PL2654778T3 - Szczepionki oparte na peptydach białka dopełniacza C5A - Google Patents

Szczepionki oparte na peptydach białka dopełniacza C5A

Info

Publication number: PL2654778T3
Authority: PL; Poland
Prior art keywords: peptides; complement protein; vaccines based; vaccines; complement
Prior art date: 2010-12-21

Application number

PL11802093T

Other languages

English (en)

Inventor

Günther STAFFLER

Christine Landlinger

Frank Mattner

Original Assignee

Affiris Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-12-21

Filing date

2011-12-21

Publication date

2019-09-30

2011-12-21 Application filed by Affiris Ag filed Critical Affiris Ag

2019-09-30 Publication of PL2654778T3 publication Critical patent/PL2654778T3/pl

Links

102000000989 Complement System Proteins Human genes 0.000 title 1
108010069112 Complement System Proteins Proteins 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
229960005486 vaccine Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Epidemiology (AREA)
Mycology (AREA)
Microbiology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Rheumatology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Zoology (AREA)
Toxicology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Transplantation (AREA)
Heart & Thoracic Surgery (AREA)

PL11802093T 2010-12-21 2011-12-21 Szczepionki oparte na peptydach białka dopełniacza C5A PL2654778T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP10196232A EP2468295A1 (en)	2010-12-21	2010-12-21	Vaccines based on peptides of the complement protein C5a
PCT/EP2011/073599 WO2012085090A1 (en)	2010-12-21	2011-12-21	Vaccines based on peptides of the complement protein c5a
EP11802093.2A EP2654778B1 (en)	2010-12-21	2011-12-21	Vaccines based on peptides of the complement protein c5a

Publications (1)

Publication Number	Publication Date
PL2654778T3 true PL2654778T3 (pl)	2019-09-30

Family

ID=43929080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL11802093T PL2654778T3 (pl)	2010-12-21	2011-12-21	Szczepionki oparte na peptydach białka dopełniacza C5A

Country Status (16)

Country	Link
US (1)	US9457078B2 (pl)
EP (2)	EP2468295A1 (pl)
JP (1)	JP6016803B2 (pl)
KR (1)	KR20140053816A (pl)
CN (1)	CN103269711B (pl)
BR (1)	BR112013011285A2 (pl)
CA (1)	CA2822266A1 (pl)
DK (1)	DK2654778T3 (pl)
ES (1)	ES2718632T3 (pl)
IL (1)	IL225671A0 (pl)
MX (1)	MX2013007007A (pl)
NZ (1)	NZ608889A (pl)
PL (1)	PL2654778T3 (pl)
RU (1)	RU2013133875A (pl)
SG (1)	SG189842A1 (pl)
WO (1)	WO2012085090A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN107074925B (zh) *	2014-07-10	2021-08-24	阿费里斯股份公司	用于预防和/或治疗亨廷顿氏病的物质和方法
CN116731149B (zh) *	2023-06-07	2024-02-27	华中农业大学	草鱼补体活化分子碳末端肽C5a-CP及应用
CN119019569B (zh) *	2024-08-19	2025-10-24	中国人民解放军陆军军医大学	一种可定向增强胸腺新生t细胞杀伤乳腺癌的多肽及其应用

