PL2624873T3 - Nadające się do wstrzykiwania hydrożele tworzące pory do terapii komórkowych opartych na materiałach - Google Patents

Nadające się do wstrzykiwania hydrożele tworzące pory do terapii komórkowych opartych na materiałach

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Publication number
PL2624873T3
PL2624873T3 PL11831641T PL11831641T PL2624873T3 PL 2624873 T3 PL2624873 T3 PL 2624873T3 PL 11831641 T PL11831641 T PL 11831641T PL 11831641 T PL11831641 T PL 11831641T PL 2624873 T3 PL2624873 T3 PL 2624873T3
Authority
PL
Poland
Prior art keywords
injectable
pore
materials
based cell
cell therapies
Prior art date
Application number
PL11831641T
Other languages
English (en)
Inventor
Nathaniel D. Huebsch
Christopher M. Madl
Kangwon Lee
Maria M. XU
David J. Mooney
Original Assignee
President And Fellows Of Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by President And Fellows Of Harvard College filed Critical President And Fellows Of Harvard College
Publication of PL2624873T3 publication Critical patent/PL2624873T3/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
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    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3821—Bone-forming cells, e.g. osteoblasts, osteocytes, osteoprogenitor cells
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3826—Muscle cells, e.g. smooth muscle cells
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2400/00—Materials characterised by their function or physical properties
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    • A61L2430/00—Materials or treatment for tissue regeneration
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    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Composite Materials (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Materials Engineering (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL11831641T 2010-10-06 2011-10-06 Nadające się do wstrzykiwania hydrożele tworzące pory do terapii komórkowych opartych na materiałach PL2624873T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39059410P 2010-10-06 2010-10-06
EP11831641.3A EP2624873B1 (en) 2010-10-06 2011-10-06 Injectable, pore-forming hydrogels for materials-based cell therapies
PCT/US2011/055174 WO2012048165A2 (en) 2010-10-06 2011-10-06 Injectable, pore-forming hydrogels for materials-based cell therapies

Publications (1)

Publication Number Publication Date
PL2624873T3 true PL2624873T3 (pl) 2020-12-14

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL11831641T PL2624873T3 (pl) 2010-10-06 2011-10-06 Nadające się do wstrzykiwania hydrożele tworzące pory do terapii komórkowych opartych na materiałach

Country Status (16)

Country Link
US (2) US11202759B2 (pl)
EP (2) EP3620185A1 (pl)
JP (3) JP6104806B2 (pl)
KR (2) KR102155383B1 (pl)
CN (2) CN107648668B (pl)
AU (1) AU2011311904B2 (pl)
CA (1) CA2813751C (pl)
CY (1) CY1122736T1 (pl)
DK (1) DK2624873T3 (pl)
ES (1) ES2773858T3 (pl)
HR (1) HRP20200310T1 (pl)
LT (1) LT2624873T (pl)
PL (1) PL2624873T3 (pl)
PT (1) PT2624873T (pl)
SI (1) SI2624873T1 (pl)
WO (1) WO2012048165A2 (pl)

Families Citing this family (56)

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Publication number Priority date Publication date Assignee Title
PL2347775T3 (pl) 2005-12-13 2020-11-16 President And Fellows Of Harvard College Rusztowania do przeszczepiania komórek
WO2009002401A2 (en) * 2007-06-21 2008-12-31 President And Fellows Of Harvard College Scaffolds for cell collection or elimination
US9370558B2 (en) 2008-02-13 2016-06-21 President And Fellows Of Harvard College Controlled delivery of TLR agonists in structural polymeric devices
WO2009102465A2 (en) 2008-02-13 2009-08-20 President And Fellows Of Harvard College Continuous cell programming devices
US9012399B2 (en) 2008-05-30 2015-04-21 President And Fellows Of Harvard College Controlled release of growth factors and signaling molecules for promoting angiogenesis
WO2010120749A2 (en) 2009-04-13 2010-10-21 President And Fellow Of Harvard College Harnessing cell dynamics to engineer materials
CA2768552A1 (en) 2009-07-31 2011-02-03 President And Fellows Of Harvard College Programming of cells for tolerogenic therapies
WO2011109834A2 (en) * 2010-03-05 2011-09-09 President And Fellows Of Harvard College Enhancement of skeletal muscle stem cell engrafment by dual delivery of vegf and igf-1
US9693954B2 (en) 2010-06-25 2017-07-04 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
CA2813751C (en) 2010-10-06 2019-11-12 President And Fellows Of Harvard College Injectable, pore-forming hydrogels for materials-based cell therapies
US9603894B2 (en) 2010-11-08 2017-03-28 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
WO2012148684A1 (en) * 2011-04-27 2012-11-01 President And Fellows Of Harvard College Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
AU2012249456A1 (en) 2011-04-28 2013-10-31 President And Fellows Of Harvard College Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration
US9486512B2 (en) 2011-06-03 2016-11-08 President And Fellows Of Harvard College In situ antigen-generating cancer vaccine
