PL2417141T3 - Pochodne 2-hydroksyetylo-1h-chinolin-2-onu i ich analogi azaizosteryczne o działaniu przeciwbakteryjnym - Google Patents

Pochodne 2-hydroksyetylo-1h-chinolin-2-onu i ich analogi azaizosteryczne o działaniu przeciwbakteryjnym

Info

Publication number
PL2417141T3
PL2417141T3 PL10714481T PL10714481T PL2417141T3 PL 2417141 T3 PL2417141 T3 PL 2417141T3 PL 10714481 T PL10714481 T PL 10714481T PL 10714481 T PL10714481 T PL 10714481T PL 2417141 T3 PL2417141 T3 PL 2417141T3
Authority
PL
Poland
Prior art keywords
quinolin
hydroxyethyl
derivatives
antibacterial activity
azaisosteric
Prior art date
Application number
PL10714481T
Other languages
English (en)
Inventor
Christian Hubschwerlen
Georg Rueedi
Jean-Philippe Surivet
Acklin Cornelia Zumbrunn
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of PL2417141T3 publication Critical patent/PL2417141T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL10714481T 2009-04-09 2010-04-08 Pochodne 2-hydroksyetylo-1h-chinolin-2-onu i ich analogi azaizosteryczne o działaniu przeciwbakteryjnym PL2417141T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2009051510 2009-04-09
PCT/IB2010/051517 WO2010116337A1 (en) 2009-04-09 2010-04-08 2-hydroxyethyl-1h-quinolin-2-one derivatives and their azaisosteric analogues with antibacterial activity
EP10714481.8A EP2417141B1 (en) 2009-04-09 2010-04-08 2-hydroxyethyl-1h-quinolin-2-one derivatives and their azaisosteric analogues with antibacterial activity

Publications (1)

Publication Number Publication Date
PL2417141T3 true PL2417141T3 (pl) 2014-03-31

Family

ID=42199672

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10714481T PL2417141T3 (pl) 2009-04-09 2010-04-08 Pochodne 2-hydroksyetylo-1h-chinolin-2-onu i ich analogi azaizosteryczne o działaniu przeciwbakteryjnym

Country Status (15)

