PL2789696T3 - Sposób wysoko przepustowej detekcji polimorfizmu opartej na AFLP - Google Patents

Sposób wysoko przepustowej detekcji polimorfizmu opartej na AFLP

Info

Publication number
PL2789696T3
PL2789696T3 PL14166884T PL14166884T PL2789696T3 PL 2789696 T3 PL2789696 T3 PL 2789696T3 PL 14166884 T PL14166884 T PL 14166884T PL 14166884 T PL14166884 T PL 14166884T PL 2789696 T3 PL2789696 T3 PL 2789696T3
Authority
PL
Poland
Prior art keywords
polymorphism detection
aflp
throughput
based polymorphism
throughput aflp
Prior art date
Application number
PL14166884T
Other languages
English (en)
Inventor
Eijk Michael Josephus Theresia Van
Anker Preben Sørensen
Schriek Marco Gerardus Maria Van
Original Assignee
Keygene Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37834098&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2789696(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Keygene Nv filed Critical Keygene Nv
Publication of PL2789696T3 publication Critical patent/PL2789696T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855Ligating adaptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL14166884T 2005-12-22 2006-12-20 Sposób wysoko przepustowej detekcji polimorfizmu opartej na AFLP PL2789696T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75259005P 2005-12-22 2005-12-22
EP10186841A EP2363504A1 (en) 2005-12-22 2006-12-20 Method for high-throughtput AFLP-based polymorphism detection
EP14166884.8A EP2789696B1 (en) 2005-12-22 2006-12-20 Method for high-throughput AFLP-based polymorphism detection
EP06835670A EP1966393B1 (en) 2005-12-22 2006-12-20 Method for high-throughput aflp-based polymorphism detection

Publications (1)

Publication Number Publication Date
PL2789696T3 true PL2789696T3 (pl) 2016-06-30

Family

ID=37834098

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14166884T PL2789696T3 (pl) 2005-12-22 2006-12-20 Sposób wysoko przepustowej detekcji polimorfizmu opartej na AFLP

Country Status (8)

Country Link
US (11) US8481257B2 (pl)
EP (5) EP2789696B1 (pl)
JP (1) JP5452021B2 (pl)
CN (2) CN101374963B (pl)
DK (3) DK1966393T3 (pl)
ES (3) ES2391837T3 (pl)
PL (1) PL2789696T3 (pl)
WO (1) WO2007073165A1 (pl)

