PL2614061T3 - Pochodne chinoliny i chinoksaliny jako inhibitory kinazy - Google Patents

Pochodne chinoliny i chinoksaliny jako inhibitory kinazy

Info

Publication number: PL2614061T3
Authority: PL; Poland
Prior art keywords: quinoline; kinase inhibitors; quinoxaline derivatives; quinoxaline; derivatives
Prior art date: 2010-09-08

Application number

PL11755423T

Other languages

English (en)

Inventor

Andrew Harry Parton

Mezher Hussein Ali

Daniel Christopher Brookings

Julien Alistair Brown

Daniel James Ford

Richard Jeremy Franklin

Barry John Langham

Judi Charlotte Neuss

Joanna Rachel Quincey

Original Assignee

Ucb Biopharma Sprl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-09-08

Filing date

2011-09-02

Publication date

2015-11-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45810169&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2614061(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-09-08 Priority claimed from GBGB1014963.1A external-priority patent/GB201014963D0/en

2011-01-21 Priority claimed from GBGB1101128.5A external-priority patent/GB201101128D0/en

2011-09-02 Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl

2015-11-30 Publication of PL2614061T3 publication Critical patent/PL2614061T3/pl

Links

SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 2
229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
125000001567 quinoxalinyl group Chemical class N1=C(C=NC2=CC=CC=C12)* 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Physical Education & Sports Medicine (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Quinoline Compounds (AREA)

PL11755423T 2010-09-08 2011-09-02 Pochodne chinoliny i chinoksaliny jako inhibitory kinazy PL2614061T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB1014963.1A GB201014963D0 (en)	2010-09-08	2010-09-08	Therapeutic agents
GBGB1101128.5A GB201101128D0 (en)	2011-01-21	2011-01-21	Therapeutic agents
PCT/GB2011/051647 WO2012032334A1 (en)	2010-09-08	2011-09-02	Quinoline and quinoxaline derivatives as kinase inhibitors
EP20110755423 EP2614061B1 (en)	2010-09-08	2011-09-02	Quinoline and quinoxaline derivatives as kinase inhibitors

Publications (1)

Publication Number	Publication Date
PL2614061T3 true PL2614061T3 (pl)	2015-11-30

Family

ID=45810169

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL11755423T PL2614061T3 (pl)	2010-09-08	2011-09-02	Pochodne chinoliny i chinoksaliny jako inhibitory kinazy

Country Status (33)

