PL2702164T3 - Sposób obniżania heterogeniczności przeciwciał i sposób ich wytwarzania - Google Patents

Sposób obniżania heterogeniczności przeciwciał i sposób ich wytwarzania

Info

Publication number
PL2702164T3
PL2702164T3 PL12777325T PL12777325T PL2702164T3 PL 2702164 T3 PL2702164 T3 PL 2702164T3 PL 12777325 T PL12777325 T PL 12777325T PL 12777325 T PL12777325 T PL 12777325T PL 2702164 T3 PL2702164 T3 PL 2702164T3
Authority
PL
Poland
Prior art keywords
antibodies
producing
reducing heterogeneity
heterogeneity
reducing
Prior art date
Application number
PL12777325T
Other languages
English (en)
Inventor
Ruchika Srivastava
Sneha Lakshmandas Hemdev
Ankur Bhatnagar
Saravanan Desan
Anuj Goel
Harish Iyer
Original Assignee
Biocon Res Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47071657&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2702164(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biocon Res Limited filed Critical Biocon Res Limited
Publication of PL2702164T3 publication Critical patent/PL2702164T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
PL12777325T 2011-04-29 2012-04-27 Sposób obniżania heterogeniczności przeciwciał i sposób ich wytwarzania PL2702164T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1483CH2011 2011-04-29
EP12777325.7A EP2702164B8 (en) 2011-04-29 2012-04-27 A method for reducing heterogeneity of antibodies and a process of producing the antibodies thereof
PCT/IB2012/052114 WO2012147053A1 (en) 2011-04-29 2012-04-27 A method for reducing heterogeneity of antibodies and a process of producing the antibodies thereof

Publications (1)

Publication Number Publication Date
PL2702164T3 true PL2702164T3 (pl) 2016-06-30

Family

ID=47071657

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12777325T PL2702164T3 (pl) 2011-04-29 2012-04-27 Sposób obniżania heterogeniczności przeciwciał i sposób ich wytwarzania

Country Status (10)

Country Link
US (1) US9631216B2 (pl)
EP (1) EP2702164B8 (pl)
KR (1) KR101591671B1 (pl)
CN (1) CN104024423B (pl)
DK (1) DK2702164T3 (pl)
ES (1) ES2560470T3 (pl)
MY (1) MY169935A (pl)
PL (1) PL2702164T3 (pl)
RU (1) RU2580020C2 (pl)
WO (1) WO2012147053A1 (pl)

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WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
HK1211981A1 (en) 2012-09-02 2016-06-03 Abbvie Inc. Methods to control protein heterogeneity
HK1207960A1 (en) 2013-03-12 2016-02-19 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
CA2902830C (en) * 2013-03-12 2023-09-19 Biocon Ltd. Fusion immunomodulatory proteins and methods for making same
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US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
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US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
KR101867134B1 (ko) * 2015-03-23 2018-06-12 한양대학교 산학협력단 포유류 세포를 이용하여 목적 물질을 고효율로 생산하기 위한 세포 배양 배지, 이를 이용한 세포 배양 방법 및 목적 물질의 생산 방법
HRP20210830T1 (hr) 2016-10-17 2021-08-20 Enzene Biosciences Ltd. Kontinuirani proces smanjenja heterogenosti terapijskog proteina
WO2020201296A1 (en) 2019-04-01 2020-10-08 The Automation Partnership (Cambridge) Ltd. Operation process for a cell cultivation system
MX2021015301A (es) * 2019-06-10 2022-02-03 Takeda Pharmaceuticals Co Métodos de cultivo celular y composiciones para la producción de anticuerpos.
WO2021066772A1 (en) * 2019-10-01 2021-04-08 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Cell culture medium for reducing fucosylation and basic variants in the production of antibodies
SG11202110968VA (en) 2019-12-06 2021-10-28 Regeneron Pharma Anti-vegf protein compositions and methods for producing the same
CN116334007A (zh) * 2023-04-10 2023-06-27 珠海市丽珠单抗生物技术有限公司 一种慢病毒的包装方法
TW202548027A (zh) * 2024-01-23 2025-12-16 美商安進公司 用於調節單株抗體電荷變體之方法
CN118240744B (zh) * 2024-03-06 2024-11-26 上海迈邦生物科技有限公司 一种同时调节细胞表达产物聚体、电荷异质性和提高产量的方法
CN118957010B (zh) * 2024-09-03 2025-04-01 上海多宁生物科技股份有限公司 一种降低碱性峰的cho细胞单克隆抗体制备方法

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Also Published As

Publication number Publication date
KR101591671B1 (ko) 2016-02-04
WO2012147053A1 (en) 2012-11-01
US9631216B2 (en) 2017-04-25
EP2702164A1 (en) 2014-03-05
CN104024423B (zh) 2017-03-15
EP2702164B1 (en) 2015-11-25
US20140199729A1 (en) 2014-07-17
CN104024423A (zh) 2014-09-03
KR20140078581A (ko) 2014-06-25
EP2702164B8 (en) 2016-03-16
MY169935A (en) 2019-06-18
RU2580020C2 (ru) 2016-04-10
RU2013152982A (ru) 2015-06-10
EP2702164A4 (en) 2014-12-17
ES2560470T3 (es) 2016-02-19
DK2702164T3 (en) 2016-02-01

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