PL2635563T3 - Postacie krystaliczne soli chlorowodorkowej (4a-r,9a-s)-1-(1h-benzoimidazolo-5-karbonylo)-2,3,4,4a,9,9a-heksahydro-1h-indeno[2,1-b]pirydyno-6-karbonitrylu i ich zastosowanie jako inhibitory hsd 1 - Google Patents

Postacie krystaliczne soli chlorowodorkowej (4a-r,9a-s)-1-(1h-benzoimidazolo-5-karbonylo)-2,3,4,4a,9,9a-heksahydro-1h-indeno[2,1-b]pirydyno-6-karbonitrylu i ich zastosowanie jako inhibitory hsd 1

Info

Publication number: PL2635563T3
Authority: PL; Poland
Prior art keywords: benzoimidazole; indeno; hsd; carbonitrile; hexahydro
Prior art date: 2010-11-05

Application number

PL11785232T

Other languages

English (en)

Inventor

Matthias Eckhardt

Hans-Juergen Martin

Martin Schuehle

Sandra Sick

Bing-Shiou Yang

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-11-05

Filing date

2011-11-04

Publication date

2015-06-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999935&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2635563(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-11-05 Priority claimed from PCT/US2010/055586 external-priority patent/WO2011057054A1/en

2011-11-04 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2015-06-30 Publication of PL2635563T3 publication Critical patent/PL2635563T3/pl

Links

QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 title 1
101100451537 Caenorhabditis elegans hsd-1 gene Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL11785232T 2010-11-05 2011-11-04 Postacie krystaliczne soli chlorowodorkowej (4a-r,9a-s)-1-(1h-benzoimidazolo-5-karbonylo)-2,3,4,4a,9,9a-heksahydro-1h-indeno[2,1-b]pirydyno-6-karbonitrylu i ich zastosowanie jako inhibitory hsd 1 PL2635563T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
PCT/US2010/055586 WO2011057054A1 (en)	2009-11-06	2010-11-05	Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
US201161484995P	2011-05-11	2011-05-11
EP11785232.7A EP2635563B1 (en)	2010-11-05	2011-11-04	Crystalline forms of hydrochloride salt of (4a-r,9a-s)-1-(1h-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1h-indeno [2,1-b]pyridine-6-carbonitrile and their use as hsd 1 inhibitors
PCT/US2011/059331 WO2012061708A1 (en)	2010-11-05	2011-11-04	Crystalline forms of hydrochloride salt of (4a-r,9a-s) -1- (1h - benzoimidazole- 5 -carbonyl) -2, 3, 4, 4a, 9, 9a - hexahydro -1h- indeno [2, 1 -b] pyridine- 6 -carbonitrile and their use as hsd 1 inhibitors

Publications (1)

Publication Number	Publication Date
PL2635563T3 true PL2635563T3 (pl)	2015-06-30

Family

ID=44999935

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL11785232T PL2635563T3 (pl)	2010-11-05	2011-11-04	Postacie krystaliczne soli chlorowodorkowej (4a-r,9a-s)-1-(1h-benzoimidazolo-5-karbonylo)-2,3,4,4a,9,9a-heksahydro-1h-indeno[2,1-b]pirydyno-6-karbonitrylu i ich zastosowanie jako inhibitory hsd 1

Country Status (36)

Country	Link
US (2)	US8686149B2 (pl)
EP (1)	EP2635563B1 (pl)
JP (1)	JP2013541592A (pl)
KR (1)	KR20130119939A (pl)
CN (1)	CN103228642B (pl)
AP (1)	AP3521A (pl)
AR (1)	AR083678A1 (pl)
AU (1)	AU2011323164B2 (pl)
BR (1)	BR112013011095A2 (pl)
CA (1)	CA2816136A1 (pl)
CL (1)	CL2013001221A1 (pl)
CO (1)	CO6781480A2 (pl)
CY (1)	CY1116043T1 (pl)
DK (1)	DK2635563T3 (pl)
EA (1)	EA022406B1 (pl)
EC (2)	ECSP12011788A (pl)
ES (1)	ES2533833T3 (pl)
GE (1)	GEP20166481B (pl)
HR (1)	HRP20150327T1 (pl)
IL (1)	IL225647A0 (pl)
ME (1)	ME02066B (pl)
MX (1)	MX2013005069A (pl)
NZ (1)	NZ609281A (pl)
PE (1)	PE20140123A1 (pl)
PH (1)	PH12013500879A1 (pl)
PL (1)	PL2635563T3 (pl)
PT (1)	PT2635563E (pl)
RS (1)	RS53900B1 (pl)
SG (1)	SG189859A1 (pl)
SI (1)	SI2635563T1 (pl)
SM (1)	SMT201500095B (pl)
TN (1)	TN2012000117A1 (pl)
TW (1)	TWI537258B (pl)
UA (1)	UA110807C2 (pl)
UY (1)	UY33701A (pl)
WO (1)	WO2012061708A1 (pl)