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2393318T3 (es) * 2005-06-23 2012-12-20 Keygene N.V. Estrategias para la identificación y detección de alto rendimiento de polimorfismos
US20090170713A1 (en) 2005-09-29 2009-07-02 Keygene N.V. High throughput screening of mutagenized populations
DK1966393T3 (da) 2005-12-22 2012-10-08 Keygene Nv Fremgangsmåde til AFLP-baseret påvisning af polymorfisme med høj omsætning
JP2009047956A (ja) * 2007-08-21 2009-03-05 Sony Corp 撮像装置
AU2008328834B2 (en) * 2007-11-27 2013-11-07 Vib Vzw Marker assisted directed evolution
EP2172565A1 (en) * 2008-09-24 2010-04-07 Cyano Biotech GmbH Method of identifying and/or differentiating cyanophyta
ES2535722T3 (es) 2008-12-05 2015-05-14 Keygene N.V. Farneseno sintasa
EP2233580A1 (en) * 2009-03-05 2010-09-29 The Ohio State University Rapid genotyping of SNPs
WO2010127186A1 (en) 2009-04-30 2010-11-04 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
CN101886132B (zh) * 2009-07-15 2013-09-18 北京百迈客生物科技有限公司 基于测序和bsa技术的性状相关的分子标记筛选方法
JP5799484B2 (ja) * 2009-12-14 2015-10-28 トヨタ自動車株式会社 Dnaマイクロアレイにおけるプローブ設計方法、当該方法により設計されたプローブを有するdnaマイクロアレイ
CN102656279A (zh) 2009-12-17 2012-09-05 凯津公司 基于全基因组测序的限制性酶
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
HRP20151294T1 (hr) 2010-04-05 2016-03-11 Prognosys Biosciences, Inc. Biološka testiranja sa prostornim kodiranjem
SG186876A1 (en) * 2010-06-30 2013-02-28 Bgi Shenzhen Co Ltd New pcr sequencing method and use thereof in hla genotyping
CN102061526B (zh) * 2010-11-23 2014-04-30 深圳华大基因科技服务有限公司 一种DNA文库及其制备方法、以及一种检测SNPs的方法和装置
EP2646573A1 (en) 2010-12-01 2013-10-09 MorphoSys AG Simultaneous detection of biomolecules in single cells
WO2012071685A1 (zh) * 2010-12-02 2012-06-07 深圳华大基因科技有限公司 Hpv精确分型的生物信息学分析的方法及系统
EP2663655B1 (en) 2011-01-14 2015-09-02 Keygene N.V. Paired end random sequence based genotyping
CN102181943B (zh) * 2011-03-02 2013-06-05 中山大学 一种配对双末端文库构建方法及用该文库进行基因组测序的方法
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
ES2625288T3 (es) 2011-04-15 2017-07-19 The Johns Hopkins University Sistema de secuenciación segura
ES2556580T3 (es) 2011-07-08 2016-01-19 Keygene N.V. Genotipado a base de secuencias en base a ensayos de ligación a oligonucleótidos
US20150120210A1 (en) * 2011-12-29 2015-04-30 Bgi Tech Solutions Co., Ltd. Method and device for labelling single nucleotide polymorphism sites in genome
US20130184165A1 (en) * 2012-01-13 2013-07-18 Data2Bio Genotyping by next-generation sequencing
DK2814959T3 (en) 2012-02-17 2018-04-23 Hutchinson Fred Cancer Res COMPOSITIONS AND PROCEDURES FOR EXACTLY IDENTIFYING MUTATIONS
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
CN104508141A (zh) * 2012-08-23 2015-04-08 深圳华大基因科技有限公司 确定个体是否患有异常状态的方法及系统
CN102864498B (zh) * 2012-09-24 2014-07-16 中国科学院天津工业生物技术研究所 一种长片段末端文库的构建方法
GB201217888D0 (en) 2012-10-05 2012-11-21 Univ Leuven Kath High-throughput genotyping by sequencing of single cell
WO2014060483A1 (en) 2012-10-17 2014-04-24 Spatial Transcriptomics Ab Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
AU2013338393C1 (en) 2012-10-29 2024-07-25 The Johns Hopkins University Papanicolaou test for ovarian and endometrial cancers
US9822408B2 (en) 2013-03-15 2017-11-21 Nugen Technologies, Inc. Sequential sequencing
EP3013983B1 (en) 2013-06-25 2023-02-15 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
CA2929596C (en) 2013-11-13 2022-07-05 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
CN104630202A (zh) * 2013-11-13 2015-05-20 北京大学 一种能够减小微量核酸物质整体扩增时产生偏倚的扩增方法
US10927408B2 (en) 2013-12-02 2021-02-23 Personal Genome Diagnostics, Inc. Method for evaluating minority variants in a sample