US8753309B2 (en) 2011-06-24 2014-06-17 The Invention Science Fund I, Llc Device, system, and method including micro-patterned cell treatment array
PL2838515T3 (pl) 2012-04-16 2020-06-29 President And Fellows Of Harvard College Kompozycje mezoporowatego krzemu do modulowania odpowiedzi odpornościowych
ITTO20121159A1 (it) * 2012-12-28 2014-06-29 Fond Istituto Italiano Di Tecnologia Procedimento per la produzione di spugne polimeriche
WO2014133027A1 (ja) * 2013-02-26 2014-09-04 株式会社スリー・ディー・マトリックス ハイドロゲル
KR101495281B1 (ko) * 2014-01-10 2015-02-24 (주)안트로젠 피부 재생 또는 상처 치유를 위한 중간엽 줄기세포-하이드로겔-생분해성 또는 중간엽 줄기세포-하이드로겔-비분해성 지지체 조성물
JP7348708B2 (ja) 2014-04-30 2023-09-21 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 組み合わせワクチン装置および癌細胞を殺滅する方法
US11065362B2 (en) 2014-06-12 2021-07-20 President And Fellows Of Harvard College Viscoelastic hydrogels with fast stress relaxation
WO2015192017A1 (en) * 2014-06-12 2015-12-17 President And Fellows Of Harvard College Interpenetrating network hydrogels with independently tunable stiffness
ES3002759T3 (en) * 2014-07-17 2025-03-07 Univ California Controllable self-annealing microgel particles for biomedical applications
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
EP3206711B1 (en) 2014-10-14 2023-05-31 Novartis AG Antibody molecules to pd-l1 and uses thereof
HK1247861A1 (zh) 2015-01-30 2018-10-05 President And Fellows Of Harvard College 用於癌症治疗的肿瘤周围和肿瘤内部材料
US10232345B2 (en) 2015-02-12 2019-03-19 Arizona Board Of Regents On Behalf Of Arizona State University Aminoglycoside hydrogel microbeads and macroporous gels with chemical crosslink, method of preparation and use thereof
US9856332B2 (en) * 2015-03-23 2018-01-02 Arizona Board Of Regents On Behalf Of Arizona State University Methods for high-throughput in-situ manufacture of user desired 3D polymeric scaffolds
KR102311639B1 (ko) * 2015-03-26 2021-10-12 주식회사 티앤알바이오팹 심근조직 재생용 3차원 구조체의 제조방법
WO2016164705A1 (en) 2015-04-10 2016-10-13 Omar Abdel-Rahman Ali Immune cell trapping devices and methods for making and using the same
CN104984403B (zh) * 2015-06-16 2017-08-25 南方医科大学珠江医院 一种荷载药物及脂肪来源间充质干细胞的多肽水凝胶支架及其制备方法
US11554195B2 (en) 2015-06-22 2023-01-17 Cedars-Sinai Medical Center Method for regenerating the interverterbral disc with notochordal cells
EP3317301B1 (en) 2015-07-29 2021-04-07 Novartis AG Combination therapies comprising antibody molecules to lag-3
WO2017019896A1 (en) 2015-07-29 2017-02-02 Novartis Ag Combination therapies comprising antibody molecules to pd-1
WO2017019897A1 (en) 2015-07-29 2017-02-02 Novartis Ag Combination therapies comprising antibody molecules to tim-3
RS62239B1 (sr) * 2015-09-09 2021-09-30 Eth Zuerich Injektibilni makroporozni hidrogelovi
CN108430458B (zh) * 2015-10-26 2022-05-10 哈佛学院院长等 还原和氧化的多糖及其使用方法
CN105250994A (zh) * 2015-10-29 2016-01-20 广州赛莱拉干细胞科技股份有限公司 一种促进皮肤伤口愈合的制剂及其制备方法和应用
EP4424322A3 (en) 2015-12-17 2025-04-16 Novartis AG Antibody molecules to pd-1 and uses thereof
CN109072197A (zh) 2016-02-06 2018-12-21 哈佛学院校长同事会 重塑造血巢以重建免疫
MA45738A (fr) 2016-07-13 2019-05-22 Harvard College Échafaudages mimétiques de cellules présentant l'antigène et procédés pour les préparer et les utiliser
IL264557B2 (en) 2016-08-02 2024-01-01 Harvard College Biological agents for regulating immune responses
US11602581B2 (en) 2017-09-27 2023-03-14 Industry-University Cooperation Foundation Hanyang University Cell-encapsulated hydrogel block preparation for 3D bioprinting-based tissue engineering and macrostructure assembly technology thereof
CN107899074A (zh) * 2017-12-29 2018-04-13 深圳清华大学研究院 皮肤细胞喷雾及其制备方法
MX2020009237A (es) 2018-03-06 2021-04-28 Epibone Inc Composiciones inyectables de reparacion de cartilagos, tendones y ligamentos fuera del estante y metodos de uso.
WO2020061129A1 (en) 2018-09-19 2020-03-26 President And Fellows Of Harvard College Compositions and methods for labeling and modulation of cells in vitro and in vivo
CN110478532B (zh) 2019-08-22 2021-12-28 上海交通大学医学院附属第九人民医院 一种可注射原位生孔水凝胶体系及其制备方法和用途
WO2021061837A1 (en) 2019-09-23 2021-04-01 President And Fellows Of Harvard College Biomaterial-based antigen free vaccine and the use thereof
GB2593203A (en) * 2020-03-19 2021-09-22 Griffin Paste Res Limited Combinations, kits and methods
CN111888524A (zh) * 2020-08-04 2020-11-06 宁波迪创医疗科技有限公司 一种组织填充材料及其制备方法、组织工程支架和应用
US20250281676A1 (en) * 2020-08-10 2025-09-11 Gel4Med, Inc. Delivery of cells and tissues with self-assembling peptide hydrogel materials
CN113813448B (zh) * 2021-10-08 2022-12-06 大连大学附属中山医院 一种含有类软骨陷窝结构的硬度可调水凝胶支架
US20260061094A1 (en) 2022-09-01 2026-03-05 Cells For Cells S.A. Method for obtaining a porous injectable scaffold based on similar biopolymers, but with different melting temperatures
EP4704933A1 (en) 2023-05-03 2026-03-11 Volumina Medical SA Devices and methods for preparing and conditioning biological assemblies for minimally invasive delivery for tissue engineering, cell therapies and other therapeutic applications
WO2025219066A1 (en) 2024-04-15 2025-10-23 Merck Patent Gmbh Alginate microbeads, methods for their preparation, and bioink formulations containing the same.

