PL2558457T3 - Pochodne aryloetynylowe - Google Patents
Pochodne aryloetynyloweInfo
- Publication number
- PL2558457T3 PL2558457T3 PL11713288.6T PL11713288T PL2558457T3 PL 2558457 T3 PL2558457 T3 PL 2558457T3 PL 11713288 T PL11713288 T PL 11713288T PL 2558457 T3 PL2558457 T3 PL 2558457T3
- Authority
- PL
- Poland
- Prior art keywords
- arylethynyl
- derivatives
- arylethynyl derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10159754 | 2010-04-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2558457T3 true PL2558457T3 (pl) | 2016-09-30 |
Family
ID=44140916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11713288.6T PL2558457T3 (pl) | 2010-04-13 | 2011-04-11 | Pochodne aryloetynylowe |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US8420661B2 (pl) |
| EP (1) | EP2558457B1 (pl) |
| JP (1) | JP5559418B2 (pl) |
| KR (1) | KR101431367B1 (pl) |
| CN (1) | CN102947289B (pl) |
| AR (1) | AR080878A1 (pl) |
| AU (1) | AU2011240131B2 (pl) |
| BR (1) | BR112012026004A2 (pl) |
| CA (1) | CA2786216C (pl) |
| CL (1) | CL2012002771A1 (pl) |
| CR (1) | CR20120480A (pl) |
| CY (1) | CY1117441T1 (pl) |
| DK (1) | DK2558457T3 (pl) |
| EC (1) | ECSP12012212A (pl) |
| ES (1) | ES2565761T3 (pl) |
| HR (1) | HRP20160617T1 (pl) |
| HU (1) | HUE027105T2 (pl) |
| IL (1) | IL220982A (pl) |
| MA (1) | MA34078B1 (pl) |
| MX (1) | MX2012011841A (pl) |
| MY (1) | MY160490A (pl) |
| NZ (1) | NZ601024A (pl) |
| PE (1) | PE20130155A1 (pl) |
| PH (1) | PH12012501773A1 (pl) |
| PL (1) | PL2558457T3 (pl) |
| RS (1) | RS54708B1 (pl) |
| RU (1) | RU2573560C2 (pl) |
| SG (1) | SG183974A1 (pl) |
| SI (1) | SI2558457T1 (pl) |
| TW (1) | TWI445706B (pl) |
| UA (1) | UA107491C2 (pl) |
| WO (1) | WO2011128279A1 (pl) |
| ZA (1) | ZA201207285B (pl) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2406233B1 (en) * | 2009-03-09 | 2013-11-13 | Bristol-Myers Squibb Company | Aza pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists |
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| EA022019B1 (ru) * | 2011-04-26 | 2015-10-30 | Ф.Хоффманн-Ля Рош Аг | Этинильные производные в качестве положительных аллостерических модуляторов mglur5 |
| US20130123254A1 (en) * | 2011-09-30 | 2013-05-16 | Barbara Biemans | Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification |
| UA110862C2 (uk) * | 2011-10-07 | 2016-02-25 | Ф. Хоффманн-Ля Рош Аг | Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5 |
| SI2875000T1 (sl) * | 2012-07-17 | 2017-01-31 | F.Hoffmann-La Roche Ag | Ariletinilni derivati |
| UA113223C2 (xx) | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
| ES2594031T3 (es) | 2012-09-27 | 2016-12-15 | F. Hoffmann-La Roche Ag | Derivados de ariletinilo |
| UA116023C2 (uk) * | 2013-07-08 | 2018-01-25 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні як антагоністи метаботропного глутаматного рецептора |
| SG11201602029VA (en) * | 2013-09-25 | 2016-04-28 | Hoffmann La Roche | Ethynyl derivatives |
| TWI649310B (zh) * | 2014-01-10 | 2019-02-01 | 赫孚孟拉羅股份公司 | 乙炔基衍生物 |
| CR20160384A (es) * | 2014-02-25 | 2016-11-07 | Hoffmann La Roche | Derivados de etilino |
| CN107207481B (zh) * | 2015-03-19 | 2020-03-03 | 豪夫迈·罗氏有限公司 | 作为mglur4的调节剂的3-(4-乙炔基苯基)六氢嘧啶-2,4-二酮衍生物 |
| AU2016273751B2 (en) * | 2015-06-03 | 2020-04-02 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| TR201909160T4 (tr) * | 2015-07-15 | 2019-07-22 | Hoffmann La Roche | Metabotropik glutamat reseptörü modülatörleri olarak etinil türevleri. |
