PL2566972T3 - Kompozycje do wiązania modułów z motywem palca cynkowego - Google Patents
Kompozycje do wiązania modułów z motywem palca cynkowegoInfo
- Publication number
- PL2566972T3 PL2566972T3 PL11777690T PL11777690T PL2566972T3 PL 2566972 T3 PL2566972 T3 PL 2566972T3 PL 11777690 T PL11777690 T PL 11777690T PL 11777690 T PL11777690 T PL 11777690T PL 2566972 T3 PL2566972 T3 PL 2566972T3
- Authority
- PL
- Poland
- Prior art keywords
- compositions
- zinc finger
- finger modules
- linking zinc
- linking
- Prior art date
Links
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000011701 zinc Substances 0.000 title 1
- 229910052725 zinc Inorganic materials 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Contacts (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34372910P | 2010-05-03 | 2010-05-03 | |
| EP11777690.6A EP2566972B1 (en) | 2010-05-03 | 2011-05-02 | Compositions for linking zinc finger modules |
| PCT/US2011/000758 WO2011139349A1 (en) | 2010-05-03 | 2011-05-02 | Compositions for linking zinc finger modules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2566972T3 true PL2566972T3 (pl) | 2020-06-29 |
Family
ID=44903931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11777690T PL2566972T3 (pl) | 2010-05-03 | 2011-05-02 | Kompozycje do wiązania modułów z motywem palca cynkowego |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8772453B2 (pl) |
| EP (2) | EP3636766A1 (pl) |
| JP (1) | JP5898179B2 (pl) |
| KR (2) | KR101974036B1 (pl) |
| CN (1) | CN102959087B (pl) |
| AU (1) | AU2011249019B2 (pl) |
| CA (1) | CA2797189C (pl) |
| CY (1) | CY1122636T1 (pl) |
| DK (1) | DK2566972T3 (pl) |
| ES (1) | ES2773052T3 (pl) |
| HR (1) | HRP20200254T1 (pl) |
| HU (1) | HUE048072T2 (pl) |
| IL (1) | IL222632B (pl) |
| LT (1) | LT2566972T (pl) |
| PL (1) | PL2566972T3 (pl) |
| PT (1) | PT2566972T (pl) |
| SI (1) | SI2566972T1 (pl) |
| WO (1) | WO2011139349A1 (pl) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120196370A1 (en) | 2010-12-03 | 2012-08-02 | Fyodor Urnov | Methods and compositions for targeted genomic deletion |
| CA3157027A1 (en) | 2010-07-21 | 2012-01-26 | Sangamo Therapeutics, Inc. | Methods and compositions for modification of a t-cell receptor gene |
| US9267123B2 (en) | 2011-01-05 | 2016-02-23 | Sangamo Biosciences, Inc. | Methods and compositions for gene correction |
| US9161995B2 (en) | 2011-07-25 | 2015-10-20 | Sangamo Biosciences, Inc. | Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene |
| US8895264B2 (en) | 2011-10-27 | 2014-11-25 | Sangamo Biosciences, Inc. | Methods and compositions for modification of the HPRT locus |
| NZ629427A (en) | 2012-02-29 | 2016-04-29 | Sangamo Biosciences Inc | Methods and compositions for treating huntington’s disease |
| EP2872154B1 (en) | 2012-07-11 | 2017-05-31 | Sangamo BioSciences, Inc. | Methods and compositions for delivery of biologics |
| US10648001B2 (en) | 2012-07-11 | 2020-05-12 | Sangamo Therapeutics, Inc. | Method of treating mucopolysaccharidosis type I or II |
| DK2890780T3 (da) | 2012-08-29 | 2020-09-21 | Sangamo Therapeutics Inc | Fremgangsmåder og sammensætninger til behandling af en genetisk tilstand |
| WO2014071070A1 (en) * | 2012-11-01 | 2014-05-08 | Pacific Biosciences Of California, Inc. | Compositions and methods for selection of nucleic acids |
| US9290800B2 (en) | 2013-03-15 | 2016-03-22 | Pacific Biosciences Of California, Inc. | Targeted rolling circle amplification |
| RU2723130C2 (ru) | 2013-04-05 | 2020-06-08 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Способы и композиции для встраивания экзогенной последовательности в геном растений |
