PL2614838T3 - Dikwafozol i kwas hialuronowy lub ich sole do zastosowania w leczeniu zespołu suchego oka - Google Patents
Dikwafozol i kwas hialuronowy lub ich sole do zastosowania w leczeniu zespołu suchego okaInfo
- Publication number
- PL2614838T3 PL2614838T3 PL11823663.7T PL11823663T PL2614838T3 PL 2614838 T3 PL2614838 T3 PL 2614838T3 PL 11823663 T PL11823663 T PL 11823663T PL 2614838 T3 PL2614838 T3 PL 2614838T3
- Authority
- PL
- Poland
- Prior art keywords
- diquafosol
- salts
- treatment
- hyaluronic acid
- dry eye
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 title 1
- 206010013774 Dry eye Diseases 0.000 title 1
- NMLMACJWHPHKGR-NCOIDOBVSA-N P(1),P(4)-bis(uridin-5'-yl) tetraphosphate Chemical compound N1([C@@H]2O[C@@H]([C@H]([C@H]2O)O)COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@H]([C@@H](O2)N2C(NC(=O)C=C2)=O)O)O)C=CC(=O)NC1=O NMLMACJWHPHKGR-NCOIDOBVSA-N 0.000 title 1
- 229950003529 diquafosol Drugs 0.000 title 1
- 229920002674 hyaluronan Polymers 0.000 title 1
- 229960003160 hyaluronic acid Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Non-Alcoholic Beverages (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010203198 | 2010-09-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2614838T3 true PL2614838T3 (pl) | 2016-10-31 |
Family
ID=45810785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11823663.7T PL2614838T3 (pl) | 2010-09-10 | 2011-09-09 | Dikwafozol i kwas hialuronowy lub ich sole do zastosowania w leczeniu zespołu suchego oka |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9006208B2 (pl) |
| EP (1) | EP2614838B1 (pl) |
| JP (1) | JP5956735B2 (pl) |
| KR (2) | KR20170018462A (pl) |
| CN (2) | CN106729718A (pl) |
| AU (2) | AU2011299851A1 (pl) |
| BR (1) | BR112013005438B1 (pl) |
| CA (1) | CA2810481C (pl) |
| DK (1) | DK2614838T3 (pl) |
| EA (1) | EA026680B1 (pl) |
| ES (1) | ES2569246T3 (pl) |
| MX (1) | MX336944B (pl) |
| MY (1) | MY170198A (pl) |
| NZ (1) | NZ608202A (pl) |
| PH (1) | PH12013500424B1 (pl) |
| PL (1) | PL2614838T3 (pl) |
| SG (1) | SG188482A1 (pl) |
| TW (1) | TWI519301B (pl) |
| WO (1) | WO2012033189A1 (pl) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA113839C2 (xx) * | 2010-12-28 | 2017-03-27 | Очний розчин, який містить диквафозол, спосіб його отримання і спосіб інгібування утворення нерозчинного осаду | |
| KR101536885B1 (ko) | 2012-03-26 | 2015-07-14 | 산텐 세이야꾸 가부시키가이샤 | 디쿠아포솔 함유 점안액 |
| ES2837626T3 (es) | 2013-07-10 | 2021-07-01 | Matrix Biology Inst | Composiciones de hialuronano con alta elasticidad y usos de las mismas |
| US9289494B2 (en) | 2013-11-20 | 2016-03-22 | RestorTears, LLC | Method of treating ocular disorders with compounds found in Harderian gland secretions |
| JP6267003B2 (ja) * | 2014-02-27 | 2018-01-24 | 参天製薬株式会社 | ジクアホソルまたはその塩およびレバミピドまたはその塩を組み合わせたことを特徴とする涙液分泌促進剤 |
| JP6608620B2 (ja) * | 2015-05-26 | 2019-11-20 | ロート製薬株式会社 | 皮膚外用剤 |
| CN107635565A (zh) | 2015-06-05 | 2018-01-26 | 参天制药株式会社 | 以向佩戴有软性隐形眼镜的干眼症患者的眼中滴入的方式使用为特征的干眼症治疗剂 |
| JP2017052723A (ja) * | 2015-09-10 | 2017-03-16 | 株式会社Ｌｔｔバイオファーマ | ドライアイ改善剤 |
| ES2871199T3 (es) | 2015-09-24 | 2021-10-28 | Matrix Biology Inst | Composiciones de hialuronano de alta elasticidad y métodos de uso de las mismas |
