PL2603513T3 - Heterocykliczny związek i jego zastosowanie jako pozytywny modulator allosteryczny receptora AMPA - Google Patents

Heterocykliczny związek i jego zastosowanie jako pozytywny modulator allosteryczny receptora AMPA

Info

Publication number: PL2603513T3
Authority: PL; Poland
Prior art keywords: heterocyclic compound; positive allosteric; receptor positive; ampa receptor; allosteric modulator
Prior art date: 2010-08-10

Application number

PL11749944T

Other languages

English (en)

Inventor

Masakuni Kori

Toshihiro Imaeda

Shinji Nakamura

Masashi Toyofuku

Eiji Honda

Yasutomi Asano

Osamu Ujikawa

Michiyo Mochizuki

Original Assignee

Takeda Pharmaceutical Company Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-08-10

Filing date

2011-08-09

Publication date

2020-07-27

2011-08-09 Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited

2020-07-27 Publication of PL2603513T3 publication Critical patent/PL2603513T3/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)

PL11749944T 2010-08-10 2011-08-09 Heterocykliczny związek i jego zastosowanie jako pozytywny modulator allosteryczny receptora AMPA PL2603513T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2010179577		2010-08-10
EP11749944.2A EP2603513B1 (en)	2010-08-10	2011-08-09	Heterocyclic compound and use thereof as ampa receptor positive allosteric modulator
PCT/JP2011/068497 WO2012020848A1 (en)	2010-08-10	2011-08-09	Heterocyclic compound and use thereof

Publications (1)

Publication Number	Publication Date
PL2603513T3 true PL2603513T3 (pl)	2020-07-27

Family

ID=44534564

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL11749944T PL2603513T3 (pl)	2010-08-10	2011-08-09	Heterocykliczny związek i jego zastosowanie jako pozytywny modulator allosteryczny receptora AMPA

Country Status (39)