US10774374B2 (en) 2015-04-10 2020-09-15 Spatial Transcriptomics AB and Illumina, Inc. Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
CN106676095A (zh) * 2015-11-09 2017-05-17 中国科学院植物研究所 用于开发遗传标记的成套试剂和高通量测序开发遗传标记的方法
EP3187040A1 (en) 2015-12-30 2017-07-05 Vilmorin et Cie Resistance to tolcndv in melons
CN105695572B (zh) * 2016-02-02 2021-02-23 中国水产科学研究院南海水产研究所 一种基于Indel和SSR位点技术大批量且高效开发分子标记的方法
ITUA20162640A1 (it) * 2016-04-15 2017-10-15 Menarini Silicon Biosystems Spa Metodo e kit per la generazione di librerie di dna per sequenziamento massivo parallelo
US10190155B2 (en) * 2016-10-14 2019-01-29 Nugen Technologies, Inc. Molecular tag attachment and transfer
CN106701949B (zh) * 2016-12-30 2019-09-17 人和未来生物科技(长沙)有限公司 一种减少扩增偏倚的基因突变检测方法和试剂
CA3198931A1 (en) 2017-01-20 2018-07-26 Sequenom, Inc. Methods for non-invasive assessment of genetic alterations
US11584958B2 (en) 2017-03-31 2023-02-21 Grail, Llc Library preparation and use thereof for sequencing based error correction and/or variant identification
US12492430B2 (en) 2017-04-11 2025-12-09 Tecan Genomics, Inc. Library quantitation and qualification
IL319255A (en) 2017-08-07 2025-04-01 Univ Johns Hopkins Methods and materials for cancer assessment and treatment
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
WO2019121603A1 (en) 2017-12-18 2019-06-27 Keygene N.V. Chemical mutagenesis of cassava
CN119753091A (zh) 2018-04-02 2025-04-04 格里尔公司 用于扩增与癌症相关联的cfDNA分子的化验板
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
IL281741B2 (en) 2018-09-27 2026-04-01 Grail Inc Methylation markers and a targeted methylation detection panel
EP3887538A1 (en) 2018-11-28 2021-10-06 Keygene N.V. Targeted enrichment by endonuclease protection
US12529094B2 (en) 2018-12-10 2026-01-20 10X Genomics, Inc. Imaging system hardware
EP3894590B1 (en) 2018-12-10 2025-10-22 10X Genomics, Inc. Methods of using master / copy arrays for spatial detection
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
WO2020169830A1 (en) 2019-02-21 2020-08-27 Keygene N.V. Genotyping of polyploids
EP3973073A1 (en) * 2019-05-20 2022-03-30 Arima Genomics, Inc. Methods and compositions for enhanced genome coverage and preservation of spatial proximal contiguity
EP3976820A1 (en) 2019-05-30 2022-04-06 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2020243678A1 (en) * 2019-05-31 2020-12-03 North Carolina State University Compositions and methods related to quantitative reduced representation sequencing
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
WO2021091611A1 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
WO2021116371A1 (en) 2019-12-12 2021-06-17 Keygene N.V. Semi-solid state nucleic acid manipulation
JP7766029B2 (ja) 2019-12-20 2025-11-07 キージーン ナムローゼ フェンノートシャップ 共有結合で閉端された核酸分子末端を使用したngsライブラリー調製
WO2021133849A1 (en) 2019-12-23 2021-07-01 10X Genomics, Inc. Methods for spatial analysis using rna-templated ligation
EP4081656A1 (en) 2019-12-23 2022-11-02 10X Genomics, Inc. Compositions and methods for using fixed biological samples in partition-based assays
CN115135984B (zh) 2019-12-23 2025-12-23 10X基因组学有限公司 可逆固定试剂及其使用方法
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
EP3851542A1 (en) 2020-01-20 2021-07-21 Tecan Genomics, Inc. Depletion of abundant uninformative sequences
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US12059674B2 (en) 2020-02-03 2024-08-13 Tecan Genomics, Inc. Reagent storage system
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
WO2021158925A1 (en) 2020-02-07 2021-08-12 10X Genomics, Inc. Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US12399123B1 (en) 2020-02-14 2025-08-26 10X Genomics, Inc. Spatial targeting of analytes
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
