PT2421879E - Novos 7-deazapurina nucleósidos para utilizações terapêuticas - Google Patents

Novos 7-deazapurina nucleósidos para utilizações terapêuticas

Info

Publication number
PT2421879E
PT2421879E PT107344335T PT10734433T PT2421879E PT 2421879 E PT2421879 E PT 2421879E PT 107344335 T PT107344335 T PT 107344335T PT 10734433 T PT10734433 T PT 10734433T PT 2421879 E PT2421879 E PT 2421879E
Authority
PT
Portugal
Prior art keywords
novel
therapeutic uses
compounds
deazapurine nucleosides
compositions
Prior art date
Application number
PT107344335T
Other languages
English (en)
Inventor
Aurelie Bourderioux
Michal Hocek
Petr Naus
Original Assignee
Acad Of Science Czech Republic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acad Of Science Czech Republic filed Critical Acad Of Science Czech Republic
Publication of PT2421879E publication Critical patent/PT2421879E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT107344335T 2009-04-22 2010-04-19 Novos 7-deazapurina nucleósidos para utilizações terapêuticas PT2421879E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17165609P 2009-04-22 2009-04-22

Publications (1)

Publication Number Publication Date
PT2421879E true PT2421879E (pt) 2013-12-09

Family

ID=42768153

Family Applications (1)

Application Number Title Priority Date Filing Date
PT107344335T PT2421879E (pt) 2009-04-22 2010-04-19 Novos 7-deazapurina nucleósidos para utilizações terapêuticas

Country Status (15)

Country Link
US (3) US9321800B2 (pt)
EP (1) EP2421879B1 (pt)
JP (2) JP5721275B2 (pt)
CN (2) CN102459300B (pt)
AU (3) AU2010238985B2 (pt)
CA (2) CA2759131C (pt)
DK (1) DK2421879T3 (pt)
ES (1) ES2437917T3 (pt)
HR (1) HRP20131021T1 (pt)
MX (1) MX2011011160A (pt)
NZ (2) NZ700583A (pt)
PL (1) PL2421879T3 (pt)
PT (1) PT2421879E (pt)
SI (1) SI2421879T1 (pt)
WO (1) WO2010121576A2 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
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PT2421879E (pt) * 2009-04-22 2013-12-09 Acad Of Science Czech Republic Novos 7-deazapurina nucleósidos para utilizações terapêuticas
SG181703A1 (en) * 2009-12-18 2012-07-30 Harvard College Beta-cell replication promoting compounds and methods of their use
CN102319254B (zh) * 2011-07-20 2013-06-19 上海交通大学 5-碘代杀菌核素在制备抗肿瘤药物中的应用
CZ305466B6 (cs) * 2013-11-04 2015-10-14 Ústav organické chemie a biochemie Akademie věd České republiky, v. v. i. Substituované 7-deazapurinové ribonukleosidy pro terapeutické použití
KR102562866B1 (ko) 2014-11-14 2023-08-04 네르비아노 메디칼 사이언시스 에스.알.엘. 단백질 키나아제 억제제로서의 6-아미노-7-바이사이클로-7-데아자-퓨린 유도체
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
EP3455219A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
EP4483875A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
JP6650074B2 (ja) 2016-06-29 2020-02-19 ウスタフ オルガニッケ ヘミエ アー ビオヘミエ アカデミエ ヴェド ツェーエル，ヴェー．ヴェー．イー 治療に使用するための、置換チエノピロロピリミジンリボヌクレオシド
CZ307334B6 (cs) 2016-08-02 2018-06-13 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití
US11168090B2 (en) 2017-01-18 2021-11-09 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
EP3641762B1 (en) 2017-06-20 2026-02-18 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
WO2019076633A1 (en) 2017-10-19 2019-04-25 Universiteit Gent NUCLEOSIDE ANALOGUES FOR THE TREATMENT OF PARASITIC INFECTIONS
EP3740490A1 (en) * 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors
CA3087972C (en) * 2018-01-18 2023-01-10 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
EP3740491A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
CZ308104B6 (cs) 2018-03-12 2020-01-08 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v. v. i. Pyridinopyrrolopyrimidinové ribonukleosidy pro terapeutické použití
BR112021002267A8 (pt) * 2018-08-07 2023-02-07 Merck Sharp & Dohme Inibidores de prmt5
JP2022500383A (ja) 2018-09-10 2022-01-04 アレイ バイオファーマ インコーポレイテッド Ｒｅｔキナーゼ阻害剤としての縮合複素環式化合物
BR112021025443A2 (pt) * 2019-06-18 2022-02-01 Taiho Pharmaceutical Co Ltd Compostos de éster fosfato com esqueleto de pirrolopirimidina ou sal farmaceuticamente aceitável do mesmo, agentes antitumorais e composições farmacêuticas compreendendo os ditos compostos, bem como usos e usos terapêuticos dos mesmos
WO2021164848A1 (en) * 2020-02-17 2021-08-26 Katholieke Universiteit Leuven Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments
KR102639275B1 (ko) * 2021-06-08 2024-02-21 퓨쳐메디신 주식회사 다중 표적 인산화효소 저해 활성을 갖는 뉴클레오사이드 유도체 및 이를 포함하는 암의 예방 및 치료용 약학적 조성물
US20250320245A1 (en) 2021-09-28 2025-10-16 Universiteit Antwerpen Nucleoside Analogues for the Treatment of Parasitic Infections