Country	Link
US (11)	US9150591B2 (pl)
EP (1)	EP2603513B1 (pl)
JP (2)	JP5788496B2 (pl)
KR (1)	KR101852215B1 (pl)
CN (2)	CN104926837A (pl)
AR (1)	AR082618A1 (pl)
AU (1)	AU2011290126B2 (pl)
BR (1)	BR112013002250B1 (pl)
CA (1)	CA2807460C (pl)
CL (1)	CL2013000380A1 (pl)
CO (1)	CO6680700A2 (pl)
CR (1)	CR20130066A (pl)
CY (1)	CY1123507T1 (pl)
DK (1)	DK2603513T3 (pl)
DO (1)	DOP2013000030A (pl)
EA (1)	EA022078B1 (pl)
EC (1)	ECSP13012478A (pl)
ES (1)	ES2793723T3 (pl)
GE (1)	GEP20156216B (pl)
HR (1)	HRP20200844T1 (pl)
HU (1)	HUE049460T2 (pl)
IL (1)	IL224452A (pl)
LT (1)	LT2603513T (pl)
MA (1)	MA34509B1 (pl)
MX (1)	MX349470B (pl)
MY (1)	MY165908A (pl)
NZ (1)	NZ607593A (pl)
PE (1)	PE20131116A1 (pl)
PH (1)	PH12013500247A1 (pl)
PL (1)	PL2603513T3 (pl)
PT (1)	PT2603513T (pl)
RS (1)	RS60311B1 (pl)
SG (1)	SG187656A1 (pl)
SI (1)	SI2603513T1 (pl)
TW (1)	TWI504604B (pl)
UA (1)	UA111594C2 (pl)
UY (1)	UY33551A (pl)
WO (1)	WO2012020848A1 (pl)
ZA (1)	ZA201301120B (pl)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9150591B2 (en) *	2010-08-10	2015-10-06	Takeda Pharmaceutical Company Limited	Heterocyclic compound and use thereof
EP2694472B1 (en)	2011-04-05	2020-03-11	Takeda Pharmaceutical Company Limited	Sulfonamide derivative and use thereof
WO2013118845A1 (ja) *	2012-02-08	2013-08-15	武田薬品工業株式会社	複素環化合物およびその用途
US20150011554A1 (en) *	2013-06-13	2015-01-08	Veroscience Llc	Compositions and Methods for Treating Metabolic Disorders
DK3013813T3 (da)	2013-06-27	2019-06-03	Pfizer	Heteroaromatiske forbindelser og anvendelse deraf som dopamin-d1-ligander
US11589583B2 (en)	2013-12-03	2023-02-28	Fmc Corporation	Pyrrolidinones herbicides
MX2016007259A (es)	2013-12-03	2016-08-04	Du Pont	Pirrolidinonas como herbicidas.
US9944602B2 (en)	2014-07-02	2018-04-17	E. I. Du Pont De Nemours And Company	Piperidinone herbicides
EP3230264B1 (en)	2014-12-08	2019-09-11	FMC Corporation	3-oxo-3-(arylamino)propanoates, a process for their preparation, and their use in preparing pyrrolidinones
EP3280709B1 (en)	2015-04-10	2021-05-26	FMC Corporation	Substituted cyclic amides as herbicides
CN107531658B (zh)	2015-04-27	2021-07-27	Fmc公司	作为除草剂的丁内酯
MX373652B (es) *	2015-04-29	2020-04-02	Janssen Pharmaceutica Nv	Imidazopirazinas y pirazolopirimidinas y su uso como moduladores del receptor de ampa.
ES2865330T3 (es)	2015-04-29	2021-10-15	Janssen Pharmaceutica Nv	Azabenzimidazoles y su uso como moduladores del receptor AMPA
PL3294743T3 (pl)	2015-05-12	2020-03-31	Fmc Corporation	Podstawione arylem związki bicykliczne jako środki chwastobójcze
WO2016196019A1 (en)	2015-05-29	2016-12-08	E I Du Pont De Nemours And Company	Substituted cyclic amides as herbicides
CN107709310B (zh)	2015-06-02	2021-09-24	Fmc公司	取代的环酰胺及其作为除草剂的用途
CN108137512B (zh)	2015-07-31	2022-05-31	Fmc公司	用作除草剂的环状n-酰胺化合物
KR102579520B1 (ko) *	2015-08-06	2023-09-15	에프. 호프만-라 로슈 아게	Galnac 산 유도체의 제조 방법
US20170181292A1 (en) *	2015-12-16	2017-06-22	Rohm And Haas Electronic Materials Llc	Method for forming organic coating on nickel surface
CN105669731B (zh) *	2016-01-10	2017-06-30	沧州普瑞东方科技有限公司	一种4‑(4‑烷基环己氧基)苯硼酸的合成方法
CA3047724A1 (en)	2016-12-21	2018-06-28	Fmc Corporation	Nitrone herbicides
CN107892697B (zh)	2016-12-26	2020-11-03	郑州泰基鸿诺医药股份有限公司	一种[1,3]噻嗪-2-胺类化合物及应用，药物组合物
WO2018175231A1 (en)	2017-03-21	2018-09-27	Fmc Corporation	Herbicidal mixture, composition and method
CA3057297A1 (en)	2017-03-21	2018-09-27	Fmc Corporation	Pyrrolidinones and a process to prepare them
AR111967A1 (es)	2017-05-30	2019-09-04	Fmc Corp	Amidas herbicidas
AR111839A1 (es)	2017-05-30	2019-08-21	Fmc Corp	Lactamas 3-sustituidas herbicidas
US11407748B2 (en)	2017-10-06	2022-08-09	Takeda Pharmaceutical Company Limited	Substituted pyrido[1,2-a]pyrimidines and pyrazino[1,2-a]pyrimidines for enhancing AMPA receptor function
ES2971497T3 (es)	2017-10-06	2024-06-05	Takeda Pharmaceuticals Co	Compuestos heterocíclicos
CR20220160A (es)	2019-09-16	2022-06-16	Takeda Pharmaceuticals Co	Derivados de piridazin-3(2h)-ona fusionados con azol
TW202207944A (zh) *	2020-05-15	2022-03-01	日商武田藥品工業股份有限公司	抑鬱症之治療
CN113943294A (zh) *	2020-07-15	2022-01-18	成都海博为药业有限公司	一种作为btk抑制剂的化合物及其制备方法与用途
WO2025224508A1 (en)	2024-04-22	2025-10-30	Takeda Pharmaceutical Company Limited	Pharmaceutical composition for treating depressive disorders
WO2026050231A1 (en)	2024-08-27	2026-03-05	Neurocrine Biosciences, Inc.	Method of treating a bipolar disorder

