PL2668183T3 - Inhibitowanie IL17 i IFN-gamma do leczenia zapalenia autoimmunologicznego - Google Patents

Inhibitowanie IL17 i IFN-gamma do leczenia zapalenia autoimmunologicznego

Info

Publication number
PL2668183T3
PL2668183T3 PL12703014T PL12703014T PL2668183T3 PL 2668183 T3 PL2668183 T3 PL 2668183T3 PL 12703014 T PL12703014 T PL 12703014T PL 12703014 T PL12703014 T PL 12703014T PL 2668183 T3 PL2668183 T3 PL 2668183T3
Authority
PL
Poland
Prior art keywords
ifn
treatment
autoimmune inflammation
gamma inhibition
gamma
Prior art date
Application number
PL12703014T
Other languages
English (en)
Inventor
Johann Leban
Stefan Tasler
Wael Saeb
Carine Chevrier
Original Assignee
Immunic Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunic Ag filed Critical Immunic Ag
Publication of PL2668183T3 publication Critical patent/PL2668183T3/pl

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL12703014T 2011-01-28 2012-01-27 Inhibitowanie IL17 i IFN-gamma do leczenia zapalenia autoimmunologicznego PL2668183T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161437080P 2011-01-28 2011-01-28
EP11152512 2011-01-28
EP12703014.6A EP2668183B1 (en) 2011-01-28 2012-01-27 Il17 and ifn-gamma inhibition for the treatment of autoimmune inflammation
PCT/EP2012/051360 WO2012101263A1 (en) 2011-01-28 2012-01-27 Il17 and ifn-gamma inhibition for the treatment of autoimmune inflammation

Publications (1)

Publication Number Publication Date
PL2668183T3 true PL2668183T3 (pl) 2018-10-31

Family

ID=46577836

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12703014T PL2668183T3 (pl) 2011-01-28 2012-01-27 Inhibitowanie IL17 i IFN-gamma do leczenia zapalenia autoimmunologicznego

Country Status (25)

Country Link
US (1) US8354436B2 (pl)
EP (1) EP2668183B1 (pl)
JP (1) JP5883034B2 (pl)
KR (1) KR101865437B1 (pl)
CN (1) CN103459385B (pl)
AR (1) AR085038A1 (pl)
AU (1) AU2012210491B2 (pl)
BR (1) BR112013019256B1 (pl)
CA (1) CA2825779C (pl)
DK (1) DK2668183T3 (pl)
EA (1) EA026361B1 (pl)
ES (1) ES2664219T3 (pl)
HU (1) HUE036027T2 (pl)
IL (1) IL227682A0 (pl)
MX (1) MX348726B (pl)
MY (1) MY183974A (pl)
PH (1) PH12013501591A1 (pl)
PL (1) PL2668183T3 (pl)
PT (1) PT2668183T (pl)
RU (1) RU2013139662A (pl)
SG (1) SG192198A1 (pl)
TW (1) TWI533867B (pl)
UA (1) UA110048C2 (pl)
UY (1) UY33885A (pl)
WO (1) WO2012101263A1 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5969505B2 (ja) * 2011-01-28 2016-08-17 4エスツェー ディスカバリー ゲゼルシャフト ミット ベシュレンクテル ハフツング 自己免疫性炎症の治療のためのIL17及びIFN−γ阻害
WO2013018695A1 (ja) * 2011-07-29 2013-02-07 武田薬品工業株式会社 複素環化合物
EP2809660B1 (en) 2012-02-02 2016-01-20 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating il-17
SG11201407919WA (en) 2012-05-31 2014-12-30 Phenex Pharmaceuticals Ag Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ror[gamma]
JO3215B1 (ar) 2012-08-09 2018-03-08 Phenex Pharmaceuticals Ag حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy
US9707154B2 (en) 2013-04-24 2017-07-18 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
WO2017221174A1 (en) * 2016-06-22 2017-12-28 Novartis Ag Methods of treating vitiligo using interleukin-17 (il-17) antibodies
CN110121359A (zh) * 2016-11-11 2019-08-13 怀特黑德生物制剂研究所 人血浆培养基
JP2020532575A (ja) * 2017-09-06 2020-11-12 イミュニック アクチェンゲゼルシャフト 自己免疫疾患及び慢性炎症を治療するためのil−17及びifn−ガンマの阻害剤としての1−(4−(イソオキサゾール−5−イル)−1h−ピラゾール−1−イル)−2−メチルプロパン−2−オール誘導体及び関連化合物
AU2019224354A1 (en) * 2018-02-22 2020-10-08 Nippon Zoki Pharmaceutical Co., Ltd. IL-17a activity inhibitor and use thereof
RU2704967C1 (ru) * 2018-06-19 2019-11-01 Федеральное государственное бюджетное образовательное учреждение высшего образования "Ярославский государственный педагогический университет им. К.Д. Ушинского (ЯГПУ им. К.Д. Ушинского) Карбоксамидные производные изоксазолина, способ их получения и применения для лечения воспалительных заболеваний
CN112341439B (zh) * 2019-08-09 2022-02-15 成都先导药物开发股份有限公司 一种免疫调节剂
WO2021027729A1 (zh) * 2019-08-09 2021-02-18 成都先导药物开发股份有限公司 一种免疫调节剂
CN112341441B (zh) * 2019-08-09 2022-02-11 成都先导药物开发股份有限公司 一种免疫调节剂
WO2023281097A1 (en) 2021-07-09 2023-01-12 Immunic Ag Methods for treating cancer
US20250243190A1 (en) 2022-04-14 2025-07-31 Immunic Ag New deuterated rorgamma/rorgammat inverse agonists
WO2023232870A1 (en) 2022-05-31 2023-12-07 Immunic Ag Rorg/rorgt modulators for the treatment of virus infections like covid-19

