DK3070091T3 - Benzodioxolderivater som phosphodiesterasehæmmere - Google Patents

Benzodioxolderivater som phosphodiesterasehæmmere Download PDF

Info

Publication number: DK3070091T3
Authority: DK; Denmark
Prior art keywords: phosphodyesterase; benzodioxoler; derivatives; benzodioxoler derivatives
Prior art date: 2010-06-24

Application number

DK16020112.5T

Other languages

English (en)

Inventor

Simon Feldbæk Nielsen

Original Assignee

Leo Pharma As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-06-24

Filing date

2011-06-24

Publication date

2019-07-08

2011-06-24 Application filed by Leo Pharma As filed Critical Leo Pharma As

2019-07-08 Application granted granted Critical

2019-07-08 Publication of DK3070091T3 publication Critical patent/DK3070091T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Immunology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Obesity (AREA)
Otolaryngology (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Hematology (AREA)

DK16020112.5T 2010-06-24 2011-06-24 Benzodioxolderivater som phosphodiesterasehæmmere DK3070091T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US35820910P	2010-06-24	2010-06-24
EP11729889.3A EP2585469B1 (en)	2010-06-24	2011-06-24	Benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors

Publications (1)

Publication Number	Publication Date
DK3070091T3 true DK3070091T3 (da)	2019-07-08

Family

ID=44351701

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK16020112.5T DK3070091T3 (da)	2010-06-24	2011-06-24	Benzodioxolderivater som phosphodiesterasehæmmere
DK11729889.3T DK2585469T3 (da)	2010-06-24	2011-06-24	Heterocykliske benzodioxol- eller benzodioxepinforbindelser som phosphodiesterasehæmmere

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK11729889.3T DK2585469T3 (da)	2010-06-24	2011-06-24	Heterocykliske benzodioxol- eller benzodioxepinforbindelser som phosphodiesterasehæmmere

Country Status (29)

Country	Link
US (3)	US8980905B2 (da)
EP (2)	EP3070091B1 (da)
JP (2)	JP6174997B2 (da)
KR (1)	KR101864578B1 (da)
CN (1)	CN102958937B (da)
AU (1)	AU2011269429B2 (da)
BR (1)	BR112012032813B1 (da)
CA (1)	CA2802895C (da)
CY (2)	CY1117862T1 (da)
DK (2)	DK3070091T3 (da)
ES (2)	ES2733092T3 (da)
HR (2)	HRP20160919T1 (da)
HU (2)	HUE044301T2 (da)
IL (1)	IL223329A (da)
LT (2)	LT2585469T (da)
MX (1)	MX2012014131A (da)
MY (1)	MY157481A (da)
NZ (1)	NZ603895A (da)
PL (2)	PL3070091T3 (da)
PT (2)	PT3070091T (da)
RS (2)	RS58945B1 (da)
RU (1)	RU2583787C2 (da)
SG (1)	SG186140A1 (da)
SI (2)	SI2585469T1 (da)
TR (1)	TR201909709T4 (da)
TW (1)	TWI507410B (da)
UA (1)	UA109140C2 (da)
WO (1)	WO2011160632A1 (da)
ZA (1)	ZA201209031B (da)

Families Citing this family (16)