Country	Link
US (1)	US9029392B2 (pl)
EP (1)	EP2614061B1 (pl)
JP (1)	JP5820882B2 (pl)
KR (1)	KR101880280B1 (pl)
CN (1)	CN103153996B (pl)
AR (1)	AR082799A1 (pl)
AU (1)	AU2011300521B2 (pl)
BR (1)	BR112013004750B1 (pl)
CA (1)	CA2808959C (pl)
CL (1)	CL2013000603A1 (pl)
CO (1)	CO6680717A2 (pl)
CY (1)	CY1116734T1 (pl)
DK (1)	DK2614061T3 (pl)
EA (1)	EA024162B1 (pl)
ES (1)	ES2544289T3 (pl)
HR (1)	HRP20150868T1 (pl)
HU (1)	HUE025223T2 (pl)
IL (1)	IL224841A (pl)
MA (1)	MA34600B1 (pl)
ME (1)	ME02203B (pl)
MX (1)	MX2013002529A (pl)
MY (1)	MY162396A (pl)
NZ (1)	NZ607966A (pl)
PH (1)	PH12013500334A1 (pl)
PL (1)	PL2614061T3 (pl)
PT (1)	PT2614061E (pl)
RS (1)	RS54202B1 (pl)
SG (1)	SG187924A1 (pl)
SI (1)	SI2614061T1 (pl)
SM (1)	SMT201500195B (pl)
TW (1)	TWI510489B (pl)
WO (1)	WO2012032334A1 (pl)
ZA (1)	ZA201301751B (pl)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8193182B2 (en)	2008-01-04	2012-06-05	Intellikine, Inc.	Substituted isoquinolin-1(2H)-ones, and methods of use thereof
CA2711558C (en)	2008-01-04	2016-12-13	Intellikine, Inc.	Phosphatidyl inositol-3 kinase inhibiting compounds
JP5731978B2 (ja)	2008-09-26	2015-06-10	インテリカイン，エルエルシー	複素環キナーゼ阻害剤
EP2427195B1 (en)	2009-05-07	2019-05-01	Intellikine, LLC	Heterocyclic compounds and uses thereof
AU2011255218B2 (en)	2010-05-21	2015-03-12	Infinity Pharmaceuticals, Inc.	Chemical compounds, compositions and methods for kinase modulation
AR082799A1 (es) *	2010-09-08	2013-01-09	Ucb Pharma Sa	Derivados de quinolina y quinoxalina como inhibidores de quinasa
JP2013545749A (ja)	2010-11-10	2013-12-26	インフィニティーファーマシューティカルズ，インコーポレイテッド	複素環化合物及びその使用
WO2012088266A2 (en)	2010-12-22	2012-06-28	Incyte Corporation	Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
AU2012205669B2 (en)	2011-01-10	2015-08-20	Infinity Pharmaceuticals Inc.	Processes for preparing isoquinolinones and solid forms of isoquinolinones
JP6027610B2 (ja)	2011-07-19	2016-11-16	インフィニティーファーマシューティカルズ，インコーポレイテッド	複素環式化合物及びその使用
US9056877B2 (en)	2011-07-19	2015-06-16	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
EP2751093A1 (en)	2011-08-29	2014-07-09	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
US8940742B2 (en)	2012-04-10	2015-01-27	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
LT3495367T (lt)	2012-06-13	2021-02-25	Incyte Holdings Corporation	Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai
US8828998B2 (en)	2012-06-25	2014-09-09	Infinity Pharmaceuticals, Inc.	Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
WO2014026125A1 (en)	2012-08-10	2014-02-13	Incyte Corporation	Pyrazine derivatives as fgfr inhibitors
KR102229478B1 (ko)	2012-11-01	2021-03-18	인피니티 파마슈티칼스, 인코포레이티드	Pi3 키나아제 동형단백질 조절인자를 사용하는 암의 치료
US9266892B2 (en)	2012-12-19	2016-02-23	Incyte Holdings Corporation	Fused pyrazoles as FGFR inhibitors
US9481667B2 (en)	2013-03-15	2016-11-01	Infinity Pharmaceuticals, Inc.	Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
LT2986610T (lt)	2013-04-19	2018-04-10	Incyte Holdings Corporation	Bicikliniai heterociklai, kaip fgfr inhibitoriai
US9751888B2 (en)	2013-10-04	2017-09-05	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
PE20160685A1 (es)	2013-10-04	2016-07-23	Infinity Pharmaceuticals Inc	Compuestos heterociclicos y usos de los mismos
CN104744435B (zh) *	2013-12-25	2017-03-01	上海医药工业研究院	喹啉类化合物、其盐、其中间体、制备方法及应用
SG10201808053XA (en)	2014-03-19	2018-10-30	Infinity Pharmaceuticals Inc	Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
US20150320755A1 (en)	2014-04-16	2015-11-12	Infinity Pharmaceuticals, Inc.	Combination therapies
US9708348B2 (en)	2014-10-03	2017-07-18	Infinity Pharmaceuticals, Inc.	Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
US10851105B2 (en)	2014-10-22	2020-12-01	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
SG11201706287PA (en)	2015-02-20	2017-09-28	Incyte Corp	Bicyclic heterocycles as fgfr inhibitors
WO2016134294A1 (en)	2015-02-20	2016-08-25	Incyte Corporation	Bicyclic heterocycles as fgfr4 inhibitors
MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
GB201506786D0 (en) *	2015-04-21	2015-06-03	Ucb Biopharma Sprl	Therapeutic use
US10160761B2 (en)	2015-09-14	2018-12-25	Infinity Pharmaceuticals, Inc.	Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
WO2017161116A1 (en)	2016-03-17	2017-09-21	Infinity Pharmaceuticals, Inc.	Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
GB201604970D0 (en)	2016-03-23	2016-05-04	Syngenta Participations Ag	Improvements in or relating to organic compounds
GB201608797D0 (en) *	2016-05-19	2016-07-06	Ucb Biopharma Sprl	Therapeutic use
US10919914B2 (en)	2016-06-08	2021-02-16	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
MX391135B (es)	2016-06-24	2025-03-21	Infinity Pharmaceuticals Inc	Terapias de combinacion.
CN108239076B (zh) *	2016-12-26	2021-07-06	中国医学科学院药物研究所	喹唑啉类化合物及其制备方法、用途和药物组合物
AR111960A1 (es)	2017-05-26	2019-09-04	Incyte Corp	Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
GB201708856D0 (en) *	2017-06-02	2017-07-19	Ucb Biopharma Sprl	Seletalisib crystalline forms
ES3061844T3 (en)	2018-05-04	2026-04-07	Incyte Corp	Salts of an fgfr inhibitor
MX2020011718A (es)	2018-05-04	2021-02-15	Incyte Corp	Formas solidas de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr) y procesos para prepararlas.
US11628162B2 (en)	2019-03-08	2023-04-18	Incyte Corporation	Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en)	2019-07-09	2023-02-28	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
US12122767B2 (en)	2019-10-01	2024-10-22	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
TWI891666B (zh)	2019-10-14	2025-08-01	美商英塞特公司	作為ｆｇｆｒ抑制劑之雙環雜環
US11566028B2 (en)	2019-10-16	2023-01-31	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
WO2021113462A1 (en)	2019-12-04	2021-06-10	Incyte Corporation	Derivatives of an fgfr inhibitor
CA3163875A1 (en)	2019-12-04	2021-06-10	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
US12012409B2 (en)	2020-01-15	2024-06-18	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
TW202304459A (zh)	2021-04-12	2023-02-01	美商英塞特公司	包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法
EP4352060A1 (en)	2021-06-09	2024-04-17	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
JP2024522189A (ja)	2021-06-09	2024-06-11	インサイト・コーポレイション	Ｆｇｆｒ阻害剤としての三環式ヘテロ環

