PL2668182T3 - Inhibitowanie IL17 i IFN-gamma do leczenia zapalenia autoimmunologicznego - Google Patents

Inhibitowanie IL17 i IFN-gamma do leczenia zapalenia autoimmunologicznego

Info

Publication number
PL2668182T3
PL2668182T3 PL12703013T PL12703013T PL2668182T3 PL 2668182 T3 PL2668182 T3 PL 2668182T3 PL 12703013 T PL12703013 T PL 12703013T PL 12703013 T PL12703013 T PL 12703013T PL 2668182 T3 PL2668182 T3 PL 2668182T3
Authority
PL
Poland
Prior art keywords
ifn
treatment
autoimmune inflammation
gamma inhibition
gamma
Prior art date
Application number
PL12703013T
Other languages
English (en)
Inventor
Johann Leban
Roland Baumgartner
Wael Saeb
Carine Chevrier
Stefan Tasler
Original Assignee
Immunic Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunic Ag filed Critical Immunic Ag
Publication of PL2668182T3 publication Critical patent/PL2668182T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PL12703013T 2011-01-28 2012-01-27 Inhibitowanie IL17 i IFN-gamma do leczenia zapalenia autoimmunologicznego PL2668182T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161437061P 2011-01-28 2011-01-28
EP11152515 2011-01-28
EP12703013.8A EP2668182B1 (en) 2011-01-28 2012-01-27 Il17 and ifn-gamma inhibition for the treatment of autoimmune inflammation
PCT/EP2012/051357 WO2012101261A1 (en) 2011-01-28 2012-01-27 Il17 and ifn-gamma inhibition for the treatment of autoimmune inflammation

Publications (1)

Publication Number Publication Date
PL2668182T3 true PL2668182T3 (pl) 2018-11-30

Family

ID=46577835

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12703013T PL2668182T3 (pl) 2011-01-28 2012-01-27 Inhibitowanie IL17 i IFN-gamma do leczenia zapalenia autoimmunologicznego

Country Status (24)

Country Link
US (1) US8592456B2 (pl)
EP (1) EP2668182B1 (pl)
JP (1) JP5969505B2 (pl)
KR (1) KR101875248B1 (pl)
CN (1) CN103476771B (pl)
AR (1) AR085040A1 (pl)
AU (1) AU2012210489B2 (pl)
BR (1) BR112013019011B1 (pl)
CA (1) CA2825684C (pl)
DK (1) DK2668182T3 (pl)
EA (1) EA027351B1 (pl)
ES (1) ES2664507T3 (pl)
IL (1) IL227626A0 (pl)
MX (1) MX353762B (pl)
MY (1) MY162397A (pl)
PH (1) PH12013501574A1 (pl)
PL (1) PL2668182T3 (pl)
PT (1) PT2668182T (pl)
RU (1) RU2013139663A (pl)
SG (1) SG192176A1 (pl)
TW (1) TWI520955B (pl)
UA (1) UA113160C2 (pl)
UY (1) UY33884A (pl)
WO (1) WO2012101261A1 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2664219T3 (es) * 2011-01-28 2018-04-18 Immunic Ag Inhibición de IL17 e IFN-gamma para el tratamiento de una inflamación autoinmunitaria
EP2738170B1 (en) * 2011-07-29 2017-08-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
EP2809660B1 (en) 2012-02-02 2016-01-20 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating il-17
CN107007597A (zh) 2012-05-31 2017-08-04 菲尼克斯药品股份公司 作为孤儿核受体RORγ调节物的经甲酰胺或磺酰胺取代的噻唑及相关衍生物的制药用途
JO3215B1 (ar) 2012-08-09 2018-03-08 Phenex Pharmaceuticals Ag حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy
CN104978732A (zh) * 2014-04-11 2015-10-14 中国船舶工业系统工程研究院 一种摄像机参数标定板
WO2015176031A2 (en) 2014-05-15 2015-11-19 Incube Labs, Llc Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
RU2580301C1 (ru) * 2015-04-21 2016-04-10 Людмила Николаевна Хон Способ лечения системной красной волчанки человека
HRP20221042T1 (hr) * 2017-09-06 2022-11-11 Immunic Ag Derivati 1-(4-(izoksazol-5-il)-1h-pirazol-1-il)-2-metilpropan-2-ola i srodni spojevi kao inhibitori il-7 i ifn-gama za liječenje autoimunih bolesti i kronične upale
WO2019223718A1 (zh) * 2018-05-22 2019-11-28 成都先导药物开发股份有限公司 一种免疫调节剂
CN112341435B (zh) * 2019-08-09 2021-10-22 成都先导药物开发股份有限公司 一种免疫调节剂
CN112341442B (zh) * 2019-08-09 2021-10-22 成都先导药物开发股份有限公司 一种免疫调节剂
CN112341519B (zh) * 2019-08-09 2025-10-03 成都先导药物开发股份有限公司 一种免疫调节剂
WO2021027729A1 (zh) * 2019-08-09 2021-02-18 成都先导药物开发股份有限公司 一种免疫调节剂
WO2023281097A1 (en) 2021-07-09 2023-01-12 Immunic Ag Methods for treating cancer
EP4508049A1 (en) 2022-04-14 2025-02-19 Immunic AG Deuterated rorgamma/rorgammat inverse agonists
WO2023232870A1 (en) 2022-05-31 2023-12-07 Immunic Ag Rorg/rorgt modulators for the treatment of virus infections like covid-19

