PL2480541T3 - Krystaliczne hydraty chlorku metylotioniny (błękitu metylenowego) - Google Patents

Krystaliczne hydraty chlorku metylotioniny (błękitu metylenowego)

Info

Publication number
PL2480541T3
PL2480541T3 PL10771516T PL10771516T PL2480541T3 PL 2480541 T3 PL2480541 T3 PL 2480541T3 PL 10771516 T PL10771516 T PL 10771516T PL 10771516 T PL10771516 T PL 10771516T PL 2480541 T3 PL2480541 T3 PL 2480541T3
Authority
PL
Poland
Prior art keywords
hydrates
crystalline
methylene blue
methylthionium chloride
methylthionium
Prior art date
Application number
PL10771516T
Other languages
English (en)
Inventor
Rolf Hilfiker
Timo Rager
Original Assignee
Wista Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43415329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2480541(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wista Lab Ltd filed Critical Wista Lab Ltd
Publication of PL2480541T3 publication Critical patent/PL2480541T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/101,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/141,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18[b, e]-condensed with two six-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4515Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/101,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/141,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18[b, e]-condensed with two six-membered rings
    • C07D279/22[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
PL10771516T 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny (błękitu metylenowego) PL2480541T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24539109P 2009-09-24 2009-09-24
PCT/IB2010/002526 WO2011036558A2 (en) 2009-09-24 2010-09-23 Crystalline methylthionium chloride (methylene blue) hydrates
EP10771516.1A EP2480541B1 (en) 2009-09-24 2010-09-23 Crystalline methylthionium chloride (methylene blue) hydrates

Publications (1)

Publication Number Publication Date
PL2480541T3 true PL2480541T3 (pl) 2016-03-31

Family

ID=43415329

Family Applications (4)

Application Number Title Priority Date Filing Date
PL18170358T PL3378856T3 (pl) 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny
PL20203173.8T PL3792254T3 (pl) 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny
PL10771516T PL2480541T3 (pl) 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny (błękitu metylenowego)
PL15176967T PL2963024T3 (pl) 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny - część 2

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PL18170358T PL3378856T3 (pl) 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny
PL20203173.8T PL3792254T3 (pl) 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL15176967T PL2963024T3 (pl) 2009-09-24 2010-09-23 Krystaliczne hydraty chlorku metylotioniny - część 2

Country Status (19)

Country Link
US (1) US8765742B2 (pl)
EP (4) EP3792254B1 (pl)
JP (1) JP5806217B2 (pl)
KR (3) KR20170061177A (pl)
CN (2) CN105061358A (pl)
AU (1) AU2010299571B2 (pl)
BR (4) BR112012006638B1 (pl)
CA (4) CA3004822C (pl)
DK (4) DK2963024T3 (pl)
ES (4) ES2960761T3 (pl)
FI (1) FI3792254T3 (pl)
HR (3) HRP20231201T1 (pl)
MX (3) MX381636B (pl)
MY (1) MY159782A (pl)
PL (4) PL3378856T3 (pl)
PT (4) PT2480541E (pl)
SG (1) SG10201408584UA (pl)
SI (4) SI3378856T1 (pl)
WO (1) WO2011036558A2 (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9925282B2 (en) 2009-01-29 2018-03-27 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
PL2480540T3 (pl) * 2009-09-24 2018-05-30 Wista Laboratories Ltd. Pentahydrat chlorku metylotioninowego, jego wytwarzanie i zastosowanie farmaceutyczne
US10058530B2 (en) 2012-10-25 2018-08-28 The General Hospital Corporation Combination therapies for the treatment of Alzheimer's disease and related disorders
US9855276B2 (en) 2012-10-25 2018-01-02 The General Hospital Corporation Combination therapies for the treatment of Alzheimer's disease and related disorders
US10525005B2 (en) 2013-05-23 2020-01-07 The General Hospital Corporation Cromolyn compositions and methods thereof
AU2014340182B2 (en) 2013-10-22 2019-05-23 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
US10765755B1 (en) 2013-11-20 2020-09-08 University Of South Florida Preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies
SI3487505T1 (sl) 2016-07-25 2023-10-30 Wista Laboratories Ltd., Dajanje in odmerek diaminofenotiazinov
CN109922800B (zh) 2016-08-31 2023-06-13 通用医疗公司 与神经退行性疾病相关的神经炎症中的巨噬细胞/小胶质细胞
GB201614834D0 (en) 2016-09-01 2016-10-19 Wista Lab Ltd Treatment of dementia
MX2020000577A (es) 2017-07-20 2020-09-10 Aztherapies Inc Formulaciones en polvo de cromolina sodica e ibuprofeno.
JP2021529771A (ja) 2018-07-02 2021-11-04 ザ ジェネラル ホスピタル コーポレイション クロモリンナトリウムおよびα−ラクトースの粉末製剤
SG11202106117SA (en) 2018-12-10 2021-07-29 Massachusetts Gen Hospital Cromolyn esters and uses thereof
WO2021207060A1 (en) 2020-04-06 2021-10-14 The General Hospital Corporation Methods of treatment of coronavirus-induced inflammation conditions
US20260048066A1 (en) 2022-05-31 2026-02-19 Wista Laboratories Ltd Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds
EP4590275A1 (en) 2022-09-21 2025-07-30 WisTa Laboratories Ltd. Novel formulations and vehicles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0322756D0 (en) 2003-09-29 2003-10-29 Univ Aberdeen Methods of chemical synthesis
PT2322517T (pt) 2004-09-23 2019-07-30 Wista Lab Ltd Métodos de síntese química e purificação de compostos de diaminofenotiazínio incluindo cloreto de metiltionínio (mtc)
US7790881B2 (en) * 2004-09-23 2010-09-07 Wista Laboratories Ltd. Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
MY153198A (en) * 2006-03-29 2015-01-29 Wista Lab Ltd Inhibitors of protein aggregation
ES2349322T7 (es) * 2006-03-29 2019-10-17 Wista Lab Ltd Sales de 3,7-diamino-10H-fenotiazina y su utilización
US8227459B2 (en) * 2007-04-03 2012-07-24 Prosetta Antiviral Inc. Diamino-phenothiazinyl derivatives as antiviral treatments
US7603854B2 (en) 2007-04-10 2009-10-20 Illinois Tool Works Inc. Pneumatically self-regulating valve

