DK2451963T3 - Fremgangsmåde til forøgelse afvitamin-k-afhængige proteiners exprimerings-ydelse - Google Patents

Fremgangsmåde til forøgelse afvitamin-k-afhængige proteiners exprimerings-ydelse

Info

Publication number
DK2451963T3
DK2451963T3 DK10796596T DK10796596T DK2451963T3 DK 2451963 T3 DK2451963 T3 DK 2451963T3 DK 10796596 T DK10796596 T DK 10796596T DK 10796596 T DK10796596 T DK 10796596T DK 2451963 T3 DK2451963 T3 DK 2451963T3
Authority
DK
Denmark
Prior art keywords
performance
vitamin
increasing expression
dependent proteins
proteins
Prior art date
Application number
DK10796596T
Other languages
English (en)
Inventor
Julian Keane
Anthony Stowers
Peter Soupourmas
Fraser Goodwin
Original Assignee
Csl Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Csl Ltd filed Critical Csl Ltd
Application granted granted Critical
Publication of DK2451963T3 publication Critical patent/DK2451963T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • C12N5/0037Serum-free medium, which may still contain naturally-sourced components
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/38Vitamins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK10796596T 2009-07-10 2010-07-09 Fremgangsmåde til forøgelse afvitamin-k-afhængige proteiners exprimerings-ydelse DK2451963T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09009064 2009-07-10
US23701609P 2009-08-26 2009-08-26
PCT/AU2010/000881 WO2011003153A1 (en) 2009-07-10 2010-07-09 Method of increasing the expression yield of vitamin k-dependent proteins

Publications (1)

Publication Number Publication Date
DK2451963T3 true DK2451963T3 (da) 2014-08-04

Family

ID=41131828

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10796596T DK2451963T3 (da) 2009-07-10 2010-07-09 Fremgangsmåde til forøgelse afvitamin-k-afhængige proteiners exprimerings-ydelse

Country Status (9)

Country Link
US (1) US9212214B2 (da)
EP (1) EP2451963B1 (da)
JP (1) JP5781067B2 (da)
CN (1) CN102471794B (da)
AU (1) AU2010269072C9 (da)
DK (1) DK2451963T3 (da)
ES (1) ES2475718T3 (da)
PL (1) PL2451963T3 (da)
WO (1) WO2011003153A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016013577A2 (pt) * 2013-12-23 2017-10-03 Csl Ltd Proteínas de fusão, seu uso e composição farmacêutica
WO2015117883A1 (en) 2014-02-07 2015-08-13 Cmc Biologics A/S A bioreactor arrangement and continuous process for producing and capturing a biopolymer
EP3132050A1 (en) 2014-04-16 2017-02-22 CMC Biologics A/S A high cell density fill and draw fermentation process
WO2017093482A1 (en) * 2015-12-02 2017-06-08 Csl Behring Recombinant Facility Ag Improved media for the expression of recombinant vitamin k-dependent proteins
US20210379203A1 (en) * 2018-10-26 2021-12-09 Vrije Universiteit Brussel New Tools for Improving Gene Therapy and Use Thereof
WO2023119230A1 (en) 2021-12-22 2023-06-29 L'oreal Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE74164T1 (de) * 1985-04-22 1992-04-15 Genetics Inst Herstellung mit hoher leistung des aktivfaktors ix.
US5268275A (en) 1991-05-08 1993-12-07 The University Of North Carolina At Chapel Hill Vitamin K-dependent carboxylase
GB9125052D0 (en) * 1991-11-26 1992-01-22 Isis Innovation Culture of bone cells
US5714583A (en) 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
AU3629800A (en) 1999-03-16 2000-10-04 Children's Hospital Of Philadelphia, The Enhanced gamma-carboxylation of recombinant vitamin k-dependent clotting factors
EP2380985B1 (en) 2003-09-23 2014-01-01 University of North Carolina at Chapel Hill Cells expressing vitamin K epoxide reductase and use thereof
ATE466074T1 (de) 2003-10-14 2010-05-15 Baxter Int Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate
ES2397530T3 (es) * 2005-02-28 2013-03-07 Baxter International Inc. Coexpresión recombinante de la subunidad 1 de la epóxido reductasa de la vitamina K para mejorar la expresión de proteína dependiente de la vitamina K
AU2005329450A1 (en) 2005-03-15 2006-09-28 University Of North Carolina At Chapel Hill Methods and compositions for producing active Vitamin K-dependent proteins
EP1963506B1 (en) 2005-12-02 2010-10-27 Wake Forest University Health Sciences Compositions and methods for increasing production of recombinant gamma-carboxylated proteins
EP1969127B8 (en) * 2005-12-21 2017-12-13 Aptevo BioTherapeutics LLC Method of producing biologically active vitamin k dependent proteins by recombinant methods

Also Published As

Publication number Publication date
JP2012531918A (ja) 2012-12-13
US20120322107A1 (en) 2012-12-20
JP5781067B2 (ja) 2015-09-16
EP2451963A1 (en) 2012-05-16
WO2011003153A1 (en) 2011-01-13
CN102471794A (zh) 2012-05-23
ES2475718T3 (es) 2014-07-11
US9212214B2 (en) 2015-12-15
CN102471794B (zh) 2014-10-29
EP2451963A4 (en) 2013-01-23
AU2010269072B2 (en) 2014-05-08
AU2010269072B9 (en) 2014-09-18
EP2451963B1 (en) 2014-04-30
AU2010269072C9 (en) 2014-09-18
PL2451963T3 (pl) 2014-09-30
AU2010269072A1 (en) 2012-02-02
HK1168127A1 (en) 2012-12-21
AU2010269072C1 (en) 2014-07-31

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