PL2513107T3 - Heteroaromatyczne pochodne fenyloimidazolu jako inhibitory enzymu PDE10A - Google Patents

Heteroaromatyczne pochodne fenyloimidazolu jako inhibitory enzymu PDE10A

Info

Publication number: PL2513107T3
Authority: PL; Poland
Prior art keywords: enzyme inhibitors; pde10a enzyme; phenylimidazole derivatives; heteroaromatic; heteroaromatic phenylimidazole
Prior art date: 2009-12-17

Application number

PL10798255T

Other languages

English (en)

Inventor

Ask Püschl

Jacob Nielsen

Jan Kehler

John Paul Kilburn

Mauro Marigo

Morten Langgård

Original Assignee

H Lundbeck As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-12-17

Filing date

2010-12-15

Publication date

2014-12-31

2010-12-15 Application filed by H Lundbeck As filed Critical H Lundbeck As

2014-12-31 Publication of PL2513107T3 publication Critical patent/PL2513107T3/pl

Links

-1 Heteroaromatic phenylimidazole derivatives Chemical class 0.000 title 1
239000002532 enzyme inhibitor Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Valve Device For Special Equipments (AREA)

PL10798255T 2009-12-17 2010-12-15 Heteroaromatyczne pochodne fenyloimidazolu jako inhibitory enzymu PDE10A PL2513107T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US28731509P	2009-12-17	2009-12-17
DKPA200901339		2009-12-17
PCT/DK2010/050341 WO2011072694A1 (en)	2009-12-17	2010-12-15	Heteroaromatic phenylimidazole derivatives as pde10a enzyme inhibitors
EP10798255.5A EP2513107B1 (en)	2009-12-17	2010-12-15	Heteroaromatic phenylimidazole derivatives as pde10a enzyme inhibitors

Publications (1)

Publication Number	Publication Date
PL2513107T3 true PL2513107T3 (pl)	2014-12-31

Family

ID=44246808

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL10798255T PL2513107T3 (pl)	2009-12-17	2010-12-15	Heteroaromatyczne pochodne fenyloimidazolu jako inhibitory enzymu PDE10A

Country Status (36)

Country	Link
US (2)	US9096589B2 (pl)
EP (1)	EP2513107B1 (pl)
JP (1)	JP5901535B2 (pl)
KR (1)	KR101803984B1 (pl)
CN (1)	CN102741250B (pl)
AR (1)	AR079495A1 (pl)
AU (1)	AU2010333435B2 (pl)
BR (1)	BR112012017205A2 (pl)
CA (1)	CA2783726A1 (pl)
CO (1)	CO6612245A2 (pl)
CR (1)	CR20120319A (pl)
CY (1)	CY1115843T1 (pl)
DK (1)	DK2513107T3 (pl)
DO (1)	DOP2012000165A (pl)
EA (1)	EA023663B1 (pl)
ES (1)	ES2514647T3 (pl)
GE (1)	GEP20156241B (pl)
GT (1)	GT201200171A (pl)
HR (1)	HRP20140898T1 (pl)
IL (1)	IL220327A (pl)
MA (1)	MA33922B1 (pl)
MX (1)	MX2012006969A (pl)
MY (1)	MY158197A (pl)
NZ (1)	NZ600260A (pl)
PH (1)	PH12012501201A1 (pl)
PL (1)	PL2513107T3 (pl)
PT (1)	PT2513107E (pl)
RS (1)	RS53579B1 (pl)
SG (1)	SG181674A1 (pl)
SI (1)	SI2513107T1 (pl)
SM (1)	SMT201400158B (pl)
TN (1)	TN2012000271A1 (pl)
TW (1)	TWI485151B (pl)
UA (1)	UA108487C2 (pl)
WO (1)	WO2011072694A1 (pl)
ZA (1)	ZA201204419B (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI481607B (zh)	2009-12-17	2015-04-21	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物
TWI485151B (zh)	2009-12-17	2015-05-21	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
TWI487705B (zh)	2009-12-17	2015-06-11	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物
US8969349B2 (en)	2010-05-26	2015-03-03	Sunovion Pharmaceuticals Inc.	Substituted quinoxalines and quinoxalinones as PDE-10 inhibitors
US8552045B2 (en)	2010-11-19	2013-10-08	H. Lundbeck A/S	Tricyclic imidazole compounds as PDE10 inhibitors
JO3089B1 (ar) *	2010-11-19	2017-03-15	H Lundbeck As	مشتقات ايميدازول كمثبطات لانزيمات pde10a
US8765760B2 (en)	2011-01-11	2014-07-01	Sunovion Pharmaceuticals, Inc.	[1,2,4] triazol [1,5-a] pyrazines useful as inhibitors of phosphodiesterases
CA2827724A1 (en)	2011-02-18	2012-08-23	Allergan, Inc.	Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a)
US9938269B2 (en) *	2011-06-30	2018-04-10	Abbvie Inc.	Inhibitor compounds of phosphodiesterase type 10A
CA2846758C (en) *	2011-09-19	2017-09-12	F. Hoffmann-La Roche Ag	Triazolopyridine compounds as pde10a inhibitors
WO2013050527A1 (en)	2011-10-05	2013-04-11	H. Lundbeck A/S	Quinazoline derivatives as pde10a enzyme inhibitors
TWI570124B (zh)	2011-12-21	2017-02-11	Ｈ朗德貝克公司	作為ｐｄｅ１０ａ酵素抑制劑的喹啉衍生物
EP2861596B1 (en)	2012-06-19	2019-03-20	Sunovion Pharmaceuticals Inc.	Heteroaryl compounds and methods of use thereof
WO2014071044A1 (en)	2012-11-01	2014-05-08	Allergan, Inc.	Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
US9790203B2 (en) *	2012-11-26	2017-10-17	Abbvie Inc.	Inhibitor compounds of phosphodiesterase type 10A
US9200016B2 (en)	2013-12-05	2015-12-01	Allergan, Inc.	Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
GB202319181D0 (en) *	2023-12-14	2024-01-31	Imperial College Innovations Ltd	Nora Inhibitors

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8307865D0 (en)	1983-03-22	1983-04-27	Fujisawa Pharmaceutical Co	Benzimidazole derivatives
US5571775A (en)	1994-07-11	1996-11-05	Dowelanco	N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides
US20030032579A1 (en)	2001-04-20	2003-02-13	Pfizer Inc.	Therapeutic use of selective PDE10 inhibitors
IL149106A0 (en)	2001-04-20	2002-11-10	Pfizer Prod Inc	Therapeutic use of selective pde10 inhibitors
FR2824065A1 (fr)	2001-04-26	2002-10-31	Neuro3D	Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
JP2006509832A (ja)	2002-10-30	2006-03-23	ニューロ３デー	サイクリックヌクレオチドホスホジエステラーゼ阻害剤、その調製及び使用
US20070105840A1 (en)	2003-06-30	2007-05-10	Altana Pharma Ag	Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
RS20050945A (sr)	2003-06-30	2008-06-05	Altana Pharma Ag.,	Novi pirolodihidroizohinolini koji se mogu upotrebiti u tretmanu kancera
EP1651251A4 (en)	2003-07-31	2008-06-18	Bayer Pharmaceuticals Corp	METHOD FOR THE TREATMENT OF DIABETES AND RELATED DISEASES USING PDE 10A INHIBITORS
EP1723134A2 (en)	2004-02-18	2006-11-22	Pfizer Products Incorporated	Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline
FR2870539B1 (fr)	2004-05-19	2006-08-04	Greenpharma Sa Sa	Nouvelles methodes et medicaments
EP1755611A1 (en)	2004-06-07	2007-02-28	Pfizer Products Inc.	Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions
US20060019975A1 (en)	2004-07-23	2006-01-26	Pfizer Inc	Novel piperidyl derivatives of quinazoline and isoquinoline
CA2578996A1 (en)	2004-09-03	2006-03-16	Memory Pharmaceuticals Corporation	4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms
NL2000397C2 (nl) *	2006-01-05	2007-10-30	Pfizer Prod Inc	Bicyclische heteroarylverbindingen als PDE10 inhibitoren.
US20080090834A1 (en) *	2006-07-06	2008-04-17	Pfizer Inc	Selective azole pde10a inhibitor compounds
ES2392553T3 (es) *	2006-07-10	2012-12-11	H. Lundbeck A/S	Derivados (3-aril-piperazina-1-ilo) de 6,7-dialcoxiquinazolina, 6,7-dialcoxiftalazina y 6,7-dialcoxiisoquinolina
EP2173728A2 (en)	2007-07-17	2010-04-14	Amgen Inc.	Heterocyclic modulators of pkb
US8133897B2 (en) *	2008-06-20	2012-03-13	H. Lundbeck A/S	Phenylimidazole derivatives as PDE10A enzyme inhibitors
TWI501965B (zh) *	2008-06-20	2015-10-01	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物
CA2765750A1 (en)	2009-06-19	2010-12-23	H. Lundbeck A/S	Novel phenylimidazole derivative as pde10a enzyme inhibitor
TWI481607B (zh)	2009-12-17	2015-04-21	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物
TWI487705B (zh)	2009-12-17	2015-06-11	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物
TW201200516A (en)	2009-12-17	2012-01-01	Lundbeck & Co As H	Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors
TWI485151B (zh)	2009-12-17	2015-05-21	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物

