PL2694513T3 - Pochodne pirazolopirymidynowe - Google Patents

Pochodne pirazolopirymidynowe

Info

Publication number: PL2694513T3
Authority: PL; Poland
Prior art keywords: pyrimidine derivatives; pyrazolo pyrimidine; pyrazolo; derivatives; pyrimidine
Prior art date: 2011-04-01

Application number

PL12715201T

Other languages

English (en)

Inventor

Zhengming Du

Rajender Reddy Leleti

Yugang Liu

Wolfgang Miltz

Berndt Oberhauser

Andrea Vaupel

Juraj Velcicky

Klaus Weigand

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-04-01

Filing date

2012-03-30

Publication date

2015-06-30

2012-03-30 Application filed by Novartis Ag filed Critical Novartis Ag

2015-06-30 Publication of PL2694513T3 publication Critical patent/PL2694513T3/pl

Links

OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical class C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)
Neurology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Dermatology (AREA)
Addiction (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Virology (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)

PL12715201T 2011-04-01 2012-03-30 Pochodne pirazolopirymidynowe PL2694513T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201161470630P	2011-04-01	2011-04-01
PCT/IB2012/051554 WO2012131633A1 (en)	2011-04-01	2012-03-30	Pyrazolo pyrimidine derivatives
EP12715201.5A EP2694513B1 (en)	2011-04-01	2012-03-30	Pyrazolo pyrimidine derivatives

Publications (1)

Publication Number	Publication Date
PL2694513T3 true PL2694513T3 (pl)	2015-06-30

Family

ID=45976462

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL12715201T PL2694513T3 (pl)	2011-04-01	2012-03-30	Pochodne pirazolopirymidynowe

Country Status (17)

Country	Link
US (1)	US8748435B2 (pl)
EP (1)	EP2694513B1 (pl)
JP (1)	JP5963843B2 (pl)
KR (1)	KR20140023331A (pl)
CN (1)	CN103502248B (pl)
AR (1)	AR085750A1 (pl)
AU (1)	AU2012235665A1 (pl)
BR (1)	BR112013025001A2 (pl)
CA (1)	CA2831929A1 (pl)
EA (1)	EA201391440A1 (pl)
ES (1)	ES2534444T3 (pl)
MX (1)	MX2013011421A (pl)
PL (1)	PL2694513T3 (pl)
PT (1)	PT2694513E (pl)
TW (1)	TW201245203A (pl)
UY (1)	UY33976A (pl)
WO (1)	WO2012131633A1 (pl)

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EP2900237A1 (en) *	2012-09-25	2015-08-05	Novartis AG	Compounds for use in gastric complication
CN105037373B (zh) *	2015-07-13	2018-07-31	北京理工大学	一种合成吡唑并[3,4-d]嘧啶类化合物的方法
CR20180109A (es) *	2015-07-20	2018-05-03	Genzyme Corp	Inhibidores de receptor del factor estimulador de colonias 1 (csf-1r)
CN108084186B (zh) *	2016-11-16	2021-06-25	江苏新元素医药科技有限公司	Urat1抑制剂及其应用
GB201700692D0 (en) *	2017-01-16	2017-03-01	Salvensis	Novel compounds and their use in the treatment of schistosomiasis
CN110636846B (zh) *	2017-05-17	2023-05-16	艾库斯生物科学有限公司	用于治疗癌症相关疾病的喹唑啉吡唑衍生物
EP3932912A4 (en) *	2019-02-28	2022-09-07	Osaka University	PROTEIN AND/OR PEPTIDE MODIFICATION MOLECULE
US11530216B2 (en)	2020-12-23	2022-12-20	Genzyme Corporation	Deuterated colony stimulating factor-1 receptor (CSF-1R) inhibitors
CN115304607B (zh) *	2022-07-06	2023-06-27	华南农业大学	吡唑并嘧啶衍生物的制备方法
EP4766405A1 (en)	2023-12-07	2026-07-01	Amphilix AG	CHIMERIC RADIOPHARMACEUTICAL PRODUCTS TARGETING THE GPR4 PROTON DETECTING RECEPTOR

