PL2623604T3 - Biologiczny system dostarczania i ekspresji oparty na adenowirusie do zastosowania w leczeniu choroby zwyrodnieniowej stawów - Google Patents
Biologiczny system dostarczania i ekspresji oparty na adenowirusie do zastosowania w leczeniu choroby zwyrodnieniowej stawówInfo
- Publication number
- PL2623604T3 PL2623604T3 PL12000703T PL12000703T PL2623604T3 PL 2623604 T3 PL2623604 T3 PL 2623604T3 PL 12000703 T PL12000703 T PL 12000703T PL 12000703 T PL12000703 T PL 12000703T PL 2623604 T3 PL2623604 T3 PL 2623604T3
- Authority
- PL
- Poland
- Prior art keywords
- adenoviral
- osteoarthritis
- treatment
- expression system
- based biological
- Prior art date
Links
- 201000008482 osteoarthritis Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10041—Use of virus, viral particle or viral elements as a vector
- C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10071—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10371—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/24—Vectors characterised by the absence of particular element, e.g. selectable marker, viral origin of replication
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20120000703 EP2623604B8 (en) | 2012-02-02 | 2012-02-02 | Adenoviral-based biological delivery and expression system for use in the treatment of osteoarthritis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2623604T3 true PL2623604T3 (pl) | 2015-07-31 |
Family
ID=47891791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12000703T PL2623604T3 (pl) | 2012-02-02 | 2012-02-02 | Biologiczny system dostarczania i ekspresji oparty na adenowirusie do zastosowania w leczeniu choroby zwyrodnieniowej stawów |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10301647B2 (pl) |
| EP (1) | EP2623604B8 (pl) |
| JP (2) | JP6340320B2 (pl) |
| CN (1) | CN104245941B (pl) |
| AU (1) | AU2013213873B2 (pl) |
| CA (1) | CA2861408C (pl) |
| DK (1) | DK2623604T3 (pl) |
| EA (1) | EA033004B1 (pl) |
| ES (1) | ES2534782T3 (pl) |
| IN (1) | IN2014KN01682A (pl) |
| PL (1) | PL2623604T3 (pl) |
| WO (1) | WO2013114199A1 (pl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014115022A1 (en) | 2013-01-25 | 2014-07-31 | Baylor College Of Medicine | A helper-dependent adenoviral gene therapy delivery and expression system |
| GB201410314D0 (en) * | 2014-06-10 | 2014-07-23 | Advanced Risc Mach Ltd | Display controller |
| KR20170121291A (ko) * | 2015-03-02 | 2017-11-01 | 신로직 인코포레이티드 | 감소된 창자 염증 및/또는 강화된 창자 점막 장벽으로부터 이익을 얻는 질병을 치료하기 위해 공학처리된 박테리아 |
| MX381665B (es) | 2016-01-13 | 2025-03-13 | Genzyme Corp Star | Vectores aav recombinantes que expresan genes osteoprotectores, que incluyen has2 y lubricina, de utilidad en el tratamiento de la osteoartritis y afecciones articulares relacionadas en mamiferos. |
| ES2982489T3 (es) | 2016-08-19 | 2024-10-16 | Univ Florida | Composiciones para el tratamiento de afecciones que utilizan virus adeno-asociados recombinantes autocomplementarios |
| WO2018071295A1 (en) | 2016-10-10 | 2018-04-19 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for inducible production of anti-inflammatory cytokines |
| US11958886B2 (en) * | 2016-12-07 | 2024-04-16 | University Of Florida Research Foundation, Incorporated | IL-1RA cDNAs |
| KR20240093758A (ko) | 2017-04-21 | 2024-06-24 | 베이롤 칼리지 오브 메드신 | 종양용해성 바이러스요법 및 면역요법 |
| JP7899083B2 (ja) * | 2019-09-18 | 2026-08-03 | パシラ・セラピューティクス・インコーポレイテッド | ヒトにおける変形性関節症の処置における使用のための有効用量のアデノウイルスに基づく生物学的送達および発現系、ならびにそれを含む組成物 |
| CN115003698A (zh) * | 2019-11-14 | 2022-09-02 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| CN117280200A (zh) * | 2021-05-06 | 2023-12-22 | 株式会社理学 | X射线造影剂和x射线图像的取得方法 |