Family Cites Families (251)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US5073627A (en) 1989-08-22 1991-12-17 Immunex Corporation Fusion proteins comprising GM-CSF and IL-3
GB9206504D0 (en) 1992-03-25 1992-05-06 Jevco Ltd Heteromorphic sponges as wound implants
JPH09506866A (ja) 1993-12-14 1997-07-08 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 医薬として活性のある物質の免疫療法のための放出制御
US5538733A (en) 1994-07-07 1996-07-23 Willmar Poultry Company, Inc. Method of priming an immune response in a one-day old animal
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
PT772619E (pt) 1994-07-15 2006-10-31 Univ Iowa Res Found Oligonucleotidos imunomoduladores
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US6329499B1 (en) 1994-11-18 2001-12-11 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein
US6251396B1 (en) 1994-11-18 2001-06-26 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
US5951976A (en) 1996-03-28 1999-09-14 Whitenead Institute For Biomedical Research Opsonin-enhanced cells, and methods of modulating an immune response to an antigen
IL118376A0 (en) 1996-05-22 1996-09-12 Univ Ben Gurion Polysaccharide sponges for cell culture and transplantation
AU3214797A (en) 1996-05-28 1998-01-05 Regents Of The University Of Michigan, The Engineering oral tissues
US6124128A (en) 1996-08-16 2000-09-26 The Regents Of The University Of California Long wavelength engineered fluorescent proteins
JP4335316B2 (ja) 1996-09-19 2009-09-30 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン アルギネートまたは修飾アルギネートのようなポリサッカライドを含むポリマー
US5863551A (en) 1996-10-16 1999-01-26 Organogel Canada Ltee Implantable polymer hydrogel for therapeutic uses
GB2318577B (en) 1996-10-28 2000-02-02 Johnson & Johnson Medical Solvent dried polysaccharide sponges
GB2323282B (en) 1997-03-17 2001-03-07 Bristol Myers Squibb Co Improvements relating to hygiene and medical products
ES2205467T3 (es) 1997-03-31 2004-05-01 The Regents Of The University Of Michigan Matrices biodegradables de poros abiertos.
ATE412383T1 (de) 1997-05-30 2008-11-15 Osteobiologics Inc Faserverstärkte,poröse,biologisch abbaubare implantatvorrichtung
CN1106846C (zh) 1997-08-21 2003-04-30 宝酒造株式会社 抗癌症剂
US6160084A (en) 1998-02-23 2000-12-12 Massachusetts Institute Of Technology Biodegradable shape memory polymers
CA2322435A1 (en) 1998-03-02 1999-09-10 Applied Vaccine Technologies Corp. Methods and devices for modulating the immune response
DE69935507T2 (de) 1998-04-03 2007-12-06 University Of Iowa Research Foundation Verfahren und produkte zur stimulierung des immunsystems mittels immunotherapeutischer oligonukleotide und zytokine
US7427602B1 (en) 1998-05-13 2008-09-23 The Regents Of The University Of Michigan Sustained DNA delivery from structural matrices
US7244714B1 (en) 1998-06-12 2007-07-17 Aradigm Corporation Methods of delivering aerosolized polynucleotides to the respiratory tract
FR2780730B1 (fr) * 1998-07-01 2000-10-13 Corneal Ind Compositions biphasiques injectables, notamment utiles en chirurgies reparatrice et esthetique
EP2311485A1 (en) 1998-07-30 2011-04-20 The Government of the United States of America, as represented by the Secretary of Health and Human Services Thymosin beta 4 promotes wound repair
JP2002527408A (ja) 1998-10-09 2002-08-27 ミシガン大学 ドラッグデリバリー用ヒドロゲル及び水溶性ポリマーキャリアー
US7109003B2 (en) 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
US6974698B1 (en) 1999-01-15 2005-12-13 The United States Of America As Represented By The Department Of Health And Human Services Methods for delivering biologically active molecules into cells
EP1156781B1 (en) 1999-02-26 2005-06-08 Chiron Corporation Microemulsions with adsorbed macromolecules and microparticles
US6767928B1 (en) 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
CA2370063C (en) 1999-03-19 2012-10-02 The Regents Of The University Of Michigan Mineralization and cellular patterning on biomaterial surfaces
EP2305324B1 (en) 1999-03-25 2014-09-17 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US6511650B1 (en) 1999-04-09 2003-01-28 The Regents Of The University Of Michigan Preparing porous hydrogel products
AU782297B2 (en) 1999-06-30 2005-07-14 Ethicon Inc. Porous tissue scaffoldings for the repair or regeneration of tissue
US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
CN1378445B (zh) 1999-08-06 2013-02-06 得克萨斯系统大学评议会 药物释放生物可降解纤维植入物
US7015205B1 (en) 1999-10-18 2006-03-21 St. Vincent's Hospital And Medical Center Of New York Melanoma vaccine and methods of making and using same
AU1622801A (en) 1999-11-18 2001-05-30 Regents Of The University Of Michigan, The Sustained drug delivery from structural matrices
US6682754B2 (en) 1999-11-24 2004-01-27 Willmar Poultry Company, Inc. Ovo delivery of an immunogen containing implant
US6790840B1 (en) 1999-11-26 2004-09-14 The Regents Of The University Of Michigan Reversibly cross-linked hydrogels
WO2002009650A2 (en) 2000-07-31 2002-02-07 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
JP2004507237A (ja) 2000-08-21 2004-03-11 ライスユニバーシティ マトリクスタンパク質の産生を促進する組織工学足場
US7785810B2 (en) 2000-09-09 2010-08-31 The Research Foundation Of State University Of New York Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof
US6748954B2 (en) 2000-10-27 2004-06-15 The Regents Of The University Of Michigan Drug release from polymer matrices through mechanical stimulation
JPWO2002040071A1 (ja) 2000-11-14 2004-03-18 上田　実 骨又は歯周組織形成用組成物、及び骨又は歯周組織形成用注射剤
CN1487839A (zh) 2000-11-27 2004-04-07 ղ˹��C��ղ˹���˹ 用作佐剂的集合素
US8554940B2 (en) 2001-01-19 2013-10-08 Single Touch Interactive, Inc. System and method for routing media
MXPA03006587A (es) 2001-01-24 2003-09-22 Schering Corp Quimiocinas como adyuvantes de respuesta inmune.