JP2023513606A (ja) 2020-02-14 2023-03-31 ザ・ジョンズ・ホプキンス・ユニバーシティー 核酸を評価するための方法および材料
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
CN116134308B (zh) 2020-05-19 2025-05-27 10X基因组学有限公司 电泳盒和仪器
EP4553168A3 (en) 2020-05-22 2025-08-27 10x Genomics, Inc. Spatial analysis to detect sequence variants
EP4153775B1 (en) 2020-05-22 2024-07-24 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
EP4025692A2 (en) 2020-06-02 2022-07-13 10X Genomics, Inc. Nucleic acid library methods
EP4158054B1 (en) 2020-06-02 2025-04-16 10X Genomics, Inc. Spatial transcriptomics for antigen-receptors
US12265079B1 (en) 2020-06-02 2025-04-01 10X Genomics, Inc. Systems and methods for detecting analytes from captured single biological particles
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
US12435363B1 (en) 2020-06-10 2025-10-07 10X Genomics, Inc. Materials and methods for spatial transcriptomics
WO2021252747A1 (en) 2020-06-10 2021-12-16 1Ox Genomics, Inc. Fluid delivery methods
EP4165207B1 (en) 2020-06-10 2024-09-25 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
EP4172362B1 (en) 2020-06-25 2024-09-18 10X Genomics, Inc. Spatial analysis of dna methylation
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US12553898B1 (en) 2020-08-10 2026-02-17 10X Genomics, Inc. Fluorescent hybridization of antibody-oligonucleotide for multiplexing and signal amplification
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
EP4491742B1 (en) 2020-09-18 2026-03-04 10X Genomics, Inc. Sample handling apparatus and image registration methods
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
WO2022074058A1 (en) 2020-10-06 2022-04-14 Keygene N.V. Targeted sequence addition
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
US20240002904A1 (en) 2020-11-24 2024-01-04 Keygene N.V. Targeted enrichment using nanopore selective sequencing
WO2022112394A1 (en) 2020-11-25 2022-06-02 Koninklijke Nederlandse Akademie Van Wetenschappen Ribosomal profiling in single cells
EP4729631A2 (en) 2020-12-21 2026-04-22 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
WO2022144003A1 (zh) * 2020-12-31 2022-07-07 东科智生基因科技(北京)有限公司 一种用于高通量靶向测序的多重pcr文库构建方法
WO2022178267A2 (en) 2021-02-19 2022-08-25 10X Genomics, Inc. Modular assay support devices
ES3008686T3 (en) 2021-03-18 2025-03-24 10X Genomics Inc Multiplex capture of gene and protein expression from a biological sample
EP4428246B1 (en) 2021-04-14 2025-12-24 10X Genomics, Inc. Methods of measuring mislocalization of an analyte
EP4320271B1 (en) 2021-05-06 2025-03-19 10X Genomics, Inc. Methods for increasing resolution of spatial analysis
EP4582555A3 (en) 2021-06-03 2025-10-22 10X Genomics, Inc. Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
US12553805B2 (en) 2021-08-02 2026-02-17 10X Genomics, Inc. Methods of preserving a biological sample
ES3011462T3 (en) 2021-09-01 2025-04-07 10X Genomics Inc Methods for blocking a capture probe on a spatial array
WO2023086880A1 (en) 2021-11-10 2023-05-19 10X Genomics, Inc. Methods, compositions, and kits for determining the location of an analyte in a biological sample
EP4305195A2 (en) 2021-12-01 2024-01-17 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
EP4441711A1 (en) 2021-12-20 2024-10-09 10X Genomics, Inc. Self-test for pathology/histology slide imaging device
CN115131784B (zh) * 2022-04-26 2023-04-18 东莞博奥木华基因科技有限公司 一种图像处理方法、装置、电子设备及存储介质
WO2024102809A1 (en) 2022-11-09 2024-05-16 10X Genomics, Inc. Methods, compositions, and kits for determining the location of multiple analytes in a biological sample
WO2024121354A1 (en) 2022-12-08 2024-06-13 Keygene N.V. Duplex sequencing with covalently closed dna ends
WO2024209000A1 (en) 2023-04-04 2024-10-10 Keygene N.V. Linkers for duplex sequencing