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514977B1 (en) * 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
PT1725544E (pt) * 2004-03-09 2009-07-02 Boehringer Ingelheim Pharma 3-[4-heterociclil-1,2,3-triazol-1-il]-n-aril-benzamidas como inibidores da produção de citocinas para o tratamento de doenças inflamatórias crónicas
RU2426731C2 (ru) * 2005-12-23 2011-08-20 Ф. Хоффманн-Ля Рош Аг Производные арил-изоксазоло-4-ил-оксадиазола
JP2012515787A (ja) * 2009-01-23 2012-07-12 ブリストル−マイヤーズ スクイブ カンパニー 自己免疫疾患および炎症性疾患の処置におけるs1pアゴニストとしての置換オキサジアゾール誘導体
JP5969505B2 (ja) * 2011-01-28 2016-08-17 4エスツェー ディスカバリー ゲゼルシャフト ミット ベシュレンクテル ハフツング 自己免疫性炎症の治療のためのIL17及びIFN−γ阻害

Also Published As

Publication number Publication date
AU2012210491A1 (en) 2013-08-15
MX348726B (es) 2017-06-26
JP5883034B2 (ja) 2016-03-09
ES2664219T3 (es) 2018-04-18
MX2013008722A (es) 2014-02-17
EA201300863A1 (ru) 2014-02-28
KR101865437B1 (ko) 2018-06-07
MY183974A (en) 2021-03-17
TW201236681A (en) 2012-09-16
AR085038A1 (es) 2013-08-07
AU2012210491B2 (en) 2016-10-13
PT2668183T (pt) 2018-02-05
KR20140041441A (ko) 2014-04-04
UA110048C2 (uk) 2015-11-10
CN103459385B (zh) 2015-08-05
WO2012101263A1 (en) 2012-08-02
EA026361B1 (ru) 2017-03-31
BR112013019256B1 (pt) 2021-10-13
HUE036027T2 (hu) 2018-08-28
EP2668183B1 (en) 2017-11-01
IL227682A0 (en) 2013-09-30
EP2668183A1 (en) 2013-12-04
CA2825779C (en) 2020-02-25
RU2013139662A (ru) 2015-03-10
SG192198A1 (en) 2013-09-30
CN103459385A (zh) 2013-12-18
US8354436B2 (en) 2013-01-15
NZ613656A (en) 2015-03-27
JP2014504609A (ja) 2014-02-24
TWI533867B (zh) 2016-05-21
DK2668183T3 (da) 2018-01-29
CA2825779A1 (en) 2012-08-02
UY33885A (es) 2012-08-31
US20120196862A1 (en) 2012-08-02
BR112013019256A2 (pt) 2017-11-14
PH12013501591A1 (en) 2015-10-07

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