| EP3871682A1 (en) * | 2016-10-14 | 2021-09-01 | i.com Medical GmbH | Method for establishing, restoring, and preserving homeostasis of the ocular surface |
| CN109843288A (zh) | 2016-10-21 | 2019-06-04 | 狮王株式会社 | 眼科用制剂和眼科用药 |
| CN107096016B (zh) * | 2017-06-26 | 2021-04-06 | 蒋广伟 | 一种缓解视力疲劳的滴液 |
| RU2652581C1 (ru) * | 2017-07-03 | 2018-04-26 | федеральное государственное бюджетное образовательное учреждение высшего образования "Приволжский исследовательский медицинский университет" Министерства здравоохранения Российской Федерации | Способ лечения роговично-конъюнктивального ксероза |
| KR102108552B1 (ko) * | 2018-05-15 | 2020-05-08 | 한국세라믹기술원 | 히알루론산 마이크로비드의 제조 방법 및 상기 히알루론산 마이크로비드의 용도 |
| CN109260146A (zh) * | 2018-10-12 | 2019-01-25 | 广州大光制药有限公司 | 地夸磷索钠眼用即用型凝胶滴眼液及制备方法 |
| ES2994624T3 (en) | 2019-02-27 | 2025-01-27 | Santen Pharmaceutical Co Ltd | Ophthalmic composition containing diquafosol or salt thereof, vinyl-based polymer and cellulose-based polymer |
| JP6966667B2 (ja) * | 2019-08-27 | 2021-11-17 | 参天製薬株式会社 | ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01115902A (ja) | 1987-10-30 | 1989-05-09 | Showa Sangyo Co Ltd | ヒアルロン酸の製造法 |
| US5900407A (en) | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
| CN1262556C (zh) * | 1997-02-06 | 2006-07-05 | 印斯拜尔药品股份有限公司 | 特定的二核苷酸和它们作为粘膜纤毛清除和纤毛颤动频率调节剂的应用 |
| US7223744B2 (en) | 1997-02-10 | 2007-05-29 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof |
| WO1999005155A2 (en) | 1997-07-25 | 1999-02-04 | Inspire Pharmaceuticals, Inc. | Salts of di(uridine 5'-tetraphosphate), method for preparation and uses thereof |
| JP2003160491A (ja) | 2001-09-11 | 2003-06-03 | Santen Pharmaceut Co Ltd | ジウリジンリン酸含有点眼液 |
-
2011
- 2011-09-09 CN CN201611152170.7A patent/CN106729718A/zh active Pending
- 2011-09-09 EA EA201390364A patent/EA026680B1/ru not_active IP Right Cessation
- 2011-09-09 PH PH1/2013/500424A patent/PH12013500424B1/en unknown
- 2011-09-09 EP EP11823663.7A patent/EP2614838B1/en not_active Not-in-force
- 2011-09-09 MX MX2013002677A patent/MX336944B/es active IP Right Grant
- 2011-09-09 MY MYPI2013000810A patent/MY170198A/en unknown
- 2011-09-09 ES ES11823663.7T patent/ES2569246T3/es active Active
- 2011-09-09 BR BR112013005438-7A patent/BR112013005438B1/pt not_active IP Right Cessation
- 2011-09-09 WO PCT/JP2011/070578 patent/WO2012033189A1/ja not_active Ceased
- 2011-09-09 AU AU2011299851A patent/AU2011299851A1/en not_active Abandoned
- 2011-09-09 TW TW100132506A patent/TWI519301B/zh not_active IP Right Cessation
- 2011-09-09 KR KR1020177003213A patent/KR20170018462A/ko not_active Ceased
- 2011-09-09 DK DK11823663.7T patent/DK2614838T3/en active
- 2011-09-09 JP JP2011197020A patent/JP5956735B2/ja active Active
- 2011-09-09 CA CA2810481A patent/CA2810481C/en not_active Expired - Fee Related
- 2011-09-09 KR KR1020137008451A patent/KR101707269B1/ko active Active
- 2011-09-09 SG SG2013017652A patent/SG188482A1/en unknown
- 2011-09-09 CN CN2011800435775A patent/CN103096929A/zh active Pending
- 2011-09-09 PL PL11823663.7T patent/PL2614838T3/pl unknown
- 2011-09-09 US US13/821,717 patent/US9006208B2/en not_active Expired - Fee Related
- 2011-09-09 NZ NZ60820211A patent/NZ608202A/en not_active IP Right Cessation
-
2017
- 2017-02-07 AU AU2017200821A patent/AU2017200821B2/en not_active Ceased
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