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX2009010050A (es)	2007-03-23	2009-10-12	Amgen Inc	Derivados de quinolina o quinoxalina 3-sustituidos y su uso como inhibidores de fosfotidilinositol 3-cinasa (p13k).
AU2008231384B2 (en) *	2007-03-23	2011-09-15	Amgen Inc.	Heterocyclic compounds and their use
RS54706B1 (sr) *	2007-03-23	2016-08-31	Amgen Inc.	Heterociklična jedinjenja i njihove upotrebe
EP2231641B1 (en) *	2007-12-21	2016-06-01	UCB Biopharma SPRL	Quinoxaline and quinoline derivatives as kinase inhibitors
GB0819593D0 (en) *	2008-10-24	2008-12-03	Ucb Pharma Sa	Therapeutic agents
ES2520345T3 (es) *	2009-11-12	2014-11-11	Ucb Pharma, S.A.	Derivados de quinolina y quinoxalina en calidad de inhibidores de quinasa
AR082799A1 (es) *	2010-09-08	2013-01-09	Ucb Pharma Sa	Derivados de quinolina y quinoxalina como inhibidores de quinasa

2011
- 2011-08-30 AR ARP110103154A patent/AR082799A1/es active IP Right Grant
- 2011-09-02 SG SG2013012794A patent/SG187924A1/en unknown
- 2011-09-02 ME MEP-2015-120A patent/ME02203B/me unknown
- 2011-09-02 HR HRP20150868TT patent/HRP20150868T1/hr unknown
- 2011-09-02 EA EA201300317A patent/EA024162B1/ru not_active IP Right Cessation
- 2011-09-02 PH PH1/2013/500334A patent/PH12013500334A1/en unknown
- 2011-09-02 ES ES11755423.8T patent/ES2544289T3/es active Active
- 2011-09-02 PL PL11755423T patent/PL2614061T3/pl unknown
- 2011-09-02 CN CN201180049091.2A patent/CN103153996B/zh not_active Expired - Fee Related
- 2011-09-02 AU AU2011300521A patent/AU2011300521B2/en not_active Ceased
- 2011-09-02 JP JP2013527681A patent/JP5820882B2/ja active Active
- 2011-09-02 CA CA2808959A patent/CA2808959C/en active Active
- 2011-09-02 DK DK11755423.8T patent/DK2614061T3/en active
- 2011-09-02 US US13/821,294 patent/US9029392B2/en active Active
- 2011-09-02 MA MA35807A patent/MA34600B1/fr unknown
- 2011-09-02 WO PCT/GB2011/051647 patent/WO2012032334A1/en not_active Ceased
- 2011-09-02 EP EP20110755423 patent/EP2614061B1/en active Active
- 2011-09-02 HU HUE11755423A patent/HUE025223T2/en unknown
- 2011-09-02 MX MX2013002529A patent/MX2013002529A/es active IP Right Grant
- 2011-09-02 SI SI201130542T patent/SI2614061T1/sl unknown
- 2011-09-02 RS RS20150538A patent/RS54202B1/sr unknown
- 2011-09-02 NZ NZ607966A patent/NZ607966A/en not_active IP Right Cessation
- 2011-09-02 KR KR1020137008975A patent/KR101880280B1/ko not_active Expired - Fee Related
- 2011-09-02 MY MYPI2013000767A patent/MY162396A/en unknown
- 2011-09-02 PT PT117554238T patent/PT2614061E/pt unknown
- 2011-09-02 BR BR112013004750-0A patent/BR112013004750B1/pt not_active IP Right Cessation
- 2011-09-06 TW TW100132061A patent/TWI510489B/zh not_active IP Right Cessation
2013
- 2013-02-21 IL IL224841A patent/IL224841A/en active IP Right Grant
- 2013-03-01 CL CL2013000603A patent/CL2013000603A1/es unknown
- 2013-03-07 ZA ZA2013/01751A patent/ZA201301751B/en unknown
- 2013-03-21 CO CO13056775A patent/CO6680717A2/es active IP Right Grant
2015
- 2015-08-11 SM SM201500195T patent/SMT201500195B/xx unknown
- 2015-08-18 CY CY20151100718T patent/CY1116734T1/el unknown