| WO2023028492A1 (en) * | 2021-08-24 | 2023-03-02 | Pacira Therapeutics, Inc. | IL-1Ra GENE THERAPY FOR INTERVERTEBRAL DISC DEGENERATION |
| KR20250157403A (ko) | 2023-03-02 | 2025-11-04 | 파시라 테라퓨틱스, 인크. | 코르티코스테로이드 치료를 활용한 개선된 아데노바이러스 기반 유전자 요법을 위한 조성물 및 방법 |
| EP4694906A1 (en) * | 2023-04-13 | 2026-02-18 | MeiraGTx Gene Regulation Limited | Inflammation-inducible promoters |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747072A (en) | 1993-07-30 | 1998-05-05 | University Of Michigan | Adenoviral-mediated gene transfer to synovial cells in vivo |
| US20030091536A1 (en) | 1999-09-07 | 2003-05-15 | Colorado State University Research Foundation | In vivo treatment of joint disease using interleukin-1 |
| FR2806418B1 (fr) * | 2000-03-14 | 2004-07-16 | Aventis Pharma Sa | Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations |
| AU2002311777A1 (en) | 2001-04-17 | 2002-10-28 | Genetix Pharmaceuticals, Inc. | Method of treating arthritis using lentiviral vectors in gene therapy |
| ES2335232T3 (es) * | 2005-06-21 | 2010-03-23 | Xoma Technology Ltd. | Anticuerpos y fragmentos de los mismos que se unen a la il-1 beta. |
| US8298533B2 (en) * | 2008-11-07 | 2012-10-30 | Medimmune Limited | Antibodies to IL-1R1 |
| JP2012525154A (ja) * | 2009-05-01 | 2012-10-22 | オレゴン ヘルス アンド サイエンス ユニバーシティ | 生体内でヒト肝細胞を増大させる方法 |
| SG2014014534A (en) * | 2009-05-29 | 2014-07-30 | Xoma Technology Ltd | CARDIOVASCULAR RELATED USES OF IL-1ß ANTIBODIES AND BINDING FRAGMENTS THEREOF |
-
2012
- 2012-02-02 ES ES12000703.4T patent/ES2534782T3/es active Active
- 2012-02-02 DK DK12000703.4T patent/DK2623604T3/da active
- 2012-02-02 EP EP20120000703 patent/EP2623604B8/en active Active
- 2012-02-02 PL PL12000703T patent/PL2623604T3/pl unknown
-
2013
- 2013-01-23 EA EA201491457A patent/EA033004B1/ru unknown
- 2013-01-23 WO PCT/IB2013/000198 patent/WO2013114199A1/en not_active Ceased
- 2013-01-23 IN IN1682KON2014 patent/IN2014KN01682A/en unknown
- 2013-01-23 AU AU2013213873A patent/AU2013213873B2/en active Active
- 2013-01-23 US US14/375,351 patent/US10301647B2/en active Active
- 2013-01-23 JP JP2014555328A patent/JP6340320B2/ja active Active
- 2013-01-23 CN CN201380007814.1A patent/CN104245941B/zh active Active
- 2013-01-23 CA CA2861408A patent/CA2861408C/en active Active
-
2018
- 2018-02-01 JP JP2018016342A patent/JP2018075035A/ja active Pending
-
2019
- 2019-04-30 US US16/398,691 patent/US20190376080A1/en not_active Abandoned
-
2021
- 2021-10-08 US US17/497,045 patent/US20220073948A1/en not_active Abandoned
-
2022
- 2022-06-30 US US17/855,322 patent/US20220348963A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2623604B1 (en) | 2015-02-25 |
| EP2623604A1 (en) | 2013-08-07 |
| WO2013114199A1 (en) | 2013-08-08 |
| AU2013213873B2 (en) | 2018-06-21 |
| US20220073948A1 (en) | 2022-03-10 |
| EP2623604B8 (en) | 2015-04-22 |
| CN104245941B (zh) | 2016-12-07 |
| ES2534782T3 (es) | 2015-04-28 |
| JP6340320B2 (ja) | 2018-06-06 |
| US20190376080A1 (en) | 2019-12-12 |
| AU2013213873A1 (en) | 2014-09-25 |
| DK2623604T3 (da) | 2015-06-01 |
| US20220348963A1 (en) | 2022-11-03 |
| US20150031083A1 (en) | 2015-01-29 |
| JP2018075035A (ja) | 2018-05-17 |
| JP2015506695A (ja) | 2015-03-05 |
| IN2014KN01682A (pl) | 2015-10-23 |
| US10301647B2 (en) | 2019-05-28 |
| EA033004B1 (ru) | 2019-08-30 |
| CA2861408A1 (en) | 2013-08-08 |
| WO2013114199A8 (en) | 2014-09-25 |
| CA2861408C (en) | 2021-10-26 |
| EA201491457A1 (ru) | 2014-11-28 |
| CN104245941A (zh) | 2014-12-24 |
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