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US24939A (en) 1859-08-02 Improvement in sewing-machines
DE3465508D1 (en) 1983-04-28 1987-09-24 Flexible Steel Lacing Co Method and apparatus for riveting fasteners to a belt
JPH04504356A (ja) 1989-01-31 1992-08-06 ユニバーシティ オブ マイアミ 染色体dnaの顕微解剖と増幅
IL103267A (en) 1991-09-24 2004-07-25 Keygene Nv Process and kit for amplification of restriction fragment obtained from starting dna
US20100267023A1 (en) 1992-09-24 2010-10-21 Keygene N.V. Selective restriction fragment amplification: fingerprinting
WO1995019697A1 (en) * 1994-01-21 1995-07-27 North Carolina State University Methods for within family selection in woody perennials using genetic markers
EG23907A (en) 1994-08-01 2007-12-30 Delta & Pine Land Co Control of plant gene expression
US6013445A (en) * 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
EP0804618B1 (en) * 1994-11-28 1999-01-27 E.I. Du Pont De Nemours And Company Compound microsatellite primers for the detection of genetic polymorphisms
US5565340A (en) * 1995-01-27 1996-10-15 Clontech Laboratories, Inc. Method for suppressing DNA fragment amplification during PCR
US6100030A (en) * 1997-01-10 2000-08-08 Pioneer Hi-Bred International, Inc. Use of selective DNA fragment amplification products for hybridization-based genetic fingerprinting, marker assisted selection, and high-throughput screening
US6090556A (en) * 1997-04-07 2000-07-18 Japan Science & Technology Corporation Method for quantitatively determining the expression of a gene
JP2001515362A (ja) 1997-05-13 2001-09-18 ディスプレイ・システムズ・バイオテック・アクティーゼルスカブ mRNAをクローニングする方法および差次的に発現された転写物のディスプレイ(DODET)
EP0930370B1 (en) 1997-12-15 2007-08-08 CSL Behring GmbH Labeled primer for use in detection of target nucleic acids
CA2273616A1 (en) 1998-06-08 1999-12-08 The Board Of Trustees Of The Leland Stanford Junior University Method for parallel screening of allelic variation
US6124201A (en) 1998-06-12 2000-09-26 Advanced Micro Devices, Inc. Method for manufacturing semiconductors with self-aligning vias
EP0976835B1 (en) 1998-07-29 2003-07-09 Keygene N.V. Method for detecting nucleic acid methylation using AFLPTM
US6232067B1 (en) 1998-08-17 2001-05-15 The Perkin-Elmer Corporation Adapter directed expression analysis
US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (en) * 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Pre-selection and isolation of single nucleotide polymorphisms
AU6372099A (en) 1998-10-16 2000-05-08 Keygene N.V. Method for the generation of dna fingerprints
WO2000024939A1 (en) 1998-10-27 2000-05-04 Affymetrix, Inc. Complexity management and analysis of genomic dna
US6480791B1 (en) 1998-10-28 2002-11-12 Michael P. Strathmann Parallel methods for genomic analysis
CA2356697C (en) 1999-01-06 2010-06-22 Cornell Research Foundation, Inc. Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing
US20040029155A1 (en) * 1999-01-08 2004-02-12 Curagen Corporation Method for identifying a biomolecule
DE60004630T2 (de) 1999-01-12 2004-06-17 Quanam Medical Corp., Santa Clara Arzneimittel und verfahren zur verabreichung von wasserunlöslichen paclitaxelderivaten
DE19911130A1 (de) 1999-03-12 2000-09-21 Hager Joerg Verfahren zur Identifikation chromosomaler Regionen und Gene
CA2367400A1 (en) 1999-04-06 2000-10-12 Yale University Fixed address analysis of sequence tags
WO2000061801A2 (en) 1999-04-09 2000-10-19 Keygene N.V. METHOD FOR THE DETECTION AND/OR ANALYSIS, BY MEANS OF PRIMER EXTENSION TECHNIQUES, OF SINGLE NUCLEOTIDE POLYMORPHISMS IN RESTRICTION FRAGMENTS, IN PARTICULAR IN AMPLIFIED RESTRICTION FRAGMENTS GENERATED USING AFLP$m(3)
US20040031072A1 (en) 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