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US9855285B2 (en) *	2012-11-30	2018-01-02	Leo Pharma A/S	Method of inhibiting the expression of IL-22 in activated T-cells
RU2697251C2 (ru) *	2014-06-23	2019-08-13	Лео Фарма А/С	Способы получения 1, 3-бензодиоксольных гетероциклических соединений
WO2017089347A1 (en)	2015-11-25	2017-06-01	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
CN114085234B (zh) *	2015-12-18	2024-12-17	联合疗法公司	用于制备1,3-苯并间二氧杂环戊烯杂环化合物的方法
KR102676384B1 (ko) *	2017-06-20	2024-06-20	유니온 테라퓨틱스 에이/에스	1,3-벤조디옥솔 헤테로시클릭 화합물의 제조방법
DK3724196T3 (da)	2017-12-15	2023-01-16	Union Therapeutics As	Substituerede azetidindihydrothienopyridiner og anvendelse deraf som phosphodiesterasehæmmere
SG11202009438UA (en)	2018-04-18	2020-11-27	Constellation Pharmaceuticals Inc	Modulators of methyl modifying enzymes, compositions and uses thereof
CN112262143A (zh)	2018-05-21	2021-01-22	星座制药公司	甲基修饰酶的调节剂、其组合物和用途
MX2021008536A (es)	2019-01-15	2021-11-12	Union Therapeutics As	Formulaciones en comprimidos de liberacion modificada que contienen inhibidores de fosfodiesterasa.
PH12022550188A1 (en)	2019-07-24	2022-11-21	Constellation Pharmaceuticals Inc	Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide
IL326442A (en) *	2019-07-24	2026-04-01	Constellation Pharmaceuticals Inc	EZH2 inhibition in combination therapies for cancer treatment
CN112552276B (zh) *	2019-09-25	2023-03-21	中国科学院上海药物研究所	苯并氧杂卓-5-酮类化合物及其制备方法和用途
AU2022245186A1 (en) *	2021-03-22	2023-10-05	UNION therapeutics A/S	Treatment of hidradenitis suppurativa with orismilast
GB202205715D0 (en)	2022-04-19	2022-06-01	Union Therapeutics As	Treatment of neutrophilic dermatoses
GB202306662D0 (en)	2023-05-05	2023-06-21	Union Therapeutics As	Dosage regimen
GB202306663D0 (en)	2023-05-05	2023-06-21	Union Therapeutics As	Combination therapy

Family Cites Families (11)

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DE59410119D1 (de) *	1993-07-02	2002-06-20	Byk Gulden Lomberg Chem Fab	Fluoralkoxy substituierte benzamide und ihre verwendung als zyklisch-nukleotid phosphodiesterase-inhibitoren
GB9507297D0 (en)	1995-04-07	1995-05-31	Rh Ne Poulenc Rorer Limited	New composition of matter
AU705690B2 (en) *	1995-05-19	1999-05-27	Kyowa Hakko Kogyo Co. Ltd.	Oxygen-containing heterocyclic compounds
TR199802386T2 (xx) *	1996-05-20	1999-02-22	Darwin Discovery Limited	Benzofuran karboksamidler ve bunlar�n terap�tik kullan�m�.
WO1998022455A1 (en) *	1996-11-19	1998-05-28	Kyowa Hakko Kogyo Co., Ltd.	Oxygenic heterocyclic compounds
JP2005060375A (ja) *	2003-07-28	2005-03-10	Kyowa Hakko Kogyo Co Ltd	含酸素複素環化合物
DE10360792A1 (de) *	2003-12-23	2005-07-28	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate
AP2334A (en) *	2004-12-17	2011-12-06	Glenmark Pharmaceuticals Sa	Novel heterocyclic compounds useful for the treatment of inflamatory and allergic disorders.
KR101571654B1 (ko) *	2007-02-28	2015-11-25	레오 파마 에이/에스	신규한 포스포디에스테라제 억제제
UA98639C2 (en) *	2007-02-28	2012-06-11	Лео Фарма А/С	Phosphodiesterase inhibitors
WO2013092739A1 (en) *	2011-12-21	2013-06-27	Leo Pharma A/S	[1,2,4]triazolopyridines and their use as phospodiesterase inhibitors