| CA2920899C (en) | 2013-08-28 | 2023-02-28 | Sangamo Biosciences, Inc. | Compositions for linking dna-binding domains and cleavage domains |
| CN110713995B (zh) | 2013-10-17 | 2023-08-01 | 桑格摩生物科学股份有限公司 | 用于核酸酶介导的基因组工程改造的递送方法和组合物 |
| CA2926078C (en) | 2013-10-17 | 2021-11-16 | Sangamo Biosciences, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells |
| AU2014346424B2 (en) | 2013-11-11 | 2020-09-17 | Sangamo Therapeutics, Inc. | Methods and compositions for treating Huntington's Disease |
| HUE056436T2 (hu) | 2013-11-13 | 2022-02-28 | Childrens Medical Center | Nukleáz közvetítette génexpresszió-szabályozás |
| HUE051232T2 (hu) | 2014-02-03 | 2021-03-01 | Sangamo Therapeutics Inc | Béta-talasszémia kezelésére szolgáló eljárások és készítmények |
| JP6594891B2 (ja) | 2014-03-18 | 2019-10-23 | サンガモ セラピューティクス， インコーポレイテッド | ジンクフィンガータンパク質発現を調節するための方法および組成物 |
| US10435685B2 (en) | 2014-08-19 | 2019-10-08 | Pacific Biosciences Of California, Inc. | Compositions and methods for enrichment of nucleic acids |
| JP6873917B2 (ja) | 2015-05-12 | 2021-05-19 | サンガモ セラピューティクス， インコーポレイテッド | ヌクレアーゼ介在性遺伝子発現調節 |
| US9957501B2 (en) | 2015-06-18 | 2018-05-01 | Sangamo Therapeutics, Inc. | Nuclease-mediated regulation of gene expression |
| CN108024544B (zh) | 2015-07-13 | 2022-04-29 | 桑格摩生物治疗股份有限公司 | 用于核酸酶介导的基因组工程化的递送方法及组合物 |
| AU2016374253B2 (en) | 2015-12-18 | 2021-10-21 | Sangamo Therapeutics, Inc. | Targeted disruption of the MHC cell receptor |
| ES2983043T3 (es) | 2015-12-18 | 2024-10-21 | Sangamo Therapeutics Inc | Alteración dirigida del receptor de células T |
| AU2017207818B2 (en) | 2016-01-15 | 2024-03-28 | Regents Of The University Of Minnesota | Methods and compositions for the treatment of neurologic disease |
| CN109069568B (zh) | 2016-02-02 | 2023-07-07 | 桑格摩生物治疗股份有限公司 | 用于连接dna结合结构域和切割结构域的组合物 |
| BR112019003100A2 (pt) | 2016-08-24 | 2019-07-09 | Sangamo Therapeutics, Inc. | regulação da expressão gênica usando nucleases manipuladas |
| IL300783B2 (en) | 2016-08-24 | 2026-03-01 | Sangamo Therapeutics Inc | Engineered nucleases with target-specific zinc fingers |
| CN110022904B (zh) | 2016-10-20 | 2024-04-19 | 桑格摩生物治疗股份有限公司 | 用于治疗法布里病的方法和组合物 |
| US11020492B2 (en) | 2016-10-31 | 2021-06-01 | Sangamo Therapeutics, Inc. | Gene correction of SCID-related genes in hematopoietic stem and progenitor cells |
| EP3548616A4 (en) | 2016-12-01 | 2020-05-13 | Sangamo Therapeutics, Inc. | TAU MODULATORS AND METHODS AND COMPOSITIONS FOR THEIR ADMINISTRATION |
| EA201992358A1 (ru) | 2017-04-03 | 2020-03-24 | Инкоудид Терапьютикс, Инк. | Тканеселективная экспрессия трансгена |
| ES2981244T3 (es) | 2017-04-28 | 2024-10-07 | Acuitas Therapeutics Inc | Novedosas formulaciones de nanopartículas de lípidos de carbonilo y lípidos para la administración de ácidos nucleicos |
| US11655275B2 (en) | 2017-05-03 | 2023-05-23 | Sangamo Therapeutics, Inc. | Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (CFTR) gene |
| US11512287B2 (en) | 2017-06-16 | 2022-11-29 | Sangamo Therapeutics, Inc. | Targeted disruption of T cell and/or HLA receptors |
| CA3071683A1 (en) | 2017-08-08 | 2019-02-14 | Sangamo Therapeutics, Inc. | Chimeric antigen receptor mediated cell targeting |
| BR112020008568A2 (pt) | 2017-11-09 | 2020-10-06 | Sangamo Therapeutics, Inc. | modificação genética de gene de proteína contendo sh2 indutível por citoquina (cish) |
| JP7401432B2 (ja) | 2017-12-01 | 2023-12-19 | エンコーデッド セラピューティクス， インコーポレイテッド | 操作されたｄｎａ結合タンパク質 |
| CN111954540A (zh) | 2018-02-08 | 2020-11-17 | 桑格摩生物治疗股份有限公司 | 工程化靶标特异性核酸酶 |
