BRPI1015310A8 - Derivados de 2-hidróxi-etil-1h-quinolin-2-ona e seus análogos azaisoestéricos com atividade antibacteriana - Google Patents

Derivados de 2-hidróxi-etil-1h-quinolin-2-ona e seus análogos azaisoestéricos com atividade antibacteriana

Info

Publication number
BRPI1015310A8
BRPI1015310A8 BRPI1015310A BRPI1015310A BRPI1015310A8 BR PI1015310 A8 BRPI1015310 A8 BR PI1015310A8 BR PI1015310 A BRPI1015310 A BR PI1015310A BR PI1015310 A BRPI1015310 A BR PI1015310A BR PI1015310 A8 BRPI1015310 A8 BR PI1015310A8
Authority
BR
Brazil
Prior art keywords
azaisosteric
quinolin
analogs
hydroxy
derivatives
Prior art date
Application number
BRPI1015310A
Other languages
English (en)
Inventor
Hubschwerlen Christian
Rueedi Georg
Surivet Jean-Philippe
Zumbrunn Acklin Cornelia
Original Assignee
Actelion Pharmaceuticals Ltd
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BRPI1015310A2 publication Critical patent/BRPI1015310A2/pt
Publication of BRPI1015310A8 publication Critical patent/BRPI1015310A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

DERIVADOS DE 2-HIDRÓXI-ETIL-1H-QUINOLIN-2-ONA E SEUS ANÁLOGOS AZAISOESTÉRICOS COM ATIVIDADE ANTIBACTERIANA A invenção se refere aos compostos antibacterianos da fórmula I, em que R1 represente alcóxi; cada um dentre U e V representa CH, e W representa CH ou N, ou U representa N, V representa CH, e W representa N, ou cada um dentre U e V representa N, e W representa CH; R2 representa hidrogênio ou flúor quando W representa CH, ou R2 representa hidrogênio quando W representa N; A representa O ou CH2; Y representa CH ou N; Q representa O ou S; e n representa O ou 1; e sais de tais compostos.
BRPI1015310A 2009-04-09 2010-04-08 Derivados de 2-hidróxi-etil-1h-quinolin-2-ona e seus análogos azaisoestéricos com atividade antibacteriana BRPI1015310A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2009051510 2009-04-09
PCT/IB2010/051517 WO2010116337A1 (en) 2009-04-09 2010-04-08 2-hydroxyethyl-1h-quinolin-2-one derivatives and their azaisosteric analogues with antibacterial activity

Publications (2)

Publication Number Publication Date
BRPI1015310A2 BRPI1015310A2 (pt) 2016-05-24
BRPI1015310A8 true BRPI1015310A8 (pt) 2017-12-26

Family

ID=42199672

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1015310A BRPI1015310A8 (pt) 2009-04-09 2010-04-08 Derivados de 2-hidróxi-etil-1h-quinolin-2-ona e seus análogos azaisoestéricos com atividade antibacteriana

Country Status (15)

Country Link
US (1) US8415375B2 (pt)
EP (1) EP2417141B1 (pt)
JP (1) JP5639639B2 (pt)
KR (1) KR101729345B1 (pt)
CN (1) CN102361875B (pt)
AR (1) AR076222A1 (pt)
AU (1) AU2010233387B2 (pt)
BR (1) BRPI1015310A8 (pt)
CA (1) CA2756727C (pt)
ES (1) ES2438742T3 (pt)
MX (1) MX2011010358A (pt)
PL (1) PL2417141T3 (pt)
RU (1) RU2540862C2 (pt)
TW (1) TWI455937B (pt)
WO (1) WO2010116337A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
JP2014518267A (ja) * 2011-06-27 2014-07-28 杏林製薬株式会社 細菌感染症の治療のための架橋二環式化合物
AR087875A1 (es) 2011-09-16 2014-04-23 Actelion Pharmaceuticals Ltd Proceso para la elaboracion de derivados de piridazina como intermediarios de sintesis de antibioticos
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
CN114507231B (zh) * 2020-11-17 2025-06-03 南京再明医药有限公司 内酰胺类化合物及其制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1095611A1 (ru) * 1982-09-10 2007-06-27 Краснодарский ордена Трудового Красного Знамени политехнический институт Хлорид 5-хлорметил-2-этил-8-метил-4Н-м-диоксино-(4,5-с)-пиридиния, обладающий антимикробной активностью
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
EP0934932A4 (en) * 1996-08-22 2002-06-26 Meiji Seika Kaisha CHINOLINE DERIVATIVES AND PSYCHOTROPES MEDIUM
GB0112834D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
AR040335A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto
EP1796466A4 (en) 2004-06-15 2009-09-02 Glaxo Group Ltd ANTIBACTERIAL AGENTS
JP4887297B2 (ja) 2004-09-24 2012-02-29 アクテリオン ファーマシューティカルズ リミテッド 新規二環式抗生物質
CA2608687A1 (en) * 2005-05-25 2006-11-30 Actelion Pharmaceuticals Ltd. New antibiotic derivatives
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
EP2468743A1 (en) 2005-06-24 2012-06-27 Toyama Chemical Co., Ltd. Nitrogen-containing bicyclic compounds useful as antibacterial agents
CN101341126A (zh) * 2005-10-13 2009-01-07 莫弗凯姆联合化学股份公司 具有抗菌活性的5-喹啉衍生物
MX2008014908A (es) 2006-05-26 2009-05-13 Toyama Chemical Co Ltd Compuesto heterociclico nuevo o sal del mismo e intermedio del mismo.
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
WO2008071964A1 (en) 2006-12-15 2008-06-19 Astrazeneca Ab Naphthyridine bactericides
WO2008071962A1 (en) 2006-12-15 2008-06-19 Astrazeneca Ab Pteridines and pyrimidinopyridines as antibacterial agents
WO2008071981A1 (en) 2006-12-15 2008-06-19 Astrazeneca Ab Piperidines for the treatment of bacterial infections
TW200831517A (en) 2006-12-15 2008-08-01 Astrazeneca Ab Chemical compounds
PT2137196E (pt) 2007-04-20 2010-12-16 Glaxo Group Ltd Compostos tricíclicos contendo azoto como agentes antibacterianos
EP2005995A1 (en) 2007-06-22 2008-12-24 Glaxo Group Limited Heterocyclic compounds for the treatment of tuberculosis
WO2009001126A1 (en) 2007-06-27 2008-12-31 Astrazeneca Ab Substituted piperidine derivatives and their use as antibaterial agents
GB0800367D0 (en) 2008-01-09 2008-02-20 Glaxo Group Ltd Compounds
CA2713187C (en) 2008-02-22 2016-06-07 Actelion Pharmaceuticals Ltd Oxazolidinone derivatives
AU2009254738B2 (en) * 2008-06-03 2014-05-08 Idorsia Pharmaceuticals Ltd [4-(1-amino-ethyl) -cyclohexyl] -methyl-amine and [6-(1-amino-ethyl) -tetrahydro- pyran-3-yl] -methyl-amine derivatives as antibacterials
JP5490809B2 (ja) 2008-10-10 2014-05-14 アクテリオン ファーマシューティカルズ リミテッド オキサゾリジニル抗生物質
CN102232078B (zh) 2008-12-12 2014-07-16 埃科特莱茵药品有限公司 5-氨基-2-(1-羟基-乙基)-四氢吡喃衍生物
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen

Also Published As

Publication number Publication date
EP2417141A1 (en) 2012-02-15
BRPI1015310A2 (pt) 2016-05-24
KR20120014240A (ko) 2012-02-16
ES2438742T3 (es) 2014-01-20
AR076222A1 (es) 2011-05-26
EP2417141B1 (en) 2013-10-16
TWI455937B (zh) 2014-10-11
MX2011010358A (es) 2011-11-01
AU2010233387B2 (en) 2015-01-15
KR101729345B1 (ko) 2017-04-21
AU2010233387A1 (en) 2011-11-24
US20120040989A1 (en) 2012-02-16
CN102361875B (zh) 2014-08-20
CN102361875A (zh) 2012-02-22
JP2012523407A (ja) 2012-10-04
PL2417141T3 (pl) 2014-03-31
JP5639639B2 (ja) 2014-12-10
RU2540862C2 (ru) 2015-02-10
US8415375B2 (en) 2013-04-09
CA2756727A1 (en) 2010-10-14
TW201040182A (en) 2010-11-16
RU2011145052A (ru) 2013-05-20
WO2010116337A1 (en) 2010-10-14
CA2756727C (en) 2017-05-02

Similar Documents

Publication Publication Date Title
AR121612A2 (es) Inhibidores de glucosilceramida sintasa
EA201170884A1 (ru) Производные пиперидина, пригодные в качестве антагонистов орексина
DOP2015000251A (es) Derivados de naftiridina utiles como antagonistas de la alfa-v-beta-6 integrina
CO6541569A2 (es) Inhibidores de n1-pirazoloespirocetona acetil-coa carboxilasa
BR112015013124A2 (pt) novos derivados de piridina
ATE524466T1 (de) 3-azabicycloä3.3.0üoktanverbindungen
BR112014011064A8 (pt) derivados de antibióticos 2-oxo-oxazolidin-3,5-diila
PE20120648A1 (es) Compuestos de 4-isopropilfenilglucitol como inhibidores de sglt1
BRPI0919810A8 (pt) Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos
BRPI0911035A2 (pt) ativadores de pirrolidinona glicoquinase
CR11251A (es) Depsipeptidos ciclicos y usos de los mismos
MX2015017512A (es) Compuestos 2,3-dihidrobenzofuran-5-ilicos como inhibidores de cinasas dyrk.
BR112014017735A2 (pt) derivados de amida heterocíclicos como antagonistas do receptor de p2x7
MA32956B1 (fr) Derives de 5-amino-2-(1-hydroxyethyl)-tetrahydropyrane
MX2016003196A (es) Derivados antibacterianos del 2h-indazol.
CO6491037A2 (es) Derivados de pirazinooxazepina
DOP2011000245A (es) Derivados de tiadiazoles y oxadiazoles, su preparacion y su aplicacion en terapeutica
BRPI0810399B8 (pt) composto, composição farmacêutica que o contém e uso do mesmo
DOP2012000156A (es) Nuevos derivados de (heterociclo-piperidina condensada)-(piperazini)-1-alcanona o de (heterociclo-pirrolidina condensada)-(piperazinil)-1-alcanona y su utilizacion como inhibidores de p75
MX2011010358A (es) Derivados de 2-hidroxietil-1h-quinolin-2-ona y sus analogos azaisostericos con actividad antibacteriana.
BR112012013319A2 (pt) derivados espiro azacíclicos
EA200702169A1 (ru) Профилактика вич-инфекции
UY35036A (es) Nuevos compuestos inhibidores de la fosfodiesterasa del tipo 10a
BRPI0721887B8 (pt) composto de sal de s-adenosilmetionina e seu uso
AR092772A1 (es) Derivado de 7-azaindol

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25A Requested transfer of rights approved

Owner name: IDORSIA PHARMACEUTICALS LTD (CH)

B25L Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled

Owner name: ACTELION PHARMACEUTICALS LTD (CH)

B25C Requirement related to requested transfer of rights

Owner name: ACTELION PHARMACEUTICALS LTD (CH)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: IDORSIA PHARMACEUTICALS LTD (CH)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements