PL2480541T3 - Krystaliczne hydraty chlorku metylotioniny (błękitu metylenowego) - Google Patents

Krystaliczne hydraty chlorku metylotioniny (błękitu metylenowego)

Info

Publication number
PL2480541T3
PL2480541T3 PL10771516T PL10771516T PL2480541T3 PL 2480541 T3 PL2480541 T3 PL 2480541T3 PL 10771516 T PL10771516 T PL 10771516T PL 10771516 T PL10771516 T PL 10771516T PL 2480541 T3 PL2480541 T3 PL 2480541T3
Authority
PL
Poland
Prior art keywords
hydrates
crystalline
methylene blue
methylthionium chloride
methylthionium
Prior art date
Application number
PL10771516T
Other languages
English (en)
Inventor
Rolf Hilfiker
Timo Rager
Original Assignee
Wista Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43415329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2480541(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wista Lab Ltd filed Critical Wista Lab Ltd
Publication of PL2480541T3 publication Critical patent/PL2480541T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/101,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/141,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18[b, e]-condensed with two six-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4515Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/101,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/141,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18[b, e]-condensed with two six-membered rings
    • C07D279/22[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Steroid Compounds (AREA)
PL10771516T 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny (błękitu metylenowego) PL2480541T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24539109P 2009-09-24 2009-09-24
PCT/IB2010/002526 WO2011036558A2 (en) 2009-09-24 2010-09-23 Crystalline methylthionium chloride (methylene blue) hydrates
EP10771516.1A EP2480541B1 (en) 2009-09-24 2010-09-23 Crystalline methylthionium chloride (methylene blue) hydrates

Publications (1)

Publication Number Publication Date
PL2480541T3 true PL2480541T3 (pl) 2016-03-31

Family

ID=43415329

Family Applications (4)

Application Number Title Priority Date Filing Date
PL20203173.8T PL3792254T3 (pl) 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny
PL15176967T PL2963024T3 (pl) 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny - część 2
PL10771516T PL2480541T3 (pl) 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny (błękitu metylenowego)
PL18170358T PL3378856T3 (pl) 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PL20203173.8T PL3792254T3 (pl) 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny
PL15176967T PL2963024T3 (pl) 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny - część 2

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL18170358T PL3378856T3 (pl) 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny

Country Status (19)

Country Link
US (1) US8765742B2 (pl)
EP (4) EP3378856B1 (pl)
JP (1) JP5806217B2 (pl)
KR (3) KR20170061177A (pl)
CN (2) CN105061358A (pl)
AU (1) AU2010299571B2 (pl)
BR (4) BR112012006638B1 (pl)
CA (4) CA3004822C (pl)
DK (4) DK3378856T3 (pl)
ES (4) ES2847003T3 (pl)
FI (1) FI3792254T3 (pl)
HR (3) HRP20181567T2 (pl)
MX (3) MX355627B (pl)
MY (1) MY159782A (pl)
PL (4) PL3792254T3 (pl)
PT (4) PT3378856T (pl)
SG (1) SG10201408584UA (pl)
SI (4) SI3792254T1 (pl)
WO (1) WO2011036558A2 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9925282B2 (en) 2009-01-29 2018-03-27 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
JP5918136B2 (ja) * 2009-09-24 2016-05-18 ウィスタ ラボラトリーズ リミテッド プロセス
US10058530B2 (en) 2012-10-25 2018-08-28 The General Hospital Corporation Combination therapies for the treatment of Alzheimer's disease and related disorders
EP3563849A3 (en) * 2012-10-25 2020-02-12 The General Hospital Corporation Combination therapies for the treatment of alzheimer's disease and related disorders
US10525005B2 (en) 2013-05-23 2020-01-07 The General Hospital Corporation Cromolyn compositions and methods thereof
CN110305095A (zh) 2013-10-22 2019-10-08 综合医院公司 色甘酸衍生物以及成像和治疗的相关方法
US10765755B1 (en) 2013-11-20 2020-09-08 University Of South Florida Preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies
JP7073330B2 (ja) 2016-07-25 2022-05-23 ウィスタ ラボラトリーズ リミテッド ジアミノフェノチアジンの投与及び投与量
JP2019524865A (ja) 2016-08-31 2019-09-05 ザ ジェネラル ホスピタル コーポレイション 神経変性疾患と関連する神経炎症におけるマクロファージ/ミクログリア
GB201614834D0 (en) 2016-09-01 2016-10-19 Wista Lab Ltd Treatment of dementia
JP7202376B2 (ja) 2017-07-20 2023-01-11 エーゼットセラピーズ, インコーポレイテッド クロモリンナトリウムおよびイブプロフェンの粉末製剤
AU2019299347A1 (en) 2018-07-02 2021-01-21 Aztherapies, Inc. Powdered formulations of cromolyn sodium and alpha-lactose
MX2021006869A (es) 2018-12-10 2021-07-02 Massachusetts Gen Hospital Esteres de cromolin y usos de los mismos.
WO2021207060A1 (en) 2020-04-06 2021-10-14 The General Hospital Corporation Methods of treatment of coronavirus-induced inflammation conditions
WO2022146914A1 (en) 2020-12-28 2022-07-07 The General Hospital Corporation Cromolyn derivatives and uses thereof
AU2023279800A1 (en) 2022-05-31 2024-12-19 TauRx Therapeutics Management Ltd Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds
EP4590306A1 (en) 2022-09-21 2025-07-30 Yin Sze Loh Oral formulation of diaminophenothiazines and methods of making and using the same in the treatment and/or prevention of diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0322756D0 (en) 2003-09-29 2003-10-29 Univ Aberdeen Methods of chemical synthesis
CN101084204B (zh) * 2004-09-23 2012-12-05 卫思道制药有限公司 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法
SI2322517T1 (sl) 2004-09-23 2019-06-28 Wista Laboratories Ltd. Postopki za kemijsko sintezo in čiščenje diaminofenotiazinijevih spojin, vključno metiltioninijevega klorida (MTC)
SI2004155T1 (en) * 2006-03-29 2018-05-31 Wista Laboratories Ltd. Inhibitors of protein aggregation
ES2349322T7 (es) * 2006-03-29 2019-10-17 Wista Lab Ltd Sales de 3,7-diamino-10H-fenotiazina y su utilización
US8227459B2 (en) * 2007-04-03 2012-07-24 Prosetta Antiviral Inc. Diamino-phenothiazinyl derivatives as antiviral treatments
US7603854B2 (en) 2007-04-10 2009-10-20 Illinois Tool Works Inc. Pneumatically self-regulating valve

