PL2741B1 - Method of obtaining salts of asymmetric dialkylbarbituric acids from piperazine - Google Patents
Method of obtaining salts of asymmetric dialkylbarbituric acids from piperazine Download PDFInfo
- Publication number
- PL2741B1 PL2741B1 PL2741A PL274122A PL2741B1 PL 2741 B1 PL2741 B1 PL 2741B1 PL 2741 A PL2741 A PL 2741A PL 274122 A PL274122 A PL 274122A PL 2741 B1 PL2741 B1 PL 2741B1
- Authority
- PL
- Poland
- Prior art keywords
- piperazine
- asymmetric
- acids
- salts
- obtaining salts
- Prior art date
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- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title claims description 6
- 239000002253 acid Substances 0.000 title claims description 4
- 150000007513 acids Chemical class 0.000 title claims description 3
- 150000003839 salts Chemical class 0.000 title description 4
- 150000007656 barbituric acids Chemical class 0.000 claims description 2
- 150000004885 piperazines Chemical class 0.000 claims 1
- -1 methylethyl Chemical group 0.000 description 3
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 1
- OSVIDGCVOGPEOK-UHFFFAOYSA-N 5-ethyl-5-(2-methylpropyl)-1,3-diazinane-2,4,6-trione Chemical class CC(C)CC1(CC)C(=O)NC(=O)NC1=O OSVIDGCVOGPEOK-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229960002319 barbital Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 150000003216 pyrazines Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Description
Wykryto, ze wszystkie djwupodstawione kwasy asymetryczne barbiturowe daja, po¬ za solami rozpuszczalnemi, sole z zasadami organicznemi, a mianowicie z piperazyna: jedna czasteczke kwasu na jedna czastecz¬ ke zasady, Sole te sa trwale i rozpuszczal¬ ne; roztwory ich wodne nie maja charakte¬ ru zasadowego.Mozna w ten sposób otrzymac sole pi- perazynowe z kwasów butyloetylobarbitu- rowych, o punkcie topliwosci w 150—155° C i kwasów izobutyloetylobarbiturowych, roz¬ puszczalne w 15 do 20 czesciach wagowych wody.Zwiazki opisane posiadaja pewne wla¬ snosci, które w nizszych iczlonach, jak me- tyloetyl, metylopropyl, etylopropyl wyste¬ puja slabiej, niz w czlonach wyzszych, a mianowicie C10, Clv C12. Dzialanie tych zwiazków wywoluje skutek trzy lub cztery razy wiekszy,niz kwasu dwuetylobarbituro- wego, wiec stosujac je, osiaga sie znaczna korzysc pod wzgledem ekonomicznym. PLIt has been found that all di-substituted asymmetric barbituric acids give, in addition to soluble salts, salts with organic bases, namely with piperazine: one molecule of acid per molecule of base. The salts are also stable and soluble; their aqueous solutions are not alkaline. In this way, it is possible to obtain pyrazine salts from butylethylbarbitric acids having a melting point of 150-155 ° C and isobutylethylbarbituric acids, soluble in 15 to 20 parts by weight of water. The described ones have certain properties which in the lower numbers, such as methylethyl, methylpropyl, ethylpropyl, are weaker than in the higher members, namely C10, Clv C12. The action of these compounds produces an effect three or four times greater than that of diethylbarbituric acid, so there is a considerable economic advantage using them. PL
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2741B1 true PL2741B1 (en) | 1925-09-30 |
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