US7029697B2 (en) 2001-02-14 2006-04-18 Northwestern University Controlled surface-associated delivery of genes and oligonucleotides
CA2439400A1 (en) 2001-02-26 2002-09-06 The Regents Of The University Of California Non-oligomerizing tandem fluorescent proteins
US20020131953A1 (en) 2001-03-14 2002-09-19 Ut Southwestern Medical Center In situ langerhans cell vaccine
JP2002263981A (ja) 2001-03-14 2002-09-17 Murata Mach Ltd 板材吸着持ち上げ装置の吸着制御装置
US6656488B2 (en) 2001-04-11 2003-12-02 Ethicon Endo-Surgery, Inc. Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering
CA2448599A1 (en) 2001-04-27 2002-11-07 Invitrogen Corporation Maturation of antigen-presenting cells using activated t cells
US20030118630A1 (en) 2001-12-07 2003-06-26 Anthony Cerami Immune modulation device for use in animals
DE60229375D1 (de) 2001-05-11 2008-11-27 Ortho Mcneil Janssen Pharm Immunmodulations-vorrichtung zur verwendung in tieren
AU2002345691C1 (en) 2001-06-13 2008-07-24 Massachusetts Institute Of Technology In vivo bioreactors
US7297343B2 (en) 2001-07-31 2007-11-20 Biosurface Engineering Technologies, Inc. Bioactive medical films
US7354909B2 (en) 2001-08-14 2008-04-08 The United States Of America As Represented By Secretary Of The Department Of Health And Human Services Method for rapid generation of mature dendritic cells
CA2412012C (en) 2001-11-20 2011-08-02 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage
WO2003057072A2 (en) 2001-12-31 2003-07-17 Ares Laboratories, Llc Hemostatic compositions and methods for controlling bleeding
US7575759B2 (en) 2002-01-02 2009-08-18 The Regents Of The University Of Michigan Tissue engineering scaffolds
US20080233181A1 (en) 2002-04-12 2008-09-25 Nagy Jon O Nanoparticle adjuvants for sub-unit vaccines
US6811777B2 (en) 2002-04-13 2004-11-02 Allan Mishra Compositions and minimally invasive methods for treating incomplete connective tissue repair
KR101092043B1 (ko) 2002-04-22 2011-12-12 바이오니취 라이프 사이언시즈 인코포레이티드 올리고뉴클레오티드 조성물 및 면역 반응 조절시 이의 용도
WO2003089506A1 (en) 2002-04-22 2003-10-30 Purdue Research Foundation Hydrogels having enhanced elasticity and mechanical strength properties
US20040242469A1 (en) 2002-05-13 2004-12-02 Lee Richard T. Angiogenesis and cardiac tissue engineering with peptide hydrogels and related compositions and methods of use thereof
AUPS312602A0 (en) 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
US7332160B2 (en) 2002-07-12 2008-02-19 Boston Scientific Scimed, Inc. Medical device and method for tissue removal and repair
EP2261247A3 (en) 2002-09-12 2011-02-16 Oncotherapy Science, Inc. KDR peptides and vaccines comprising the same
US20040136968A1 (en) 2002-09-27 2004-07-15 Verigen Ag Autologous cells on a support matrix for tissue repair
US20040063206A1 (en) 2002-09-30 2004-04-01 Rowley Jon A. Programmable scaffold and method for making and using the same
AU2003272805A1 (en) 2002-10-01 2004-04-23 Peter K. Law Bioactive implants
JP2004159849A (ja) 2002-11-12 2004-06-10 National Institute Of Advanced Industrial & Technology 細胞接着性生体吸収材料、人工血管およびそれらの製造方法
JP4511943B2 (ja) 2002-12-23 2010-07-28 ワイス エルエルシー Ｐｄ−１に対する抗体およびその使用
US8940292B2 (en) 2003-01-28 2015-01-27 Wake Forest University Health Sciences Enhancement of angiogenesis to grafts using cells engineered to produce growth factors
SE0301109D0 (sv) 2003-04-14 2003-04-14 Mallen Huang Nucleotide vaccine composition
EP2314327B2 (en) * 2003-05-05 2017-09-20 Ben-Gurion University Of The Negev Research And Development Authority Injectable cross-linked polymeric preparations and uses thereof
EP1475434A1 (en) 2003-05-09 2004-11-10 Oncoscience AG Method for storing tumor cells
CA2531032A1 (en) 2003-07-09 2005-02-17 Vaxdesign Corporation Programmed immune responses using a vaccination node
US20060264380A1 (en) 2003-07-21 2006-11-23 Mats Hellstrom Compounds and Methods for Promoting Angiogenesis
GB0317999D0 (en) 2003-07-31 2003-09-03 Univ Liege Improvements in or relating to drug delivery systems
US8247231B2 (en) 2003-07-31 2012-08-21 Wilson Constance N Methods and compositions for producing antigenic responses
EP1664168B1 (en) * 2003-08-29 2008-12-03 Mayo Foundation for Medical Education and Research Hydrogel porogens for fabricating biodegradable scaffolds
EP2481422A3 (en) 2003-09-03 2013-04-03 Dendritherapeutics, Inc. Multiplex vaccines
GB0321615D0 (en) 2003-09-15 2003-10-15 Glaxo Group Ltd Improvements in vaccination
JP5021309B2 (ja) 2003-10-16 2012-09-05 ステファン ジョン ラルフ 免疫調節性組成物およびその使用方法