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0437742Y2 (pl)	1986-10-22	1992-09-04
JPH0285851A (ja) *	1988-09-22	1990-03-27	Konica Corp	新規な写真用カプラー
JPH037742A (ja)	1989-06-05	1991-01-14	Toyo Tire & Rubber Co Ltd	ラバーチエーン用ゴム組成物
JP2874960B2 (ja) *	1990-06-03	1999-03-24	コニカ株式会社	新規な染料を含有するハロゲン化銀写真感光材料
JPH04119890A (ja)	1990-09-11	1992-04-21	Konica Corp	ピラゾロチアジアジン系色素
JP3430375B2 (ja)	1993-11-12	2003-07-28	コニカ株式会社	感熱転写材料及び該材料に好適な色素
DE19704923A1 (de)	1997-02-10	1998-08-13	Hoechst Schering Agrevo Gmbh	Klebstoffhaltige Schädlingsbekämpfungsmittel
JP2003526341A (ja)	1999-11-04	2003-09-09	コロラドステートユニバーシティーリサーチファウンデーション	昆虫を誘引するための装置および方法
FR2801587B1 (fr)	1999-11-30	2002-01-11	Adir	Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MXPA04003297A (es)	2001-10-10	2004-07-23	Neurosearch As	Derivados novedosos de benzotiacina su preparacion y uso.
FR2833955B1 (fr) *	2001-12-21	2004-01-30	Servier Lab	Nouveaux derives de benzothiazine et de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2854634B1 (fr)	2003-05-05	2005-07-08	Servier Lab	Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2865474B1 (fr)	2004-01-26	2008-06-13	Servier Lab	Nouveaux derives de benzothiazines fluorees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2879201B1 (fr)	2004-12-10	2007-02-16	Servier Lab	Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2007262661A1 (en)	2006-06-23	2007-12-27	Nufarm Australia Limited	Phenoxy alkanoate herbicidal composition and method of preparation and use
WO2008073789A1 (en) *	2006-12-11	2008-06-19	Eli Lilly And Company	Ampa receptor potentiators
US20080167374A1 (en)	2007-01-09	2008-07-10	Loveland Products, Inc.	Pesticide composition and method of use
MX2010005028A (es)	2007-11-05	2010-05-27	Schering Corp	Moduladores de gamma secretasa.
WO2009086303A2 (en) *	2007-12-21	2009-07-09	University Of Rochester	Method for altering the lifespan of eukaryotic organisms
WO2009119088A1 (ja)	2008-03-25	2009-10-01	武田薬品工業株式会社	複素環化合物
JP2009248543A (ja)	2008-04-11	2009-10-29	Fujifilm Corp	光情報記録媒体および情報記録方法
TW201012803A (en)	2008-06-06	2010-04-01	Organon Nv	Heterocyclic derivatives
AU2009313527A1 (en)	2008-11-06	2010-05-14	Merck Sharp & Dohme Corp.	Gamma secretase modulators
TW201030002A (en)	2009-01-16	2010-08-16	Bristol Myers Squibb Co	Bicyclic compounds for the reduction of beta-amyloid production
JP2012051806A (ja)	2009-02-26	2012-03-15	Eisai R & D Management Co Ltd	イミダゾリルピラジン誘導体
FR2943342B1 (fr)	2009-03-20	2011-03-04	Servier Lab	Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
WO2010140339A1 (ja)	2009-06-01	2010-12-09	武田薬品工業株式会社	複素環化合物
WO2011007756A1 (ja)	2009-07-13	2011-01-20	武田薬品工業株式会社	複素環化合物及びその用途
WO2011036889A1 (ja)	2009-09-25	2011-03-31	武田薬品工業株式会社	複素環化合物
WO2011036885A1 (ja)	2009-09-25	2011-03-31	武田薬品工業株式会社	複素環化合物
US9150591B2 (en) *	2010-08-10	2015-10-06	Takeda Pharmaceutical Company Limited	Heterocyclic compound and use thereof