2011
- 2011-06-24 NZ NZ603895A patent/NZ603895A/en unknown
- 2011-06-24 EP EP16020112.5A patent/EP3070091B1/en active Active
- 2011-06-24 WO PCT/DK2011/000069 patent/WO2011160632A1/en not_active Ceased
- 2011-06-24 KR KR1020137001855A patent/KR101864578B1/ko active Active
- 2011-06-24 PT PT16020112T patent/PT3070091T/pt unknown
- 2011-06-24 PL PL16020112T patent/PL3070091T3/pl unknown
- 2011-06-24 RU RU2013103079/04A patent/RU2583787C2/ru active
- 2011-06-24 HR HRP20160919TT patent/HRP20160919T1/hr unknown
- 2011-06-24 DK DK16020112.5T patent/DK3070091T3/da active
- 2011-06-24 BR BR112012032813-1A patent/BR112012032813B1/pt active IP Right Grant
- 2011-06-24 LT LTEP11729889.3T patent/LT2585469T/lt unknown
- 2011-06-24 MX MX2012014131A patent/MX2012014131A/es active IP Right Grant
- 2011-06-24 HU HUE16020112 patent/HUE044301T2/hu unknown
- 2011-06-24 UA UAA201300812A patent/UA109140C2/uk unknown
- 2011-06-24 TW TW100122303A patent/TWI507410B/zh active
- 2011-06-24 PL PL11729889T patent/PL2585469T3/pl unknown
- 2011-06-24 ES ES16020112T patent/ES2733092T3/es active Active
- 2011-06-24 CN CN201180031069.5A patent/CN102958937B/zh active Active
- 2011-06-24 EP EP11729889.3A patent/EP2585469B1/en active Active
- 2011-06-24 CA CA2802895A patent/CA2802895C/en active Active
- 2011-06-24 TR TR2019/09709T patent/TR201909709T4/tr unknown
- 2011-06-24 AU AU2011269429A patent/AU2011269429B2/en active Active
- 2011-06-24 MY MYPI2012005553A patent/MY157481A/en unknown
- 2011-06-24 LT LTEP16020112.5T patent/LT3070091T/lt unknown
- 2011-06-24 DK DK11729889.3T patent/DK2585469T3/da active
- 2011-06-24 JP JP2013515698A patent/JP6174997B2/ja active Active
- 2011-06-24 RS RS20190851A patent/RS58945B1/sr unknown
- 2011-06-24 HU HUE11729889A patent/HUE030081T2/en unknown
- 2011-06-24 RS RS20160581A patent/RS55104B1/sr unknown
- 2011-06-24 SG SG2012088761A patent/SG186140A1/en unknown
- 2011-06-24 SI SI201130896A patent/SI2585469T1/sl unknown
- 2011-06-24 US US13/806,659 patent/US8980905B2/en active Active
- 2011-06-24 PT PT117298893T patent/PT2585469T/pt unknown
- 2011-06-24 ES ES11729889.3T patent/ES2584055T3/es active Active
- 2011-06-24 SI SI201131743T patent/SI3070091T1/sl unknown
2012
- 2012-11-28 IL IL223329A patent/IL223329A/en active IP Right Grant
- 2012-11-29 ZA ZA2012/09031A patent/ZA201209031B/en unknown
2014
- 2014-12-30 US US14/586,681 patent/US9273064B2/en active Active
2015
- 2015-10-01 US US14/872,487 patent/US9637499B2/en active Active
2016
- 2016-03-16 JP JP2016052707A patent/JP2016164168A/ja active Pending
- 2016-07-28 CY CY20161100745T patent/CY1117862T1/el unknown
2019
- 2019-06-21 HR HRP20191136TT patent/HRP20191136T1/hr unknown
- 2019-06-28 CY CY20191100679T patent/CY1122201T1/el unknown