| US11421007B2 (en) * | 2018-04-18 | 2022-08-23 | Sangamo Therapeutics, Inc. | Zinc finger protein compositions for modulation of huntingtin (Htt) |
| US11690921B2 (en) | 2018-05-18 | 2023-07-04 | Sangamo Therapeutics, Inc. | Delivery of target specific nucleases |
| EP3841204A4 (en) | 2018-08-23 | 2022-05-18 | Sangamo Therapeutics, Inc. | CHANGED TARGET SPECIFIC BASE EDITORS |
| AU2019344927A1 (en) | 2018-09-18 | 2021-04-01 | Sangamo Therapeutics, Inc. | Programmed cell death 1 (PD1) specific nucleases |
| IL281615B2 (en) | 2018-09-21 | 2026-01-01 | Acuitas Therapeutics Inc | Systems and methods for producing lipid nanoparticles and liposomes |
| KR20210069692A (ko) * | 2018-10-02 | 2021-06-11 | 상가모 테라퓨틱스, 인코포레이티드 | 조작된 유전자 조정제 |
| CN113226333A (zh) | 2018-10-02 | 2021-08-06 | 桑格摩生物治疗股份有限公司 | 用于调控Tau蛋白的方法和组合物 |
| US12583816B2 (en) | 2018-10-18 | 2026-03-24 | Acuitas Therapeutics, Inc. | Lipids for lipid nanoparticle delivery of active agents |
| JP7523449B2 (ja) | 2019-01-11 | 2024-07-26 | アクイタス セラピューティクス インコーポレイテッド | 活性剤の脂質ナノ粒子送達のための脂質 |
| US11857641B2 (en) | 2019-02-06 | 2024-01-02 | Sangamo Therapeutics, Inc. | Method for the treatment of mucopolysaccharidosis type I |
| US20200316116A1 (en) | 2019-04-02 | 2020-10-08 | Sangamo Therapeutics, Inc. | Method for the treatment of beta-thalassemia |
| PH12021552554A1 (en) | 2019-04-23 | 2022-07-04 | Sangamo Therapeutics Inc | Modulators of chromosome 9 open reading frame 72 gene expression and uses thereof |
| JP2022533713A (ja) | 2019-05-21 | 2022-07-25 | サンガモ セラピューティクス， インコーポレイテッド | 調節性ｔ細胞における制御された導入遺伝子発現 |
| WO2020243651A1 (en) | 2019-05-29 | 2020-12-03 | Encoded Therapeutics, Inc. | Compositions and methods for selective gene regulation |
| WO2021028359A1 (en) | 2019-08-09 | 2021-02-18 | Sangamo Therapeutics France | Controlled expression of chimeric antigen receptors in t cells |
| US20220324928A1 (en) | 2019-10-02 | 2022-10-13 | Sangamo Therapeutics, Inc. | Zinc Finger Protein Transcription Factors for Repressing Alpha-Synuclein Expression |
| US20230002459A1 (en) | 2019-10-02 | 2023-01-05 | Sangamo Therapeutics, Inc. | Zinc Finger Protein Transcription Factors for Treatment of Prion Disease |
| US20230048224A1 (en) | 2019-11-01 | 2023-02-16 | Sangamo Therapeutics, Inc. | Zinc finger nuclease variants for treating or preventing lysosomal storage diseases |
| UY39036A (es) | 2020-01-22 | 2021-08-31 | Sangamo Therapeutics Inc | Factores de transcripción de proteína de dedos de zinc para represión de la expresión tau |
| WO2021206910A1 (en) * | 2020-04-09 | 2021-10-14 | The Regents Of The University Of California | Notch receptors with zinc finger-containing transcriptional effector |
| JP7798855B2 (ja) | 2020-07-16 | 2026-01-14 | アクイタス セラピューティクス インコーポレイテッド | 脂質ナノ粒子に使用するためのカチオン性脂質 |
| EP4501951A3 (en) | 2020-08-25 | 2025-04-30 | Kite Pharma, Inc. | T cells with improved functionality |
| KR20230074519A (ko) | 2020-09-25 | 2023-05-30 | 상가모 테라퓨틱스, 인코포레이티드 | 핵염기 편집을 위한 아연 핑거 융합 단백질 |
| WO2022072826A1 (en) | 2020-10-02 | 2022-04-07 | Sangamo Therapeutics, Inc. | Novel zinc finger protein transcription factors for repressing alpha-synuclein expression |
| AU2021409729A1 (en) | 2020-12-22 | 2023-07-13 | Nchroma Bio, Inc. | Compositions and methods for epigenetic editing |
| EP4426832A1 (en) | 2021-11-03 | 2024-09-11 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Precise genome editing using retrons |
