BRPI0407106A - Soluções de hemoglobina polimerizadas com quantidade reduzida de tetrâmero e método para preparação - Google Patents

Soluções de hemoglobina polimerizadas com quantidade reduzida de tetrâmero e método para preparação

Info

Publication number
BRPI0407106A
BRPI0407106A BR0407106-9A BRPI0407106A BRPI0407106A BR PI0407106 A BRPI0407106 A BR PI0407106A BR PI0407106 A BRPI0407106 A BR PI0407106A BR PI0407106 A BRPI0407106 A BR PI0407106A
Authority
BR
Brazil
Prior art keywords
tetramer
preparation
cured
hemoglobin solution
hemoglobin solutions
Prior art date
Application number
BR0407106-9A
Other languages
English (en)
Inventor
Anthony Avella
Richard E Dewoskin
Marc D Doubleday
Original Assignee
Northfield Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northfield Lab filed Critical Northfield Lab
Publication of BRPI0407106A publication Critical patent/BRPI0407106A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"SOLUçõES DE HEMOGLOBINA POLIMERIZADAS COM QUANTIDADE REDUZIDA DE TETRâMERO E MéTODO PARA PREPARAçãO". A presente invenção refere-se a uma solução de hemoglobina substancialmente isenta de tetrâmero e a um método para produzir uma solução de hemoglobina substancialmente isenta de tetrâmero. O método inclui a polimerização de uma solução de hemoglobina, tratamento da solução de hemoglobina polimerizada, a fim de degradar parcialmente o polímero em tetrâmero e remover o tetrâmero da solução de hemoglobina.
BR0407106-9A 2003-01-29 2004-01-29 Soluções de hemoglobina polimerizadas com quantidade reduzida de tetrâmero e método para preparação BRPI0407106A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44343603P 2003-01-29 2003-01-29
PCT/US2004/002512 WO2004066953A2 (en) 2003-01-29 2004-01-29 Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing

Publications (1)

Publication Number Publication Date
BRPI0407106A true BRPI0407106A (pt) 2006-01-24

Family

ID=32825331

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0407106-9A BRPI0407106A (pt) 2003-01-29 2004-01-29 Soluções de hemoglobina polimerizadas com quantidade reduzida de tetrâmero e método para preparação

Country Status (14)

Country Link
US (2) US7135553B2 (pt)
EP (1) EP1592437A4 (pt)
JP (1) JP2006516994A (pt)
KR (1) KR20050095636A (pt)
CN (1) CN100431602C (pt)
AU (1) AU2004207595B2 (pt)
BR (1) BRPI0407106A (pt)
CA (1) CA2512169A1 (pt)
MX (1) MXPA05007885A (pt)
NO (1) NO20053745L (pt)
NZ (1) NZ541340A (pt)
RU (1) RU2337705C2 (pt)
WO (1) WO2004066953A2 (pt)
ZA (1) ZA200505814B (pt)

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US7135553B2 (en) * 2003-01-29 2006-11-14 Northfield Laboratories, Inc. Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
US20070196810A1 (en) * 2006-01-24 2007-08-23 Northfield Laboratories Inc. Polymerized Hemoglobin Media and its Use in Isolation and Transplantation of Islet Cells
RU2361608C1 (ru) * 2008-03-18 2009-07-20 Общество С Ограниченной Ответственностью "Научно-Производственная Компания "Медбиофарм" Кровезаменитель с функцией переноса кислорода, фармацевтическая композиция (варианты)
US8273857B2 (en) 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
US7989593B1 (en) 2010-05-27 2011-08-02 Bing Lou Wong Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
US8048856B1 (en) 2010-06-23 2011-11-01 Billion King, Ltd. Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
US7932356B1 (en) 2010-06-23 2011-04-26 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition
US8889830B2 (en) 2011-03-01 2014-11-18 Chuo University Hemoglobin-albumin complex, and artificial plasma expander and artificial oxygen carrier containing the complex
US8084581B1 (en) 2011-04-29 2011-12-27 Bing Lou Wong Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus
US20130052232A1 (en) 2011-08-31 2013-02-28 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
CN103690978B (zh) * 2013-12-19 2017-01-25 陕西佰美基因股份有限公司 一种用于血红蛋白及血红蛋白氧载体灭活病毒的方法
WO2018008729A1 (ja) 2016-07-06 2018-01-11 学校法人 中央大学 虚血性疾患の治療剤
CA3070172A1 (en) 2017-07-18 2019-01-24 VirTech Bio, Inc. Blood substitutes comprising hemoglobin and methods of making
JP7593609B2 (ja) * 2020-02-28 2024-12-03 学校法人 中央大学 ヘモグロビン微粒子及び人工酸素運搬体

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US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
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Also Published As

Publication number Publication date
US20040186047A1 (en) 2004-09-23
JP2006516994A (ja) 2006-07-13
NZ541340A (en) 2008-04-30
NO20053745L (no) 2005-10-03
AU2004207595B2 (en) 2009-02-05
CN1741813A (zh) 2006-03-01
ZA200505814B (en) 2006-05-31
KR20050095636A (ko) 2005-09-29
NO20053745D0 (no) 2005-08-04
CA2512169A1 (en) 2004-08-12
RU2337705C2 (ru) 2008-11-10
WO2004066953A3 (en) 2005-04-07
MXPA05007885A (es) 2005-09-21
EP1592437A4 (en) 2007-12-26
RU2005127050A (ru) 2006-01-20
WO2004066953A2 (en) 2004-08-12
US7411044B2 (en) 2008-08-12
EP1592437A2 (en) 2005-11-09
US20060287222A1 (en) 2006-12-21
US7135553B2 (en) 2006-11-14
CN100431602C (zh) 2008-11-12
AU2004207595A1 (en) 2004-08-12

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.