Also Published As

Publication number	Publication date
CN102958937B (zh)	2016-03-30
BR112012032813A2 (pt)	2016-11-08
IL223329A0 (en)	2013-02-03
SI3070091T1 (sl)	2019-08-30
JP6174997B2 (ja)	2017-08-02
ZA201209031B (en)	2014-02-26
HUE030081T2 (en)	2017-04-28
ES2584055T3 (es)	2016-09-23
US20150111915A1 (en)	2015-04-23
TR201909709T4 (tr)	2019-07-22
SG186140A1 (en)	2013-01-30
TWI507410B (zh)	2015-11-11
HK1182699A1 (zh)	2013-12-06
SI2585469T1 (sl)	2016-11-30
US9637499B2 (en)	2017-05-02
DK2585469T3 (da)	2016-08-29
UA109140C2 (uk)	2015-07-27
CA2802895C (en)	2019-05-21
HRP20160919T1 (hr)	2016-10-07
JP2013529602A (ja)	2013-07-22
AU2011269429B2 (en)	2015-07-09
US20160022657A1 (en)	2016-01-28
PL3070091T3 (pl)	2019-09-30
MX2012014131A (es)	2013-01-29
KR101864578B1 (ko)	2018-06-07
PT2585469T (pt)	2016-08-29
AU2011269429A1 (en)	2012-12-20
CN102958937A (zh)	2013-03-06
RU2583787C2 (ru)	2016-05-10
BR112012032813B1 (pt)	2022-02-01
EP2585469A1 (en)	2013-05-01
HUE044301T2 (hu)	2019-10-28
CA2802895A1 (en)	2011-12-29
PT3070091T (pt)	2019-07-22
NZ603895A (en)	2014-10-31
RS55104B1 (sr)	2016-12-30
HRP20191136T1 (hr)	2019-09-20
EP3070091A1 (en)	2016-09-21
CY1122201T1 (el)	2020-11-25
IL223329A (en)	2017-01-31
LT3070091T (lt)	2019-07-25
PL2585469T3 (pl)	2017-07-31
TW201206940A (en)	2012-02-16
US9273064B2 (en)	2016-03-01
CY1117862T1 (el)	2017-05-17
EP2585469B1 (en)	2016-05-25
KR20130038341A (ko)	2013-04-17
ES2733092T3 (es)	2019-11-27
RU2013103079A (ru)	2014-07-27
US8980905B2 (en)	2015-03-17
LT2585469T (lt)	2016-10-10
JP2016164168A (ja)	2016-09-08
RS58945B1 (sr)	2019-08-30
US20130123291A1 (en)	2013-05-16
WO2011160632A1 (en)	2011-12-29
EP3070091B1 (en)	2019-04-17
MY157481A (en)	2016-06-15

Publication	Publication Date	Title
DK2590974T3 (da)	2014-07-28	Tetrahydropyridopyrimidinderivater
EP2563129A4 (en)	2013-08-07	N3-SUBSTITUTED N1-SULFONYL-5-FLUORPYRIMIDINONE DERIVATIVES
PT2684880T (pt)	2018-04-27	Derivado de dispiropirrolidina
CO6890099A2 (es)	2014-03-10	Nuevos derivados dihidroquinolina-2-ona
DK3124483T3 (da)	2019-09-02	Pyrazolaminopyrimidin-derivater som LRRK2-modulatorer
DK2421825T3 (da)	2014-02-03	Azetidinyldiamider som monoacylglycerollipase-inhibitorer
PL2614063T3 (pl)	2016-06-30	Podstawione imidazopirydazyny
DK3225404T3 (da)	2020-02-10	Fluidpatron
EP2578585A4 (en)	2013-10-23	Purinone derivative
BR112012028556A2 (pt)	2014-04-01	Indóis
DE102011100241A8 (de)	2012-03-01	Nitridhalbleiterbauteil
CR20130111A (es)	2013-05-29	Triazina-oxidiazoles
DE10170954T8 (de)	2013-04-25	Mikrowellendruckgarer
EP2529782A4 (en)	2013-09-11	INTRODUCER SLEEVE ASSEMBLY
DE112011104226A5 (de)	2013-09-26	Käfigmutter
DE102011117046A8 (de)	2012-12-27	Doppelkupplungswindungsgetriebe
DE112011101226A5 (de)	2013-01-24	Linearwegmesssystem
DK2539163T3 (da)	2015-09-21	Dækventil
DE102010038420A8 (de)	2013-01-10	Reinigungungsvorrichtung
EP2646037A4 (en)	2015-03-18	INHIBITION OF HISTONES
DK2448659T3 (da)	2013-07-22	Rotorskive
CO6960557A2 (es)	2014-05-30	Derivados de 2-yodo-imidazol
BR112012022411A2 (pt)	2016-07-05	articulador
DE112011102711A5 (de)	2013-05-29	Hydrostataktor
DK2447426T3 (da)	2013-06-03	Vaske-WC