WO2005046461A1 (en) 2003-11-07 2005-05-26 Carnegie Mellon University Robot for minimally invasive interventions
CA2448995A1 (en) 2003-11-12 2005-05-12 James Keenan Device and method for attracting diseased cells and foreign substances
JP2005160669A (ja) 2003-12-02 2005-06-23 Olympus Corp 生体組織補填体の製造方法
JP2005170816A (ja) 2003-12-09 2005-06-30 Naoki Ishiguro 軟骨修復用材料、およびその製造方法
EP1697511A4 (en) 2003-12-11 2007-11-21 Vaxdesign Corp IMMUNOTHERAPY COMPOSITIONS, METHODS FOR PREPARING AND USING THE SAME
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US7192693B2 (en) 2004-02-24 2007-03-20 University Of Washington Methods for photopatterning hydrogels
JP4931798B2 (ja) 2004-03-15 2012-05-16 ケイ．アール． カラオリス，デイヴィッド 免疫、炎症または神経保護応答のための方法
US7592326B2 (en) 2004-03-15 2009-09-22 Karaolis David K R Method for stimulating the immune, inflammatory or neuroprotective response
WO2005104755A2 (en) 2004-04-28 2005-11-10 Vaxdesign Corporation Artificial immune system: methods for making and use
WO2006080946A2 (en) 2004-06-08 2006-08-03 Coley Pharmaceutical Gmbh Abasic oligonucleotide as carrier platform for antigen and immunostimulatory agonist and antagonist
WO2007001332A2 (en) 2004-08-04 2007-01-04 University Of Massachusetts Anti-pathogen immunoadhesins
JP2008511336A (ja) 2004-09-01 2008-04-17 アメリカ合衆国 免疫原性が増加したアデノウイルスベクターをインビボで用いる方法
AU2005295927B2 (en) 2004-10-12 2012-02-02 Fmc Biopolymer As Self-gelling alginate systems and uses thereof
US7235592B2 (en) 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
JP4487734B2 (ja) * 2004-11-10 2010-06-23 株式会社デンソー フィン製造装置
US7999161B2 (en) 2005-01-22 2011-08-16 Alexander Oraevsky Laser-activated nanothermolysis of cells
US7569850B2 (en) 2005-01-24 2009-08-04 Lawrence Livermore National Security, Llc Lipid bilayers on nano-templates
WO2006102530A1 (en) 2005-03-23 2006-09-28 Mayo Foundation For Medical Education And Research Photocrosslinkable oligo(poly (ethylene glycol) fumarate) hydrogels for cell and drug delivery
EP1869169A4 (en) 2005-03-29 2015-11-04 Univ California REGULATION OF THE DESTINATION OF STEM CELLS BY ADJUSTABLE NETWORK
EP1712238A1 (en) 2005-04-11 2006-10-18 Institut Gustave Roussy Anthracyclin induced immunogenic dead or dying cells composition
US8828433B2 (en) 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US20070003595A1 (en) 2005-04-19 2007-01-04 Shaopeng Wang Three dimensional micro-environments and methods of making and using same
CN101355928B (zh) 2005-04-26 2013-05-22 卫材R&D管理株式会社 用于癌症免疫疗法的组合物和方法
WO2006119619A1 (en) 2005-05-06 2006-11-16 Replicor Inc. Oligonucleotides inhibiting cell proliferation
ITPI20050071A1 (it) * 2005-06-20 2006-12-21 Giuseppe Calvosa Composizione biocompatibile per la sostituzione/rigenerazione di tessuti
US7645742B2 (en) 2005-06-22 2010-01-12 Advocare International, L.P. Composition for enhancing cellular energy
CN1302050C (zh) 2005-07-07 2007-02-28 复旦大学 一种互穿网络聚合物超多孔水凝胶及其制备方法和应用
US20090017096A1 (en) * 2005-08-15 2009-01-15 Anthony Lowman Porous non-biodegradable hydrogel admixed with a chemoattractant for tissue replacement
CN101291586A (zh) * 2005-09-02 2008-10-22 英特菲思生物技术公司 用于细胞植入的方法
BRPI0503817A (pt) 2005-09-12 2007-05-15 Cristalia Prod Quimicos Farm complexo imunogênico formado por antìgenos vacinais encapsulados por sìlica mesoporosa nanoestruturada
US20090130067A1 (en) 2005-09-23 2009-05-21 Dirk Buscher Cell Population Having Immunoregulatory Activity, Method for Isolation and Uses
US20070081972A1 (en) 2005-09-30 2007-04-12 The University Of Iowa Research Foundation Polymer-based delivery system for immunotherapy of cancer
KR20080065656A (ko) 2005-10-12 2008-07-14 캔써 리서치 테크놀로지 리미티드 면역질환을 치료하기 위한 방법 및 조성물
US8029575B2 (en) 2005-10-25 2011-10-04 Globus Medical, Inc. Porous and nonporous materials for tissue grafting and repair
US20070116680A1 (en) 2005-11-18 2007-05-24 Rensselaer Polytechnic Institute Stem cells within gel microenvironments
DK2119450T3 (da) 2005-11-29 2013-05-06 Actogenix Nv Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener
KR100687281B1 (ko) 2005-11-30 2007-02-27 한국과학기술연구원 생리 활성 물질이 결합된 조직 재생용 주입형 온도 감응성플루로닉 유도체 하이드로겔 및 이의 제조 방법
CA2631677C (en) 2005-12-01 2014-08-12 Pronai Therapeutics, Inc. Amphoteric liposome formulation
AU2015264807A1 (en) 2005-12-13 2015-12-17 President And Fellows Of Harvard College Scaffolds for Cell Transplantation
PL2347775T3 (pl) 2005-12-13 2020-11-16 President And Fellows Of Harvard College Rusztowania do przeszczepiania komórek
JP5068269B2 (ja) * 2005-12-14 2012-11-07 シル テクノロジー ゲーエムベーハー 骨再生のための成形可能な生体材料
EP1806395A1 (en) 2006-01-06 2007-07-11 Stichting Sanquin Bloedvoorziening Maturation of dendritic cells
US7615556B2 (en) 2006-01-27 2009-11-10 Bristol-Myers Squibb Company Piperazinyl derivatives as modulators of chemokine receptor activity
US20070178159A1 (en) 2006-01-30 2007-08-02 Alza Corporation In-Situ Forming Porous Scaffold
JP2009525341A (ja) 2006-01-31 2009-07-09 メディバス エルエルシー ワクチン送達組成物および使用法
US20070190646A1 (en) 2006-02-10 2007-08-16 The Trustees Of The University Of Pennsylvania Regulating stem cell differentiation by controlling matrix elasticity
US20100015709A1 (en) 2006-02-10 2010-01-21 Trustees Of The University Of Pennsylvania Regulating Stem Cell Differentiation By Controlling 2D and 3D Matrix Elasticity
US20090169532A1 (en) 2006-02-27 2009-07-02 Ying Jackie Y Curable bone cement
US9456860B2 (en) 2006-03-14 2016-10-04 Kci Licensing, Inc. Bioresorbable foaming tissue dressing
GB0605521D0 (en) 2006-03-18 2006-04-26 Isis Innovation Adjuvant
US20090297579A1 (en) 2006-06-01 2009-12-03 Massachusetts Institute Of Technology Control of Cells and Cell Multipotentiality in Three Dimensional Matrices
EP2032149A4 (en) * 2006-06-13 2010-09-01 Fmc Biopolymer As METHOD AND SYSTEMS FOR THE USE OF BIOPOLYMER-BASED BEADS AND HYDROGELS
ES2386123T3 (es) * 2006-06-16 2012-08-09 Fmc Biopolymer As Dispositivo celular con una matriz de colágeno revestida de alginato, proceso para su formación y utilizaciones
US20070298067A1 (en) 2006-06-22 2007-12-27 Boston Scientific Scimed, Inc. Control release drug coating for medical devices
CA2690973A1 (en) 2006-06-23 2007-12-27 Paul M. Simon Targeted immune conjugates
US8535719B2 (en) 2006-07-07 2013-09-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biohybrid elastomeric scaffolds and methods of use thereof
US7993918B2 (en) 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
KR100802139B1 (ko) 2006-08-08 2008-02-11 한국생명공학연구원 자성 나노입자를 함유하는 골드 나노케이지
KR100818708B1 (ko) 2006-08-18 2008-04-01 주식회사 하이닉스반도체 표면 세정을 포함하는 반도체소자 제조방법
ITMI20061726A1 (it) 2006-09-11 2008-03-12 Fidia Farmaceutici Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
GB2455041B (en) 2006-09-21 2012-03-07 Purdue Research Foundation Collagen preparation and method of isolation
EP3590503A1 (en) 2006-10-12 2020-01-08 The University of Queensland Compositions and methods for modulating immune responses
US20080114277A1 (en) 2006-11-09 2008-05-15 Archel Ambrosio Porous bioresorbable dressing conformable to a wound and methods of making same
WO2008086486A1 (en) 2007-01-10 2008-07-17 The Regents Of The University Of Michigan Porous objects having immobilized encapsulated biomolecules
EP2842570B1 (en) 2007-03-07 2020-05-06 UTI Limited Partnership Compositions and methods for the prevention and treatment of autoimmune conditions
JP2010522540A (ja) 2007-03-21 2010-07-08 アイディー バイオメディカル コーポレイション オブ ケベック キメラ抗原
WO2008118392A2 (en) 2007-03-22 2008-10-02 The Regents Of The University Of California Synthetic cell platforms and methods of use thereof
EP1975230A1 (en) 2007-03-30 2008-10-01 Capsulution Nanoscience AG Method for forming glucose sensing micro-particles, use of micro-particles, and kit
EP2209476A4 (en) 2007-04-19 2011-01-19 Univ Pittsburgh USE OF TOLL-LIKE RECEPTOR 9 AGONISTS; TOLL-LIKE RECEPTOR-4 ANTAGONISTS AND / OR NUCLEAR OLIGOMERIZATION DOMAIN-2-AGONSITES FOR TREATING OR PREVENTING DISEASES RELATED TO TOLL-LIKE RECEPTOR-4
EA200901621A1 (ru) 2007-06-05 2010-06-30 Новартис Аг Индукция толерогенного фенотипа у зрелых дендритных клеток
JP2010531138A (ja) 2007-06-13 2010-09-24 ラ ホヤ インスティテュート フォア アラージー アンド イムノロジー 制御性ｔ細胞ならびに同製造および使用方法
US20100178313A1 (en) * 2007-06-13 2010-07-15 Fmc Corporation Implantable Degradable Biopolymer Fiber Devices
WO2009002401A2 (en) 2007-06-21 2008-12-31 President And Fellows Of Harvard College Scaffolds for cell collection or elimination
EP2173859B1 (en) 2007-06-29 2016-05-11 Makoto Funaki Soft gel systems in modulating stem cell development
CN102317303A (zh) 2007-07-31 2012-01-11 约翰·霍普金斯大学 用于肿瘤或感染性疾病的免疫预防或免疫治疗的多肽-核酸偶联物
GB0716264D0 (en) 2007-08-21 2007-09-26 Isis Innovation Bilayers
US8426179B2 (en) 2007-08-30 2013-04-23 Northwestern University Synthetic peptide and peptide conjugates and related tissue coupling methods via transglutaminase enzyme
US20090192079A1 (en) 2007-10-09 2009-07-30 Genzyme Corporation Prolonged delivery of heparin-binding growth factors from heparin-derivatized collagen