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JP5860042B2 (ja)	2010-06-16	2016-02-16	ヴァイティーファーマシューティカルズ，インコーポレイテッド	置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh)	2010-11-05	2016-06-11	百靈佳殷格翰國際股份有限公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
JP2014524438A (ja)	2011-08-17	2014-09-22	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	インデノピリジン誘導体
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CN111315735B (zh)	2017-09-04	2024-03-08	C4医药公司	二氢苯并咪唑酮
WO2020181232A1 (en)	2019-03-06	2020-09-10	C4 Therapeutics, Inc.	Heterocyclic compounds for medical treatment
CN118005644B (zh) *	2024-01-29	2025-12-16	中国科学院南海海洋研究所	十氢芴型生物碱及其制备方法和在制备抗菌药物中应用

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TWI537258B (zh)	2010-11-05	2016-06-11	百靈佳殷格翰國際股份有限公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物

2011
- 2011-10-18 TW TW100137675A patent/TWI537258B/zh not_active IP Right Cessation
- 2011-11-01 UY UY0001033701A patent/UY33701A/es not_active Application Discontinuation
- 2011-11-01 AR ARP110104053A patent/AR083678A1/es unknown
- 2011-11-04 AP AP2013006902A patent/AP3521A/xx active
- 2011-11-04 KR KR1020137014295A patent/KR20130119939A/ko not_active Withdrawn
- 2011-11-04 AU AU2011323164A patent/AU2011323164B2/en not_active Ceased
- 2011-11-04 UA UAA201307042A patent/UA110807C2/uk unknown
- 2011-11-04 MX MX2013005069A patent/MX2013005069A/es unknown
- 2011-11-04 GE GEAP201113105A patent/GEP20166481B/en unknown
- 2011-11-04 NZ NZ609281A patent/NZ609281A/en not_active IP Right Cessation
- 2011-11-04 US US13/289,418 patent/US8686149B2/en active Active
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- 2011-11-04 WO PCT/US2011/059331 patent/WO2012061708A1/en not_active Ceased
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- 2011-11-04 DK DK11785232.7T patent/DK2635563T3/en active
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- 2011-11-04 CN CN201180053044.5A patent/CN103228642B/zh not_active Expired - Fee Related
2012
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2013
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Also Published As

Publication number	Publication date
ES2533833T3 (es)	2015-04-15
TN2012000117A1 (en)	2013-09-19
UY33701A (es)	2012-05-31
PH12013500879A1 (en)	2013-07-01
EA022406B1 (ru)	2015-12-30
CA2816136A1 (en)	2012-05-10
KR20130119939A (ko)	2013-11-01
EA201390643A1 (ru)	2013-11-29
PT2635563E (pt)	2015-04-13
CN103228642B (zh)	2015-02-18
ECSP13012664A (es)	2013-08-30
NZ609281A (en)	2015-02-27
CL2013001221A1 (es)	2013-11-08
SI2635563T1 (sl)	2015-04-30
CO6781480A2 (es)	2013-10-31
ECSP12011788A (es)	2012-10-30
JP2013541592A (ja)	2013-11-14
US9120769B2 (en)	2015-09-01
RS53900B1 (sr)	2015-08-31
BR112013011095A2 (pt)	2016-08-02
SG189859A1 (en)	2013-06-28
AU2011323164A1 (en)	2013-05-02
AR083678A1 (es)	2013-03-13
TW201242960A (en)	2012-11-01
PE20140123A1 (es)	2014-03-02
WO2012061708A1 (en)	2012-05-10
CN103228642A (zh)	2013-07-31
UA110807C2 (uk)	2016-02-25
AP2013006902A0 (en)	2013-06-30
US20120157488A1 (en)	2012-06-21
AP3521A (en)	2016-01-11
AU2011323164B2 (en)	2015-07-23
SMT201500095B (it)	2015-07-09
US20140249174A1 (en)	2014-09-04
EP2635563A1 (en)	2013-09-11
CY1116043T1 (el)	2017-01-25
TWI537258B (zh)	2016-06-11
HK1184144A1 (en)	2014-01-17
US8686149B2 (en)	2014-04-01
IL225647A0 (en)	2013-06-27
GEP20166481B (en)	2016-05-25
HRP20150327T1 (hr)	2015-04-24
MX2013005069A (es)	2013-08-29
ME02066B (me)	2015-05-20
DK2635563T3 (en)	2015-02-02
EP2635563B1 (en)	2015-01-14

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