2010
- 2010-12-10 TW TW099143184A patent/TWI485151B/zh not_active IP Right Cessation
- 2010-12-15 SI SI201030765T patent/SI2513107T1/sl unknown
- 2010-12-15 CN CN201080063808.4A patent/CN102741250B/zh not_active Expired - Fee Related
- 2010-12-15 MX MX2012006969A patent/MX2012006969A/es active IP Right Grant
- 2010-12-15 JP JP2012543475A patent/JP5901535B2/ja not_active Expired - Fee Related
- 2010-12-15 PL PL10798255T patent/PL2513107T3/pl unknown
- 2010-12-15 HR HRP20140898AT patent/HRP20140898T1/hr unknown
- 2010-12-15 SG SG2012043519A patent/SG181674A1/en unknown
- 2010-12-15 US US13/513,867 patent/US9096589B2/en not_active Expired - Fee Related
- 2010-12-15 WO PCT/DK2010/050341 patent/WO2011072694A1/en not_active Ceased
- 2010-12-15 ES ES10798255.5T patent/ES2514647T3/es active Active
- 2010-12-15 UA UAA201207960A patent/UA108487C2/uk unknown
- 2010-12-15 KR KR1020127015655A patent/KR101803984B1/ko not_active Expired - Fee Related
- 2010-12-15 CA CA2783726A patent/CA2783726A1/en not_active Abandoned
- 2010-12-15 DK DK10798255.5T patent/DK2513107T3/da active
- 2010-12-15 NZ NZ600260A patent/NZ600260A/en not_active IP Right Cessation
- 2010-12-15 PH PH1/2012/501201A patent/PH12012501201A1/en unknown
- 2010-12-15 EA EA201290516A patent/EA023663B1/ru not_active IP Right Cessation
- 2010-12-15 RS RSP20140527 patent/RS53579B1/sr unknown
- 2010-12-15 EP EP10798255.5A patent/EP2513107B1/en active Active
- 2010-12-15 PT PT107982555T patent/PT2513107E/pt unknown
- 2010-12-15 BR BR112012017205A patent/BR112012017205A2/pt not_active Application Discontinuation
- 2010-12-15 MA MA35063A patent/MA33922B1/fr unknown
- 2010-12-15 AU AU2010333435A patent/AU2010333435B2/en not_active Ceased
- 2010-12-15 GE GEAP201012785A patent/GEP20156241B/en unknown
- 2010-12-15 MY MYPI2012002598A patent/MY158197A/en unknown
- 2010-12-16 AR ARP100104668A patent/AR079495A1/es unknown
2012
- 2012-05-29 TN TNP2012000271A patent/TN2012000271A1/en unknown
- 2012-05-31 GT GT201200171A patent/GT201200171A/es unknown
- 2012-06-12 CR CR20120319A patent/CR20120319A/es unknown
- 2012-06-12 IL IL220327A patent/IL220327A/en not_active IP Right Cessation
- 2012-06-13 CO CO12099152A patent/CO6612245A2/es active IP Right Grant
- 2012-06-14 DO DO2012000165A patent/DOP2012000165A/es unknown
- 2012-06-15 ZA ZA2012/04419A patent/ZA201204419B/en unknown
2014
- 2014-09-26 CY CY20141100789T patent/CY1115843T1/el unknown
- 2014-10-29 SM SM201400158T patent/SMT201400158B/xx unknown
2015
- 2015-06-25 US US14/749,754 patent/US9669029B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BR112012017205A2 (pt)	2018-08-14
CR20120319A (es)	2012-08-16
AU2010333435B2 (en)	2016-09-08
KR20120112460A (ko)	2012-10-11
UA108487C2 (en)	2015-05-12
ZA201204419B (en)	2013-08-28
NZ600260A (en)	2014-08-29
GT201200171A (es)	2015-01-16
GEP20156241B (en)	2015-02-10
EP2513107B1 (en)	2014-07-30
AU2010333435A1 (en)	2012-06-21
JP2013514284A (ja)	2013-04-25
MX2012006969A (es)	2012-07-17
WO2011072694A1 (en)	2011-06-23
CN102741250A (zh)	2012-10-17
EA201290516A1 (ru)	2013-01-30
US20120309714A1 (en)	2012-12-06
SG181674A1 (en)	2012-07-30
CN102741250B (zh)	2015-10-14
EA023663B1 (ru)	2016-06-30
IL220327A0 (en)	2012-08-30
JP5901535B2 (ja)	2016-04-13
CY1115843T1 (el)	2017-01-25
US9669029B2 (en)	2017-06-06
AR079495A1 (es)	2012-02-01
MY158197A (en)	2016-09-15
RS53579B1 (sr)	2015-02-27
US9096589B2 (en)	2015-08-04
ES2514647T3 (es)	2014-10-28
TN2012000271A1 (en)	2013-12-12
TW201200515A (en)	2012-01-01
HRP20140898T1 (hr)	2014-11-07
CA2783726A1 (en)	2011-06-23
TWI485151B (zh)	2015-05-21
MA33922B1 (fr)	2013-01-02
PT2513107E (pt)	2014-10-22
HK1177208A1 (en)	2013-08-16
IL220327A (en)	2014-12-31
KR101803984B1 (ko)	2017-12-01
CO6612245A2 (es)	2013-02-01
EP2513107A1 (en)	2012-10-24
SI2513107T1 (sl)	2014-11-28
SMT201400158B (it)	2015-01-15
DK2513107T3 (da)	2014-10-13
DOP2012000165A (es)	2012-12-15
PH12012501201A1 (en)	2017-01-27
US20150290191A1 (en)	2015-10-15