CN101439206A (zh) * 2007-11-22 2009-05-27 郭倩 酶催化快速固化水凝胶的制备及其应用
KR100900837B1 (ko) 2007-12-07 2009-06-04 (주)두비엘 리포펩타이드와 폴리(ｉ:ｃ)를 아쥬반트로 포함하는 강력한백신 조성물
EP2072617A1 (en) 2007-12-12 2009-06-24 Trimed Biotech GmbH Method for producing dendritic cells
DE102008008522A1 (de) 2008-02-11 2009-08-13 Magforce Nanotechnologies Ag Implantierbare Nanopartikel-enthaltende Produkte
WO2011063336A2 (en) 2009-11-20 2011-05-26 President And Fellows Of Harvard College Secondary site of antigen stimulation for therapeutic vaccination
US9370558B2 (en) 2008-02-13 2016-06-21 President And Fellows Of Harvard College Controlled delivery of TLR agonists in structural polymeric devices
WO2009102465A2 (en) 2008-02-13 2009-08-20 President And Fellows Of Harvard College Continuous cell programming devices
WO2009117721A1 (en) 2008-03-21 2009-09-24 3D Biotek, Llc Hybrid biomedical device fabricated from biomaterials and coated with a cell culture derived ecm coating
US9012399B2 (en) 2008-05-30 2015-04-21 President And Fellows Of Harvard College Controlled release of growth factors and signaling molecules for promoting angiogenesis
WO2009155583A1 (en) 2008-06-19 2009-12-23 The Trustees Of The University Of Pennsylvania Biomaterials for tissue replacement
PL2350129T3 (pl) 2008-08-25 2015-12-31 Amplimmune Inc Kompozycje antagonistów PD-1 i sposoby stosowania
US8889124B2 (en) 2008-09-25 2014-11-18 The Board Of Trustees Of The Leland Stanford Junior University Tolerogenic populations of dendritic cells
US8940331B2 (en) 2008-11-22 2015-01-27 The Board Of Trustees Of The Leland Stanford Junior University Hydrogels, methods of making hydrogels, methods of using hydrogels, and methods of isolating, trapping, attracting, and/or killing cancer cells
KR101132732B1 (ko) 2008-11-26 2012-04-06 한국과학기술연구원 인 시튜 조직재생용 지능형 다공성 생분해 고분자 지지체 및 이의 제조방법
US8273373B2 (en) 2008-12-30 2012-09-25 Case Western Reserve University Photocrosslinked biodegradable hydrogel
JP2012514476A (ja) 2009-01-08 2012-06-28 アルバート アインシュタイン カレッジ オブ メディシン オブ イェシバ ユニバーシティ，ア ディビジョン オブ イェシバ ユニバーシティ 細胞壁結合セラミド様糖脂質による細菌ワクチンおよびその使用
CN101612437B (zh) * 2009-01-09 2011-09-14 清华大学 纳曲酮微球-水凝胶骨架原位埋植给药系统
JP2010227012A (ja) 2009-03-27 2010-10-14 Seiko Epson Corp がん細胞捕捉デバイス
WO2010120749A2 (en) 2009-04-13 2010-10-21 President And Fellow Of Harvard College Harnessing cell dynamics to engineer materials
US8551749B2 (en) 2009-04-23 2013-10-08 The Invention Science Fund I, Llc Device including bone cage and method for treatment of disease in a subject
CA2768552A1 (en) 2009-07-31 2011-02-03 President And Fellows Of Harvard College Programming of cells for tolerogenic therapies
CN101655611B (zh) 2009-09-11 2011-06-08 中国科学院长春应用化学研究所 一种具有双层杂化结构的反蛋白石水凝胶光子晶体的制备方法
CN102686606A (zh) 2009-10-09 2012-09-19 阿纳福公司 结合il-23r的多肽
EP2486132A1 (en) 2009-10-09 2012-08-15 Anaphore, Inc. Combinatorial libraries based on c-type lectin domain
US20110207166A1 (en) 2009-11-06 2011-08-25 Sarah Rivkah Vaiselbuh Human bone marrow microenvironments and uses thereof
EP2514718A4 (en) 2009-12-18 2013-09-04 Kao Corp METHOD FOR PRODUCING MESOPOROUS SILICONE ARTICLES
JP5603063B2 (ja) 2009-12-21 2014-10-08 花王株式会社 複合シリカ粒子の製造方法
AU2011207626B2 (en) 2010-01-19 2015-06-18 President And Fellows Of Harvard College Engineered opsonin for pathogen detection and treatment
CN102858188A (zh) 2010-02-22 2013-01-02 维基塞尔设计股份有限公司 在天然运输系统中包封物质
CN102869446B (zh) 2010-03-02 2016-03-30 阿卜杜拉国王科技大学 高比表面积纤维二氧化硅纳米颗粒
WO2011108649A1 (ja) 2010-03-04 2011-09-09 地方独立行政法人東京都立産業技術研究センター 多孔質シリカの製造方法および多孔質シリカ
WO2011109834A2 (en) 2010-03-05 2011-09-09 President And Fellows Of Harvard College Enhancement of skeletal muscle stem cell engrafment by dual delivery of vegf and igf-1
US20130029030A1 (en) 2010-03-15 2013-01-31 Kristian Larsen Method for promotion of hemostasis and/or wound healing
US20110300186A1 (en) 2010-04-14 2011-12-08 Battelle Memorial Institute Functionalized Nano- and Micro-materials for Medical Therapies
US20110256184A1 (en) 2010-04-14 2011-10-20 Battelle Memorial Institute Non-ordered Mesoporous Silica Structure for Biomolecule Loading and Release
US20110293723A1 (en) 2010-05-26 2011-12-01 Selecta Biosciences, Inc. Synthetic nanocarrier combination vaccines
GB201009273D0 (en) 2010-06-03 2010-07-21 Glaxosmithkline Biolog Sa Novel vaccine
US9693954B2 (en) 2010-06-25 2017-07-04 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
CN103118678A (zh) 2010-07-16 2013-05-22 约翰斯·霍普金斯大学 用于癌症免疫治疗的方法和组合物