| AR105556A1 (es) * | 2015-08-03 | 2017-10-18 | Hoffmann La Roche | Derivados de etinilo |
| CN106632243B (zh) * | 2015-10-28 | 2019-03-15 | 华领医药技术（上海）有限公司 | 吡咯烷衍生物 |
| WO2018015235A1 (en) | 2016-07-18 | 2018-01-25 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| CN108947883A (zh) * | 2017-05-25 | 2018-12-07 | 北京万全德众医药生物技术有限公司 | 布瓦西坦的制备 |
| ES2927480T3 (es) * | 2017-06-02 | 2022-11-07 | Hoffmann La Roche | Compuestos de isoindolina-acetileno para el tratamiento del cáncer |
| WO2018220149A1 (en) | 2017-06-02 | 2018-12-06 | F. Hoffmann-La Roche Ag | Compounds |
| IL279800B2 (en) | 2018-06-29 | 2024-02-01 | Hoffmann La Roche | Selective allosteric inhibitors of epidermal growth factor receptor mutants, pharmaceutical preparations containing them and their use |
| EP3837264A1 (en) * | 2018-08-13 | 2021-06-23 | F. Hoffmann-La Roche AG | New heterocyclic compounds as monoacylglycerol lipase inhibitors |
| MY210507A (en) | 2018-08-13 | 2025-09-28 | Hoffmann La Roche | New heterocyclic compounds as monoacylglycerol lipase inhibitors |
| WO2020048826A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-substituted 1-oxa-3,9-diazaspiro[5.5]undecan-2-one compounds |
| WO2020104494A1 (en) | 2018-11-22 | 2020-05-28 | F. Hoffmann-La Roche Ag | New heterocyclic compounds |
| TW202115073A (zh) | 2019-06-21 | 2021-04-16 | 瑞士商赫孚孟拉羅股份公司 | 新穎的egfr抑制劑 |
| ES2961187T3 (es) | 2019-06-21 | 2024-03-08 | Hoffmann La Roche | Inhibidor de EGFR para el tratamiento del cáncer |
| PH12022550339A1 (en) | 2019-09-12 | 2023-03-13 | Hoffmann La Roche | 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors |
| CN114018880B (zh) * | 2021-10-22 | 2024-02-27 | 杭州食疗晶元生物科技有限公司 | 基于内源活性中间体对纯净水和天然矿泉水的鉴别方法 |
| USD1130132S1 (en) | 2024-06-05 | 2026-06-16 | Pepsico, Inc. | Bottle |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI90869C (fi) * | 1986-11-14 | 1994-04-11 | Tanabe Seiyaku Co | Menetelmä lääkeaineena käyttökelpoisten imidatsolidinonijohdannaisten valmistamiseksi |
| GB9510744D0 (en) | 1995-05-26 | 1995-07-19 | Zeneca Ltd | Chemical process |
| DE19546462A1 (de) * | 1995-12-13 | 1997-06-19 | Bayer Ag | Diarylacetylenketone |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| JP4815083B2 (ja) * | 1999-08-31 | 2011-11-16 | メルク・シャープ・エンド・ドーム・コーポレイション | 複素環化合物およびそれの使用方法 |
| HUP0203514A3 (en) * | 1999-09-28 | 2004-01-28 | Eisai Co Ltd | Quinuclidine compounds and drugs containing them and process for preparation the same |
| ATE366248T1 (de) * | 2001-03-27 | 2007-07-15 | Eisai R&D Man Co Ltd | N-aryl-substituiertes cyclisches aminderivat und medizin, die dieses als wirkstoff enthält |
| EP1622912B1 (en) * | 2003-04-23 | 2009-05-27 | Schering Corporation | 2-alkynyl-and 2-alkenyl-pyrazolo- [4,3-e ] -1,2,4-triazolo- [1,5-c] -pyrimidine adenosine a2a receptor antagonists |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| ES2332184T3 (es) * | 2004-03-22 | 2010-01-28 | ELI LILLY & COMPANY | Derivados de piridilo y su uso como antagonistas del receptor mglu5. |
| WO2005108370A1 (ja) * | 2004-04-16 | 2005-11-17 | Ajinomoto Co., Inc. | ベンゼン化合物 |
| AU2005336513B2 (en) | 2004-10-07 | 2012-08-09 | Merck Sharp & Dohme Llc | Thiazolyl mGluR5 antagonists and methods for their use |