Also Published As

Publication number Publication date
EP3378856B1 (en) 2020-12-02
BR122019022631B1 (pt) 2021-03-16
EP2963024A2 (en) 2016-01-06
MY159782A (en) 2017-01-31
SG10201408584UA (en) 2015-02-27
BR122019022628B8 (pt) 2021-07-27
AU2010299571A1 (en) 2012-04-12
CA3077911C (en) 2022-03-01
US8765742B2 (en) 2014-07-01
DK3792254T3 (da) 2023-09-25
CA3004822C (en) 2020-07-21
PT3792254T (pt) 2023-10-19
AU2010299571B2 (en) 2014-07-31
PT2480541E (pt) 2016-01-26
SI2963024T1 (sl) 2018-10-30
SI2480541T1 (sl) 2016-02-29
CN102666511A (zh) 2012-09-12
FI3792254T3 (fi) 2023-09-22
HRP20231201T1 (hr) 2024-01-19
CA3141737A1 (en) 2011-03-31
ES2689029T3 (es) 2018-11-08
EP2480541A2 (en) 2012-08-01
WO2011036558A9 (en) 2011-08-04
KR20170061177A (ko) 2017-06-02
PL2963024T3 (pl) 2019-02-28
ES2557318T3 (es) 2016-01-25
EP2963024B1 (en) 2018-07-18
CN102666511B (zh) 2015-09-16
WO2011036558A3 (en) 2011-11-24
JP2013505925A (ja) 2013-02-21
SI3378856T1 (sl) 2021-03-31
US20120238556A1 (en) 2012-09-20
DK3378856T3 (da) 2020-12-21
DK2480541T3 (en) 2016-02-01
MX381636B (es) 2025-03-13
PT2963024T (pt) 2018-10-16
CA3141737C (en) 2023-10-03
PL3378856T3 (pl) 2021-05-31
BR122019022631B8 (pt) 2021-07-27
HRP20181567T2 (hr) 2022-09-30
MX355627B (es) 2018-04-25
EP2480541B1 (en) 2015-11-04
ES2847003T3 (es) 2021-07-30
EP2963024A3 (en) 2016-02-17
WO2011036558A2 (en) 2011-03-31
PT3378856T (pt) 2021-02-02
CA2773305C (en) 2018-07-03
CA3004822A1 (en) 2011-03-31
BR112012006638A2 (pt) 2016-05-03
KR20180094126A (ko) 2018-08-22
HK1167653A1 (zh) 2012-12-07
HRP20210086T1 (hr) 2021-03-05
MX2012003083A (es) 2012-04-30
HK1213897A1 (en) 2016-07-15
CA2773305A1 (en) 2011-03-31
EP3378856A2 (en) 2018-09-26
EP3792254A1 (en) 2021-03-17
KR20120099409A (ko) 2012-09-10
EP3378856A3 (en) 2018-11-07
ES2960761T3 (es) 2024-03-06
JP5806217B2 (ja) 2015-11-10
HRP20181567T1 (hr) 2018-11-30
PL3792254T3 (pl) 2024-02-12
SI3792254T1 (sl) 2023-11-30
DK2963024T3 (en) 2018-10-08
BR122019022628B1 (pt) 2021-03-16
BR112012006638B1 (pt) 2020-05-26
CA3077911A1 (en) 2011-03-31
CN105061358A (zh) 2015-11-18
EP3792254B1 (en) 2023-07-26
BR122019022612B8 (pt) 2021-07-27
BR122019022612B1 (pt) 2021-03-09

Similar Documents

Publication Publication Date Title
SI2480541T1 (sl) Kristalinični hidrati metiltioninijevega klorida (metilen modrega)
GB0906472D0 (en) New compounds
GB0906470D0 (en) New compounds
EP2483254A4 (en) NEW COMPOUNDS
GB0905955D0 (en) Novel compounds
GB0900388D0 (en) New compounds
GB0903493D0 (en) New compounds
EP2512242A4 (en) NEW COMPOUNDS
GB0910009D0 (en) Novel compounds
AU2014253566B2 (en) Crystalline methylthionium chloride (methylene blue) hydrates
GB0910667D0 (en) Novel compounds
GB0907825D0 (en) Novel compound
GB0903482D0 (en) New compounds
GB0906571D0 (en) Novel compounds
GB0907118D0 (en) Novel compounds
GB0906288D0 (en) Novel compounds
GB0902727D0 (en) Novel compounds
GB0906577D0 (en) Novel compounds
GB0906578D0 (en) Novel compounds
GB0907104D0 (en) Novel compounds
GB0907105D0 (en) Novel compounds
GB0907106D0 (en) Novel compounds
GB0907107D0 (en) Novel compounds
GB0907112D0 (en) Novel compounds
GB0907113D0 (en) Novel compounds