2011
- 2011-08-09 US US13/816,137 patent/US9150591B2/en active Active
- 2011-08-09 AU AU2011290126A patent/AU2011290126B2/en active Active
- 2011-08-09 UY UY0001033551A patent/UY33551A/es not_active Application Discontinuation
- 2011-08-09 TW TW100128311A patent/TWI504604B/zh active
- 2011-08-09 MY MYPI2013000428A patent/MY165908A/en unknown
- 2011-08-09 MX MX2013001614A patent/MX349470B/es active IP Right Grant
- 2011-08-09 PE PE2013000244A patent/PE20131116A1/es active IP Right Grant
- 2011-08-09 DK DK11749944.2T patent/DK2603513T3/da active
- 2011-08-09 NZ NZ607593A patent/NZ607593A/en unknown
- 2011-08-09 WO PCT/JP2011/068497 patent/WO2012020848A1/en not_active Ceased
- 2011-08-09 HU HUE11749944A patent/HUE049460T2/hu unknown
- 2011-08-09 CN CN201510259936.0A patent/CN104926837A/zh active Pending
- 2011-08-09 JP JP2013506362A patent/JP5788496B2/ja active Active
- 2011-08-09 GE GEAP201113021A patent/GEP20156216B/en unknown
- 2011-08-09 CN CN201180048970.3A patent/CN103180326B/zh active Active
- 2011-08-09 PL PL11749944T patent/PL2603513T3/pl unknown
- 2011-08-09 KR KR1020137006113A patent/KR101852215B1/ko active Active
- 2011-08-09 ES ES11749944T patent/ES2793723T3/es active Active
- 2011-08-09 US US13/206,113 patent/US8575154B2/en active Active
- 2011-08-09 RS RS20200574A patent/RS60311B1/sr unknown
- 2011-08-09 PT PT117499442T patent/PT2603513T/pt unknown
- 2011-08-09 SI SI201131887T patent/SI2603513T1/sl unknown
- 2011-08-09 SG SG2013007463A patent/SG187656A1/en unknown
- 2011-08-09 CA CA2807460A patent/CA2807460C/en active Active
- 2011-08-09 PH PH1/2013/500247A patent/PH12013500247A1/en unknown
- 2011-08-09 BR BR112013002250-7A patent/BR112013002250B1/pt active IP Right Grant
- 2011-08-09 HR HRP20200844TT patent/HRP20200844T1/hr unknown
- 2011-08-09 MA MA35708A patent/MA34509B1/fr unknown
- 2011-08-09 AR ARP110102905A patent/AR082618A1/es active IP Right Grant
- 2011-08-09 EP EP11749944.2A patent/EP2603513B1/en active Active
- 2011-08-09 LT LTEP11749944.2T patent/LT2603513T/lt unknown
- 2011-08-09 EA EA201390222A patent/EA022078B1/ru not_active IP Right Cessation
- 2011-09-08 UA UAA201302884A patent/UA111594C2/uk unknown
2013
- 2013-01-28 IL IL224452A patent/IL224452A/en active IP Right Grant
- 2013-02-05 DO DO2013000030A patent/DOP2013000030A/es unknown
- 2013-02-07 CL CL2013000380A patent/CL2013000380A1/es unknown
- 2013-02-12 ZA ZA2013/01120A patent/ZA201301120B/en unknown
- 2013-02-18 CR CR20130066A patent/CR20130066A/es unknown
- 2013-02-22 US US13/774,635 patent/US8778934B2/en active Active
- 2013-02-22 US US13/774,707 patent/US8916551B2/en active Active
- 2013-03-06 EC ECSP13012478 patent/ECSP13012478A/es unknown
- 2013-03-07 CO CO13046020A patent/CO6680700A2/es active IP Right Grant
2014
- 2014-11-13 US US14/540,699 patent/US20150073137A1/en not_active Abandoned
2015
- 2015-07-21 US US14/804,935 patent/US9499568B2/en active Active
- 2015-07-29 JP JP2015149216A patent/JP6113789B2/ja active Active
2016
- 2016-10-10 US US15/289,650 patent/US9884875B2/en active Active
2017
- 2017-12-18 US US15/845,621 patent/US20180162875A1/en not_active Abandoned
2019
- 2019-01-24 US US16/256,773 patent/US10654874B2/en active Active
2020
- 2020-03-23 US US16/827,316 patent/US11279713B2/en active Active
- 2020-05-25 CY CY20201100475T patent/CY1123507T1/el unknown
2024
- 2024-03-01 US US18/592,897 patent/US20240360156A1/en active Pending

