PL2421879T3 - Nowe nukleozydy 7-deazapurynowe do zastosowań terapeutycznych - Google Patents

Nowe nukleozydy 7-deazapurynowe do zastosowań terapeutycznych

Info

Publication number
PL2421879T3
PL2421879T3 PL10734433T PL10734433T PL2421879T3 PL 2421879 T3 PL2421879 T3 PL 2421879T3 PL 10734433 T PL10734433 T PL 10734433T PL 10734433 T PL10734433 T PL 10734433T PL 2421879 T3 PL2421879 T3 PL 2421879T3
Authority
PL
Poland
Prior art keywords
novel
therapeutic uses
deazapurine nucleosides
deazapurine
nucleosides
Prior art date
Application number
PL10734433T
Other languages
English (en)
Inventor
Aurelie Bourderioux
Michal Hocek
Petr Naus
Original Assignee
Inst Of Organic Chemistry And Biochemistry As Cr V V I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Of Organic Chemistry And Biochemistry As Cr V V I filed Critical Inst Of Organic Chemistry And Biochemistry As Cr V V I
Publication of PL2421879T3 publication Critical patent/PL2421879T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL10734433T 2009-04-22 2010-04-19 Nowe nukleozydy 7-deazapurynowe do zastosowań terapeutycznych PL2421879T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17165609P 2009-04-22 2009-04-22
PCT/CZ2010/000050 WO2010121576A2 (en) 2009-04-22 2010-04-19 Novel 7-deazapurine nucleosides for therapeutic uses
EP10734433.5A EP2421879B1 (en) 2009-04-22 2010-04-19 Novel 7-deazapurine nucleosides for therapeutic uses

Publications (1)

Publication Number Publication Date
PL2421879T3 true PL2421879T3 (pl) 2014-02-28

Family

ID=42768153

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10734433T PL2421879T3 (pl) 2009-04-22 2010-04-19 Nowe nukleozydy 7-deazapurynowe do zastosowań terapeutycznych

Country Status (15)

Country Link
US (3) US9321800B2 (pl)
EP (1) EP2421879B1 (pl)
JP (2) JP5721275B2 (pl)
CN (2) CN104497084B (pl)
AU (3) AU2010238985B2 (pl)
CA (2) CA2759131C (pl)
DK (1) DK2421879T3 (pl)
ES (1) ES2437917T3 (pl)
HR (1) HRP20131021T1 (pl)
MX (1) MX2011011160A (pl)
NZ (2) NZ700583A (pl)
PL (1) PL2421879T3 (pl)
PT (1) PT2421879E (pl)
SI (1) SI2421879T1 (pl)
WO (1) WO2010121576A2 (pl)

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NZ700583A (en) * 2009-04-22 2016-04-29 Acad Of Science Czech Republic Novel 7-deazapurine nucleosides for therapeutic uses
MX2012007026A (es) * 2009-12-18 2013-03-18 Joslin Diabetes Center Inc Compuestos que promueven la replicacion de celula beta y metodos de su uso.
CN102319254B (zh) * 2011-07-20 2013-06-19 上海交通大学 5-碘代杀菌核素在制备抗肿瘤药物中的应用
CZ305466B6 (cs) * 2013-11-04 2015-10-14 Ústav organické chemie a biochemie Akademie věd České republiky, v. v. i. Substituované 7-deazapurinové ribonukleosidy pro terapeutické použití
CA2967125C (en) 2014-11-14 2022-10-25 Nerviano Medical Sciences S.R.L. 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors
WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
CN109562113A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的螺环降解决定子体
ES2989988T3 (es) 2016-05-10 2024-11-28 C4 Therapeutics Inc Degronímeros heterorocíclicos para la degradación de proteínas diana
WO2017197051A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Amine-linked c3-glutarimide degronimers for target protein degradation
WO2018001393A1 (en) 2016-06-29 2018-01-04 Ustav Organicke Chemie A Biochemie Av Cr, V.V.I. Substituted thienopyrrolopyrimidine ribonucleosides for therapeutic use
CZ307334B6 (cs) 2016-08-02 2018-06-13 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití
JP6888101B2 (ja) 2017-01-18 2021-06-16 アレイ バイオファーマ インコーポレイテッド ＲＥＴキナーゼ阻害剤としての置換ピラゾロ［１，５−ａ］ピラジン化合物
CN110769822A (zh) 2017-06-20 2020-02-07 C4医药公司 用于蛋白降解的n/o-连接的降解决定子和降解决定子体
EP3697800A1 (en) 2017-10-19 2020-08-26 Universiteit Gent Nucleoside analogues for the treatment of parasitic infections
WO2019143991A1 (en) 2018-01-18 2019-07-25 Array Biopharma Inc. SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS
JP6997876B2 (ja) * 2018-01-18 2022-02-04 アレイ バイオファーマ インコーポレイテッド Ｒｅｔキナーゼ阻害剤としての置換ピラゾリル［４，３－ｃ］ピリジン化合物
WO2019143977A1 (en) * 2018-01-18 2019-07-25 Array Biopharma Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
CZ308104B6 (cs) 2018-03-12 2020-01-08 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v. v. i. Pyridinopyrrolopyrimidinové ribonukleosidy pro terapeutické použití
CA3108388A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
CA3111984A1 (en) 2018-09-10 2020-03-19 Array Biopharma Inc. Fused heterocyclic compounds as ret kinase inhibitors
JP7354246B2 (ja) * 2019-06-18 2023-10-02 大鵬薬品工業株式会社 ピロロピリミジン骨格を有する新規なリン酸エステル化合物又はその薬学的に許容可能な塩
WO2021164848A1 (en) * 2020-02-17 2021-08-26 Katholieke Universiteit Leuven Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments
KR102639275B1 (ko) * 2021-06-08 2024-02-21 퓨쳐메디신 주식회사 다중 표적 인산화효소 저해 활성을 갖는 뉴클레오사이드 유도체 및 이를 포함하는 암의 예방 및 치료용 약학적 조성물
CA3233416A1 (en) 2021-09-28 2023-04-06 Universiteit Antwerpen Nucleoside analogues for the treatment of parasitic infections

