PL2470520T3 - Pochodne chromonu, sposób ich wytwarzania i ich zastosowania lecznicze - Google Patents

Pochodne chromonu, sposób ich wytwarzania i ich zastosowania lecznicze

Info

Publication number
PL2470520T3
PL2470520T3 PL10754594T PL10754594T PL2470520T3 PL 2470520 T3 PL2470520 T3 PL 2470520T3 PL 10754594 T PL10754594 T PL 10754594T PL 10754594 T PL10754594 T PL 10754594T PL 2470520 T3 PL2470520 T3 PL 2470520T3
Authority
PL
Poland
Prior art keywords
preparation
therapeutic applications
chromone derivatives
chromone
derivatives
Prior art date
Application number
PL10754594T
Other languages
English (en)
Inventor
Pierre Sokoloff
Thierry Imbert
Ludovic Leriche
Jean-François Patoiseau
Jean-Pierre Rieu
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of PL2470520T3 publication Critical patent/PL2470520T3/pl

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
PL10754594T 2009-09-01 2010-08-31 Pochodne chromonu, sposób ich wytwarzania i ich zastosowania lecznicze PL2470520T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0955944A FR2949465B1 (fr) 2009-09-01 2009-09-01 Derives chromones, leur procede de preparation et leurs applications therapeutiques
US33699210P 2010-01-29 2010-01-29
EP10754594.9A EP2470520B1 (en) 2009-09-01 2010-08-31 Chromone derivatives, a process for their preparation and their therapeutic applications
PCT/IB2010/053895 WO2011027289A1 (en) 2009-09-01 2010-08-31 Chromone derivatives, a process for their preparation and their therapeutic applications

Publications (1)

Publication Number Publication Date
PL2470520T3 true PL2470520T3 (pl) 2013-10-31

Family

ID=41403421

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10754594T PL2470520T3 (pl) 2009-09-01 2010-08-31 Pochodne chromonu, sposób ich wytwarzania i ich zastosowania lecznicze

Country Status (31)

Country Link
US (1) US8546402B2 (pl)
EP (1) EP2470520B1 (pl)
JP (1) JP5786229B2 (pl)
KR (1) KR101663635B1 (pl)
CN (1) CN102482251B (pl)
AR (1) AR078114A1 (pl)
AU (1) AU2010290871B2 (pl)
BR (1) BR112012003741B1 (pl)
CA (1) CA2771061C (pl)
CL (1) CL2012000516A1 (pl)
CO (1) CO6491096A2 (pl)
DK (1) DK2470520T3 (pl)
ES (1) ES2428751T3 (pl)
FR (1) FR2949465B1 (pl)
GE (1) GEP20146080B (pl)
HR (1) HRP20130832T1 (pl)
IL (1) IL217729A (pl)
MA (1) MA35674B1 (pl)
MX (1) MX2012002543A (pl)
MY (1) MY162345A (pl)
NZ (1) NZ597930A (pl)
PL (1) PL2470520T3 (pl)
PT (1) PT2470520E (pl)
RU (1) RU2545214C2 (pl)
SG (1) SG178198A1 (pl)
SI (1) SI2470520T1 (pl)
TN (1) TN2012000049A1 (pl)
TW (1) TWI510483B (pl)
UA (1) UA109260C2 (pl)
WO (1) WO2011027289A1 (pl)
ZA (1) ZA201200770B (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2731926A1 (en) 2008-08-05 2010-02-11 Boehringer Ingelheim International Gmbh 4-dimethylamino-phenyl-substituted naphthyridines, and use thereof as medicaments
HUE030465T2 (hu) 2009-05-13 2017-05-29 Antivirális vegyületek
PH12012501535A1 (en) 2010-01-29 2012-10-22 Boehringer Ingelheim Int Substituted naphthyridines and their use as syk kinase inhibitors
KR101986484B1 (ko) 2011-07-26 2019-06-10 베링거 인겔하임 인터내셔날 게엠베하 치환된 퀴놀린 및 이의 약제로서의 용도
EP2709613B2 (en) 2011-09-16 2020-08-12 Gilead Pharmasset LLC Methods for treating hcv
EP2950786B1 (en) 2013-01-31 2019-11-27 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
PT3038601T (pt) 2013-08-27 2020-06-30 Gilead Pharmasset Llc Formulação combinada de dois compostos antivirais
RU2019104946A (ru) * 2013-12-13 2019-04-01 Пьер Фабр Медикамент Применение производного хромона в качестве антагониста дофаминового рецептора d3 для лечения расстройства аутистического спектра
CN111295191A (zh) * 2017-11-03 2020-06-16 皮埃尔法布雷医药公司 精神分裂症的治疗
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
AU2021341879A1 (en) * 2020-09-09 2023-04-13 Aurigene Oncology Limited Heterocyclic compounds as CBP/EP300 bromodomain inhibitors
CN112220782B (zh) * 2020-11-11 2021-08-20 中国人民解放军军事科学院军事医学研究院 1,2,4-三甲氧基苯在防治创伤后应激障碍中的应用
US12037340B2 (en) 2021-05-21 2024-07-16 Gilead Sciences, Inc. Pentacyclic derivatives as Zika virus inhibitors
US12497408B2 (en) 2021-05-21 2025-12-16 Gilead Sciences, Inc. Tetracyclic compounds and methods for the treatment of Zika virus infection