Publication	Publication Date	Title
ZA201204419B (en)	2013-08-28	Heteroaromatic phenylimidazole derivatives as pde10a enzyme inhibitors
IL209834A (en)	2014-02-27	Phenylimidazole derivatives as a10pde enzyme sequences
ZA201204418B (en)	2013-08-28	2-arylimidazole derivatives as pde10a enzyme inhibitors
ZA201204420B (en)	2013-09-25	Heteroaromatic aryl triazole derivatives as pde10a enzyme inhibitors
IL216684A0 (en)	2012-02-29	Novel phenylimidazole derivative as pde10a enzyme inhibitor
IL220212A0 (en)	2012-07-31	Aminopyrimidine kinase inhibitors
EP2552208A4 (en)	2014-07-09	IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS
GB201004179D0 (en)	2010-04-28	Enzyme inhibitors
AP3342A (en)	2015-07-31	Imidazole derivatives as PDE10A enzyme inhibitors
PT2448938E (pt)	2014-07-31	Pirimidinonas como inibidoras de pi3k
GB201004178D0 (en)	2010-04-28	Enzyme inhibitors
EP2552214A4 (en)	2013-10-16	PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS
EP2552211A4 (en)	2013-10-23	INDAZOLYL-PYRIMIDINE AS KINASEHEMMER
ZA201202776B (en)	2013-06-26	Imidazole derivatives as casein kinase inhibitors
IL226344A0 (en)	2013-07-31	Imiazole derivatives as enzyme inhibitors@pde
GB0908068D0 (en)	2009-06-24	Enzyme inhibitors
GB0901616D0 (en)	2009-03-11	Enzyme inhibitors