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0610744B1 (en) * 1993-02-09 1998-11-04 Bayer Corporation Sulfonamide aminomethylene derivatives as immunosuppressants
JP3237608B2 (ja) * 1997-04-21 2001-12-10 住友製薬株式会社 イソキサゾール誘導体
US6100260A (en) * 1997-04-21 2000-08-08 Sumitomo Pharmaceutical Company, Limited Isoxazole derivatives
ID22897A (id) * 1997-04-21 1999-12-16 Sumitomo Pharmaceutical Compan Turunan isoksazol
US20060089398A1 (en) * 2003-03-19 2006-04-27 Gang Liu Isoxazole carboxamide derivatives as ghrelin receptor modulators
EP1725544B1 (en) * 2004-03-09 2009-05-27 Boehringer Ingelheim Pharmaceuticals Inc. 3-[4-heterocyclyl-1,2,3-triazol-1-yl]-n-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases
TW200826936A (en) * 2006-12-01 2008-07-01 Merck Frosst Canada Ltd Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
EP2350064A1 (en) * 2008-10-01 2011-08-03 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
AR076984A1 (es) * 2009-06-08 2011-07-20 Merck Serono Sa Derivados de pirazol oxadiazol
ES2664219T3 (es) * 2011-01-28 2018-04-18 Immunic Ag Inhibición de IL17 e IFN-gamma para el tratamiento de una inflamación autoinmunitaria

Also Published As

Publication number Publication date
US20120196861A1 (en) 2012-08-02
DK2668182T3 (da) 2018-01-29
AU2012210489B2 (en) 2017-01-12
PT2668182T (pt) 2018-01-31
EA201300862A1 (ru) 2014-04-30
MY162397A (en) 2017-06-15
UY33884A (es) 2012-08-31
TW201309682A (zh) 2013-03-01
CN103476771A (zh) 2013-12-25
UA113160C2 (xx) 2016-12-26
SG192176A1 (en) 2013-08-30
EP2668182A1 (en) 2013-12-04
KR20140041440A (ko) 2014-04-04
JP2014504608A (ja) 2014-02-24
EP2668182B1 (en) 2017-11-01
NZ613592A (en) 2015-03-27
CA2825684C (en) 2021-11-23
IL227626A0 (en) 2013-09-30
WO2012101261A1 (en) 2012-08-02
CA2825684A1 (en) 2012-08-02
MX353762B (es) 2018-01-26
AU2012210489A1 (en) 2013-08-15
TWI520955B (zh) 2016-02-11
BR112013019011B1 (pt) 2021-10-13
US8592456B2 (en) 2013-11-26
ES2664507T3 (es) 2018-04-19
BR112013019011A2 (pt) 2017-07-11
KR101875248B1 (ko) 2018-08-02
MX2013008718A (es) 2014-02-17
EA027351B1 (ru) 2017-07-31
PH12013501574A1 (en) 2013-09-30
RU2013139663A (ru) 2015-03-10
CN103476771B (zh) 2015-12-23
JP5969505B2 (ja) 2016-08-17
AR085040A1 (es) 2013-08-07

Similar Documents

Publication Publication Date Title
PT2668182T (pt) Inibição de il-7 e de ifn gama para o tratamento de inflamação autoimune
PT2668183T (pt) Inibição de il-7 e de ifn gama para o tratamento de inflamação autoimune
IL273815B (en) Secondary vaccine particles for the treatment of inflammation
IL261768B (en) Devices and methods for tissue treatment
TWI560200B (en) Anti-kir antibodies for the treatment of inflammatory and autoimmune disorders
EP2709562A4 (en) FABRIC BACKUP DEVICES AND USE METHOD THEREFOR
EP2678018A4 (en) COMBINATION OF CHINESE HEMMER AND USES THEREOF
EP2699199A4 (en) SYSTEMS AND METHODS FOR BARIATRIC THERAPY
SG10201707020TA (en) Substituted 3-haloallylamine inhibitors of ssao and uses thereof
IL233111A0 (en) Preparations for the treatment of inflammation
GB201411462D0 (en) Prebiotic formulations and methods of use
EP2771030A4 (en) COMPOSITIONS AND METHOD FOR THE TREATMENT OF PROTEINOPATHIES
IL229079A0 (en) Methods and compositions using 4pde inhibitors for the treatment and management of autoimmune and inflammatory diseases
PH12014500815A1 (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune
EP2574172A4 (en) MATERIALS AND METHOD FOR TREATING INFLAMMATION
PL2830654T3 (pl) Sposoby i kompozycje do leczenia zapalenia
EP2866830A4 (en) ANTI-CXCL9, ANTI-CXCL10, ANTI-CXCL11, ANTI-CXCL13, ANTI-CXCR3 AND ANTI-CXCR5 ACTIVITIES FOR INHIBITING IGNITION
ZA201408055B (en) Compositions and methods for the treatment of local pain
EP2673288A1 (en) Peptide for use in the treatment of skin conditions
SI2827883T1 (sl) Inhibitorji TFPI in postopki uporabe
ZA201408062B (en) Compositions and methods for the treatment of multiple sclerosis
IL233080B (en) Bisarylsulfonamides used to treat inflammation and cancer
IL239308A0 (en) Treatment of diseases of endothelial dysfunction and inflammation
PL2744497T3 (pl) Terapeutyczne połączenia netupitantu i palonosetronu
IL223385B (en) Treatment of inflammatory disorders