PL2530093T3 - Związek indocyjaninowy, jego metoda syntezy, metoda jego oczyszczania, kompozycja diagnostyczna wykorzystująca związek indocyjaninowy oraz urządzenie do pomiaru biokinetyki in vivo i urządzenie do wizualizacji krążenia wykorzystujące kompozycję diagnostyczną - Google Patents

Związek indocyjaninowy, jego metoda syntezy, metoda jego oczyszczania, kompozycja diagnostyczna wykorzystująca związek indocyjaninowy oraz urządzenie do pomiaru biokinetyki in vivo i urządzenie do wizualizacji krążenia wykorzystujące kompozycję diagnostyczną

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Publication number
PL2530093T3
PL2530093T3 PL11736813T PL11736813T PL2530093T3 PL 2530093 T3 PL2530093 T3 PL 2530093T3 PL 11736813 T PL11736813 T PL 11736813T PL 11736813 T PL11736813 T PL 11736813T PL 2530093 T3 PL2530093 T3 PL 2530093T3
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PL
Poland
Prior art keywords
diagnostic composition
indocyanine compound
biokinetics
visualization
vivo
Prior art date
Application number
PL11736813T
Other languages
English (en)
Inventor
Katsunori Teranishi
Hitoshi Hirata
Tetsuya Arai
Original Assignee
National University Corporation Mie University
National University Corporation Nagoya University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Mie University, National University Corporation Nagoya University filed Critical National University Corporation Mie University
Publication of PL2530093T3 publication Critical patent/PL2530093T3/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
    • A61B5/201—Assessing renal or kidney functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
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    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/742—Details of notification to user or communication with user or patient; User input means using visual displays
    • A61B5/7425—Displaying combinations of multiple images regardless of image source, e.g. displaying a reference anatomical image with a live image
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
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    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
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    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
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    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
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    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
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    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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    • A61M5/007—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
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    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B68/00—Organic pigments surface-modified by grafting, e.g. by establishing covalent or complex bonds, in order to improve the pigment properties, e.g. dispersibility or rheology
    • C09B68/40—Organic pigments surface-modified by grafting, e.g. by establishing covalent or complex bonds, in order to improve the pigment properties, e.g. dispersibility or rheology characterised by the chemical nature of the attached groups
    • C09B68/48—Non-aromatic cyclic groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B68/00—Organic pigments surface-modified by grafting, e.g. by establishing covalent or complex bonds, in order to improve the pigment properties, e.g. dispersibility or rheology
    • C09B68/40—Organic pigments surface-modified by grafting, e.g. by establishing covalent or complex bonds, in order to improve the pigment properties, e.g. dispersibility or rheology characterised by the chemical nature of the attached groups
    • C09B68/48—Non-aromatic cyclic groups
    • C09B68/485—Substituted non-aromatic cyclic groups
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    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B5/026—Measuring blood flow
    • A61B5/0275—Measuring blood flow using tracers, e.g. dye dilution
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B68/00—Organic pigments surface-modified by grafting, e.g. by establishing covalent or complex bonds, in order to improve the pigment properties, e.g. dispersibility or rheology
    • C09B68/40—Organic pigments surface-modified by grafting, e.g. by establishing covalent or complex bonds, in order to improve the pigment properties, e.g. dispersibility or rheology characterised by the chemical nature of the attached groups
    • C09B68/41—Polymers attached to the pigment surface