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Publication number Priority date Publication date Assignee Title
IL108523A0 (en) * 1993-02-03 1994-05-30 Gensia Inc Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain
DZ3487A1 (fr) * 2001-01-22 2002-07-25 Merck Sharp & Dohme Derives de nucleoside comme inhibiteurs de l'arn polymerase virale d'arn-dependant
AU2002353165A1 (en) * 2001-12-17 2003-06-30 Ribapharm Inc. Deazapurine nucleoside libraries and compounds
US20040063658A1 (en) * 2002-05-06 2004-04-01 Roberts Christopher Don Nucleoside derivatives for treating hepatitis C virus infection
US20040157892A1 (en) 2003-02-12 2004-08-12 Crompton Co./Cie Pesticidal fluoroethyl pyrazoles
MXPA06004680A (es) * 2003-10-27 2007-04-17 Genelabs Tech Inc Compuestos de nucleosido para el tratamiento de infecciones virales.
WO2005044835A1 (en) * 2003-10-27 2005-05-19 Genelabs Technologies, Inc. METHODS FOR PREPARING 7-(2'-SUBSTITUTED-ß-D-RIBOFURANOSYL)-4-(NR2R3)-5-(SUBSTITUTED ETHYN-1-YL)-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES
US7202223B2 (en) * 2003-10-27 2007-04-10 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
JP2008508319A (ja) * 2004-07-29 2008-03-21 メタバシス・セラピューティクス・インコーポレイテッド 新規ヌクレオシド誘導体
PL3133080T3 (pl) * 2008-01-18 2018-12-31 Inst Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nowe cytostatyczne nukleozydy 7-deazapurynowe
JP5530430B2 (ja) * 2008-06-23 2014-06-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃｃｒ２のピペリジルアクリルアミドアンタゴニスト
GB0815968D0 (en) * 2008-09-03 2008-10-08 Angeletti P Ist Richerche Bio Antiviral agents
NZ700583A (en) * 2009-04-22 2016-04-29 Acad Of Science Czech Republic Novel 7-deazapurine nucleosides for therapeutic uses

Also Published As

Publication number Publication date
JP2015013901A (ja) 2015-01-22
SI2421879T1 (sl) 2014-01-31
EP2421879A2 (en) 2012-02-29
JP5721275B2 (ja) 2015-05-20
AU2015205885A1 (en) 2015-09-03
WO2010121576A3 (en) 2011-06-16
CA2759131A1 (en) 2010-10-28
CA2966647A1 (en) 2010-10-28
AU2017204148A1 (en) 2017-07-06
US20170240584A1 (en) 2017-08-24
DK2421879T3 (da) 2013-11-25
CN104497084A (zh) 2015-04-08
PT2421879E (pt) 2013-12-09
JP6087889B2 (ja) 2017-03-01
AU2017204148B2 (en) 2018-12-06
CN102459300B (zh) 2014-12-10
JP2012524731A (ja) 2012-10-18
CA2759131C (en) 2017-06-20
NZ596301A (en) 2014-10-31
AU2010238985A1 (en) 2011-12-01
WO2010121576A2 (en) 2010-10-28
US9624257B2 (en) 2017-04-18
EP2421879B1 (en) 2013-09-04
US20160318970A1 (en) 2016-11-03
US10294262B2 (en) 2019-05-21
AU2015205885B2 (en) 2017-04-06
HK1209129A1 (en) 2016-03-24
ES2437917T3 (es) 2014-01-15
HK1166325A1 (en) 2012-12-14
US20150218201A1 (en) 2015-08-06
MX2011011160A (es) 2012-01-27
NZ700583A (en) 2016-04-29
AU2010238985B2 (en) 2015-04-23
US9321800B2 (en) 2016-04-26
CN102459300A (zh) 2012-05-16
CN104497084B (zh) 2018-06-05
HRP20131021T1 (hr) 2014-01-31

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