Country Link
US (1) US8415375B2 (pl)
EP (1) EP2417141B1 (pl)
JP (1) JP5639639B2 (pl)
KR (1) KR101729345B1 (pl)
CN (1) CN102361875B (pl)
AR (1) AR076222A1 (pl)
AU (1) AU2010233387B2 (pl)
BR (1) BRPI1015310A8 (pl)
CA (1) CA2756727C (pl)
ES (1) ES2438742T3 (pl)
MX (1) MX2011010358A (pl)
PL (1) PL2417141T3 (pl)
RU (1) RU2540862C2 (pl)
TW (1) TWI455937B (pl)
WO (1) WO2010116337A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
CA2840060A1 (en) * 2011-06-27 2013-01-03 Kyorin Pharmaceutical Co., Ltd. Bridged bicyclic compounds for the treatment of bacterial infections
AR087875A1 (es) 2011-09-16 2014-04-23 Actelion Pharmaceuticals Ltd Proceso para la elaboracion de derivados de piridazina como intermediarios de sintesis de antibioticos
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
CN114507231B (zh) * 2020-11-17 2025-06-03 南京再明医药有限公司 内酰胺类化合物及其制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1095611A1 (ru) * 1982-09-10 2007-06-27 Краснодарский ордена Трудового Красного Знамени политехнический институт Хлорид 5-хлорметил-2-этил-8-метил-4Н-м-диоксино-(4,5-с)-пиридиния, обладающий антимикробной активностью
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
WO1998007703A1 (en) * 1996-08-22 1998-02-26 Meiji Seika Kaisha, Ltd. Quinoline derivatives and psychotropic agent
GB0112834D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
TW200406413A (en) * 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
WO2006002047A2 (en) 2004-06-15 2006-01-05 Glaxo Group Limited Antibacterial agents
JP4887297B2 (ja) * 2004-09-24 2012-02-29 アクテリオン ファーマシューティカルズ リミテッド 新規二環式抗生物質
ATE441645T1 (de) * 2005-05-25 2009-09-15 Actelion Pharmaceuticals Ltd Neue antibiotische derivate
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
EP1900732A4 (en) * 2005-06-24 2009-11-18 Toyama Chemical Co Ltd NEW NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF
CN101341126A (zh) * 2005-10-13 2009-01-07 莫弗凯姆联合化学股份公司 具有抗菌活性的5-喹啉衍生物
AU2007268749B2 (en) * 2006-05-26 2012-07-26 Taisho Pharmaceutical Co., Ltd. Novel heterocyclic compound or salt thereof and intermediate thereof
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
TW200831517A (en) 2006-12-15 2008-08-01 Astrazeneca Ab Chemical compounds
WO2008071962A1 (en) 2006-12-15 2008-06-19 Astrazeneca Ab Pteridines and pyrimidinopyridines as antibacterial agents
WO2008071981A1 (en) 2006-12-15 2008-06-19 Astrazeneca Ab Piperidines for the treatment of bacterial infections
WO2008071964A1 (en) 2006-12-15 2008-06-19 Astrazeneca Ab Naphthyridine bactericides
AU2008240764C1 (en) 2007-04-20 2011-10-20 Glaxo Group Limited Tricyclic nitrogen containing compounds as antibacterial agents
EP2005995A1 (en) 2007-06-22 2008-12-24 Glaxo Group Limited Heterocyclic compounds for the treatment of tuberculosis
WO2009001126A1 (en) 2007-06-27 2008-12-31 Astrazeneca Ab Substituted piperidine derivatives and their use as antibaterial agents
GB0800367D0 (en) 2008-01-09 2008-02-20 Glaxo Group Ltd Compounds
KR101592046B1 (ko) 2008-02-22 2016-02-05 액테리온 파마슈티칼 리미티드 옥사졸리디논 유도체
MX2010012855A (es) 2008-06-03 2010-12-21 Actelion Pharmaceuticals Ltd Derivados de [4-(1-amino-etil)-ciclohexil]-metil-amina y [6-(1-amino-etil)-tetrahidro-piran-3-il]-metil-amina como antibacterianos.
RU2516701C2 (ru) 2008-10-10 2014-05-20 Актелион Фармасьютиклз Лтд Оксазолидиниловые антибиотики
AU2009325902B2 (en) 2008-12-12 2015-01-29 Idorsia Pharmaceuticals Ltd 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen

Also Published As

Publication number Publication date
AU2010233387B2 (en) 2015-01-15
EP2417141A1 (en) 2012-02-15
CN102361875A (zh) 2012-02-22
ES2438742T3 (es) 2014-01-20
RU2540862C2 (ru) 2015-02-10
JP5639639B2 (ja) 2014-12-10
AU2010233387A1 (en) 2011-11-24
TWI455937B (zh) 2014-10-11
CA2756727C (en) 2017-05-02
CA2756727A1 (en) 2010-10-14
CN102361875B (zh) 2014-08-20
US20120040989A1 (en) 2012-02-16
JP2012523407A (ja) 2012-10-04
US8415375B2 (en) 2013-04-09
KR101729345B1 (ko) 2017-04-21
RU2011145052A (ru) 2013-05-20
MX2011010358A (es) 2011-11-01
EP2417141B1 (en) 2013-10-16
BRPI1015310A8 (pt) 2017-12-26
BRPI1015310A2 (pt) 2016-05-24
TW201040182A (en) 2010-11-16
AR076222A1 (es) 2011-05-26
WO2010116337A1 (en) 2010-10-14
KR20120014240A (ko) 2012-02-16

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