| CA3242402A1 (en) | 2021-12-16 | 2023-06-22 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| US20250361528A1 (en) | 2021-12-22 | 2025-11-27 | Sangamo Therapeutics, Inc. | Novel zinc finger fusion proteins for nucleobase editing |
| WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| WO2023215711A1 (en) | 2022-05-01 | 2023-11-09 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of pcsk9 expression |
| WO2023250512A1 (en) | 2022-06-23 | 2023-12-28 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of ciita expression |
| EP4544059A1 (en) | 2022-06-23 | 2025-04-30 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of b2m expression |
| JP2025524455A (ja) | 2022-06-23 | 2025-07-30 | エヌクロマ・バイオ，インコーポレーテッド | Ｔｒａｃ発現のエピジェネティック調節のための組成物及び方法 |
| WO2024044723A1 (en) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| IL319704A (en) | 2022-09-23 | 2025-05-01 | Nchroma Bio Inc | Compositions and methods for epigenetic regulation of HBV gene expression |
| WO2024081879A1 (en) | 2022-10-14 | 2024-04-18 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of cd247 expression |
| IL324634A (en) | 2023-05-15 | 2026-01-01 | Nchroma Bio Inc | Compositions and methods for epigenetic regulation of hbv gene expression |
| WO2025049959A2 (en) | 2023-09-01 | 2025-03-06 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4512110A (en) | 1981-12-10 | 1985-04-23 | Timesavers, Inc. | Endless abrasive belts |
| US5422251A (en) | 1986-11-26 | 1995-06-06 | Princeton University | Triple-stranded nucleic acids |
| US5176996A (en) | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US5420032A (en) | 1991-12-23 | 1995-05-30 | Universitge Laval | Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence |
| US5356802A (en) | 1992-04-03 | 1994-10-18 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease |
| US5436150A (en) | 1992-04-03 | 1995-07-25 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease |
| US5487994A (en) | 1992-04-03 | 1996-01-30 | The Johns Hopkins University | Insertion and deletion mutants of FokI restriction endonuclease |
| US5792632A (en) | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US6242568B1 (en) | 1994-01-18 | 2001-06-05 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| EP0770129B1 (en) | 1994-01-18 | 2005-11-23 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US5585245A (en) | 1994-04-22 | 1996-12-17 | California Institute Of Technology | Ubiquitin-based split protein sensor |
| CA2196419C (en) | 1994-08-20 | 2007-08-21 | Yen Choo | Improvements in or relating to binding proteins for recognition of dna |
| US7285416B2 (en) * | 2000-01-24 | 2007-10-23 | Gendaq Limited | Regulated gene expression in plants |
| GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
| US5789538A (en) | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US5925523A (en) | 1996-08-23 | 1999-07-20 | President & Fellows Of Harvard College | Intraction trap assay, reagents and uses thereof |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| GB2338237B (en) | 1997-02-18 | 2001-02-28 | Actinova Ltd | In vitro peptide or protein expression library |
| US6342345B1 (en) | 1997-04-02 | 2002-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| US6410248B1 (en) | 1998-01-30 | 2002-06-25 | Massachusetts Institute Of Technology | General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites |
| AU746454B2 (en) | 1998-03-02 | 2002-05-02 | Massachusetts Institute Of Technology | Poly zinc finger proteins with improved linkers |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6794136B1 (en) | 2000-11-20 | 2004-09-21 | Sangamo Biosciences, Inc. | Iterative optimization in the design of binding proteins |