| EP1809620B1 (en) | 2004-11-04 | 2010-12-29 | Addex Pharma SA | Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| US8853392B2 (en) | 2007-06-03 | 2014-10-07 | Vanderbilt University | Benzamide mGluR5 positive allosteric modulators and methods of making and using same |
| KR20100033981A (ko) | 2007-06-03 | 2010-03-31 | 벤더르빌트 유니버시티 | 벤즈아미드 대사성 글루타민산염 수용체5 양성 알로스테릭 조절자 및 이의 제조 및 사용방법 |
| WO2010063487A1 (en) * | 2008-12-05 | 2010-06-10 | Merz Pharma Gmbh & Co. Kgaa | Pyrazolopyrimidines, a process for their preparation and their use as medicine |
| CN101544892B (zh) * | 2009-05-07 | 2012-10-03 | 石家庄诚志永华显示材料有限公司 | 一种合成二芳基乙炔类单体液晶的方法 |
| TW201116532A (en) * | 2009-08-05 | 2011-05-16 | Merz Pharma Gmbh & Co Kgaa | Metabotropic glutamate receptor modulators |
| US8389536B2 (en) * | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| UA110862C2 (uk) * | 2011-10-07 | 2016-02-25 | Ф. Хоффманн-Ля Рош Аг | Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5 |
-
2011
- 2011-04-05 US US13/066,044 patent/US8420661B2/en active Active
- 2011-04-11 HU HUE11713288A patent/HUE027105T2/en unknown
- 2011-04-11 TW TW100112500A patent/TWI445706B/zh not_active IP Right Cessation
- 2011-04-11 KR KR1020127029579A patent/KR101431367B1/ko not_active Expired - Fee Related
- 2011-04-11 PL PL11713288.6T patent/PL2558457T3/pl unknown
- 2011-04-11 EP EP11713288.6A patent/EP2558457B1/en active Active
- 2011-04-11 MY MYPI2012004559A patent/MY160490A/en unknown
- 2011-04-11 AR ARP110101210A patent/AR080878A1/es unknown
- 2011-04-11 HR HRP20160617TT patent/HRP20160617T1/hr unknown
- 2011-04-11 WO PCT/EP2011/055585 patent/WO2011128279A1/en not_active Ceased
- 2011-04-11 SG SG2012066759A patent/SG183974A1/en unknown
- 2011-04-11 DK DK11713288.6T patent/DK2558457T3/en active
- 2011-04-11 CN CN201180015120.3A patent/CN102947289B/zh not_active Expired - Fee Related
- 2011-04-11 RS RS20160259A patent/RS54708B1/sr unknown
- 2011-04-11 JP JP2013504215A patent/JP5559418B2/ja not_active Expired - Fee Related
- 2011-04-11 AU AU2011240131A patent/AU2011240131B2/en not_active Ceased
- 2011-04-11 MX MX2012011841A patent/MX2012011841A/es active IP Right Grant
- 2011-04-11 PE PE2012002013A patent/PE20130155A1/es active IP Right Grant
- 2011-04-11 NZ NZ601024A patent/NZ601024A/en not_active IP Right Cessation
- 2011-04-11 ES ES11713288.6T patent/ES2565761T3/es active Active
- 2011-04-11 BR BR112012026004A patent/BR112012026004A2/pt not_active Application Discontinuation
- 2011-04-11 MA MA35234A patent/MA34078B1/fr unknown
- 2011-04-11 CA CA2786216A patent/CA2786216C/en not_active Expired - Fee Related
- 2011-04-11 PH PH1/2012/501773A patent/PH12012501773A1/en unknown
- 2011-04-11 RU RU2012145237/04A patent/RU2573560C2/ru not_active IP Right Cessation
- 2011-04-11 SI SI201130777A patent/SI2558457T1/sl unknown
- 2011-11-04 UA UAA201212800A patent/UA107491C2/uk unknown
-
2012
- 2012-07-16 IL IL220982A patent/IL220982A/en active IP Right Grant
- 2012-09-24 CR CR20120480A patent/CR20120480A/es unknown
- 2012-09-28 ZA ZA2012/07285A patent/ZA201207285B/en unknown
- 2012-10-02 EC ECSP12012212 patent/ECSP12012212A/es unknown
- 2012-10-03 CL CL2012002771A patent/CL2012002771A1/es unknown
-
2013
- 2013-02-28 US US13/779,782 patent/US8513273B2/en active Active
- 2013-06-10 US US13/914,336 patent/US8618296B2/en not_active Expired - Fee Related
- 2013-11-20 US US14/085,064 patent/US9315498B2/en active Active
-
2016
- 2016-04-27 CY CY20161100357T patent/CY1117441T1/el unknown
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