PL2451963T3 - Sposób zwiększania wydajności ekspresji białek zależnych od witaminy K - Google Patents

Sposób zwiększania wydajności ekspresji białek zależnych od witaminy K

Info

Publication number
PL2451963T3
PL2451963T3 PL10796596T PL10796596T PL2451963T3 PL 2451963 T3 PL2451963 T3 PL 2451963T3 PL 10796596 T PL10796596 T PL 10796596T PL 10796596 T PL10796596 T PL 10796596T PL 2451963 T3 PL2451963 T3 PL 2451963T3
Authority
PL
Poland
Prior art keywords
vitamin
increasing
expression yield
dependent proteins
proteins
Prior art date
Application number
PL10796596T
Other languages
English (en)
Inventor
Julian Keane
Anthony Stowers
Peter Soupourmas
Fraser Goodwin
Original Assignee
Csl Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Csl Ltd filed Critical Csl Ltd
Publication of PL2451963T3 publication Critical patent/PL2451963T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL10796596T 2009-07-10 2010-07-09 Sposób zwiększania wydajności ekspresji białek zależnych od witaminy K PL2451963T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09009064 2009-07-10
US23701609P 2009-08-26 2009-08-26
PCT/AU2010/000881 WO2011003153A1 (en) 2009-07-10 2010-07-09 Method of increasing the expression yield of vitamin k-dependent proteins
EP20100796596 EP2451963B1 (en) 2009-07-10 2010-07-09 Method of increasing the expression yield of vitamin k-dependent proteins

Publications (1)

Publication Number Publication Date
PL2451963T3 true PL2451963T3 (pl) 2014-09-30

Family

ID=41131828

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10796596T PL2451963T3 (pl) 2009-07-10 2010-07-09 Sposób zwiększania wydajności ekspresji białek zależnych od witaminy K

Country Status (9)

Country Link
US (1) US9212214B2 (pl)
EP (1) EP2451963B1 (pl)
JP (1) JP5781067B2 (pl)
CN (1) CN102471794B (pl)
AU (1) AU2010269072B9 (pl)
DK (1) DK2451963T3 (pl)
ES (1) ES2475718T3 (pl)
PL (1) PL2451963T3 (pl)
WO (1) WO2011003153A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015095925A1 (en) * 2013-12-23 2015-07-02 Csl Limited Fusion proteins comprising factor ix for prophylactic treatment of hemophilia and methods thereof
US11286292B2 (en) 2014-02-07 2022-03-29 Cmc Biologics A/S Bioreactor arrangement and continuous process for producing and capturing a biopolymer
NZ724826A (en) * 2014-04-16 2022-07-29 Cmc Biologics As A high cell density fill and draw fermentation process
ES2803773T3 (es) 2015-12-02 2021-01-29 CSL Behring Lengnau AG Medios mejorados para la expresión de proteínas recombinantes dependientes de vitamina k
CN113164560A (zh) * 2018-10-26 2021-07-23 Vrije布鲁塞尔大学 改善基因疗法的新工具及其用途
WO2023119230A1 (en) 2021-12-22 2023-06-29 L'oreal Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4770999A (en) * 1985-04-22 1988-09-13 Genetics Institute, Inc. High yield production of active Factor IX
US5268275A (en) 1991-05-08 1993-12-07 The University Of North Carolina At Chapel Hill Vitamin K-dependent carboxylase
GB9125052D0 (en) * 1991-11-26 1992-01-22 Isis Innovation Culture of bone cells
US5714583A (en) 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
WO2000054787A1 (en) 1999-03-16 2000-09-21 The Children's Hospital Of Philadelphia Enhanced gamma-carboxylation of recombinant vitamin k-dependent clotting factors
DE602004025157D1 (de) 2003-09-23 2010-03-04 Univ North Carolina Zellen, die Vitamin-K-Reduktase und Vitamin-K-abhängiges Protein coexprimieren und deren Anwendung zur Verbesserung der Produktivität von diesem Vitamin-K-abhängigen Protein
DE602004026897D1 (de) 2003-10-14 2010-06-10 Baxter Healthcare Sa Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate
PL1853700T3 (pl) 2005-02-28 2013-05-31 Baxalta Inc Koekspresja przez rekombinowanie podjednostki 1 reduktazy epoksydu witaminy K w celu poprawy ekspresji białka zależnego od witaminy K
CA2601574C (en) 2005-03-15 2014-12-02 University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin k-dependent proteins
AU2006320168B2 (en) * 2005-12-02 2012-02-23 Wake Forest University Health Sciences Compositions and methods for increasing production of recombinant gamma-carboxylated proteins
AU2006331501B2 (en) * 2005-12-21 2013-09-05 Aptevo Biotherapeutics Llc Method of producing biologically active vitamin K dependent proteins by recombinant methods

Also Published As

Publication number Publication date
EP2451963A1 (en) 2012-05-16
US9212214B2 (en) 2015-12-15
JP5781067B2 (ja) 2015-09-16
JP2012531918A (ja) 2012-12-13
DK2451963T3 (da) 2014-08-04
HK1168127A1 (en) 2012-12-21
ES2475718T3 (es) 2014-07-11
AU2010269072B2 (en) 2014-05-08
AU2010269072C1 (en) 2014-07-31
US20120322107A1 (en) 2012-12-20
CN102471794A (zh) 2012-05-23
AU2010269072A1 (en) 2012-02-02
AU2010269072C9 (en) 2014-09-18
CN102471794B (zh) 2014-10-29
EP2451963B1 (en) 2014-04-30
WO2011003153A1 (en) 2011-01-13
EP2451963A4 (en) 2013-01-23
AU2010269072B9 (en) 2014-09-18

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