PL2601196T3 - N-demetylowanie 6-ketomorfinanów - Google Patents

N-demetylowanie 6-ketomorfinanów

Info

Publication number: PL2601196T3
Authority: PL; Poland
Prior art keywords: demethylation; morphinans; keto; keto morphinans
Prior art date: 2010-08-04

Application number

PL11746372T

Other languages

English (en)

Inventor

Peter X Wang

Tao Jiang

David W Berberich

Subo Liao

Original Assignee

Mallinckrodt Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-08-04

Filing date

2011-08-03

Publication date

2014-09-30

2011-08-03 Application filed by Mallinckrodt Llc filed Critical Mallinckrodt Llc

2014-09-30 Publication of PL2601196T3 publication Critical patent/PL2601196T3/pl

Links

XUSCOHKHRDQKCI-ARFHVFGLSA-N (1S,9R,10R)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-13-one Chemical class C1C(=O)CC[C@H]2[C@]3([H])NCC[C@@]21C1=CC=CC=C1C3 XUSCOHKHRDQKCI-ARFHVFGLSA-N 0.000 title 1
238000010520 demethylation reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL11746372T 2010-08-04 2011-08-03 N-demetylowanie 6-ketomorfinanów PL2601196T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US37065310P	2010-08-04	2010-08-04
PCT/US2011/046345 WO2012018872A1 (en)	2010-08-04	2011-08-03	N-demethylation of 6-keto morphinans
EP11746372.9A EP2601196B1 (en)	2010-08-04	2011-08-03	N-demethylation of 6-keto morphinans

Publications (1)

Publication Number	Publication Date
PL2601196T3 true PL2601196T3 (pl)	2014-09-30

Family

ID=44513172

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL11746372T PL2601196T3 (pl)	2010-08-04	2011-08-03	N-demetylowanie 6-ketomorfinanów

Country Status (8)

Country	Link
US (1)	US8624030B2 (pl)
EP (1)	EP2601196B1 (pl)
JP (2)	JP2013532731A (pl)
AU (1)	AU2011285840B2 (pl)
CA (1)	CA2806596A1 (pl)
ES (1)	ES2470315T3 (pl)
PL (1)	PL2601196T3 (pl)
WO (1)	WO2012018872A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ME03468B (me)	2009-12-04	2020-01-20	Alkermes Pharma Ireland Ltd	Derivati morfinana za liječenje predoziranja lijekom
US8624030B2 (en) *	2010-08-04	2014-01-07	Mallinckrodt Llc	N-demethylation of 6-keto morphinans
WO2012018871A1 (en) *	2010-08-04	2012-02-09	Mallinckrodt Llc	Tandem process for preparing n-alkyl morphinans
ES2969625T3 (es)	2010-08-23	2024-05-21	Alkermes Pharma Ireland Ltd	Procedimientos para tratar el aumento de peso inducido por antipsicóticos
US9211293B2 (en)	2011-12-15	2015-12-15	Alkermes Pharma Ireland Limited	Opioid agonist antagonist combinations
US20160244459A1 (en)	2013-05-24	2016-08-25	Rhodes Technologies	Opioid ketal compounds and uses thereof
BR112016010098A2 (pt) *	2013-11-18	2021-07-06	Mallinckrodt Llc	Preparação de normorfinanos
EP4243768A1 (en)	2020-11-12	2023-09-20	Alkermes Pharma Ireland Limited	Immediate release multilayer tablet

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9713703D0 (en) *	1997-06-30	1997-09-03	Johnson Matthey Plc	Preparation of opiates
CA2709882A1 (en) *	2007-12-17	2009-06-25	Peter X. Wang	N-demethylation of n-methyl morphinans
EP2231674A1 (en) *	2007-12-17	2010-09-29	Mallinckrodt Inc.	Processes for the preparation of normorphinan salts
US8624030B2 (en) *	2010-08-04	2014-01-07	Mallinckrodt Llc	N-demethylation of 6-keto morphinans

2011
- 2011-08-03 US US13/196,929 patent/US8624030B2/en active Active
- 2011-08-03 JP JP2013523294A patent/JP2013532731A/ja active Pending
- 2011-08-03 EP EP11746372.9A patent/EP2601196B1/en not_active Not-in-force
- 2011-08-03 ES ES11746372.9T patent/ES2470315T3/es active Active
- 2011-08-03 CA CA2806596A patent/CA2806596A1/en not_active Abandoned
- 2011-08-03 AU AU2011285840A patent/AU2011285840B2/en not_active Ceased
- 2011-08-03 PL PL11746372T patent/PL2601196T3/pl unknown
- 2011-08-03 WO PCT/US2011/046345 patent/WO2012018872A1/en not_active Ceased
2015
- 2015-07-29 JP JP2015149359A patent/JP2015193658A/ja active Pending

Also Published As

Publication number	Publication date
US8624030B2 (en)	2014-01-07
WO2012018872A1 (en)	2012-02-09
US20120035366A1 (en)	2012-02-09
AU2011285840B2 (en)	2014-07-10
AU2011285840A1 (en)	2013-03-21
EP2601196B1 (en)	2014-04-30
JP2015193658A (ja)	2015-11-05
CA2806596A1 (en)	2012-02-09
ES2470315T3 (es)	2014-06-23
EP2601196A1 (en)	2013-06-12
JP2013532731A (ja)	2013-08-19

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