AU2011285639B2 (en) 2010-08-04 2014-12-18 Georgia Tech Research Corporation Devices, systems, and methods for excavating cancer cells
CA2813751C (en) 2010-10-06 2019-11-12 President And Fellows Of Harvard College Injectable, pore-forming hydrogels for materials-based cell therapies
US9603894B2 (en) 2010-11-08 2017-03-28 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
WO2012148684A1 (en) 2011-04-27 2012-11-01 President And Fellows Of Harvard College Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
AU2012249456A1 (en) 2011-04-28 2013-10-31 President And Fellows Of Harvard College Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
EA027259B1 (ru) 2011-04-29 2017-07-31 Селекта Байосайенсиз, Инк. Наноносители, вырабатывающие иммунную толерантность, для антиген-специфического удаления т-эффекторных клеток
US9486512B2 (en) 2011-06-03 2016-11-08 President And Fellows Of Harvard College In situ antigen-generating cancer vaccine
EP2723741B8 (en) 2011-06-24 2016-09-21 ArQule, Inc. Substituted imidazopyridinyl-aminopyridine compounds
EP3081937B1 (en) 2011-07-18 2019-11-13 President and Fellows of Harvard College Engineered microbe-targeting molecules and uses thereof
CN110446037B (zh) 2011-11-08 2022-01-04 韩国电子通信研究院 用于共享候选者列表的方法和装置
US20130145488A1 (en) 2011-12-06 2013-06-06 Iowa State University Research Foundation, Inc. Mesoporous silica nanoparticles suitable for co-delivery
CN109125718A (zh) 2012-01-13 2019-01-04 哈佛学院董事会 在结构聚合装置中tlr激动剂的控制传递
CA2867169C (en) 2012-03-16 2021-07-06 Merck Patent Gmbh Targeting aminoacid lipids
PL2838515T3 (pl) 2012-04-16 2020-06-29 President And Fellows Of Harvard College Kompozycje mezoporowatego krzemu do modulowania odpowiedzi odpornościowych
CN108524919A (zh) 2012-05-17 2018-09-14 延伸生物科学股份有限公司 用于改进的药物递送的载体
EP2744830A4 (en) 2012-06-21 2015-06-17 Compugen Ltd LSR ANTIBODIES AND USES THEREOF FOR THE TREATMENT OF CANCER
US20140072510A1 (en) 2012-09-13 2014-03-13 Northwestern University Synthetic Scaffolds for Metastasis Detection
WO2014063128A1 (en) 2012-10-20 2014-04-24 Board Of Regents, The University Of Texas System Cancer cell trap
SI2931738T1 (sl) 2012-12-13 2019-05-31 Aduro Biotech, Inc. Sestave, ki vsebujejo ciklične purin dinukleotide z definirano stereokemijo, ter metode za njihovo pripravo in uporabo
CA2902841A1 (en) 2013-03-13 2014-10-02 Creatics Llc Methods and compositions for detecting pancreatic cancer
JP6453855B2 (ja) 2013-05-18 2019-01-16 アドゥロ バイオテック，インク． 「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を活性化するための組成物及び方法
EP3848045A1 (en) 2013-05-21 2021-07-14 President and Fellows of Harvard College Engineered heme-binding compositions and uses thereof
WO2014190229A1 (en) 2013-05-24 2014-11-27 President And Fellows Of Harvard College Methods of isolating microorganisms and uses thereof
US9884026B2 (en) 2013-11-01 2018-02-06 Yale University Modular particles for immunotherapy
JP2016538344A (ja) 2013-11-19 2016-12-08 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ 癌処置としてのｓｔｉｎｇアゴニストの使用
ES2811301T3 (es) 2014-04-04 2021-03-11 Harvard College Hidrogeles reticulados por química clic y métodos de uso
JP7348708B2 (ja) 2014-04-30 2023-09-21 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 組み合わせワクチン装置および癌細胞を殺滅する方法
US11065362B2 (en) 2014-06-12 2021-07-20 President And Fellows Of Harvard College Viscoelastic hydrogels with fast stress relaxation
WO2016004068A1 (en) 2014-06-30 2016-01-07 Jae-Won Shin Hydrogel compositions comprising encapsulated cells and methods of use thereof
HK1247861A1 (zh) 2015-01-30 2018-10-05 President And Fellows Of Harvard College 用於癌症治疗的肿瘤周围和肿瘤内部材料
WO2016161372A1 (en) 2015-04-01 2016-10-06 President And Fellows Of Harvard College Immunoconjugates for programming or reprogramming of cells
WO2016164705A1 (en) 2015-04-10 2016-10-13 Omar Abdel-Rahman Ali Immune cell trapping devices and methods for making and using the same
CN108289928B (zh) 2015-08-06 2024-09-17 哈佛大学校长及研究员协会 改进的微生物-结合分子和其用途
CN109072197A (zh) 2016-02-06 2018-12-21 哈佛学院校长同事会 重塑造血巢以重建免疫
JP6854530B2 (ja) 2016-02-16 2021-04-07 プレジデント アンド フェローズ オブ ハーバード カレッジ 病原体ワクチンならびにその製造および使用方法
MA45738A (fr) 2016-07-13 2019-05-22 Harvard College Échafaudages mimétiques de cellules présentant l'antigène et procédés pour les préparer et les utiliser
IL264557B2 (en) 2016-08-02 2024-01-01 Harvard College Biological agents for regulating immune responses

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