Also Published As

Publication number	Publication date
HUE025223T2 (en)	2016-02-29
MY162396A (en)	2017-06-15
EA024162B1 (ru)	2016-08-31
MX2013002529A (es)	2013-10-28
PT2614061E (pt)	2015-10-01
DK2614061T3 (en)	2015-08-10
CA2808959A1 (en)	2012-03-15
CA2808959C (en)	2018-07-17
CN103153996B (zh)	2016-01-27
RS54202B1 (sr)	2015-12-31
WO2012032334A1 (en)	2012-03-15
ES2544289T3 (es)	2015-08-28
CY1116734T1 (el)	2017-03-15
TWI510489B (zh)	2015-12-01
PH12013500334A1 (en)	2017-07-26
TW201217371A (en)	2012-05-01
CN103153996A (zh)	2013-06-12
AU2011300521B2 (en)	2017-05-25
SMT201500195B (it)	2015-09-07
ZA201301751B (en)	2014-05-28
BR112013004750A2 (pt)	2016-08-02
US20130296338A1 (en)	2013-11-07
EP2614061B1 (en)	2015-05-20
JP5820882B2 (ja)	2015-11-24
CL2013000603A1 (es)	2013-06-21
EP2614061A1 (en)	2013-07-17
BR112013004750B1 (pt)	2021-06-15
ME02203B (me)	2016-02-20
HK1181754A1 (en)	2013-11-15
SI2614061T1 (sl)	2015-08-31
AU2011300521A1 (en)	2013-04-04
KR20130139909A (ko)	2013-12-23
NZ607966A (en)	2014-07-25
HRP20150868T1 (hr)	2015-09-25
JP2013537183A (ja)	2013-09-30
CO6680717A2 (es)	2013-05-31
US9029392B2 (en)	2015-05-12
EA201300317A1 (ru)	2013-11-29
MA34600B1 (fr)	2013-10-02
IL224841A (en)	2017-03-30
SG187924A1 (en)	2013-03-28
KR101880280B1 (ko)	2018-07-20
AR082799A1 (es)	2013-01-09

Publication	Publication Date	Title
ZA201301751B (en)	2014-05-28	Quinoline and quinoxaline derivatives as kinase inhibitors
HUS2500011I1 (hu)	2025-03-28	Pirazolil-kinoxalin kináz inhibitorok
IL252517A0 (en)	2017-07-31	Uracil derivatives as axl and c-met kinase inhibitors
EP2552208A4 (en)	2014-07-09	IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS
IL223871A (en)	2016-11-30	Quinoline derivatives and milk inhibitors containing them
ZA201301951B (en)	2014-08-27	Benzimidazole derivatives as p13 kinase inhibitors
EP2552214A4 (en)	2013-10-16	PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS
EP2552211A4 (en)	2013-10-23	INDAZOLYL-PYRIMIDINE AS KINASEHEMMER
GB201009731D0 (en)	2010-07-21	Kinase inhibitors
EP2603218A4 (en)	2014-01-15	CHINOLYLAMINE AS A KINASEHEMMER
EP2895166A4 (en)	2016-03-16	AMINOISOQUINOLINE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES
IL233415A0 (en)	2014-08-31	Imidazopyridine derivatives of tyrosine kinase inhibitors, preparations containing them and their uses
AP2012006419A0 (en)	2012-08-31	Aminoquinoline derivatives
ZA201404533B (en)	2015-12-23	Quinoline derivatives as pde10a enzyme inhibitors
ZA201706763B (en)	2021-02-24	Pyrazolyl quinoxaline kinase inhibitors