US20020119448A1 (en) 1999-06-23 2002-08-29 Joseph A. Sorge Methods of enriching for and identifying polymorphisms
US20030204075A9 (en) * 1999-08-09 2003-10-30 The Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
WO2001021840A2 (en) * 1999-09-23 2001-03-29 Gene Logic, Inc. Indexing populations
US6287778B1 (en) 1999-10-19 2001-09-11 Affymetrix, Inc. Allele detection using primer extension with sequence-coded identity tags
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
AU1413601A (en) 1999-11-19 2001-06-04 Takara Bio Inc. Method of amplifying nucleic acids
AU2001253063A1 (en) 2000-03-31 2001-10-15 Fred Hutchinson Cancer Research Center Reverse genetic strategy for identifying functional mutations in genes of known sequence
US20110131679A2 (en) 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
EP1282729A2 (en) 2000-05-15 2003-02-12 Keygene N.V. Microsatellite-aflp
US7300751B2 (en) * 2000-06-30 2007-11-27 Syngenta Participations Ag Method for identification of genetic markers
DE60131903T2 (de) 2000-10-24 2008-11-27 The Board of Trustees of the Leland S. Stanford Junior University, Palo Alto Direkte multiplex charakterisierung von genomischer dna
US7141364B1 (en) * 2001-03-29 2006-11-28 Council Of Scientific And Industrial Research Universal primers for wildlife identification
US20040053236A1 (en) 2001-03-30 2004-03-18 Mccallum Claire M. Reverse genetic strategy for identifying functional mutations in genes of known sequences
WO2002083911A1 (en) 2001-04-12 2002-10-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Production of plants with increased tolerance to drought stress or with increased transpiration
EP1386005A1 (en) 2001-04-20 2004-02-04 Karolinska Innovations AB Methods for high throughput genome analysis using restriction site tagged microarrays
EP1417475A4 (en) 2001-07-06 2006-06-28 454 Corp METHOD FOR ISOLATING INDEPENDENT, PARALLEL CHEMICAL MICRORE ACTIONS USING A POROUS FILTER
WO2003020015A2 (en) 2001-08-30 2003-03-13 Purdue Research Foundation Methods to produce transgenic plants resistant to osmotic stress
EP1288301A1 (en) 2001-08-31 2003-03-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin Plant-derived resistance gene
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US7504222B2 (en) 2001-10-31 2009-03-17 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
JP2005535283A (ja) * 2001-11-13 2005-11-24 ルビコン ゲノミクス インコーポレイテッド ランダムフラグメント化により生成されたdna分子を用いたdna増幅および配列決定
WO2003081988A2 (en) 2002-03-27 2003-10-09 Agrinomics Llc Generation of plants with improved drought tolerance
US6815167B2 (en) 2002-04-25 2004-11-09 Geneohm Sciences Amplification of DNA to produce single-stranded product of defined sequence and length
US20070065816A1 (en) * 2002-05-17 2007-03-22 Affymetrix, Inc. Methods for genotyping
US7108976B2 (en) 2002-06-17 2006-09-19 Affymetrix, Inc. Complexity management of genomic DNA by locus specific amplification
WO2004001074A1 (en) 2002-06-21 2003-12-31 Lynx Therapeutics, Inc. Method for detecting foreign dna in a host genome
AU2003260790A1 (en) 2002-09-05 2004-03-29 Plant Bioscience Limited Genome partitioning
US20040157238A1 (en) 2002-09-20 2004-08-12 Quinn John J. Method for detection of multiple nucleic acid sequence variations
US7847156B2 (en) 2003-10-20 2010-12-07 Cropdesign N.V. Plants having improved growth characteristics and methods for making the same
EP1573009B1 (en) 2002-12-18 2011-09-21 Third Wave Technologies, Inc. Detection of small nucleic acids
JP2004208586A (ja) 2002-12-27 2004-07-29 Wakunaga Pharmaceut Co Ltd Hlaの検出
ES2394881T3 (es) * 2003-01-10 2013-02-06 Keygene N.V. Procedimiento basado en la AFLP para la integración de mapas físicos y genéticos