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IL108523A0 (en) * 1993-02-03 1994-05-30 Gensia Inc Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain
SI1355916T1 (sl) * 2001-01-22 2007-04-30 Merck & Co Inc Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
AU2002353165A1 (en) * 2001-12-17 2003-06-30 Ribapharm Inc. Deazapurine nucleoside libraries and compounds
KR20050006221A (ko) * 2002-05-06 2005-01-15 제네랩스 테크놀로지스, 인코포레이티드 Ｃ형 간염 바이러스 감염 치료용의 뉴클레오시드 유도체
US20040157892A1 (en) 2003-02-12 2004-08-12 Crompton Co./Cie Pesticidal fluoroethyl pyrazoles
US7202223B2 (en) * 2003-10-27 2007-04-10 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
WO2005044835A1 (en) * 2003-10-27 2005-05-19 Genelabs Technologies, Inc. METHODS FOR PREPARING 7-(2'-SUBSTITUTED-ß-D-RIBOFURANOSYL)-4-(NR2R3)-5-(SUBSTITUTED ETHYN-1-YL)-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES
EP1680436A1 (en) * 2003-10-27 2006-07-19 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
JP2008508319A (ja) * 2004-07-29 2008-03-21 メタバシス・セラピューティクス・インコーポレイテッド 新規ヌクレオシド誘導体
WO2009089804A1 (en) * 2008-01-18 2009-07-23 Institute Of Organic Chemistry And Biochemistry As Cr, V.V.I. Novel cytostatic 7-deazapurine nucleosides
MX2010014501A (es) * 2008-06-23 2011-02-25 Janssen Pharmaceutica Nv Antagonistas de piperidil acrilamida de receptor 2 de citocina quimioatrayente.
GB0815968D0 (en) * 2008-09-03 2008-10-08 Angeletti P Ist Richerche Bio Antiviral agents
PT2421879E (pt) * 2009-04-22 2013-12-09 Acad Of Science Czech Republic Novos 7-deazapurina nucleósidos para utilizações terapêuticas

Also Published As

Publication number Publication date
AU2017204148B2 (en) 2018-12-06
JP5721275B2 (ja) 2015-05-20
NZ700583A (en) 2016-04-29
WO2010121576A2 (en) 2010-10-28
EP2421879A2 (en) 2012-02-29
MX2011011160A (es) 2012-01-27
CA2759131A1 (en) 2010-10-28
CA2759131C (en) 2017-06-20
NZ596301A (en) 2014-10-31
DK2421879T3 (da) 2013-11-25
US9321800B2 (en) 2016-04-26
AU2015205885A1 (en) 2015-09-03
CN102459300A (zh) 2012-05-16
US20170240584A1 (en) 2017-08-24
US10294262B2 (en) 2019-05-21
CA2966647A1 (en) 2010-10-28
AU2017204148A1 (en) 2017-07-06
AU2010238985B2 (en) 2015-04-23
ES2437917T3 (es) 2014-01-15
JP6087889B2 (ja) 2017-03-01
CN102459300B (zh) 2014-12-10
AU2010238985A1 (en) 2011-12-01
WO2010121576A3 (en) 2011-06-16
HK1209129A1 (en) 2016-03-24
SI2421879T1 (sl) 2014-01-31
US9624257B2 (en) 2017-04-18
US20160318970A1 (en) 2016-11-03
PL2421879T3 (pl) 2014-02-28
JP2015013901A (ja) 2015-01-22
EP2421879B1 (en) 2013-09-04
HRP20131021T1 (hr) 2014-01-31
US20150218201A1 (en) 2015-08-06
HK1166325A1 (en) 2012-12-14
JP2012524731A (ja) 2012-10-18
AU2015205885B2 (en) 2017-04-06
CN104497084A (zh) 2015-04-08
CN104497084B (zh) 2018-06-05

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