PL2563771T3 - Związki inhibitora metaloenzymu - Google Patents

Związki inhibitora metaloenzymu

Info

Publication number
PL2563771T3
PL2563771T3 PL11772772T PL11772772T PL2563771T3 PL 2563771 T3 PL2563771 T3 PL 2563771T3 PL 11772772 T PL11772772 T PL 11772772T PL 11772772 T PL11772772 T PL 11772772T PL 2563771 T3 PL2563771 T3 PL 2563771T3
Authority
PL
Poland
Prior art keywords
inhibitor compounds
metalloenzyme inhibitor
metalloenzyme
compounds
inhibitor
Prior art date
Application number
PL11772772T
Other languages
English (en)
Inventor
William J Hoekstra
Robert J Schotzinger
Stephen William Rafferty
Original Assignee
Viamet Pharmaceuticals Nc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viamet Pharmaceuticals Nc Inc filed Critical Viamet Pharmaceuticals Nc Inc
Publication of PL2563771T3 publication Critical patent/PL2563771T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/08Antibacterial agents for leprosy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL11772772T 2010-04-24 2011-04-22 Związki inhibitora metaloenzymu PL2563771T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32766310P 2010-04-24 2010-04-24
EP11772772.7A EP2563771B1 (en) 2010-04-24 2011-04-22 Metalloenzyme inhibitor compounds
PCT/US2011/033597 WO2011133875A2 (en) 2010-04-24 2011-04-22 Metalloenzyme inhibitor compounds

Publications (1)

Publication Number Publication Date
PL2563771T3 true PL2563771T3 (pl) 2016-06-30

Family

ID=44834829

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11772772T PL2563771T3 (pl) 2010-04-24 2011-04-22 Związki inhibitora metaloenzymu

Country Status (20)