WO2005003375A2 (en) 2003-01-29 2005-01-13 454 Corporation Methods of amplifying and sequencing nucleic acids
EP2365095A1 (en) * 2003-02-26 2011-09-14 Callida Genomics, Inc. Random array DNA analysis by hybridization
JP4888876B2 (ja) 2003-06-13 2012-02-29 田平 武 アルツハイマー病の治療のための組換えアデノ随伴ウィルスベクター
WO2005002325A2 (en) 2003-06-24 2005-01-13 Agrinomics Llc Generation of plants with improved drought tolerance
ATE506442T1 (de) 2003-06-24 2011-05-15 Agrigenetics Inc Erzeugung von pflanzen mit verbesserter toleranz gegenüber trockenheit
US7051935B2 (en) 2003-07-28 2006-05-30 Imageid Ltd. Color calibration for color bar codes
US7365179B2 (en) 2003-09-09 2008-04-29 Compass Genetics, Llc Multiplexed analytical platform
CA2543786A1 (en) * 2003-10-24 2005-05-06 Mmi Genomics, Inc. Methods and systems for inferring traits to manage non-beef livestock
EP1701785A1 (en) 2004-01-07 2006-09-20 Solexa Ltd. Modified molecular arrays
US20050233354A1 (en) 2004-01-22 2005-10-20 Affymetrix, Inc. Genotyping degraded or mitochandrial DNA samples
DE602005018166D1 (de) 2004-02-12 2010-01-21 Population Genetics Technologi Genetische analyse mittels sequenzspezifischem sortieren
CA2556981C (en) 2004-02-18 2015-10-13 The Trustees Of Boston University Method for detecting and quantifying rare mutations or polymorphisms
EP1574585A1 (en) 2004-03-12 2005-09-14 Plant Research International B.V. Method for selective amplification of DNA fragments for genetic fingerprinting
JP4809594B2 (ja) 2004-08-02 2011-11-09 東京エレクトロン株式会社 検査装置
FR2876479B1 (fr) 2004-10-11 2006-12-15 Parkeon Machine a pieces a receptacle de pieces de monnaie amovible
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US7407757B2 (en) 2005-02-10 2008-08-05 Population Genetics Technologies Genetic analysis by sequence-specific sorting
DK1885882T3 (da) 2005-05-10 2011-04-11 State Of Oregon Acting By & Through The State Board Of Higher Eduction On Behalf Of The University O Fremgangsmåder til kortlægning af polymorfier og polymorfi-mikroarray
JP5331476B2 (ja) 2005-06-15 2013-10-30 カリダ・ジェノミックス・インコーポレイテッド 遺伝子解析および化学解析用の単分子アレイ
ES2393318T3 (es) 2005-06-23 2012-12-20 Keygene N.V. Estrategias para la identificación y detección de alto rendimiento de polimorfismos
JP2008546405A (ja) * 2005-06-23 2008-12-25 キージーン ナムローゼ フェンノートシャップ ハイスループットシーケンシング技術を使用して複雑なゲノムをシーケンシングするための改善された戦略
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
US20090170713A1 (en) 2005-09-29 2009-07-02 Keygene N.V. High throughput screening of mutagenized populations
US10316364B2 (en) 2005-09-29 2019-06-11 Keygene N.V. Method for identifying the source of an amplicon
EP1960541B1 (en) * 2005-11-14 2013-04-24 Keygene N.V. Method for high throughput screening of transposon tagging populations and massive parallel sequence identification of insertion sites
DK1966393T3 (da) 2005-12-22 2012-10-08 Keygene Nv Fremgangsmåde til AFLP-baseret påvisning af polymorfisme med høj omsætning
WO2007087312A2 (en) 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Molecular counting
DK3239304T3 (da) 2006-04-04 2020-10-26 Keygene Nv Højgennemløbsdetektering af molekylære markører baseret på AFLP og sekventering med højt gennemløb
US8330560B2 (en) 2007-08-06 2012-12-11 Nihon Dempa Kogyo Co., Ltd. Tuning-fork type crystal resonator and method of frequency adjustment thereof
US8362325B2 (en) 2007-10-03 2013-01-29 Ceres, Inc. Nucleotide sequences and corresponding polypeptides conferring modulated plant characteristics
US20090124758A1 (en) 2007-11-09 2009-05-14 Bridgestone Sports Co., Ltd. Golf ball
US20140051585A1 (en) 2012-08-15 2014-02-20 Natera, Inc. Methods and compositions for reducing genetic library contamination
EP3004381A1 (en) 2013-06-07 2016-04-13 Keygene N.V. Method for targeted sequencing

