PL2729167T3 - Sposób wolnego od detergentów wytwarzania pęcherzyków zewnątrzbłonowych bakterii Gram-ujemnych - Google Patents

Sposób wolnego od detergentów wytwarzania pęcherzyków zewnątrzbłonowych bakterii Gram-ujemnych

Info

Publication number
PL2729167T3
PL2729167T3 PL12740235T PL12740235T PL2729167T3 PL 2729167 T3 PL2729167 T3 PL 2729167T3 PL 12740235 T PL12740235 T PL 12740235T PL 12740235 T PL12740235 T PL 12740235T PL 2729167 T3 PL2729167 T3 PL 2729167T3
Authority
PL
Poland
Prior art keywords
detergent
gram
outer membrane
membrane vesicles
negative bacterium
Prior art date
Application number
PL12740235T
Other languages
English (en)
Inventor
Bas VAN DE WATERBEEMD
Leonardus Aldolfus Van Der Pol
Original Assignee
De Staat Der Nederlanden, Vert. Door De Minister Van Vws
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by De Staat Der Nederlanden, Vert. Door De Minister Van Vws filed Critical De Staat Der Nederlanden, Vert. Door De Minister Van Vws
Publication of PL2729167T3 publication Critical patent/PL2729167T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/095Neisseria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/04Chelating agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/60Buffer, e.g. pH regulation, osmotic pressure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
PL12740235T 2011-07-07 2012-07-05 Sposób wolnego od detergentów wytwarzania pęcherzyków zewnątrzbłonowych bakterii Gram-ujemnych PL2729167T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161505221P 2011-07-07 2011-07-07
EP11173085 2011-07-07
EP12740235.2A EP2729167B1 (en) 2011-07-07 2012-07-05 A process for detergent-free production of outer membrane vesicles of a gram-negative bacterium
PCT/NL2012/050478 WO2013006055A1 (en) 2011-07-07 2012-07-05 A process for detergent-free production of outer membrane vesicles

Publications (1)

Publication Number Publication Date
PL2729167T3 true PL2729167T3 (pl) 2018-08-31

Family

ID=47437254

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12740235T PL2729167T3 (pl) 2011-07-07 2012-07-05 Sposób wolnego od detergentów wytwarzania pęcherzyków zewnątrzbłonowych bakterii Gram-ujemnych

Country Status (19)

Country Link
US (2) US9272006B2 (pl)
EP (1) EP2729167B1 (pl)
JP (1) JP6002763B2 (pl)
CN (1) CN103687612B (pl)
AU (1) AU2012278407B2 (pl)
CA (1) CA2840096C (pl)
DK (1) DK2729167T3 (pl)
ES (1) ES2670669T3 (pl)
HR (1) HRP20180890T1 (pl)
HU (1) HUE037969T2 (pl)
IL (1) IL230326B (pl)
LT (1) LT2729167T (pl)
PL (1) PL2729167T3 (pl)
PT (1) PT2729167T (pl)
RS (1) RS57267B1 (pl)
RU (1) RU2607021C2 (pl)
SI (1) SI2729167T1 (pl)
TR (1) TR201808206T4 (pl)
WO (1) WO2013006055A1 (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011126863A1 (en) 2010-03-30 2011-10-13 Children's Hospital & Research Center Oakland Factor h binding proteins (fhbp) with altered properties and methods of use thereof
PL2729167T3 (pl) * 2011-07-07 2018-08-31 De Staat Der Nederlanden, Vert. Door De Minister Van Vws Sposób wolnego od detergentów wytwarzania pęcherzyków zewnątrzbłonowych bakterii Gram-ujemnych
WO2014174043A1 (en) * 2013-04-24 2014-10-30 Novartis Ag Mutant bacteria for production of generalized modules for membrane antigens
US9914756B2 (en) 2013-08-02 2018-03-13 Children's Hospital & Research Center At Oakland Non-naturally occurring factor H binding proteins (fHbp) and methods of use thereof
CN119613509A (zh) 2014-07-23 2025-03-14 奥克兰儿童医院及研究中心 因子h结合蛋白变体及其使用方法
KR101715366B1 (ko) * 2014-09-04 2017-03-14 한국과학기술연구원 지질의 탈인산화용 조성물, 키트, 및 이를 이용한 탈인산화된 지질을 생산하는 방법
JP2017536823A (ja) * 2014-11-28 2017-12-14 ヤンセン ヴァクシーンズ アンド プリベンション ビー.ブイ. 髄膜炎bワクチン
CN117247460A (zh) 2015-06-02 2023-12-19 Intravacc有限责任公司 革兰氏阴性菌外膜囊泡抗原表面展示
US11292808B2 (en) 2016-01-28 2022-04-05 Intravacc B.V. Modified hexa-acylated neisserial LPS
KR102888356B1 (ko) * 2016-01-28 2025-11-19 인트라백 비.브이. 변형된 테트라-아실화된 나이세리아 lps
WO2018096007A2 (en) * 2016-11-25 2018-05-31 Glaxosmithkline Biologicals S.A. Immunogenic conjugates and use thereof
BR112019018905A2 (pt) 2017-03-13 2020-05-19 De Staat Der Nederlanden Vert Door De Mini Van Vws Miniie Van Volksgezondheid Welzijn En Sport vacinas contra bordetella compreendendo lps com reatogenicidade reduzida
US11542467B2 (en) * 2017-12-04 2023-01-03 Intravacc B.V. Process for producing outer membrane vesicles
TW202045192A (zh) * 2019-02-22 2020-12-16 美商艾弗洛生物科技股份有限公司 細菌膜製劑
WO2021224439A1 (en) 2020-05-08 2021-11-11 De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport CLICK OMVs
WO2022049222A1 (en) 2020-09-04 2022-03-10 Intravacc B.V. Ompa mutations enhance omv production in bordetella pertussis
EP4211147A1 (en) * 2020-09-11 2023-07-19 GlaxoSmithKline Biologicals S.A. Outer membrane vesicles
KR102413278B1 (ko) * 2021-06-21 2022-06-27 (주)로제타엑소좀 박테리아 유래 고순도 세포밖 소포체의 상업적 정제 방법
CN115216478B (zh) * 2022-06-01 2024-03-26 华南农业大学 一种禽多杀性巴氏杆菌内毒素减毒灭活疫苗菌株的构建方法及应用
CN115976088B (zh) * 2022-07-21 2023-09-19 深圳蓝晶生物科技有限公司 低内毒素含量的罗氏真养菌及其应用
CN118240723B (zh) * 2024-05-29 2024-08-23 上海羽冠生物技术有限公司 一种通过发酵产生细菌外膜囊泡的方法
WO2026047244A1 (en) 2024-09-02 2026-03-05 Intravacc B.V. Modified meningococcal omvs