Country Link
US (2) US8236962B2 (pl)
EP (1) EP2563771B1 (pl)
JP (2) JP5266430B2 (pl)
KR (1) KR101379370B1 (pl)
CN (1) CN103097374B (pl)
AU (1) AU2011242562B2 (pl)
BR (1) BR112012027308B1 (pl)
CA (2) CA2792950C (pl)
CY (1) CY1117678T1 (pl)
DK (1) DK2563771T3 (pl)
EA (1) EA024341B1 (pl)
ES (1) ES2563319T3 (pl)
HR (1) HRP20160172T1 (pl)
HU (1) HUE026474T2 (pl)
PL (1) PL2563771T3 (pl)
PT (1) PT2563771E (pl)
RS (1) RS55010B1 (pl)
SI (1) SI2563771T1 (pl)
TW (1) TWI578987B (pl)
WO (1) WO2011133875A2 (pl)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3178321T3 (da) 2009-10-07 2019-08-26 Dow Agrosciences Llc Synergistiske fungicide blandninger af epoxiconazol til bekæmpelse af svamp i korn
AU2011242562B2 (en) * 2010-04-24 2016-10-13 Mycovia Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
KR101926320B1 (ko) 2010-08-04 2018-12-06 펠피큐어 파마슈티걸즈 아이엔씨 전립선 암종의 치료를 위한 병용 요법
AU2012273100B2 (en) * 2011-06-19 2017-05-25 Viamet Pharmaceuticals (NC), Inc. Metalloenzyme inhibitor compounds
KR20140040235A (ko) * 2011-06-19 2014-04-02 비아멧 파마슈티컬즈, 인코포레이티드 금속효소 억제제 화합물
US8940735B2 (en) * 2011-06-23 2015-01-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
IN2014MN01378A (pl) 2011-12-11 2015-07-03 Viamet Pharmaceuticals Inc
WO2013109998A1 (en) 2012-01-20 2013-07-25 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
US9414596B2 (en) * 2012-01-20 2016-08-16 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
TWI646088B (zh) * 2012-03-16 2019-01-01 維愛美製藥公司 金屬酶抑制劑化合物
TWI654180B (zh) 2012-06-29 2019-03-21 美商艾佛艾姆希公司 殺真菌之雜環羧醯胺
US20150246898A1 (en) * 2012-09-12 2015-09-03 Dow Agrosciences Llc Metalloenzyme inhibitor compounds
EP2938191B1 (en) 2012-12-28 2018-01-31 Dow AgroSciences LLC Synergistic fungicidal mixtures for fungal control in cereals
BR112015015243B8 (pt) 2012-12-31 2022-08-23 Dow Agrosciences Llc Composto contendo picolinamidas macrocíclicas, composição e método para controle e prevenção de doença em planta
US9655363B2 (en) * 2013-02-04 2017-05-23 Syngenta Participations Ag Microbiocides
CA2902335C (en) 2013-03-14 2021-09-14 Pellficure Pharmaceuticals, Inc. Novel therapy for prostate carcinoma
AU2014278172B2 (en) * 2013-06-12 2018-08-09 Mycovia Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
WO2015100182A1 (en) 2013-12-26 2015-07-02 Dow Agrosciences Llc Use of macrocyclic picolinamides as fungicides
EP3099170A4 (en) 2013-12-26 2017-06-21 Dow AgroSciences LLC Use of macrocyclic picolinamides as fungicides
WO2015143184A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
JP6606508B2 (ja) 2014-03-19 2019-11-13 マイコヴィア ファーマシューティカルズ,インコーポレイテッド 抗真菌化合物の調製方法
US9802914B2 (en) 2014-03-19 2017-10-31 Viamet Pharmaceuticals, Inc. Antifungal compound process
KR102441243B1 (ko) 2014-03-19 2022-09-07 브이피에스-3, 엘엘씨 2-(2,4-디플루오르페닐)-1,1-디플루오르-1-(5-치환된-피리딘-2-일)-3-(1h-테트라졸-1-일)프로판-2-올 및 이의 제조방법
AU2015231275B2 (en) * 2014-03-19 2019-03-07 Mycovia Pharmaceuticals, Inc. Antifungal compound process
JP2017509646A (ja) * 2014-03-19 2017-04-06 ヴィアメット ファーマスーティカルズ,インコーポレイテッド 抗真菌化合物の調製方法
CN109970629B (zh) * 2014-03-19 2023-04-11 迈科维亚医药公司 抗真菌化合物的制备方法
CA2942936A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
AU2015231216B2 (en) * 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
EP3119753B1 (en) 2014-03-19 2020-11-04 Dow AgroSciences LLC 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
WO2015160665A1 (en) * 2014-04-15 2015-10-22 Dow Agrosciences Llc Metalloenzyme inhibitor compounds as fungicides
EP3139916A4 (en) 2014-05-06 2017-11-15 Dow AgroSciences LLC Macrocyclic picolinamides as fungicides
RU2016149812A (ru) 2014-06-06 2018-07-17 Флексус Байосайенсиз, Инк. Иммунорегулирующие средства
WO2016007529A1 (en) 2014-07-08 2016-01-14 Dow Agrosciences Llc Macrocyclic picolinamides as fungicides
BR112017000104A2 (pt) 2014-07-08 2017-10-31 Dow Agrosciences Llc picolinamidas macrocíclicas como fungicidas
WO2016040896A1 (en) 2014-09-12 2016-03-17 Pellficure Pharmaceuticals, Inc. Compositions and methods for treatment of prostate carcinoma
BR112017008809A2 (pt) 2014-11-05 2017-12-19 Flexus Biosciences Inc agentes imunorreguladores
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
UY36391A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
EP3240408B1 (en) 2014-12-30 2020-04-08 Dow Agrosciences LLC Picolinamides with fungicidal activity
AU2015374459A1 (en) 2014-12-30 2017-06-29 Dow Agrosciences Llc Picolinamide compounds with fungicidal activity
WO2016109634A1 (en) 2014-12-30 2016-07-07 Dow Agrosciences Llc Fungicidal compositions
US20170290333A1 (en) 2014-12-30 2017-10-12 Dow Agrosciences Llc Picolinamide compounds with fungicidal activity
MX2017008444A (es) 2014-12-30 2017-10-02 Dow Agrosciences Llc Picolinamidas como fungicidas.
MX2017008439A (es) 2014-12-30 2017-10-02 Dow Agrosciences Llc Compuestos de picolinamida con actividad fungicida.
KR102603277B1 (ko) 2015-03-19 2023-11-17 마이코비아 파마슈티컬즈, 인코포레이티드 항진균성 화합물 및 이의 제조 방법
CR20170574A (es) 2015-05-18 2018-07-19 Viamet Pharmaceuticals Inc Compuestos antifíngicos
CN108289457B (zh) 2015-09-18 2021-08-06 迈科维亚医药公司 抗真菌化合物制备方法
EA038421B1 (ru) 2015-12-30 2021-08-26 ВиПиЭс-3, ИНК. Соединения, ингибирующие металлоферменты
US10172358B2 (en) 2016-08-30 2019-01-08 Dow Agrosciences Llc Thiopicolinamide compounds with fungicidal activity
WO2018045012A1 (en) 2016-08-30 2018-03-08 Dow Agrosciences Llc Pyrido-1,3-oxazine-2,4-dione compounds with fungicidal activity
US10214490B2 (en) 2016-08-30 2019-02-26 Dow Agrosciences Llc Picolinamides as fungicides
US10111432B2 (en) 2016-08-30 2018-10-30 Dow Agrosciences Llc Picolinamide N-oxide compounds with fungicidal activity
AU2017350690A1 (en) 2016-10-24 2019-06-13 Pellficure Pharmaceuticals Inc. Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione
CN114989205A (zh) 2016-12-22 2022-09-02 卡里塞拉生物科学股份公司 用于抑制精氨酸酶活性的组合物和方法
JP7227157B2 (ja) * 2016-12-29 2023-02-21 フェーズバイオ ファーマシューティカルズ,インコーポレイテッド 金属酵素阻害剤化合物
BR102018000183B1 (pt) 2017-01-05 2023-04-25 Dow Agrosciences Llc Picolinamidas, composição para controle de um patógeno fúngico, e método para controle e prevenção de um ataque por fungos em uma planta
TW201842851A (zh) 2017-05-02 2018-12-16 美商陶氏農業科學公司 用於穀類中的真菌防治之協同性混合物
TWI774761B (zh) 2017-05-02 2022-08-21 美商科迪華農業科技有限責任公司 用於穀物中的真菌防治之協同性混合物
US11191269B2 (en) 2017-05-02 2021-12-07 Dow Agrosciences Llc Use of an acyclic picolinamide compound as a fungicide for fungal diseases on turfgrasses
BR112020009446A2 (pt) 2017-11-13 2020-11-03 Bayer Aktiengesellschaft derivados de tetrazólio propila e seu uso como fungicida
BR102019004480B1 (pt) 2018-03-08 2023-03-28 Dow Agrosciences Llc Picolinamidas como fungicidas
KR20210076072A (ko) 2018-10-15 2021-06-23 코르테바 애그리사이언스 엘엘씨 옥시피콜린아미드의 합성 방법
CN114554848A (zh) 2019-10-18 2022-05-27 科迪华农业科技有限责任公司 用于合成吡啶酰胺的方法
WO2021143811A1 (zh) * 2020-01-17 2021-07-22 上海森辉医药有限公司 四氮唑类化合物的可药用盐及其结晶形式、制备方法和用途
WO2021188404A1 (en) 2020-03-19 2021-09-23 Assia Chemical Industries Ltd Solid state forms of oteseconazole and process for preparation thereof
CN117069693A (zh) * 2022-05-16 2023-11-17 上海济煜医药科技有限公司 一类含胺基结构化合物的制备方法及作为抗菌剂的应用
TW202423418A (zh) * 2022-09-30 2024-06-16 大陸商上海濟煜醫藥科技有限公司 雙環類化合物的無定形、結晶固體及其製備方法
WO2025109158A1 (en) 2023-11-23 2025-05-30 Basf Se Process for the chemical recycling of plastic waste containing polyethylene or polypropylene
WO2026006142A1 (en) * 2024-06-24 2026-01-02 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Azole compounds useful as inhibitors of voltage-dependent anion channel oligomerization