Also Published As

Publication number	Publication date
MY165908A (en)	2018-05-18
HUE049460T2 (hu)	2020-09-28
LT2603513T (lt)	2020-05-25
AU2011290126A1 (en)	2013-03-07
CO6680700A2 (es)	2013-05-31
BR112013002250B1 (pt)	2020-10-27
EA022078B1 (ru)	2015-10-30
CN104926837A (zh)	2015-09-23
US20180162875A1 (en)	2018-06-14
US20130190291A1 (en)	2013-07-25
US20150073137A1 (en)	2015-03-12
DK2603513T3 (da)	2020-06-15
CN103180326A (zh)	2013-06-26
CL2013000380A1 (es)	2013-05-31
JP2013535408A (ja)	2013-09-12
US8916551B2 (en)	2014-12-23
CR20130066A (es)	2013-05-03
US20190263832A1 (en)	2019-08-29
NZ607593A (en)	2015-01-30
EA201390222A1 (ru)	2013-08-30
WO2012020848A8 (en)	2012-09-27
EP2603513A1 (en)	2013-06-19
TWI504604B (zh)	2015-10-21
US8575154B2 (en)	2013-11-05
MX2013001614A (es)	2013-07-05
CA2807460A1 (en)	2012-02-16
UY33551A (es)	2012-03-30
AR082618A1 (es)	2012-12-19
DOP2013000030A (es)	2013-03-15
MA34509B1 (fr)	2013-09-02
US20150353578A1 (en)	2015-12-10
JP6113789B2 (ja)	2017-04-12
US9150591B2 (en)	2015-10-06
US9884875B2 (en)	2018-02-06
US9499568B2 (en)	2016-11-22
US20240360156A1 (en)	2024-10-31
BR112013002250A2 (pt)	2016-05-24
TW201217386A (en)	2012-05-01
AU2011290126B2 (en)	2016-01-07
SI2603513T1 (sl)	2020-07-31
UA111594C2 (uk)	2016-05-25
SG187656A1 (en)	2013-03-28
CN103180326B (zh)	2015-06-10
GEP20156216B (en)	2015-01-12
PE20131116A1 (es)	2013-10-24
JP2016006080A (ja)	2016-01-14
US20120077799A1 (en)	2012-03-29
US20200317692A1 (en)	2020-10-08
MX349470B (es)	2017-07-31
CY1123507T1 (el)	2022-03-24
WO2012020848A1 (en)	2012-02-16
ZA201301120B (en)	2014-04-30
US10654874B2 (en)	2020-05-19
US11279713B2 (en)	2022-03-22
CA2807460C (en)	2018-09-18
ES2793723T3 (es)	2020-11-16
US20130184266A1 (en)	2013-07-18
US20140080817A1 (en)	2014-03-20
PT2603513T (pt)	2020-06-08
US8778934B2 (en)	2014-07-15
PH12013500247A1 (en)	2013-03-11
ECSP13012478A (es)	2013-04-30
IL224452A (en)	2017-11-30
EP2603513B1 (en)	2020-03-11
US20170022222A1 (en)	2017-01-26
RS60311B1 (sr)	2020-07-31
HRP20200844T1 (hr)	2020-08-21
KR101852215B1 (ko)	2018-04-25
KR20130138738A (ko)	2013-12-19
JP5788496B2 (ja)	2015-09-30

Publication	Publication Date	Title
HUE049460T2 (hu)	2020-09-28	Heterociklusos vegyület és annak alkalmazása ampa receptor pozitív allosztérikus modulátorként
IL246600B (en)	2018-10-31	Heterocyclic compounds and their use
EP2637669A4 (en)	2014-04-02	Heterocyclic compounds and their use
IL222288A0 (en)	2012-12-31	Heterocyclic compounds and their uses
IL225770A0 (en)	2013-06-27	Heterocyclic compounds
IL221442A0 (en)	2012-10-31	Heterocyclic compound
ZA201300950B (en)	2014-04-30	Heterocyclic compound
IL237581B (en)	2018-11-29	Derivatives of 6-oxo-pyrazinopyrrolopyrimidines
LT2594567T (lt)	2020-12-28	Heterocikliniai alkinilbenzeno junginiai ir jų medicininės kompozicijos bei panaudojimas
IL231145A0 (en)	2014-04-30	Heterocyclic compounds and their uses
PL2521450T3 (pl)	2015-07-31	Grzybobójcze związki heterocykliczne
IL230536A0 (en)	2014-03-31	Heterocyclic compounds and their uses
EP2678016A4 (en)	2014-11-19	HETEROCYCLIC COMPOUNDS AND USES THEREOF
IL231783A0 (en)	2014-05-28	History of ethinyl as allosteric modulators of 5mglur
ZA201306586B (en)	2014-05-28	Thynyl derivatives as positive allosteric modulators of the mglur5
IL223721A0 (en)	2013-03-05	Heterocyclic compounds, their preparation and their therapeutic application
ZA201300157B (en)	2017-05-31	Fused heterocyclic derivatives as s1p modulators
EP2782571A4 (en)	2015-04-01	HETEROCYCLIC COMPOUNDS AND USES THEREOF
PL2769720T3 (pl)	2017-12-29	Heterocykliczne allosteryczne modulatory gsk-3
GB2477949B (en)	2016-01-06	Powering of devices
GB201009514D0 (en)	2010-07-21	Novel heterocyclic compounds
GB201021416D0 (en)	2011-01-26	Novel heterocyclic compounds
AU331233S (en)	2010-06-07	Powder applicator