Also Published As

Publication number Publication date
EP3378856A2 (en) 2018-09-26
CN102666511B (zh) 2015-09-16
DK3792254T3 (da) 2023-09-25
FI3792254T3 (fi) 2023-09-22
MX355627B (es) 2018-04-25
WO2011036558A9 (en) 2011-08-04
ES2960761T3 (es) 2024-03-06
AU2010299571A1 (en) 2012-04-12
DK2963024T3 (en) 2018-10-08
CA3004822C (en) 2020-07-21
CA3141737C (en) 2023-10-03
PL3792254T3 (pl) 2024-02-12
CN102666511A (zh) 2012-09-12
CN105061358A (zh) 2015-11-18
BR112012006638B1 (pt) 2020-05-26
SI2480541T1 (sl) 2016-02-29
EP3378856A3 (en) 2018-11-07
MX2012003083A (es) 2012-04-30
CA3141737A1 (en) 2011-03-31
HRP20181567T1 (hr) 2018-11-30
PL2963024T3 (pl) 2019-02-28
BR122019022612B1 (pt) 2021-03-09
EP2963024A3 (en) 2016-02-17
CA3004822A1 (en) 2011-03-31
JP5806217B2 (ja) 2015-11-10
CA3077911A1 (en) 2011-03-31
ES2557318T3 (es) 2016-01-25
DK3378856T3 (da) 2020-12-21
SI3378856T1 (sl) 2021-03-31
HRP20231201T1 (hr) 2024-01-19
ES2689029T3 (es) 2018-11-08
BR122019022628B1 (pt) 2021-03-16
CA2773305A1 (en) 2011-03-31
HRP20181567T2 (hr) 2022-09-30
BR122019022628B8 (pt) 2021-07-27
EP3792254B1 (en) 2023-07-26
KR20120099409A (ko) 2012-09-10
JP2013505925A (ja) 2013-02-21
CA3077911C (en) 2022-03-01
PT2963024T (pt) 2018-10-16
MX381636B (es) 2025-03-13
BR112012006638A2 (pt) 2016-05-03
EP2963024B1 (en) 2018-07-18
EP3792254A1 (en) 2021-03-17
WO2011036558A3 (en) 2011-11-24
EP2963024A2 (en) 2016-01-06
AU2010299571B2 (en) 2014-07-31
PT3378856T (pt) 2021-02-02
BR122019022631B1 (pt) 2021-03-16
SG10201408584UA (en) 2015-02-27
EP2480541A2 (en) 2012-08-01
PL3378856T3 (pl) 2021-05-31
BR122019022631B8 (pt) 2021-07-27
PT3792254T (pt) 2023-10-19
EP2480541B1 (en) 2015-11-04
US8765742B2 (en) 2014-07-01
HRP20210086T1 (hr) 2021-03-05
US20120238556A1 (en) 2012-09-20
KR20180094126A (ko) 2018-08-22
MY159782A (en) 2017-01-31
BR122019022612B8 (pt) 2021-07-27
DK2480541T3 (en) 2016-02-01
HK1213897A1 (en) 2016-07-15
EP3378856B1 (en) 2020-12-02
KR20170061177A (ko) 2017-06-02
CA2773305C (en) 2018-07-03
SI3792254T1 (sl) 2023-11-30
WO2011036558A2 (en) 2011-03-31
ES2847003T3 (es) 2021-07-30
HK1167653A1 (zh) 2012-12-07
PT2480541E (pt) 2016-01-26
SI2963024T1 (sl) 2018-10-30

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