| US7151201B2 (en) | 2000-01-21 | 2006-12-19 | The Scripps Research Institute | Methods and compositions to modulate expression in plants |
| WO2001053480A1 (en) * | 2000-01-24 | 2001-07-26 | Sangamo Biosciences, Inc. | Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules |
| DE60143192D1 (de) | 2000-02-08 | 2010-11-18 | Sangamo Biosciences Inc | Zellen zur entdeckung von medikamenten |
| US20020061512A1 (en) | 2000-02-18 | 2002-05-23 | Kim Jin-Soo | Zinc finger domains and methods of identifying same |
| US20030044787A1 (en) | 2000-05-16 | 2003-03-06 | Joung J. Keith | Methods and compositions for interaction trap assays |
| US20060268407A1 (en) | 2000-07-07 | 2006-11-30 | Fergason James L | Display system using two displays and polarization direction rotation for showing high-resolution and three-dimensional images and method and use of a DBEF beam splitter |
| JP2002060786A (ja) | 2000-08-23 | 2002-02-26 | Kao Corp | 硬質表面用殺菌防汚剤 |
| US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| GB0108491D0 (en) | 2001-04-04 | 2001-05-23 | Gendaq Ltd | Engineering zinc fingers |
| US20040197892A1 (en) | 2001-04-04 | 2004-10-07 | Michael Moore | Composition binding polypeptides |
| WO2003016496A2 (en) | 2001-08-20 | 2003-02-27 | The Scripps Research Institute | Zinc finger binding domains for cnn |
| US7262054B2 (en) | 2002-01-22 | 2007-08-28 | Sangamo Biosciences, Inc. | Zinc finger proteins for DNA binding and gene regulation in plants |
| AU2003274404A1 (en) * | 2002-06-11 | 2003-12-22 | The Scripps Research Institute | Artificial transcription factors |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| US7407776B2 (en) | 2003-09-19 | 2008-08-05 | Sangamo Biosciences, Inc. | Engineered zinc finger proteins for regulation of gene expression |
| KR20060123382A (ko) * | 2003-12-23 | 2006-12-01 | 주식회사 툴젠 | 징크 핑거 단백질을 이용한 원핵세포의 유전자 발현 조절 |
| US7972854B2 (en) | 2004-02-05 | 2011-07-05 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| EP1737498A2 (en) | 2004-04-08 | 2007-01-03 | Sangamo Biosciences Inc. | Zinc finger proteins for treatment of neuropathic pain |
| EP2292274A1 (en) | 2004-09-16 | 2011-03-09 | Sangamo BioSciences, Inc. | Compositions and methods for protein production |
| MX2007013757A (es) | 2005-05-05 | 2008-01-24 | Univ Arizona | Reagrupacion permitida de secuencia (seer)-met odo de novedad para visualizar secuencias de adn especificas. |
| WO2007014275A2 (en) | 2005-07-26 | 2007-02-01 | Sangamo Biosciences, Inc. | Targeted integration and expression of exogenous nucleic acid sequences |
| EP2650366B1 (en) | 2005-10-18 | 2017-03-22 | Precision Biosciences | Rationally designed meganucleases with altered sequence specificity and DNA-binding affinity |
| WO2007136685A2 (en) | 2006-05-19 | 2007-11-29 | Sangamo Biosciences, Inc. | Methods and compositions for inactivation of dihydrofolate reductase |
| JP5266210B2 (ja) | 2006-05-25 | 2013-08-21 | サンガモ バイオサイエンシズ インコーポレイテッド | 改変開裂ハーフドメイン |
| ES2465996T3 (es) | 2006-05-25 | 2014-06-09 | Sangamo Biosciences, Inc. | Métodos y composiciones para la inactivación genética |
| WO2008060510A2 (en) | 2006-11-13 | 2008-05-22 | Sangamo Biosciences, Inc. | Zinc finger nuclease for targeting the human glucocorticoid receptor locus |
| CA2684378C (en) | 2007-04-26 | 2016-11-29 | Sangamo Biosciences, Inc. | Targeted integration into the ppp1r12c locus |
| EP2188384B1 (en) | 2007-09-27 | 2015-07-15 | Sangamo BioSciences, Inc. | Rapid in vivo identification of biologically active nucleases |
| CA2767377A1 (en) * | 2009-07-24 | 2011-01-27 | Sigma-Aldrich Co. Llc | Method for genome editing |