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8304282D0 (en) * 1983-02-16 1983-03-23 Pfizer Ltd Antifungal agents
US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US4738851A (en) 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
US5084465A (en) * 1986-06-23 1992-01-28 Du Pont Merck Pharmaceutical Company Antifungal carbinols
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US4882150A (en) 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5521222A (en) 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
DK0431519T3 (da) 1989-12-04 1994-07-04 Searle & Co System til transdermal indgivelse af albuterol
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
JP2594486B2 (ja) 1991-01-15 1997-03-26 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
DE69228827T2 (de) 1991-12-18 1999-10-21 Minnesota Mining And Mfg. Co., Saint Paul Mehrschichtige sperrstrukturen
ATE132381T1 (de) 1992-01-29 1996-01-15 Voelkl Franz Ski Ballspielschläger, insbesondere tennisschläger
JP3452213B2 (ja) * 1994-07-05 2003-09-29 エーザイ株式会社 抗真菌剤及びその製造方法
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
ES2094688B1 (es) 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
GB9512961D0 (en) * 1995-06-26 1995-08-30 Pfizer Ltd Antifungal agents
JPH1045750A (ja) * 1995-09-20 1998-02-17 Takeda Chem Ind Ltd アゾール化合物、その製造方法及び用途
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
GB9605705D0 (en) * 1996-03-19 1996-05-22 Pfizer Ltd Therapeutic agents
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
JP2000344744A (ja) * 1999-06-04 2000-12-12 Ss Pharmaceut Co Ltd アセトフェノン誘導体およびその製法
JP2004359646A (ja) 2003-06-09 2004-12-24 Ss Pharmaceut Co Ltd 抗真菌活性を有する新規アゾール誘導体
AU2011242562B2 (en) * 2010-04-24 2016-10-13 Mycovia Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds

