PL2603512T3 - Pochodne 6,7-dihydro-3h-oksazolo[3,4-a]pirazyno-5,8-dionu - Google Patents

Pochodne 6,7-dihydro-3h-oksazolo[3,4-a]pirazyno-5,8-dionu

Info

Publication number
PL2603512T3
PL2603512T3 PL11815927.6T PL11815927T PL2603512T3 PL 2603512 T3 PL2603512 T3 PL 2603512T3 PL 11815927 T PL11815927 T PL 11815927T PL 2603512 T3 PL2603512 T3 PL 2603512T3
Authority
PL
Poland
Prior art keywords
oksazolo
dion
pyrazine
dihydro
derivatives
Prior art date
Application number
PL11815927.6T
Other languages
English (en)
Inventor
Sérgio Luiz Sacurai
Márcio Henrique Zaim
Carlos Eduardo Da Costa Touzarim
Artur Franz Keppler
Nucci Gilberto De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2603512T3 publication Critical patent/PL2603512T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D503/02—Preparation
    • C07D503/04—Preparation by forming the ring or condensed ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL11815927.6T 2010-08-13 2011-08-02 Pochodne 6,7-dihydro-3h-oksazolo[3,4-a]pirazyno-5,8-dionu PL2603512T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37348310P 2010-08-13 2010-08-13

Publications (1)

Publication Number Publication Date
PL2603512T3 true PL2603512T3 (pl) 2016-09-30

Family

ID=45023415

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11815927.6T PL2603512T3 (pl) 2010-08-13 2011-08-02 Pochodne 6,7-dihydro-3h-oksazolo[3,4-a]pirazyno-5,8-dionu

Country Status (21)

Country Link
US (1) US8338432B2 (pl)
EP (1) EP2603512B1 (pl)
JP (1) JP5940535B2 (pl)
KR (1) KR101871856B1 (pl)
CN (1) CN103108878B (pl)
AR (1) AR082661A1 (pl)
BR (1) BR112013003225B1 (pl)
CA (1) CA2807872C (pl)
CL (1) CL2013000434A1 (pl)
CO (1) CO6680703A2 (pl)
DK (1) DK2603512T3 (pl)
EC (1) ECSP13012486A (pl)
ES (1) ES2565493T3 (pl)
HU (1) HUE027903T2 (pl)
IL (1) IL224683A (pl)
MX (1) MX347632B (pl)
PL (1) PL2603512T3 (pl)
PY (1) PY1132289A (pl)
RU (1) RU2581831C2 (pl)
UY (1) UY33535A (pl)
WO (1) WO2012019254A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY33535A (es) * 2010-08-13 2011-12-01 Biolab Sanus Farmaceutuca Limitada Derivados de 6,7-dihidro-3h-oxazolo[3,4]pirazin-5,8-diona
AR099523A1 (es) * 2014-02-24 2016-07-27 Biolab Sanus Farmacêutica Ltda Compuestos derivados de 6,7-dihidro-3h-oxazolo[3,4-a]pirazina-5,8-diona
HUE040387T2 (hu) * 2014-09-12 2019-03-28 Biolab Sanus Farmaceutica Ltda Piridopirimidin-származékok
US20220296590A1 (en) * 2019-07-15 2022-09-22 Biolab Sanus Farmaceutica Ltda Stereoisomers of the compound 3-(benzo[d][1,3]dioxol-5-yl)-7-(1-hydroxypropan-2-yl)-1-(1h-indol-3-yl)-6,7-dihydro-3h-oxazol[3,4-a]pyrazine-5,8-dione and use thereof as an antitumor agent and phosphodiesterase enzyme inhibitor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026940A1 (en) 1995-03-01 1996-09-06 Kyowa Hakko Kogyo Co., Ltd. Imidazoquinazoline derivatives
GB9514464D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Medicaments
US7098209B2 (en) * 2001-06-05 2006-08-29 Lilly Icos Llc Pyrazino [1'2':1,6 ] pyrido [3, 4-b] indole-1,4-dione derivatives
ES2269679T3 (es) * 2001-06-21 2007-04-01 Lilly Icos Llc Derivados de carbolina como inhibidores de pdev.
AR045950A1 (es) * 2003-10-09 2005-11-16 Speedel Experimenta Ag Compuestos derivados de piperazina, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos.
DK1742950T3 (da) 2004-04-07 2009-03-16 Pfizer Ltd Pyrazolo-[4,3-D]-pyrimidiner
RU2418590C2 (ru) * 2006-04-04 2011-05-20 Донг-А Фарматех Ко. Лтд. Средство для предупреждения и лечения гиперплазии предстательной железы, содержащее производное пиразолопиримидинона
BRPI0903803B1 (pt) * 2009-09-30 2019-07-09 Biolab Sanus Farmacêutica Ltda. Composto, processo de preparação, composição farmacêutica e uso dos compostos
UY33535A (es) * 2010-08-13 2011-12-01 Biolab Sanus Farmaceutuca Limitada Derivados de 6,7-dihidro-3h-oxazolo[3,4]pirazin-5,8-diona

