865784A (en) 1995-06-07 1999-02-02 Alliance Pharmaceutical Corp. Method of hemodilution facilitated by monitoring oxygenation status
JP2000502058A (ja) 1995-11-30 2000-02-22 ソマトジェン,インコーポレイテッド ヘモグロビン架橋の際の機能性制御のための方法
US6127043A (en) 1996-03-21 2000-10-03 Sengewald Verpackungen Gmbh Multilayered sheet, process for the production thereof and use thereof
WO1997039761A1 (en) 1996-04-19 1997-10-30 Alpha Therapeutic Corporation A process for viral inactivation of lyophilized blood proteins
RU2080865C1 (ru) * 1996-07-08 1997-06-10 Станислав Людвигович Люблинский Способ получения гемоглобина
DE69823211T2 (de) * 1997-02-06 2004-08-26 Duke University No-modifizierte Hämoglobine und Verwendung dafür
US5814601A (en) 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
AU735799C (en) 1997-02-28 2005-04-28 Regents Of The University Of California, The Methods and compositions for optimisation of oxygen transport by cell-free systems
US6270952B1 (en) 1998-01-06 2001-08-07 Cerus Corporation Methods for quenching pathogen inactivators in biological materials
CA2233725A1 (en) * 1998-03-31 1999-09-30 Hemosol Inc. Hemoglobin-hydroxyethyl starch complexes
US6894150B1 (en) 1999-10-01 2005-05-17 Ross Walden Tye Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
US6518010B2 (en) 2001-02-28 2003-02-11 Biopure Corporation Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
WO2002085111A1 (en) 2001-04-18 2002-10-31 Northfield Laboratories Flexible container system for storage of stabilized hemoglobin solutions
JP4260417B2 (ja) 2001-05-23 2009-04-30 ノバルティス アクチエンゲゼルシャフト 溶液を輸送し脱酸素するためのシステム及び方法
US7038016B2 (en) 2001-08-21 2006-05-02 Apex Bioscience, Inc. Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution
US20050164915A1 (en) 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20030153491A1 (en) 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
ATE497776T1 (de) 2002-12-23 2011-02-15 Einstein Coll Med Nicht-hypertensive pegylierte hämoglobine und deren herstellungsverfahren
CN100431602C (zh) 2003-01-29 2008-11-12 北原实验室有限公司 具有低量四聚体的聚合血红蛋白溶液及制备方法
US7135554B1 (en) * 2004-01-27 2006-11-14 Biopure Corporation Method of forming a polymerized hemoglobin solution from stabilized hemoglobin
CN101094692A (zh) 2004-10-29 2007-12-26 塞鲁斯公司 用于红细胞灭活过程的改进的猝灭方法
WO2007065265A1 (en) 2005-12-08 2007-06-14 Ronald Kluger Cross-linking reagents for hemoglobin and hemoglobin products cross-linked therewith
US7759306B2 (en) 2006-05-16 2010-07-20 Simoni Jan S Methods of treating acute blood loss
US7795401B2 (en) 2006-09-06 2010-09-14 National Chung Cheng University Modified hemoglobin with allosteric effector conjugated
CN101168565A (zh) * 2006-10-23 2008-04-30 爱科有限公司 一氧化氮阻断的交联四聚体血红蛋白
US7494974B2 (en) 2006-10-24 2009-02-24 Ikor, Inc. Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en) * 2006-10-23 2009-03-17 Ikor, Inc. Nitric oxide-blocked cross-linked tetrameric hemoglobin
US7932356B1 (en) 2010-06-23 2011-04-26 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition

Also Published As

Publication number Publication date
JP2012526859A (ja) 2012-11-01
CY1115986T1 (el) 2017-01-25
KR20110138215A (ko) 2011-12-26
AU2011221433A1 (en) 2011-12-15
CN103169954B (zh) 2016-01-20
ZA201208726B (en) 2013-09-25
RU2475252C1 (ru) 2013-02-20
EP2411025A1 (en) 2012-02-01
TW201141493A (en) 2011-12-01
SA111320476B1 (ar) 2013-07-28
TWI377947B (en) 2012-12-01
JP5261806B2 (ja) 2013-08-14
EP2411025B1 (en) 2014-11-05
CN102405051B (zh) 2013-01-23
EP2411025A4 (en) 2012-11-14
US7989593B1 (en) 2011-08-02
SG182237A1 (en) 2012-08-30
ES2527608T3 (es) 2015-01-27
HK1166258A1 (en) 2012-10-26
HK1160604A1 (en) 2012-08-10
AR081222A1 (es) 2012-07-04
CA2752943A1 (en) 2011-11-27
CN103169954A (zh) 2013-06-26
WO2011149602A1 (en) 2011-12-01
NZ594915A (en) 2013-06-28
KR101185437B1 (ko) 2012-10-02
DK2411025T3 (en) 2015-02-16
AU2011221433B2 (en) 2012-03-29
CN102405051A (zh) 2012-04-04
PT2411025E (pt) 2015-02-04
WO2011149602A8 (en) 2012-05-24
CA2752943C (en) 2013-10-08

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