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FR2690442A1 (fr)	1992-04-27	1993-10-29	Union Pharma Scient Appl	Nouveaux dérivés de pyrazolopyrimidine antagonistes des récepteurs à l'Angiotensine II; leurs procédés de préparation, compositions pharmaceutiques les contenant .
JPH069638A (ja)	1992-06-19	1994-01-18	Ube Ind Ltd	ピラゾロピリミジン誘導体
DE4333705C2 (de)	1993-10-02	2003-10-30	Guenter Ege	Arylmethylsubstituierte Pyrazolo-azine, insbesondere 3-Arylmethylpyrazolo[1,5-a]pyrimidine und Verfahren zur Herstellung von 8-Arylmethyl-pyrazolo[5,1-c][1,2,4]triazinen
JP3163412B2 (ja) *	1994-06-21	2001-05-08	株式会社大塚製薬工場	ピラゾロ〔１，５−ａ〕ピリミジン誘導体
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WO2009017954A1 (en)	2007-08-01	2009-02-05	Phenomix Corporation	Inhibitors of jak2 kinase
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WO2010086040A1 (en)	2009-01-29	2010-08-05	Biomarin Iga, Ltd.	Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
US8207139B2 (en)	2009-09-15	2012-06-26	Li Yang	Function of GPR4 in vascular inflammatory response to acidosis and related methods

2012
- 2012-03-26 US US13/429,726 patent/US8748435B2/en not_active Expired - Fee Related
- 2012-03-28 UY UY0001033976A patent/UY33976A/es not_active Application Discontinuation
- 2012-03-29 AR ARP120101075A patent/AR085750A1/es not_active Application Discontinuation
- 2012-03-30 TW TW101111548A patent/TW201245203A/zh unknown
- 2012-03-30 EA EA201391440A patent/EA201391440A1/ru unknown
- 2012-03-30 PL PL12715201T patent/PL2694513T3/pl unknown
- 2012-03-30 PT PT127152015T patent/PT2694513E/pt unknown
- 2012-03-30 KR KR1020137028503A patent/KR20140023331A/ko not_active Withdrawn
- 2012-03-30 WO PCT/IB2012/051554 patent/WO2012131633A1/en not_active Ceased
- 2012-03-30 MX MX2013011421A patent/MX2013011421A/es not_active Application Discontinuation
- 2012-03-30 AU AU2012235665A patent/AU2012235665A1/en not_active Abandoned
- 2012-03-30 CN CN201280021124.7A patent/CN103502248B/zh not_active Expired - Fee Related
- 2012-03-30 CA CA2831929A patent/CA2831929A1/en not_active Abandoned
- 2012-03-30 BR BR112013025001A patent/BR112013025001A2/pt not_active IP Right Cessation
- 2012-03-30 JP JP2014501801A patent/JP5963843B2/ja not_active Expired - Fee Related
- 2012-03-30 ES ES12715201.5T patent/ES2534444T3/es active Active
- 2012-03-30 EP EP12715201.5A patent/EP2694513B1/en not_active Not-in-force

Also Published As

Publication number	Publication date
MX2013011421A (es)	2013-12-09
EP2694513A1 (en)	2014-02-12
PT2694513E (pt)	2015-04-09
US20120252778A1 (en)	2012-10-04
JP2014514293A (ja)	2014-06-19
US8748435B2 (en)	2014-06-10
AU2012235665A1 (en)	2013-10-10
UY33976A (es)	2012-10-31
CN103502248A (zh)	2014-01-08
TW201245203A (en)	2012-11-16
CA2831929A1 (en)	2012-10-04
JP5963843B2 (ja)	2016-08-03
EA201391440A1 (ru)	2014-03-31
ES2534444T3 (es)	2015-04-23
KR20140023331A (ko)	2014-02-26
EP2694513B1 (en)	2015-01-07
AR085750A1 (es)	2013-10-23
WO2012131633A1 (en)	2012-10-04
BR112013025001A2 (pt)	2017-01-17
CN103502248B (zh)	2015-03-11

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