Also Published As

Publication number Publication date
CL2013000434A1 (es) 2013-06-07
JP5940535B2 (ja) 2016-06-29
UY33535A (es) 2011-12-01
CA2807872C (en) 2018-07-24
KR20130109110A (ko) 2013-10-07
BR112013003225A2 (pt) 2016-06-07
MX2013001692A (es) 2013-03-18
WO2012019254A1 (en) 2012-02-16
DK2603512T3 (en) 2016-04-04
EP2603512B1 (en) 2015-12-30
ES2565493T3 (es) 2016-04-05
CN103108878B (zh) 2016-01-27
CN103108878A (zh) 2013-05-15
AR082661A1 (es) 2012-12-26
EP2603512A4 (en) 2014-07-16
PY1132289A (es) 2015-04-01
CO6680703A2 (es) 2013-05-31
HUE027903T2 (hu) 2016-11-28
CA2807872A1 (en) 2012-02-16
IL224683A (en) 2016-03-31
US8338432B2 (en) 2012-12-25
HK1184786A1 (zh) 2014-01-30
JP2013533290A (ja) 2013-08-22
MX347632B (es) 2017-05-04
US20120040988A1 (en) 2012-02-16
KR101871856B1 (ko) 2018-06-28
ECSP13012486A (es) 2013-04-30
RU2581831C2 (ru) 2016-04-20
EP2603512A1 (en) 2013-06-19
RU2013110795A (ru) 2014-09-20
BR112013003225B1 (pt) 2021-03-30

Similar Documents

Publication Publication Date Title
FR17C1040I2 (fr) Derive antiviraux de 2,5-dibenzimidazol-5-yl-1-phenyl-pyrrolidine
ZA201205788B (en) 1,2,4-triazine-4-amine derivatives
EP2762476A4 (en) 1,2,4-triazine-6-carboxamide derivative
FR2962442B1 (fr) Composition stable de 2,3,3,3-tetrafluoropropene
CU24152B1 (es) 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr
PL2630108T3 (pl) Sposób wytwarzania 2,3,3,3-tetrafluoropropenu
BR112012028519A2 (pt) compostos de 2,5,6,7-tetrahidro-[1,4]oxazepin-3-ilamina ou 2,3,6,7-tetrahidro-[1,4]oxazepin-5-ilamina
DK2590974T3 (da) Tetrahydropyridopyrimidinderivater
LT2616102T (lt) Provaistas, apimantis eksendino-linkerio konjugatą
IL221029B (en) Targeted genomic alteration
EP2563129A4 (en) N3-SUBSTITUTED N1-SULFONYL-5-FLUORPYRIMIDINONE DERIVATIVES
PT2641343T (pt) Configuração de subtrama
UY33125A (es) Diaza-espiro-[5,5]-undecanos
DK3070091T3 (da) Benzodioxolderivater som phosphodiesterasehæmmere
FIC20260012I1 (fi) Molidustaatti, erityisesti molidustaattinatrium
DE112011102080A5 (de) Kupplungszentralausrücker
ITMI20110483A1 (it) Durometro.
PL2623499T3 (pl) Pochodne 1,2,4-triazolonu
BR112013007056A2 (pt) compostos de imina
EP2558094A4 (en) pyridone derivatives
EP2635274A4 (en) CELECOXIB DERIVATIVES AGAINST STAPHYLOKOKEN
EP2628733A4 (en) ACYLBENZEN DERIVATIVE
BR112013011418A8 (pt) derivado de pirazino [2,3-d] isoxadol
EP2603512A4 (en) DERIVATIVES OF 6,7-DIHYDRO-3H-OXAZOLO- [3,4-A] PYRAZIN-5,8-DION
BR112013007492A2 (pt) glicodendrímeros de polipropileterimina