Also Published As

Publication number Publication date
AU2011242562A1 (en) 2012-12-20
EP2563771A4 (en) 2013-11-06
CY1117678T1 (el) 2017-05-17
TW201204354A (en) 2012-02-01
EA201291107A1 (ru) 2013-04-30
US8754227B2 (en) 2014-06-17
AU2011242562B2 (en) 2016-10-13
ES2563319T3 (es) 2016-03-14
EP2563771A2 (en) 2013-03-06
US20110306644A1 (en) 2011-12-15
CN103097374A (zh) 2013-05-08
SI2563771T1 (sl) 2016-05-31
TWI578987B (zh) 2017-04-21
CA2837400C (en) 2017-12-12
KR101379370B1 (ko) 2014-03-28
BR112012027308A2 (pt) 2016-08-02
JP5944343B2 (ja) 2016-07-05
EA024341B1 (ru) 2016-09-30
WO2011133875A2 (en) 2011-10-27
BR112012027308B1 (pt) 2021-07-06
WO2011133875A3 (en) 2012-03-08
CA2792950E (en) 2011-10-27
US20130005776A1 (en) 2013-01-03
PT2563771E (pt) 2016-03-31
HRP20160172T1 (hr) 2016-05-06
DK2563771T3 (en) 2016-02-29
JP2013525375A (ja) 2013-06-20
CN103097374B (zh) 2015-01-07
CA2792950C (en) 2014-02-11
KR20120135529A (ko) 2012-12-14
RS55010B1 (sr) 2016-11-30
EP2563771B1 (en) 2015-11-25
JP2013177409A (ja) 2013-09-09
CA2792950A1 (en) 2011-10-27
US8236962B2 (en) 2012-08-07
HUE026474T2 (en) 2016-06-28
CA2837400A1 (en) 2011-10-27
JP5266430B2 (ja) 2013-08-21

Similar Documents

Publication Publication Date Title
PT2563771E (pt) Compostos inibidores de metaloenzimas
ZA201400232B (en) Metalloenzyme inhibitor compounds
EP2723731A4 (en) COMPOUNDS INHIBITING METALLOENZYMES
PT2788343T (pt) Compostos inibidores de metaloenzimas
EP2804479A4 (en) METALLOENZYME INHIBITOR COMPOUNDS
GB201004311D0 (en) New enzyme inhibitor compounds
GB201008134D0 (en) Compounds
EP2894981A4 (en) METALLO ENZYME INHIBITOR COMPOUNDS
GB201015949D0 (en) Compounds
PL2804858T3 (pl) Związki - inhibitory metaloenzymu
EP2519508A4 (en) METALLO ENZYME INHIBITOR COMPOUNDS
GB201007347D0 (en) Compounds
ZA201206456B (en) Uses of dgati inhibitors
EP2632903A4 (en) METALLOENZYMHEMMERVERBINDUNGEN
EP2651905A4 (en) METALLOENZYMHEMMERVERBINDUNGEN
GB201001688D0 (en) Compounds
EP2751117A4 (en) METALLOENZYMHEMMERVERBINDUNGEN
GB201002216D0 (en) Compounds
GB201001796D0 (en) Compounds
GB201015537D0 (en) Compounds
PL2558462T3 (pl) Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1
GB201013507D0 (en) Compounds
TWI561515B (en) Metalloenzyme inhibitor compounds
GB201004308D0 (en) New inhibitor compounds
GB201018597D0 (en) Inhibitors