Also Published As

Publication number Publication date
CN101374963B (zh) 2014-06-04
EP2789696B1 (en) 2015-12-16
WO2007073165A1 (en) 2007-06-28
DK3404114T3 (da) 2021-06-28
US20170081718A1 (en) 2017-03-23
ES2391837T3 (es) 2012-11-30
US20170356042A1 (en) 2017-12-14
US20190144938A1 (en) 2019-05-16
DK1966393T3 (da) 2012-10-08
US20160258013A1 (en) 2016-09-08
CN103937899B (zh) 2017-09-08
US8911945B2 (en) 2014-12-16
US20200181698A1 (en) 2020-06-11
ES2558124T3 (es) 2016-02-02
EP2363504A1 (en) 2011-09-07
US9702004B2 (en) 2017-07-11
EP1966393A1 (en) 2008-09-10
EP3404114A1 (en) 2018-11-21
US11008615B2 (en) 2021-05-18
JP2009520497A (ja) 2009-05-28
US20150344946A1 (en) 2015-12-03
CN103937899A (zh) 2014-07-23
US9334536B2 (en) 2016-05-10
US20140315728A1 (en) 2014-10-23
EP3404114B1 (en) 2021-05-05
US8481257B2 (en) 2013-07-09
US20140295428A1 (en) 2014-10-02
JP5452021B2 (ja) 2014-03-26
EP3045544A1 (en) 2016-07-20
US9328383B2 (en) 2016-05-03
EP2789696A1 (en) 2014-10-15
US20130059739A1 (en) 2013-03-07
US20090269749A1 (en) 2009-10-29
US20150159217A1 (en) 2015-06-11
CN101374963A (zh) 2009-02-25
US10106850B2 (en) 2018-10-23
US8815512B2 (en) 2014-08-26
US9777324B2 (en) 2017-10-03
ES2882401T3 (es) 2021-12-01
EP1966393B1 (en) 2012-07-25
US9062348B1 (en) 2015-06-23
DK2789696T3 (en) 2016-02-29
HK1200497A1 (en) 2015-08-07

Similar Documents

Publication Publication Date Title
PL2789696T3 (pl) Sposób wysoko przepustowej detekcji polimorfizmu opartej na AFLP
ZA200810140B (en) Detection Method
ZA200705549B (en) Fluorescence detection system
EP1974199A4 (en) DETECTION SYSTEM
GB0519968D0 (en) Object detection
GB0821683D0 (en) Spsis detection microarray
GB2442343B (en) Method for detecting small oligonucleotides
IL192459A0 (en) Method for detecting alkylating agents
ZA200710087B (en) Method for identifying guignardia citricarpa
GB0520527D0 (en) Automated method
GB2464222B (en) Analysis method
GB0624148D0 (en) Detection method
IL188695A0 (en) Method for evaluating drug candidates
GB0503244D0 (en) Method for separation
GB0624462D0 (en) Method for determining gentoxicity
GB0509898D0 (en) Analysis method
EP1926066A4 (en) METHOD FOR DETECTING MOBILITY OF CONDUCTIVE CONDUCTIVE OBJECTS
GB0514678D0 (en) Method for high-throughput screening
ZA200708154B (en) Nucleic acid detection
GB0501623D0 (en) Reaction method
GB0505089D0 (en) System and methods for detecting environmental conditions
GB0510916D0 (en) Detection system
GB0617730D0 (en) Analyte detection
GB2422970B (en) Detection apparatus
GB2432948B (en) Detection apparatus