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  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
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  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
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  • Pathology (AREA)
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  • Epidemiology (AREA)
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  • Polymers & Plastics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
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  • Endocrinology (AREA)
  • Nanotechnology (AREA)
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  • Urology & Nephrology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL11736813T 2010-01-28 2011-01-28 Związek indocyjaninowy, jego metoda syntezy, metoda jego oczyszczania, kompozycja diagnostyczna wykorzystująca związek indocyjaninowy oraz urządzenie do pomiaru biokinetyki in vivo i urządzenie do wizualizacji krążenia wykorzystujące kompozycję diagnostyczną PL2530093T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2010017255 2010-01-28
JP2010132923 2010-06-10
EP11736813.4A EP2530093B1 (en) 2010-01-28 2011-01-28 Indocyanine compound, synthesis method thereof, purification method thereof, diagnostic composition using indocyanine compound, and device for measuring in vivo kinetics and device for visualizing circulation using diagnostic composition
PCT/JP2011/000489 WO2011093098A1 (ja) 2010-01-28 2011-01-28 新規インドシアニン化合物、その合成法及びその精製法、そのインドシアニン化合物を用いた診断用組成物、その診断用組成物を使用する生体内動態測定装置、並びに循環可視化装置

Publications (1)

Publication Number Publication Date
PL2530093T3 true PL2530093T3 (pl) 2019-06-28

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PL11736813T PL2530093T3 (pl) 2010-01-28 2011-01-28 Związek indocyjaninowy, jego metoda syntezy, metoda jego oczyszczania, kompozycja diagnostyczna wykorzystująca związek indocyjaninowy oraz urządzenie do pomiaru biokinetyki in vivo i urządzenie do wizualizacji krążenia wykorzystujące kompozycję diagnostyczną

Country Status (10)

Country Link
US (5) US9056131B2 (pl)
EP (1) EP2530093B1 (pl)
JP (1) JP5721234B2 (pl)
CN (2) CN102770460A (pl)
DK (1) DK2530093T3 (pl)
ES (1) ES2708697T3 (pl)
HU (1) HUE041616T2 (pl)
PL (1) PL2530093T3 (pl)
PT (1) PT2530093T (pl)
WO (1) WO2011093098A1 (pl)

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JP6029050B2 (ja) * 2012-06-22 2016-11-24 国立大学法人三重大学 血管透過性亢進評価剤、血管透過性亢進評価方法、および血管透過性亢進評価装置
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US10245329B2 (en) * 2014-09-08 2019-04-02 Canon Kabushiki Kaisha Composition having dye and conjugate of polyethyleneglycol and additive and contrast agent for photoacoustic imaging having the same
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GB2568550B (en) * 2017-11-21 2021-06-30 Univ Cape Town Method of synthesising 6-deoxy-6-amino-ß-d-glucopyranoside-containing polymers
US12247126B2 (en) 2018-05-09 2025-03-11 Board Of Trustees Of Michigan State University Near-infrared harvesting transparent luminescent solar concentrators with engineered stokes shift
WO2020159448A1 (en) * 2019-02-01 2020-08-06 Nanyang Technological University Molecular renal probes for detecting acute kidney injury
CN111134622B (zh) * 2019-05-24 2021-03-02 四川大学华西医院 一种无创检测体内吲哚菁绿含量的装置
JP2023502865A (ja) * 2019-11-27 2023-01-26 アステラス製薬株式会社 インドシアニン化合物の結晶
CN112891557A (zh) * 2021-02-03 2021-06-04 柯阳 一种ICG-β-环糊精载药系统及其制备方法和应用
CN117042811A (zh) * 2021-03-24 2023-11-10 安斯泰来制药株式会社 癌造影用组合物
CN117715661A (zh) 2021-07-28 2024-03-15 安斯泰来制药株式会社 用于nirf成像的普地沙铵
KR20240105503A (ko) 2021-11-26 2024-07-05 아스테라스 세이야쿠 가부시키가이샤 인도시아닌 화합물 함유 고형 의약 조성물
US20240125703A1 (en) 2022-09-16 2024-04-18 Stryker Corporation Systems and methods for quantifying user observed visualization of fluorescence imaging agents
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EP2530093A1 (en) 2012-12-05
US20120302881A1 (en) 2012-11-29
CN106977628B (zh) 2021-04-13
PT2530093T (pt) 2018-12-28
US9056131B2 (en) 2015-06-16
US20180353626A1 (en) 2018-12-13
HUE041616T2 (hu) 2019-05-28
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