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5997881A (en) 1995-11-22 1999-12-07 University Of Maryland, Baltimore Method of making non-pyrogenic lipopolysaccharide or A
US6558677B2 (en) * 1996-10-15 2003-05-06 Wendell D. Zollinger Vaccine against gram negative bacteria
PT1127137E (pt) 1998-11-03 2007-12-28 Staat Nl Verteg Door Min Welzi Lps com toxicidade reduzida a partir de bactérias gramnegativas modificadas geneticamente
GB0103170D0 (en) * 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
CA2493124C (en) * 2002-08-02 2014-04-29 Glaxosmithkline Biologicals S.A. Vaccine
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
CN1997392B (zh) 2004-05-11 2011-06-01 荷兰健康、福利与体育部部长代表的荷兰国 作为佐剂的脑膜炎奈瑟氏菌lgtB LOS
LT2682126T (lt) * 2005-01-27 2017-02-27 Children`s Hospital & Research Center at Oakland Gna1870 pagrindu gaminamos pūslelių pavidalo vakcinos, skirtos plataus spektro apsaugai nuo neisseria meningitidis sukeltų ligų
PL2729167T3 (pl) * 2011-07-07 2018-08-31 De Staat Der Nederlanden, Vert. Door De Minister Van Vws Sposób wolnego od detergentów wytwarzania pęcherzyków zewnątrzbłonowych bakterii Gram-ujemnych

Also Published As

Publication number Publication date
HUE037969T2 (hu) 2018-09-28
LT2729167T (lt) 2018-06-25
US20140147469A1 (en) 2014-05-29
HRP20180890T1 (hr) 2018-09-07
EP2729167B1 (en) 2018-03-14
RU2014104241A (ru) 2015-08-20
CN103687612B (zh) 2017-12-15
SI2729167T1 (sl) 2018-09-28
AU2012278407B2 (en) 2017-01-19
AU2012278407A1 (en) 2014-01-16
US9272006B2 (en) 2016-03-01
CA2840096C (en) 2021-07-06
IL230326B (en) 2018-03-29
RS57267B1 (sr) 2018-08-31
CN103687612A (zh) 2014-03-26
US20160303214A1 (en) 2016-10-20
NZ618918A (en) 2015-10-30
CA2840096A1 (en) 2013-01-10
DK2729167T3 (en) 2018-04-30
RU2607021C2 (ru) 2017-01-10
JP2014520801A (ja) 2014-08-25
TR201808206T4 (tr) 2018-07-23
JP6002763B2 (ja) 2016-10-05
PT2729167T (pt) 2018-06-20
WO2013006055A1 (en) 2013-01-10
ES2670669T3 (es) 2018-05-31
EP2729167A1 (en) 2014-05-14
WO2013006055A8 (en) 2013-08-15
US9707286B2 (en) 2017-07-18

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