-
2011
- 2011-05-02 PL PL11777690T patent/PL2566972T3/pl unknown
- 2011-05-02 EP EP19211724.0A patent/EP3636766A1/en active Pending
- 2011-05-02 JP JP2013509041A patent/JP5898179B2/ja not_active Expired - Fee Related
- 2011-05-02 AU AU2011249019A patent/AU2011249019B2/en active Active
- 2011-05-02 CA CA2797189A patent/CA2797189C/en active Active
- 2011-05-02 EP EP11777690.6A patent/EP2566972B1/en active Active
- 2011-05-02 WO PCT/US2011/000758 patent/WO2011139349A1/en not_active Ceased
- 2011-05-02 SI SI201131844T patent/SI2566972T1/sl unknown
- 2011-05-02 KR KR1020187017770A patent/KR101974036B1/ko active Active
- 2011-05-02 LT LTEP11777690.6T patent/LT2566972T/lt unknown
- 2011-05-02 ES ES11777690T patent/ES2773052T3/es active Active
- 2011-05-02 HR HRP20200254TT patent/HRP20200254T1/hr unknown
- 2011-05-02 US US13/068,102 patent/US8772453B2/en active Active
- 2011-05-02 DK DK11777690.6T patent/DK2566972T3/da active
- 2011-05-02 CN CN201180022329.2A patent/CN102959087B/zh active Active
- 2011-05-02 PT PT117776906T patent/PT2566972T/pt unknown
- 2011-05-02 KR KR1020127028770A patent/KR20130073887A/ko not_active Ceased
- 2011-05-02 HU HUE11777690A patent/HUE048072T2/hu unknown
-
2012
- 2012-10-23 IL IL222632A patent/IL222632B/en active IP Right Grant
-
2014
- 2014-06-04 US US14/296,159 patent/US9163245B2/en active Active
-
2020
- 2020-02-14 CY CY20201100140T patent/CY1122636T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5898179B2 (ja) | 2016-04-06 |
| US9163245B2 (en) | 2015-10-20 |
| EP3636766A1 (en) | 2020-04-15 |
| EP2566972B1 (en) | 2020-01-15 |
| PT2566972T (pt) | 2020-03-02 |
| HUE048072T2 (hu) | 2020-05-28 |
| CA2797189A1 (en) | 2011-11-10 |
| US8772453B2 (en) | 2014-07-08 |
| KR101974036B1 (ko) | 2019-04-30 |
| DK2566972T3 (da) | 2020-02-17 |
| KR20180077284A (ko) | 2018-07-06 |
| IL222632A0 (en) | 2012-12-31 |
| EP2566972A1 (en) | 2013-03-13 |
| AU2011249019B2 (en) | 2015-01-22 |
| WO2011139349A1 (en) | 2011-11-10 |
| KR20130073887A (ko) | 2013-07-03 |
| IL222632B (en) | 2018-12-31 |
| SI2566972T1 (sl) | 2020-04-30 |
| CN102959087A (zh) | 2013-03-06 |
| CN102959087B (zh) | 2015-04-29 |
| CA2797189C (en) | 2020-05-26 |
| HRP20200254T1 (hr) | 2020-05-29 |
| JP2013527765A (ja) | 2013-07-04 |
| US20110287512A1 (en) | 2011-11-24 |
| ES2773052T3 (es) | 2020-07-09 |
| LT2566972T (lt) | 2020-03-10 |
| EP2566972A4 (en) | 2014-01-01 |
| CY1122636T1 (el) | 2021-03-12 |
| US20140287500A1 (en) | 2014-09-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL222632A0 (en) | Compositions for linking zinc finger modules | |
| HRP20181658T1 (hr) | Kruti pripravci | |
| SI2640893T1 (sl) | Sestavki | |
| ZA201207093B (en) | Solid compositions | |
| GB201009549D0 (en) | Compositions | |
| GB201119596D0 (en) | Improved compositions | |
| GB201009546D0 (en) | Compositions | |
| GB201010954D0 (en) | Compositions | |
| EP2625231A4 (en) | INK PRESERVATIVE COMPOSITIONS | |
| GB201002861D0 (en) | Compositions | |
| IL225952A0 (en) | preparations@rokkhot | |
| GB201014591D0 (en) | Compositions | |
| GB201007790D0 (en) | Compositions | |
| PL2549850T3 (pl) | Miotła wachlarzowa | |
| GB201018314D0 (en) | Lead | |
| GB201019606D0 (en) | Compositions | |
| GB201008043D0 (en) | Compositions | |
| TWM385393U (en) | Linking component | |
| GB201012508D0 (en) | Compositions | |
| GB201012588D0 (en) | Compositions | |
| GB201008369D0 (en) | Compositions | |
| GB201012760D0 (en) | MustPush rake | |
| PH32010000321S1 (en) | Lead case | |
| PL118949U1 (pl) | Zgrabiarka dwukaruzelowa |