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US4686100A (en)	1985-04-02	1987-08-11	The Board Of Trustees Of The Leland Stanford Junior University	Method for the treatment of adult respiratory distress syndrome
JP2703764B2 (ja)	1986-04-28	1998-01-26	シータスオンコロジーコーポレイション	補体成分Ｃ５ａに対するモノクローナル抗体
JPH04503073A (ja) *	1989-01-31	1992-06-04	アボツト・ラボラトリーズ	アナフィラトキシン受容体リガンド
US5807824A (en)	1993-12-06	1998-09-15	Ciba-Geigy Corporation	C5A receptor antagonists having substantially no agonist activity
US6074642A (en)	1994-05-02	2000-06-13	Alexion Pharmaceuticals, Inc.	Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
JPH08109200A (ja)	1994-08-19	1996-04-30	Takeda Chem Ind Ltd	抗Ｃ５ａレセプター抗体、その製造法および用途
US5696230A (en)	1994-08-31	1997-12-09	The Board Of Regents Of The University Of Nebraska	High-affinity response-selective C-terminal analogs of C5a anaphylatoxin
WO1996039503A1 (en) *	1995-06-05	1996-12-12	Novartis Ag	C5a RECEPTOR ANTAGONISTS HAVING SUBSTANTIALLY NO AGONIST ACTIVITY AND METHODS FOR PREPARATION
AUPO755097A0 (en)	1997-06-25	1997-07-17	University Of Queensland, The	Receptor agonist and antagonist
US6673346B1 (en) *	1999-08-31	2004-01-06	The Regents Of The University Of Michigan	Compositions and methods for the treatment of sepsis
EP3372243A1 (en)	2001-08-17	2018-09-12	Genentech, Inc.	Complement pathway inhibitors binding to c5 and c5a without preventing formation of c5b
CA2457461C (en)	2001-08-17	2013-12-24	Tanox, Inc.	Complement pathway inhibitors binding to c5 and c5a without preventing the formation of c5b
NZ534399A (en)	2002-01-25	2008-08-29	G2 Therapies Ltd	Monoclonal antibodies against extracellular loops of C5aR
ITMI20021527A1 (it) *	2002-07-11	2004-01-12	Consiglio Nazionale Ricerche	Anticorpi anti componente c5 del complemento e loro uso
ES2614274T3 (es)	2002-09-06	2017-05-30	Alexion Pharmaceuticals, Inc.	Procedimiento de tratamiento de asma usando anticuerpos frente al componente de complemento C5
ES2323692T3 (es) *	2002-12-02	2009-07-23	Resistentia Holding Ab	Metodos y materiales para tratar afecciones inflamatorias usando un polipeptido que comprende un segmento de aminoacidos c5 autogenicos y un segmento de aminoacidos no autogenicos.
DK1727567T3 (da) *	2004-02-12	2013-10-14	Archemix Llc	Aptamer-terapeutiske midler nyttige i behandling af komplementrelaterede forstyrrelser
JP2006151866A (ja)	2004-11-29	2006-06-15	Canon Inc	フェナントロリン化合物及び発光素子
DE602006019948D1 (de)	2005-03-11	2011-03-17	Potentia Pharmaceuticals Inc	Koppelten rezeptors zur behandlung von makuladegeneration
RU2007147938A (ru)	2005-06-14	2009-07-20	Цитос Биотехнологи Аг (Ch)	Конъюгаты антигенов и их применение
US20110092446A1 (en) *	2007-07-20	2011-04-21	Cedric Francois	Compositions and methods for treatment of trauma
CN104193824A (zh)	2008-02-20	2014-12-10	G2炎症私人有限公司	人源化抗-C5aR抗体
JP6022441B2 (ja) *	2010-04-30	2016-11-09	アレクシオンファーマシューティカルズ，インコーポレイテッド	抗Ｃ５ａ抗体およびその抗体の使用のための方法

2010
- 2010-12-21 EP EP10196232A patent/EP2468295A1/en not_active Withdrawn
2011
- 2011-12-21 CA CA2822266A patent/CA2822266A1/en not_active Abandoned
- 2011-12-21 JP JP2013545364A patent/JP6016803B2/ja not_active Expired - Fee Related
- 2011-12-21 PL PL11802093T patent/PL2654778T3/pl unknown
- 2011-12-21 BR BR112013011285A patent/BR112013011285A2/pt not_active IP Right Cessation
- 2011-12-21 NZ NZ608889A patent/NZ608889A/en not_active IP Right Cessation
- 2011-12-21 MX MX2013007007A patent/MX2013007007A/es not_active Application Discontinuation
- 2011-12-21 EP EP11802093.2A patent/EP2654778B1/en not_active Not-in-force
- 2011-12-21 KR KR1020137013674A patent/KR20140053816A/ko not_active Withdrawn
- 2011-12-21 SG SG2013025804A patent/SG189842A1/en unknown
- 2011-12-21 DK DK11802093.2T patent/DK2654778T3/en active
- 2011-12-21 ES ES11802093T patent/ES2718632T3/es active Active
- 2011-12-21 WO PCT/EP2011/073599 patent/WO2012085090A1/en not_active Ceased
- 2011-12-21 US US13/879,740 patent/US9457078B2/en not_active Expired - Fee Related
- 2011-12-21 CN CN201180061862.XA patent/CN103269711B/zh not_active Expired - Fee Related
- 2011-12-21 RU RU2013133875/10A patent/RU2013133875A/ru not_active Application Discontinuation
2013
- 2013-04-10 IL IL225671A patent/IL225671A0/en unknown

Also Published As

Publication number	Publication date
AU2011347341B2 (en)	2016-05-12
MX2013007007A (es)	2013-07-29
US20130216565A1 (en)	2013-08-22
IL225671A0 (en)	2013-06-27
WO2012085090A1 (en)	2012-06-28
US9457078B2 (en)	2016-10-04
AU2011347341A8 (en)	2016-06-16
KR20140053816A (ko)	2014-05-08
DK2654778T3 (en)	2019-04-15
CN103269711A (zh)	2013-08-28
EP2468295A1 (en)	2012-06-27
CN103269711B (zh)	2016-06-08
NZ608889A (en)	2014-05-30
CA2822266A1 (en)	2012-06-28
EP2654778B1 (en)	2019-01-23
ES2718632T3 (es)	2019-07-03
JP6016803B2 (ja)	2016-10-26
BR112013011285A2 (pt)	2019-09-24
AU2011347341A1 (en)	2013-05-02
SG189842A1 (en)	2013-06-28
EP2654778A1 (en)	2013-10-30
RU2013133875A (ru)	2015-01-27
JP2014501745A (ja)	2014-01-23

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