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089497A (en) * 1990-09-20 1992-02-18 Warner-Lambert Company Substituted piperazines as central nervous system agents
DE4233963A1 (de) * 1992-10-08 1994-04-14 Schwabe Willmar Gmbh & Co Neue Benzopyranone, Verfahren zu ihrer Herstellung und Verwendung
KR20050075281A (ko) * 2002-07-04 2005-07-20 쉬바르츠파르마에이지 씨엔에스 질병의 치료를 위한 도파민-디3 리간드로서헤테로아렌 카복스아미드의 용도
EP1683790A1 (en) * 2005-01-24 2006-07-26 Institut National De La Sante Et De La Recherche Medicale (Inserm) 3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands
KR20070106636A (ko) * 2005-02-18 2007-11-02 아르피다 아게 벤조퓨란의 제조를 위한 신규한 방법들
FR2903986A1 (fr) * 2006-07-21 2008-01-25 Pierre Fabre Medicament Sa Nouveaux derives chromenes ou thiochromenes carboxamides, leur procede de preparation et leurs applications en therapeutique

Also Published As

Publication number Publication date
EP2470520A1 (en) 2012-07-04
HK1170724A1 (en) 2013-03-08
BR112012003741B1 (pt) 2021-06-22
AR078114A1 (es) 2011-10-12
MY162345A (en) 2017-06-15
JP2013503848A (ja) 2013-02-04
MX2012002543A (es) 2012-06-25
MA35674B1 (fr) 2014-12-01
CN102482251B (zh) 2015-01-28
TN2012000049A1 (en) 2013-09-19
US20120157463A1 (en) 2012-06-21
WO2011027289A1 (en) 2011-03-10
ES2428751T3 (es) 2013-11-11
RU2012106743A (ru) 2013-10-10
AU2010290871B2 (en) 2014-06-26
RU2545214C2 (ru) 2015-03-27
IL217729A (en) 2015-09-24
FR2949465B1 (fr) 2011-08-12
UA109260C2 (uk) 2015-08-10
TW201111369A (en) 2011-04-01
AU2010290871A1 (en) 2012-02-16
CN102482251A (zh) 2012-05-30
CO6491096A2 (es) 2012-07-31
NZ597930A (en) 2013-09-27
SG178198A1 (en) 2012-03-29
TWI510483B (zh) 2015-12-01
CA2771061C (en) 2015-06-02
IL217729A0 (en) 2012-03-29
JP5786229B2 (ja) 2015-09-30
CL2012000516A1 (es) 2012-08-31
FR2949465A1 (fr) 2011-03-04
PT2470520E (pt) 2013-10-02
KR101663635B1 (ko) 2016-10-10
CA2771061A1 (en) 2011-03-10
GEP20146080B (en) 2014-04-25
HRP20130832T1 (en) 2013-10-11
US8546402B2 (en) 2013-10-01
KR20120060835A (ko) 2012-06-12
SI2470520T1 (sl) 2013-10-30
DK2470520T3 (da) 2013-08-26
EP2470520B1 (en) 2013-07-17
ZA201200770B (en) 2012-10-31

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